JP2021534084A - ヒストンデメチラーゼ5阻害剤およびその使用 - Google Patents
ヒストンデメチラーゼ5阻害剤およびその使用 Download PDFInfo
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- JP2021534084A JP2021534084A JP2021505646A JP2021505646A JP2021534084A JP 2021534084 A JP2021534084 A JP 2021534084A JP 2021505646 A JP2021505646 A JP 2021505646A JP 2021505646 A JP2021505646 A JP 2021505646A JP 2021534084 A JP2021534084 A JP 2021534084A
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- 235000013337 tricalcium citrate Nutrition 0.000 description 1
- LADGBHLMCUINGV-UHFFFAOYSA-N tricaprin Chemical compound CCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCC)COC(=O)CCCCCCCCC LADGBHLMCUINGV-UHFFFAOYSA-N 0.000 description 1
- 229940066528 trichloroacetate Drugs 0.000 description 1
- YNJBWRMUSHSURL-UHFFFAOYSA-N trichloroacetic acid Chemical compound OC(=O)C(Cl)(Cl)Cl YNJBWRMUSHSURL-UHFFFAOYSA-N 0.000 description 1
- 229940117013 triethanolamine oleate Drugs 0.000 description 1
- KAKQVSNHTBLJCH-UHFFFAOYSA-N trifluoromethanesulfonimidic acid Chemical compound NS(=O)(=O)C(F)(F)F KAKQVSNHTBLJCH-UHFFFAOYSA-N 0.000 description 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 description 1
- VLPFTAMPNXLGLX-UHFFFAOYSA-N trioctanoin Chemical compound CCCCCCCC(=O)OCC(OC(=O)CCCCCCC)COC(=O)CCCCCCC VLPFTAMPNXLGLX-UHFFFAOYSA-N 0.000 description 1
- BZVJOYBTLHNRDW-UHFFFAOYSA-N triphenylmethanamine Chemical compound C=1C=CC=CC=1C(C=1C=CC=CC=1)(N)C1=CC=CC=C1 BZVJOYBTLHNRDW-UHFFFAOYSA-N 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- 229960005066 trisodium edetate Drugs 0.000 description 1
- 229910052722 tritium Inorganic materials 0.000 description 1
- 229960000281 trometamol Drugs 0.000 description 1
- 210000004881 tumor cell Anatomy 0.000 description 1
- WFKWXMTUELFFGS-UHFFFAOYSA-N tungsten Chemical compound [W] WFKWXMTUELFFGS-UHFFFAOYSA-N 0.000 description 1
- 229910052721 tungsten Inorganic materials 0.000 description 1
- 239000010937 tungsten Substances 0.000 description 1
- 229940094060 tykerb Drugs 0.000 description 1
- ZDPHROOEEOARMN-UHFFFAOYSA-N undecanoic acid Chemical compound CCCCCCCCCCC(O)=O ZDPHROOEEOARMN-UHFFFAOYSA-N 0.000 description 1
- 229930195735 unsaturated hydrocarbon Natural products 0.000 description 1
- 229940045136 urea Drugs 0.000 description 1
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- 229940070710 valerate Drugs 0.000 description 1
- ATCJTYORYKLVIA-SRXJVYAUSA-N vamp regimen Chemical compound O=C1C=C[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1.C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1.O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1.C([C@H](C[C@]1(C(=O)OC)C=2C(=CC3=C(C45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C=O)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 ATCJTYORYKLVIA-SRXJVYAUSA-N 0.000 description 1
- UHTHHESEBZOYNR-UHFFFAOYSA-N vandetanib Chemical compound COC1=CC(C(/N=CN2)=N/C=3C(=CC(Br)=CC=3)F)=C2C=C1OCC1CCN(C)CC1 UHTHHESEBZOYNR-UHFFFAOYSA-N 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 239000010679 vetiver oil Substances 0.000 description 1
- 229940061389 viadur Drugs 0.000 description 1
- 229960004528 vincristine Drugs 0.000 description 1
- OGWKCGZFUXNPDA-XQKSVPLYSA-N vincristine Chemical compound C([N@]1C[C@@H](C[C@]2(C(=O)OC)C=3C(=CC4=C([C@]56[C@H]([C@@]([C@H](OC(C)=O)[C@]7(CC)C=CCN([C@H]67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)C[C@@](C1)(O)CC)CC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-XQKSVPLYSA-N 0.000 description 1
- OGWKCGZFUXNPDA-UHFFFAOYSA-N vincristine Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(OC(C)=O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-UHFFFAOYSA-N 0.000 description 1
- CILBMBUYJCWATM-PYGJLNRPSA-N vinorelbine ditartrate Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O.OC(=O)[C@H](O)[C@@H](O)C(O)=O.C1N(CC=2C3=CC=CC=C3NC=22)CC(CC)=C[C@H]1C[C@]2(C(=O)OC)C1=CC([C@]23[C@H]([C@@]([C@H](OC(C)=O)[C@]4(CC)C=CCN([C@H]34)CC2)(O)C(=O)OC)N2C)=C2C=C1OC CILBMBUYJCWATM-PYGJLNRPSA-N 0.000 description 1
- LVLANIHJQRZTPY-UHFFFAOYSA-N vinyl carbamate Chemical compound NC(=O)OC=C LVLANIHJQRZTPY-UHFFFAOYSA-N 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
- 210000001835 viscera Anatomy 0.000 description 1
- BPQMGSKTAYIVFO-UHFFFAOYSA-N vismodegib Chemical compound ClC1=CC(S(=O)(=O)C)=CC=C1C(=O)NC1=CC=C(Cl)C(C=2N=CC=CC=2)=C1 BPQMGSKTAYIVFO-UHFFFAOYSA-N 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 239000011719 vitamin A Substances 0.000 description 1
- 235000019155 vitamin A Nutrition 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 229940045997 vitamin a Drugs 0.000 description 1
- 239000000341 volatile oil Substances 0.000 description 1
- WAEXFXRVDQXREF-UHFFFAOYSA-N vorinostat Chemical compound ONC(=O)CCCCCCC(=O)NC1=CC=CC=C1 WAEXFXRVDQXREF-UHFFFAOYSA-N 0.000 description 1
- 229940069559 votrient Drugs 0.000 description 1
- 201000005102 vulva cancer Diseases 0.000 description 1
- 208000028010 vulval Paget disease Diseases 0.000 description 1
- 239000008170 walnut oil Substances 0.000 description 1
- 239000010497 wheat germ oil Substances 0.000 description 1
- 239000002023 wood Substances 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
- 229940049068 xalkori Drugs 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 125000001834 xanthenyl group Chemical group C1=CC=CC=2OC3=CC=CC=C3C(C12)* 0.000 description 1
- 229940053867 xeloda Drugs 0.000 description 1
- 229940014556 xgeva Drugs 0.000 description 1
- 229940066799 xofigo Drugs 0.000 description 1
- 229940085728 xtandi Drugs 0.000 description 1
- 229940055760 yervoy Drugs 0.000 description 1
- 229940036061 zaltrap Drugs 0.000 description 1
- 229940033942 zoladex Drugs 0.000 description 1
- XRASPMIURGNCCH-UHFFFAOYSA-N zoledronic acid Chemical compound OP(=O)(O)C(P(O)(O)=O)(O)CN1C=CN=C1 XRASPMIURGNCCH-UHFFFAOYSA-N 0.000 description 1
- 229940061261 zolinza Drugs 0.000 description 1
- 229940002005 zometa Drugs 0.000 description 1
- 229940095188 zydelig Drugs 0.000 description 1
- 229940052129 zykadia Drugs 0.000 description 1
- 229940051084 zytiga Drugs 0.000 description 1
- 239000002076 α-tocopherol Substances 0.000 description 1
- 235000004835 α-tocopherol Nutrition 0.000 description 1
- OENHQHLEOONYIE-JLTXGRSLSA-N β-Carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-JLTXGRSLSA-N 0.000 description 1
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- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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Abstract
Description
本出願は、内容全体が参照により本明細書に組み込まれる、米国仮特許出願:2018年8月6日に出願されたU.S.S.N.62/715,122号、2018年8月7日に出願されたU.S.S.N.62/715,687号および2019年2月8日に出願されたU.S.S.N.62/803,332号に基づく米国特許法第119条(e)の下での優先権を主張するものである。
定義
あるいは炭素原子上の2個のジェミナル水素は、基=O、=S、=NN(Rbb)2、=NNRbbC(=O)Raa、=NNRbbC(=O)ORaa、=NNRbbS(=O)2Raa、=NRbbまたは=NORccで置き換えられており;
Raaの各例は独立に、C1〜10アルキル、C1〜10ペルハロアルキル、C2〜10アルケニル、C2〜10アルキニル、ヘテロC1〜10アルキル、ヘテロC2〜10アルケニル、ヘテロC2〜10アルキニル、C3〜10カルボシクリル、3〜14員ヘテロシクリル、C6〜14アリールおよび5〜14員ヘテロアリールから選択される、あるいは2つのRaa基は結合して、3〜14員ヘテロシクリルまたは5〜14員ヘテロアリール環を形成し;各アルキル、アルケニル、アルキニル、ヘテロアルキル、ヘテロアルケニル、ヘテロアルキニル、カルボシクリル、ヘテロシクリル、アリールおよびヘテロアリールは独立に、0、1、2、3、4または5個のRdd基で置換されており;
Rbbの各例は独立に、水素、−OH、−ORaa、−N(Rcc)2、−CN、−C(=O)Raa、−C(=O)N(Rcc)2、−CO2Raa、−SO2Raa、−C(=NRcc)ORaa、−C(=NRcc)N(Rcc)2、−SO2N(Rcc)2、−SO2Rcc、−SO2ORcc、−SORaa、−C(=S)N(Rcc)2、−C(=O)SRcc、−C(=S)SRcc、−P(=O)(Raa)2、−P(=O)(ORcc)2、−P(=O)(N(Rcc)2)2、C1〜10アルキル、C1〜10ペルハロアルキル、C2〜10アルケニル、C2〜10アルキニル、ヘテロC1〜10アルキル、ヘテロC2〜10アルケニル、ヘテロC2〜10アルキニル、C3〜10カルボシクリル、3〜14員ヘテロシクリル、C6〜14アリールおよび5〜14員ヘテロアリールから選択される、あるいは2つのRbb基は結合して、3〜14員ヘテロシクリルまたは5〜14員ヘテロアリール環を形成し、各アルキル、アルケニル、アルキニル、ヘテロアルキル、ヘテロアルケニル、ヘテロアルキニル、カルボシクリル、ヘテロシクリル、アリールおよびヘテロアリールは独立に、0、1、2、3、4または5個のRdd基で置換されており;X−は対イオンであり;
Rccの各例は独立に、水素、C1〜10アルキル、C1〜10ペルハロアルキル、C2〜10アルケニル、C2〜10アルキニル、ヘテロC1〜10アルキル、ヘテロC2〜10アルケニル、ヘテロC2〜10アルキニル、C3〜10カルボシクリル、3〜14員ヘテロシクリル、C6〜14アリールおよび5〜14員ヘテロアリールから選択される、あるいは2つのRcc基は結合して、3〜14員ヘテロシクリルまたは5〜14員ヘテロアリール環を形成し、各アルキル、アルケニル、アルキニル、ヘテロアルキル、ヘテロアルケニル、ヘテロアルキニル、カルボシクリル、ヘテロシクリル、アリールおよびヘテロアリールは独立に、0、1、2、3、4または5個のRdd基で置換されており;
Rddの各例は独立に、ハロゲン、−CN、−NO2、−N3、−SO2H、−SO3H、−OH、−ORee、−ON(Rff)2、−N(Rff)2、−N(Rff)3 +X−、−N(ORee)Rff、−SH、−SRee、−SSRee、−C(=O)Ree、−CO2H、−CO2Ree、−OC(=O)Ree、−OCO2Ree、−C(=O)N(Rff)2、−OC(=O)N(Rff)2、−NRffC(=O)Ree、−NRffCO2Ree、−NRffC(=O)N(Rff)2、−C(=NRff)ORee、−OC(=NRff)Ree、−OC(=NRff)ORee、−C(=NRff)N(Rff)2、−OC(=NRff)N(Rff)2、−NRffC(=NRff)N(Rff)2、−NRffSO2Ree、−SO2N(Rff)2、−SO2Ree、−SO2ORee、−OSO2Ree、−S(=O)Ree、−Si(Ree)3、−OSi(Ree)3、−C(=S)N(Rff)2、−C(=O)SRee、−C(=S)SRee、−SC(=S)SRee、−P(=O)(ORee)2、−P(=O)(Ree)2、−OP(=O)(Ree)2、−OP(=O)(ORee)2、C1〜6アルキル、C1〜6ペルハロアルキル、C2〜6アルケニル、C2〜6アルキニル、ヘテロC1〜6アルキル、ヘテロC2〜6アルケニル、ヘテロC2〜6アルキニル、C3〜10カルボシクリル、3〜10員ヘテロシクリル、C6〜10アリール、5〜10員ヘテロアリールから選択され、各アルキル、アルケニル、アルキニル、ヘテロアルキル、ヘテロアルケニル、ヘテロアルキニル、カルボシクリル、ヘテロシクリル、アリールおよびヘテロアリールは独立に、0、1、2、3、4または5個のRgg基で置換されている、あるいは2つのジェミナルRdd置換基は結合して、=Oまたは=Sを形成することができ;X−は対イオンであり;
Reeの各例は独立に、C1〜6アルキル、C1〜6ペルハロアルキル、C2〜6アルケニル、C2〜6アルキニル、ヘテロC1〜6アルキル、ヘテロC2〜6アルケニル、ヘテロC2〜6アルキニル、C3〜10カルボシクリル、C6〜10アリール、3〜10員ヘテロシクリおよび3〜10員ヘテロアリールから選択され、各アルキル、アルケニル、アルキニル、ヘテロアルキル、ヘテロアルケニル、ヘテロアルキニル、カルボシクリル、ヘテロシクリル、アリールおよびヘテロアリールは独立に、0、1、2、3、4または5個のRgg基で置換されており;
Rffの各例は独立に、水素、C1〜6アルキル、C1〜6ペルハロアルキル、C2〜6アルケニル、C2〜6アルキニル、ヘテロC1〜6アルキル、ヘテロC2〜6アルケニル、ヘテロC2〜6アルキニル、C3〜10カルボシクリル、3〜10員ヘテロシクリル、C6〜10アリールおよび5〜10員ヘテロアリールから選択される、あるいは2つのRff基は結合して、3〜10員ヘテロシクリルまたは5〜10員ヘテロアリール環を形成し、各アルキル、アルケニル、アルキニル、ヘテロアルキル、ヘテロアルケニル、ヘテロアルキニル、カルボシクリル、ヘテロシクリル、アリールおよびヘテロアリールは独立に、0、1、2、3、4または5個のRgg基で置換されており;
Rggの各例は独立に、ハロゲン、−CN、−NO2、−N3、−SO2H、−SO3H、−OH、−OC1〜6アルキル、−ON(C1〜6アルキル)2、−N(C1〜6アルキル)2、−N(C1〜6アルキル)3 +X−、−NH(C1〜6アルキル)2+X−、−NH2(C1〜6アルキル)+X−、−NH3 +X−、−N(OC1〜6アルキル)(C1〜6アルキル)、−N(OH)(C1〜6アルキル)、−NH(OH)、−SH、−SC1〜6アルキル、−SS(C1〜6アルキル)、−C(=O)(C1〜6アルキル)、−CO2H、−CO2(C1〜6アルキル)、−OC(=O)(C1〜6アルキル)、−OCO2(C1〜6アルキル)、−C(=O)NH2、−C(=O)N(C1〜6アルキル)2、−OC(=O)NH(C1〜6アルキル)、−NHC(=O)(C1〜6アルキル)、−N(C1〜6アルキル)C(=O)(C1〜6アルキル)、−NHCO2(C1〜6アルキル)、−NHC(=O)N(C1〜6アルキル)2、−NHC(=O)NH(C1〜6アルキル)、−NHC(=O)NH2、−C(=NH)O(C1〜6アルキル)、−OC(=NH)(C1〜6アルキル)、−OC(=NH)OC1〜6アルキル、−C(=NH)N(C1〜6アルキル)2、−C(=NH)NH(C1〜6アルキル)、−C(=NH)NH2、−OC(=NH)N(C1〜6アルキル)2、−OC(NH)NH(C1〜6アルキル)、−OC(NH)NH2、−NHC(NH)N(C1〜6アルキル)2、−NHC(=NH)NH2、−NHSO2(C1〜6アルキル)、−SO2N(C1〜6アルキル)2、−SO2NH(C1〜6アルキル)、−SO2NH2、−SO2C1〜6アルキル、−SO2OC1〜6アルキル、−OSO2C1〜6アルキル、−SOC1〜6アルキル、−Si(C1〜6アルキル)3、−OSi(C1〜6アルキル)3−C(=S)N(C1〜6アルキル)2、C(=S)NH(C1〜6アルキル)、C(=S)NH2、−C(=O)S(C1〜6アルキル)、C(=S)SC1〜6アルキル、−SC(=S)SC1〜6アルキル、−P(=O)(OC1〜6アルキル)2、−P(=O)(C1〜6アルキル)2、−OP(=O)(C1〜6アルキル)2、−OP(=O)(OC1〜6アルキル)2、C1〜6アルキル、C1〜6ペルハロアルキル、C2〜6アルケニル、C2〜6アルキニル、ヘテロC1〜6アルキル、ヘテロC2〜6アルケニル、ヘテロC2〜6アルキニル、C3〜10カルボシクリル、C6〜10アリール、3〜10員ヘテロシクリル、5〜10員ヘテロアリールである;あるいは2つのジェミナルRgg置換基は結合して、=Oまたは=Sを形成することができ;X−は対イオンである。
化合物
R1は、水素、場合により置換されたアルキル、または窒素保護基であり;
R1Bは、水素、場合により置換されたアルキル、場合により置換されたカルボシクリル、または窒素保護基であり;
R2の各例は独立に、場合により置換されたアルキルまたは窒素保護基であり;
R3の各例は独立に、ハロゲン、場合により置換されたアシル、場合により置換されたアルキル、場合により置換されたアルケニル、場合により置換されたアルキニル、場合により置換されたカルボシクリル、場合により置換されたヘテロシクリル、場合により置換されたアリール、場合により置換されたヘテロアリール、−CN、−SCN、−NO2、−N3、−ORA、−N(RB)2、または−SRAであり;
RAの各例は独立に、水素、場合により置換されたアシル、場合により置換されたアルキル、場合により置換されたアルケニル、場合により置換されたアルキニル、場合により置換されたカルボシクリル、場合により置換されたヘテロシクリル、場合により置換されたアリール、場合により置換されたヘテロアリール、酸素原子に結合している場合の酸素保護基、または硫黄原子に結合している場合の硫黄保護基であり;
RBの各例は独立に、水素、場合により置換されたアシル、場合により置換されたアルキル、場合により置換されたアルケニル、場合により置換されたアルキニル、場合により置換されたカルボシクリル、場合により置換されたヘテロシクリル、場合により置換されたアリール、場合により置換されたヘテロアリール、または窒素保護基である;あるいは、場合により、RBの2つの例は、これらの介在原子と一緒になって、置換もしくは非置換複素環式環または置換もしくは非置換ヘテロアリール環を形成し;
nは0、1、2または3であり;
zは0または1であり;
Xは−N(R1A)−または−O−であり;
Lは−C(R6)2−であり;
R6の各例は独立に、水素、ハロゲン、または場合により置換されたアルキルであり;
R1Aの各例は独立に、水素、場合により置換されたアシル、場合により置換されたアルキル、場合により置換されたカルボシクリル、または窒素保護基であり;
環
但し、Xが−N(R1A)−であり、zが0である場合、部分
但し、化合物は式:
が本明細書に記載される。
R4の各例は独立に、ハロゲン、場合により置換されたアルキル、場合により置換されたアルケニル、場合により置換されたアルキニル、場合により置換されたカルボシクリル、場合により置換されたヘテロシクリル、場合により置換されたアリール、場合により置換されたヘテロアリール、−CN、−SCN、−NO2、−N3、−ORA、−N(RB)2、または−SRAである、あるいは、場合により、R4の2つの例は、これらの介在原子と一緒になって、置換もしくは非置換炭素環式環、置換もしくは非置換アリール環、置換もしくは非置換複素環式環、または置換もしくは非置換ヘテロアリール環を形成し;
xは0、1、2、3、4または5であり;他の置換基R1、R1BおよびR2は本明細書で定義される通りである)
である。
R4の各例は独立に、場合により置換されたアルキル、場合により置換されたアルケニル、場合により置換されたアルキニル、場合により置換されたカルボシクリル、場合により置換されたヘテロシクリル、場合により置換されたアリール、場合により置換されたヘテロアリール、−ORA、−N(RB)2、または−SRAである、あるいは、場合により、R4の2つの例は、これらの介在原子と一緒になって、置換もしくは非置換炭素環式環、置換もしくは非置換アリール環、置換もしくは非置換複素環式環、または置換もしくは非置換ヘテロアリール環を形成し;
xは0、1、2、3、4または5であり;他の置換基R1、R1A、R1BおよびR2は本明細書で定義される通りである)
である。
R1は独立に、水素、場合により置換されたアルキル、または窒素保護基であり;
R1Bは独立に、水素、場合により置換されたアルキル、場合により置換されたカルボシクリル、または窒素保護基であり;
R2の各例は独立に、場合により置換されたアルキルまたは窒素保護基であり;
R3の各例は独立に、ハロゲン、場合により置換されたアシル、場合により置換されたアルキル、場合により置換されたアルケニル、場合により置換されたアルキニル、場合により置換されたカルボシクリル、場合により置換されたヘテロシクリル、場合により置換されたアリール、場合により置換されたヘテロアリール、−CN、−SCN、−NO2、−N3、−ORA、−N(RB)2、または−SRAであり;
RAの各例は独立に、水素、場合により置換されたアシル、場合により置換されたアルキル、場合により置換されたアルケニル、場合により置換されたアルキニル、場合により置換されたカルボシクリル、場合により置換されたヘテロシクリル、場合により置換されたアリール、場合により置換されたヘテロアリール、酸素原子に結合している場合の酸素保護基、または硫黄原子に結合している場合の硫黄保護基であり;
RBの各例は独立に、水素、場合により置換されたアシル、場合により置換されたアルキル、場合により置換されたアルケニル、場合により置換されたアルキニル、場合により置換されたカルボシクリル、場合により置換されたヘテロシクリル、場合により置換されたアリール、場合により置換されたヘテロアリール、または窒素保護基である;あるいは、場合により、RBの2つの例は、これらの介在原子と一緒になって、置換もしくは非置換複素環式環または置換もしくは非置換ヘテロアリール環を形成し;
nは0、1、2または3であり;
R7は水素または場合により置換されたアルキルである)
である。
一定の実施形態では、環
医薬組成物、キットおよび投与
リゾチニブ)、XELODA(カペシタビン)、XELOX、XGEVA(デノスマブ)、XOFIGO(二塩化ラジウム223)、XTANDI(エンザルタミド)、YERVOY(イピリムマブ)、ZALTRAP(ziv−アフリベルセプト)、ZELBORAF(ベムラフェニブ)、ZOLADEX(ゴセレリン酢酸塩)、ZOMETA(ゾレドロン酸)、ZYKADIA(セリチニブ)、ZYTIGA(アビラテロン酢酸エステル)、ENMD−2076、PCI−32765、AC220、ドビチニブ乳酸塩(TKI258、CHIR−258)、BIBW 2992(TOVOK(商標))、SGX523、PF−04217903、PF−02341066、PF−299804、BMS−777607、ABT−869、MP470、BIBF 1120(VARGATEF(登録商標))、AP24534、JNJ−26483327、MGCD265、DCC−2036、BMS−690154、CEP−11981、チボザニブ(AV−951)、OSI−930、MM−121、XL−184、XL−647および/またはXL228)、プロテアソーム阻害剤、mTOR阻害剤、オブリメルセン、ゲムシタビン、カルミノマイシン、ロイコボリン、ペメトレキセド、シクロホスファミド、ダカルバジン、プロカルビジン、プレドニゾロン、デキサメタゾン、カムパテシン(campathecin)、プリカマイシン、アスパラギナーゼ、アミノプテリン、メトプテリン、ポルフィロマイシン、メルファラン、ロイロシジン(leurosidine)、ロイロシン、クロラムブシル、トラベクテジン、プロカルバジン、ディスコデルモリド、カルミノマイシン、アミノプテリンおよびヘキサメチルメラミン、またはこれらの組み合わせである。一定の実施形態では、プロテアソーム阻害剤がボルテゾミブ(Velcade)である。一定の実施形態では、mTOR阻害剤がラパマイシンである。一定の実施形態では、mTOR阻害剤がテムシロリムス(CCI−779)である。一定の実施形態では、mTOR阻害剤がエベロリムス(RAD−001)である。一定の実施形態では、mTOR阻害剤がリダフォロリムスである。一定の実施形態では、mTOR阻害剤がAP23573(Ariad)である。一定の実施形態では、mTOR阻害剤がAZD8055(AstraZeneca)である。一定の実施形態では、mTOR阻害剤がBEZ235(Novartis)である。一定の実施形態では、mTOR阻害剤がBGT226(Norvartis)である。一定の実施形態では、mTOR阻害剤がXL765(Sanofi Aventis)である。一定の実施形態では、mTOR阻害剤がPF−4691502(Pfizer)である。一定の実施形態では、mTOR阻害剤がGDC0980(Genetech)である。一定の実施形態では、mTOR阻害剤がSF1126(Semafoe)である。一定の実施形態では、mTOR阻害剤がOSI−027(OSI)である。一定の実施形態では、追加の医薬品がイブルチニブである。一定の実施形態では、追加の医薬品がプロテインキナーゼ阻害剤である。一定の実施形態では、追加のプロテインキナーゼ阻害剤がチロシンプロテインキナーゼ阻害剤である。一定の実施形態では、追加の医薬品がヒストンデメチラーゼの結合剤または阻害剤である。一定の実施形態では、ヒストンデメチラーゼがKDMである。一定の実施形態では、KDMがKDM5である。一定の実施形態では、追加の医薬品がKDMの結合剤または阻害剤である。一定の実施形態では、追加の医薬品がKDM5の結合剤または阻害剤である。一定の実施形態では、追加の医薬品がブルトン型チロシンキナーゼ(BTK)の結合剤または阻害剤である。一定の実施形態では、追加の医薬品が、エピジェネティックまたは転写モジュレーター、有糸分裂阻害剤、ホルモン受容体モジュレーター、Hsp90阻害剤、糖質コルチコイド、全トランス型レチノイン酸、および分化を促進する他の薬剤からなる群から選択される。一定の実施形態では、本明細書に記載される化合物または医薬組成物が、それだけに限らないが、外科手術、放射線療法、移植、免疫療法および化学療法を含む抗がん治療と組み合わせて投与され得る。一定の実施形態では、移植が幹細胞移植である。一定の実施形態では、移植が骨髄移植である。一定の実施形態では、転写モジュレーターがDNAメチルトランスフェラーゼ阻害剤である。一定の実施形態では、転写モジュレーターがヒストンデアセチラーゼ阻害剤(HDAC阻害剤)である。一定の実施形態では、転写モジュレーターがリジンメチルトランスフェラーゼ阻害剤である。一定の実施形態では、有糸分裂阻害剤がタキサンである。一定の実施形態では、有糸分裂阻害剤がビンカアルカロイドである。一定の実施形態では、ホルモン受容体モジュレーターがエストロゲン受容体モジュレーターである。一定の実施形態では、ホルモン受容体モジュレーターがアンドロゲン受容体モジュレーターである。一定の実施形態では、細胞シグナル伝達経路阻害剤がチロシンプロテインキナーゼ阻害剤である。一定の実施形態では、タンパク質安定性のモジュレーターがプロテアソーム阻害剤である。
処置および使用の方法
実施例
実施例1.例示的な化合物のIC50.
表1.KDM5B alphascreen活性アッセイにおける例示的なKDM5阻害剤のIC50データ.
実施例3.例示的な化合物のCTGアッセイ.
実施例4.shRNA媒介ノックダウンによる多発性骨髄腫におけるKDM5Aの生物学的機能
レンチウイルスshRNA感染
細胞周期アッセイ
表4.各ベクターのRNAi ConsortiumクローンIDおよび標的配列.
実施例5.KDM5阻害剤の例示的な合成
スキーム1.PCK62の例示的な合成(JADA62)
実施例6.インビボマウス試験
表5.BLIイメージングからの正規化された全流束
等価物および範囲
Claims (57)
- 式(I)の化合物:
R1は、水素、場合により置換されたアルキル、または窒素保護基であり;
R1Bは、水素、場合により置換されたアルキル、場合により置換されたカルボシクリル、または窒素保護基であり;
R2の各例は独立に、場合により置換されたアルキルまたは窒素保護基であり;
R3の各例は独立に、ハロゲン、場合により置換されたアシル、場合により置換されたアルキル、場合により置換されたアルケニル、場合により置換されたアルキニル、場合により置換されたカルボシクリル、場合により置換されたヘテロシクリル、場合により置換されたアリール、場合により置換されたヘテロアリール、−CN、−SCN、−NO2、−N3、−ORA、−N(RB)2、または−SRAであり;
RAの各例は独立に、水素、場合により置換されたアシル、場合により置換されたアルキル、場合により置換されたアルケニル、場合により置換されたアルキニル、場合により置換されたカルボシクリル、場合により置換されたヘテロシクリル、場合により置換されたアリール、場合により置換されたヘテロアリール、酸素原子に結合している場合の酸素保護基、または硫黄原子に結合している場合の硫黄保護基であり;
RBの各例は独立に、水素、場合により置換されたアシル、場合により置換されたアルキル、場合により置換されたアルケニル、場合により置換されたアルキニル、場合により置換されたカルボシクリル、場合により置換されたヘテロシクリル、場合により置換されたアリール、場合により置換されたヘテロアリール、または窒素保護基である;あるいは、場合により、RBの2つの例は、これらの介在原子と一緒になって、置換もしくは非置換複素環式環または置換もしくは非置換ヘテロアリール環を形成し;
nは0、1、2または3であり;
zは0または1であり;
Xは−N(R1A)−または−O−であり;
Lは−C(R6)2−であり;
R6の各例は独立に、水素、ハロゲン、または場合により置換されたアルキルであり;
R1Aは、水素、場合により置換されたアシル、場合により置換されたアルキル、場合により置換されたカルボシクリル、または窒素保護基であり;
環
但し、Xが−N(R1A)−であり、zが0である場合、部分
但し、化合物は式:
- 式(I−A)の化合物:
各R4は独立に、ハロゲン、場合により置換されたアルキル、場合により置換されたアルケニル、場合により置換されたアルキニル、場合により置換されたカルボシクリル、場合により置換されたヘテロシクリル、場合により置換されたアリール、場合により置換されたヘテロアリール、−CN、−SCN、−NO2、−N3、−ORA、−N(RB)2、または−SRAである、あるいは、場合により、R4の2つの例は、これらの介在原子と一緒になって、置換もしくは非置換炭素環式環、置換もしくは非置換アリール環、置換もしくは非置換複素環式環、または置換もしくは非置換ヘテロアリール環を形成し;
xは0、1、2、3、4または5である)
である、請求項1に記載の化合物。 - 式(I−B)の化合物:
各R4は独立に、場合により置換されたアルキル、場合により置換されたアルケニル、場合により置換されたアルキニル、場合により置換されたカルボシクリル、場合により置換されたヘテロシクリル、場合により置換されたアリール、場合により置換されたヘテロアリール、−ORA、−N(RB)2、または−SRAである、あるいは、場合により、R4の2つの例は、これらの介在原子と一緒になって、置換もしくは非置換複素環式環、または置換もしくは非置換ヘテロアリール環を形成し;
xは0、1、2、3、4または5である)
である、請求項1に記載の化合物。 - R4の少なくとも1つの例が場合により置換されたアルケニルである、請求項2または3に記載の化合物、またはその薬学的に許容される塩、溶媒和物、水和物、多形、共結晶、互変異性体、立体異性体、同位体標識誘導体もしくはプロドラッグ。
- R4の少なくとも1つの例が−ORAであり、RAが水素、場合により置換されたC1〜6アルキル、または場合により置換されたアリールである、請求項2または3に記載の化合物、またはその薬学的に許容される塩、溶媒和物、水和物、多形、共結晶、互変異性体、立体異性体、同位体標識誘導体もしくはプロドラッグ。
- R4の少なくとも1つの例が−NHC(=O)Rxであり、Rxが場合により置換されたC1〜6アルキルまたは場合により置換されたアルケニルである、請求項2または3に記載の化合物、またはその薬学的に許容される塩、溶媒和物、水和物、多形、共結晶、互変異性体、立体異性体、同位体標識誘導体もしくはプロドラッグ。
- xが0である、請求項2、3または5から7のいずれか一項に記載の化合物、またはその薬学的に許容される塩、溶媒和物、水和物、多形、共結晶、互変異性体、立体異性体、同位体標識誘導体もしくはプロドラッグ。
- xが1である、請求項2、3または5から7のいずれか一項に記載の化合物、またはその薬学的に許容される塩、溶媒和物、水和物、多形、共結晶、互変異性体、立体異性体、同位体標識誘導体もしくはプロドラッグ。
- xが2である、請求項2、3または5から7のいずれか一項に記載の化合物、またはその薬学的に許容される塩、溶媒和物、水和物、多形、共結晶、互変異性体、立体異性体、同位体標識誘導体もしくはプロドラッグ。
- R1が水素である、請求項1から16のいずれか一項に記載の化合物、またはその薬学的に許容される塩、溶媒和物、水和物、多形、共結晶、互変異性体、立体異性体、同位体標識誘導体もしくはプロドラッグ。
- R1Bが場合により置換されたC1〜6アルキルである、請求項1から17のいずれか一項に記載の化合物、またはその薬学的に許容される塩、溶媒和物、水和物、多形、共結晶、互変異性体、立体異性体、同位体標識誘導体もしくはプロドラッグ。
- R1Bが非置換メチルまたは非置換エチルである、請求項18に記載の化合物、またはその薬学的に許容される塩、溶媒和物、水和物、多形、共結晶、互変異性体、立体異性体、同位体標識誘導体もしくはプロドラッグ。
- R1Bが場合により置換されたカルボシクリルである、請求項1から17のいずれか一項に記載の化合物、またはその薬学的に許容される塩、溶媒和物、水和物、多形、共結晶、互変異性体、立体異性体、同位体標識誘導体もしくはプロドラッグ。
- R1Bが非置換シクロプロピルである、請求項20に記載の化合物、またはその薬学的に許容される塩、溶媒和物、水和物、多形、共結晶、互変異性体、立体異性体、同位体標識誘導体もしくはプロドラッグ。
- R2の少なくとも1つの例が場合により置換されたC1〜6アルキルである、請求項1から21のいずれか一項に記載の化合物、またはその薬学的に許容される塩、溶媒和物、水和物、多形、共結晶、互変異性体、立体異性体、同位体標識誘導体もしくはプロドラッグ。
- R2の少なくとも1つの例が非置換メチルである、請求項22に記載の化合物、またはその薬学的に許容される塩、溶媒和物、水和物、多形、共結晶、互変異性体、立体異性体、同位体標識誘導体もしくはプロドラッグ。
- R2の両例が非置換メチルである、請求項22または23に記載の化合物、またはその薬学的に許容される塩、溶媒和物、水和物、多形、共結晶、互変異性体、立体異性体、同位体標識誘導体もしくはプロドラッグ。
- nが0である、請求項1または4から24のいずれか一項に記載の化合物、またはその薬学的に許容される塩、溶媒和物、水和物、多形、共結晶、互変異性体、立体異性体、同位体標識誘導体もしくはプロドラッグ。
- Xが−O−である、請求項1または4から25のいずれか一項に記載の化合物、またはその薬学的に許容される塩、溶媒和物、水和物、多形、共結晶、互変異性体、立体異性体、同位体標識誘導体もしくはプロドラッグ。
- Xが−NH−である、請求項1または4から25のいずれか一項に記載の化合物、またはその薬学的に許容される塩、溶媒和物、水和物、多形、共結晶、互変異性体、立体異性体、同位体標識誘導体もしくはプロドラッグ。
- 式(II)の化合物:
R1は水素、場合により置換されたアルキル、または窒素保護基であり;
R1Bは水素、場合により置換されたアルキル、場合により置換されたカルボシクリル、または窒素保護基であり;
R2の各例は独立に、場合により置換されたアルキルまたは窒素保護基であり;
R3の各例は独立に、ハロゲン、場合により置換されたアシル、場合により置換されたアルキル、場合により置換されたアルケニル、場合により置換されたアルキニル、場合により置換されたカルボシクリル、場合により置換されたヘテロシクリル、場合により置換されたアリール、場合により置換されたヘテロアリール、−CN、−SCN、−NO2、−N3、−ORA、−N(RB)2、または−SRAであり;
RAの各例は独立に、水素、場合により置換されたアシル、場合により置換されたアルキル、場合により置換されたアルケニル、場合により置換されたアルキニル、場合により置換されたカルボシクリル、場合により置換されたヘテロシクリル、場合により置換されたアリール、場合により置換されたヘテロアリール、酸素原子に結合している場合の酸素保護基、または硫黄原子に結合している場合の硫黄保護基であり;
RBの各例は独立に、水素、場合により置換されたアシル、場合により置換されたアルキル、場合により置換されたアルケニル、場合により置換されたアルキニル、場合により置換されたカルボシクリル、場合により置換されたヘテロシクリル、場合により置換されたアリール、場合により置換されたヘテロアリール、または窒素保護基である;あるいは、場合により、RBの2つの例は、これらの介在原子と一緒になって、置換もしくは非置換複素環式環または置換もしくは非置換ヘテロアリール環を形成し;
nは0、1、2または3であり;
R7は水素または場合により置換されたアルキルであり;
但し、化合物は式:
- 請求項1から30のいずれか一項に記載の化合物、またはその薬学的に許容される塩、溶媒和物、水和物、多形、共結晶、互変異性体、立体異性体、同位体標識誘導体もしくはプロドラッグと、場合により薬学的に許容される賦形剤とを含む医薬組成物。
- それを必要とする対象の増殖性疾患を処置するための、治療上有効量の前記化合物を含む、請求項31に記載の医薬組成物。
- それを必要とする対象の増殖性疾患を処置する方法であって、治療上有効量の請求項1から30のいずれか一項に記載の化合物、またはその薬学的に許容される塩、溶媒和物、水和物、多形、共結晶、互変異性体、立体異性体、同位体標識誘導体もしくはプロドラッグ、あるいは請求項31または32に記載の医薬組成物を前記対象に投与するステップを含む方法。
- 前記増殖性疾患が、がんである、請求項33に記載の方法。
- 前記がんが癌腫である、請求項34に記載の方法。
- 前記がんが肺がんである、請求項34に記載の方法。
- 前記肺がんが非小細胞肺がんである、請求項36に記載の方法。
- 前記がんが乳がんである、請求項34に記載の方法。
- 前記がんが肝臓がんである、請求項34に記載の方法。
- 前記がんが膵臓がんである、請求項34に記載の方法。
- 前記がんが胃がんである、請求項34に記載の方法。
- 前記がんが卵巣がんである、請求項34に記載の方法。
- 前記がんが結腸がんである、請求項34に記載の方法。
- 前記がんが白血病である、請求項34に記載の方法。
- 前記がんが肉腫である、請求項34に記載の方法。
- 前記肉腫がユーイング肉腫である、請求項45に記載の方法。
- 前記がんが多発性骨髄腫である、請求項34に記載の方法。
- それを必要とする対象のヒストンデメチラーゼを阻害する方法であって、
治療上有効量の請求項1から30のいずれか一項に記載の化合物、またはその薬学的に許容される塩、溶媒和物、水和物、多形、共結晶、互変異性体、立体異性体、同位体標識誘導体もしくはプロドラッグ、あるいは請求項31または32に記載の医薬組成物を前記対象に投与するステップ
を含む方法。 - 生物学的試料のヒストンデメチラーゼを阻害する方法であって、
前記生物学的試料を有効量の請求項1から30のいずれか一項に記載の化合物、またはその薬学的に許容される塩、溶媒和物、水和物、多形、共結晶、互変異性体、立体異性体、同位体標識誘導体もしくはプロドラッグ、あるいは請求項31または32に記載の医薬組成物と接触させるステップ
を含む方法。 - 前記ヒストンデメチラーゼがKDM5である、請求項48または49に記載の方法。
- 前記化合物、またはその薬学的に許容される塩、溶媒和物、水和物、多形、共結晶、互変異性体、立体異性体、同位体標識誘導体もしくはプロドラッグ、または前記医薬組成物と組み合わせた治療上有効量の追加の医薬品を前記対象に投与するステップをさらに含む、請求項33から47のいずれか一項に記載の方法。
- 前記生物学的試料を、前記化合物、またはその薬学的に許容される塩、溶媒和物、水和物、多形、共結晶、互変異性体、立体異性体、同位体標識誘導体もしくはプロドラッグ、または前記医薬組成物と組み合わせた追加の医薬品と接触させるステップをさらに含む、請求項49に記載の方法。
- 前記生物学的試料が細胞または組織である、請求項49に記載の方法。
- 前記追加の医薬品が抗増殖剤である、請求項50または51に記載の方法。
- それを必要とする対象の疾患を処置するための、請求項1から30のいずれか一項に記載の化合物、またはその薬学的に許容される塩、溶媒和物、水和物、多形、共結晶、互変異性体、立体異性体、同位体標識誘導体もしくはプロドラッグ、あるいは請求項31または32に記載の医薬組成物の使用。
- それを必要とする対象の疾患の処置に使用するための、請求項1から30のいずれか一項に記載の化合物、またはその薬学的に許容される塩、溶媒和物、水和物、多形、共結晶、互変異性体、立体異性体、同位体標識誘導体もしくはプロドラッグ、あるいは請求項31または32に記載の医薬組成物。
- 請求項1から30のいずれか一項に記載の化合物、またはその薬学的に許容される塩、溶媒和物、水和物、多形、共結晶、互変異性体、立体異性体、同位体標識誘導体もしくはプロドラッグ、あるいは請求項31または32に記載の医薬組成物と;
前記化合物、またはその薬学的に許容される塩、溶媒和物、水和物、互変異性体もしくは立体異性体、または前記医薬組成物を対象に投与する、あるいは細胞、組織または生物学的試料をこれと接触させるための説明書と
を含むキット。
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Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2015532295A (ja) * | 2012-10-02 | 2015-11-09 | エピセラピューティックス・エイ・ピー・エス | ヒストン脱メチル化酵素の阻害剤 |
JP2016509047A (ja) * | 2013-02-27 | 2016-03-24 | エピセラピューティクス アーペーエス | ヒストン脱メチル化酵素の阻害剤 |
JP2017512804A (ja) * | 2014-03-31 | 2017-05-25 | ギリアード サイエンシーズ, インコーポレイテッド | ヒストン脱メチル化酵素の阻害剤 |
JP2017526675A (ja) * | 2014-08-27 | 2017-09-14 | ギリアード サイエンシーズ, インコーポレイテッド | ヒストンデメチラーゼを阻害するための化合物および方法 |
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EP3833347A4 (en) | 2022-04-27 |
EP3833347A1 (en) | 2021-06-16 |
AU2019318046A1 (en) | 2021-01-14 |
US20230382865A1 (en) | 2023-11-30 |
WO2020033377A1 (en) | 2020-02-13 |
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