JP2021531314A - ピリドンa2rアンタゴニスト - Google Patents
ピリドンa2rアンタゴニスト Download PDFInfo
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- JP2021531314A JP2021531314A JP2021504283A JP2021504283A JP2021531314A JP 2021531314 A JP2021531314 A JP 2021531314A JP 2021504283 A JP2021504283 A JP 2021504283A JP 2021504283 A JP2021504283 A JP 2021504283A JP 2021531314 A JP2021531314 A JP 2021531314A
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Abstract
Description
本出願は、2018年7月27日に出願された米国仮出願第62/711,273号に対する優先権の利益を主張し、その開示内容は参照によりその全体が本明細書に組み込まれる。
該当なし。
添付書類の参照
該当なし。
本発明は、アデノシンA2A受容体(A2AR)及び/又はアデノシンA2B受容体(A2BR)を調節する化合物、及びこれらの化合物を含む組成物(例えば医薬組成物)に関する。これらの合成方法を含むそのような化合物及び組成物は、以下に詳細に記載される。
A2AR(ADORA2Aとも呼ばれる)は、Gタンパク質共役受容体(GPCR)であり、そのファミリーメンバーは7つの膜貫通アルファらせんを保有する。その結晶構造に基づいて、A2ARは他の構造決定されたGPCR(例えばベータ2アドレナリン受容体)とは異なるリガンド結合ポケットを含む。
A2bR(ADORA2Bとも呼ばれる)は、多くの異なる細胞型に見られるGPCRである。これは、活性化のために、他のアデノシン受容体サブタイプ(例えばA1R、A2AR、及びA3R)よりも高濃度のアデノシンを必要とする(Fredholm BB, et al. (2001) Biochem Pharmacol 61:443-448)。そのような状態は、例えば低酸素症が一般的に観察される腫瘍で見られる。他のアデノシン受容体サブタイプとは対照的に、A2BRは大量のアデノシン放出に関連する病態生理学的状態において重要な役割を果たす可能性がある。すなわちこのアデノシン受容体サブタイプの選択的遮断又は刺激は、他のアデノシン受容体サブタイプを介して媒介されるアデノシンの多くの重要な生理学的機能を妨害しない可能性がある。しかし、A2BRを介する阻害につながる経路は、完全には理解されていない。
G1は、N又はCR3aであり;
G2は、N又はCR3bであり;
R3aとR3bは、それぞれ独立してH又はC1-3アルキルであり;
R1aとR1bは、それぞれ独立して、
i)H、
ii)1〜3個のR5置換基で任意選択的に置換されたC1-8アルキル、
iii)1〜3個のR5置換基で任意選択的に置換された−X1−O−C1-8アルキル、
iv)−C(O)−R6、
v)1〜3個のR7置換基で任意選択的に置換されたY、及び
vi)1〜3個のR7置換基で任意選択的に置換された−X1−Yからなる群から選択されるか;又は
vii)R1aとR1bは、それらが結合している窒素とともに、1〜3個のR8置換基で任意選択的に置換された5〜6員のヘテロシクロアルキル環を形成し、ここで前記ヘテロシクロアルキルは、O、N、及びSからなる群から選択される0〜2個の追加のヘテロ原子環頂点を有し;
各Yは、C3-8シクロアルキル、又はO、N、及びSからなる群から選択される1〜3個のヘテロ原子環頂点を有する4〜6員のヘテロシクロアルキルであり:
R2とR4は、それぞれ独立してH又はC1-3アルキルであり;
各X1は、C1-6アルキレンであり;
各R5は、ヒドロキシル、C3-8シクロアルキル、フェニル、−O−フェニル、−C(O)ORa、及びオキソからなる群から独立して選択され;
各R6は、C1-8アルキル又はYであり、その各々は、ヒドロキシル、−O−フェニル、フェニル、及び−O−C1-8アルキルからなる群から選択される1〜3個の置換基で任意選択的に置換されており;
各R7は、C1-8アルキル、ヒドロキシル、−O−C1-8アルキル、オキソ、及びC(O)ORaからなる群から独立して選択され;
各R8は、C1-8アルキル、ヒドロキシル、及びオキソからなるから独立して選択され;
下付き文字nは、0、1、2、又は3であり;
各R9は、C1-8アルキル、−O−C1-8アルキル、−X1−O−C1-8アルキル、−O−X1−O−C1-8アルキル、−X1−O−X1−O−C1-8アルキル、−C(O)ORa、ハロゲン、シアノ、−NRbRc、Y、−X1−C3-8シクロアルキル、及び−X2−Zからなる群から独立して選択され、ここで、X2は、C1-6アルキレン、−C1-6アルキレン−O−、−C1-4アルキレン−O−C1-4アルキレン、−C(O)−、及び−S(O)2−からなる群から選択され、Zは、O、N、及びSからなる群から選択される1〜3個のヘテロ原子環頂点を有する4〜6員のヘテロシクロアルキルであり、ここで、前記R9置換基の各々は、1〜3個のR11で任意選択的に置換され;
R10a、R10b、R10c、及びR10dの各々は、H、C1-8アルキル、ハロ、シアノ、−O−C1-8アルキル、−X1−O−C1-8アルキル、−O−X1−O−C1-8アルキル、−S(O)2−C1-6アルキル、−C(O)NRdRe、及びO、N、及びSからなる群から選択される1〜3個のヘテロ原子環頂点を有する4〜6員のヘテロアリールからなる群から独立して選択され、ここで、前記R10a~d置換基の各々は、1〜3個のR12で任意選択的に置換されるか、又は隣接する環頂点上のR10a、R10b、R10c、及びR10dのうちの2つは、任意選択的に組み合わさって、1〜2個のハロゲンで任意選択的に置換された5員複素環を形成し;
各R11は、ヒドロキシル、オキソ、ハロ、シアノ、−NRdRe、−C(O)ORa、フェニル、C3-8シクロアルキル、及びC(O)ORaで任意選択に置換されたC1-4アルキルからなる群から独立して選択され;
各R12は、ハロ、シアノ、ヒドロキシ、−C(O)ORaからなる群から独立して選択され;そして
各Raは、H又はC1-6アルキルであり;
各RbとRcは、H、C1-8アルキル、−S(O)2−C1-6アルキル、−C(O)ORa、及び−X1−C(O)ORaからなる群から独立して選択され;そして
各Rd及びReは、H、C1-8アルキル、−S(O)2−C1-6アルキルからなる群から独立して選択される。
本発明をさらに説明する前に、本発明が本明細書に記載の特定の実施態様に限定されず、本明細書で使用される用語が、特定の実施態様を説明することのみを目的としており、決して本発明を現地することを意図したものではないことを理解されたい。
本明細書において、例えばアデノシンA2A受容体(A2AR)及び/又はアデノシンA2B受容体(A2BR)を阻害するための化合物及び組成物、並びにこれらを含む医薬組成物が提供される。また本明細書において、例えばアデノシンA2A受容体(A2AR)及び/又はアデノシンA2B受容体(A2BR)の阻害により媒介される、疾患、障害、若しくは状態、又はこれらの症状を治療又は予防するための方法が提供される。
他に明記しない限り、以下の用語は、以下に記載される意味を有することを意図している。その他の用語は、本明細書の別の場所で定義されている。
多形は、さまざまな温度と圧力での安定性に応じて、2つのタイプのいずれかに分類できる。モノトロピックシステムでは、1つの多形(すなわちモノトロープ)のみが安定しており、融点より低いすべての温度と圧力で、より低い自由エネルギー含量と溶解度を示す。エナンチオトロピックシステムでは、1つの多形は特定の温度と圧力では安定であるが、他の多形はさまざまな温度と圧力で安定である。
上記のように、本発明の化合物がその活性を示す根本的な作用機序の正確な理解は、本発明を実施するために必要とされないが、化合物(又はそのサブセット)は、アデノシンA2A受容体(A2AR)及び/又はアデノシンA2B受容体(A2BR)を阻害すると考えられる。あるいは、化合物(又はそのサブセット)は、アデニル酸シクラーゼ機能を阻害し得る。化合物(又はそのサブセット)はまた、A2A受容体(A2AR)、アデノシンA2B受容体(A2BR)、並びにアデニル酸シクラーゼに対して阻害活性を有し得る。本発明の化合物は、本明細書では一般にアデノシンA2A受容体(A2AR)阻害剤及び/又はアデノシンA2B受容体(A2BR)阻害剤と呼ばれるが、「A2AR/A2BR阻害剤」という用語は、A2AR、A2BR、又はアデニリルシクラーゼの阻害を介して個別に作用する化合物、及び/又はA2AR、A2BR、及びアデニリルシクラーゼの阻害を介して作用する化合物を包含することを理解されたい。
本発明は、一部は、治療に関連する少なくとも1つの特性又は特徴を有するアデノシンA2A受容体及び/又はアデノシンA2B受容体の阻害剤の同定に関する。候補阻害剤は、例えば当技術分野で認められたアッセイ又はモデルを使用することにより同定することができ、その例は本明細書に記載されている。
1つの特定の態様において、本明細書で提供されるのは、式(I)を有する化合物:
G1は、N又はCR3aであり;
G2は、N又はCR3bであり;
R3aとR3bは、それぞれ独立してH又はC1-3アルキルであり;
R1aとR1bは、それぞれ独立して、
i)H、
ii)1〜3個のR5置換基で任意選択的に置換されたC1-8アルキル、
iii)1〜3個のR5置換基で任意選択的に置換された−X1−O−C1-8アルキル、
iv)−C(O)−R6、
v)1〜3個のR7置換基で任意選択的に置換されたY、及び
vi)1〜3個のR7置換基で任意選択的に置換された−X1−Yから成る群から選択されるか;又は
vii)R1aとR1bは、それらが結合している窒素とともに、1〜3個のR8置換基で任意選択的に置換された5〜6員のヘテロシクロアルキル環を形成し、ここで前記ヘテロシクロアルキルは、O、N、及びSからなる群から選択される0〜2個の追加のヘテロ原子環頂点を有し;
各Yは、C3-8シクロアルキル、又はO、N、及びSからなる群から選択される1〜3個のヘテロ原子環頂点を有する4〜6員のヘテロシクロアルキルであり:
R2とR4は、それぞれ独立してH又はC1-3アルキルであり;
各X1は、C1-6アルキレンであり;
各R5は、ヒドロキシル、C3-8シクロアルキル、フェニル、−O−フェニル、−C(O)ORa、及びオキソからなる群から独立して選択され;
各R6は、C1-8アルキル又はYであり、その各々は、ヒドロキシル、−O−フェニル、フェニル、及び−O−C1-8アルキルからなる群から選択される1〜3個の置換基で任意選択的に置換されており;
各R7は、C1-8アルキル、ヒドロキシル、−O−C1-8アルキル、オキソ、及びC(O)ORaからなる群から独立して選択され;
各R8は、C1-8アルキル、ヒドロキシル、及びオキソからなるから独立して選択され;
下付き文字nは、0、1、2、又は3であり;
各R9は、C1-8アルキル、−O−C1-8アルキル、−X1−O−C1-8アルキル、−O−X1−O−C1-8アルキル、−X1−O−X1−O−C1-8アルキル、−C(O)ORa、ハロゲン、シアノ、−NRbRc、Y、−X1−C3-8シクロアルキル、及び−X2−Zからなる群から独立して選択され、ここで、X2は、C1-6アルキレン、−C1-6アルキレン−O−、−C1-4アルキレン−O−C1-4アルキレン、−C(O)−、及び−S(O)2−からなる群から選択され、Zは、O、N、及びSからなる群から選択される1〜3個のヘテロ原子環頂点を有する4〜6員のヘテロシクロアルキルであり、ここで、前記R9置換基の各々は、1〜3個のR11で任意選択的に置換され;
R10a、R10b、R10c、及びR10dの各々は、C1-8アルキル、ハロ、シアノ、−O−C1-8アルキル、−X1−O−C1-8アルキル、−O−X1−O−C1-8アルキル、−S(O)2−C1-6アルキル、−C(O)NRdRe、及びO、N、及びSからなる群から選択される1〜3個のヘテロ原子環頂点を有する4〜6員のヘテロアリールからなる群から独立して選択され、ここで、前記R10a~d置換基の各々は、1〜3個のR12で任意選択的に置換されるか、又は隣接する環頂点上のR10a、R10b、R10c、及びR10dのうち2つは、任意選択的に組み合わさって、1〜2個のハロゲンで任意選択的に置換された5員複素環を形成し;
各R11は、ヒドロキシル、オキソ、ハロ、シアノ、−NRdRe、−C(O)ORa、フェニル、C3-8シクロアルキル、及びC(O)ORaで任意選択に置換されたC1-4アルキルからなる群から独立して選択され;
各R12は、ハロ、シアノ、ヒドロキシ、−C(O)ORaからなる群から独立して選択され;そして
各Raは、H又はC1-6アルキルであり;
各RbとRcは、H、C1-8アルキル、−S(O)2−C1-6アルキル、−C(O)ORa、及び−X1−C(O)ORaからなる群から独立して選択され;そして
各Rd及びReは、H、C1-8アルキル、−S(O)2−C1-6アルキルからなる群から独立して選択される]。
一般に、本明細書で提供される化合物は、以下の実施例に記載されるような従来の方法により調製することができる。
本発明のいくつかの態様において、本明細書に記載の化合物はプロドラッグの形態で投与される。
本明細書に開示される治療様式及び/又はそれらが施される方法の1つ以上の物理的特性を改善することは、しばしば有益であり、時には必須である。物理的特性の改善には、例えば水溶性、生物学的利用能、血清半減期、及び/又は治療的半減期を増加させるか、及び/又は生物活性を調節する方法が含まれる。
本発明は、広範囲の疾患、障害、及び/又は状態、及び/又はこれらの症状の治療又は予防における、本明細書に記載のA2AR/A2BR阻害剤の使用を企図する。以下、特定の使用について詳細に説明するが、本発明はそれらにより限定されないことを理解されたい。さらに、特定の疾患、障害、及び状態の一般的なカテゴリーが以下に記載されているが、いくつかの疾患、障害、及び状態は、複数のカテゴリーのメンバーであり、他は、開示されたカテゴリーのいずれのメンバーでもない可能性がある。
本発明のA2AR/A2BR阻害剤は、被験体への投与に適した組成物の形態であり得る。一般にそのような組成物は、A2AR/A2BR阻害剤と、1種以上の医薬的に許容し得るか又は生理学的に許容し得る希釈剤、担体、又は賦形剤とを含む「医薬組成物」である。特定の実施態様において、A2AR/A2BR阻害剤は、治療的に許容し得る量で存在する。医薬組成物は、本発明の方法で使用することができる。すなわち、例えば医薬組成物は、エクスビボ又はインビボで被験体に投与して、本明細書に記載の治療的及び予防的方法及び使用を実施することができる。
本発明は、任意の適切な方法によるA2AR/A2BR阻害剤及びその組成物の投与を企図する。適切な投与経路には、経口、非経口(例えば筋肉内、静脈内、皮下(例えば注射又はインプラント)、腹腔内、大槽内、関節内、腹腔内、脳内(実質内)及び脳室内)、鼻内、膣内、舌下、眼内、直腸内、局所(例えば皮下)、頬、及び吸入が含まれる。一般に皮下又は筋肉内に投与されるデポ注射もまた、定義された期間にわたって、本明細書に開示されるA2AR/A2BR阻害剤を放出するために利用し得る。
本発明は、A2AR/A2BR阻害剤を単独で、又は1種以上の活性治療薬と組み合わせて使用することを企図している。追加の活性治療薬は、小さな化学分子;タンパク質、抗体、ペプチド体、ペプチド、DNA、RNAなどの巨大分子、又はそのような巨大分子の断片;又は細胞又は遺伝子治療薬でもよい。このような併用療法では、さまざまな活性薬剤が、異なる補完的な作用機序を持っていることがよくある。そのような併用療法は、1種以上の薬剤の用量を減らすことを可能にし、それにより1種以上の薬剤に関連する有害作用を低減又は排除するため、特に有利であり得る。さらに、そのような併用療法は、基礎疾患、障害、又は状態に対して相乗的な治療又は予防効果をもたらす可能性がある。
本発明のA2AR/A2BR阻害剤は、例えば投与の目的(例えば所望の治療程度);製剤が投与される被験体の年齢、体重、性別、及び健康と体調;投与経路;及びその疾患、障害、状態、又は症状の性質に依存する量で、被験体に投与することができる。投薬計画はまた、投与されている薬剤に関連する副作用の存在、性質、及び程度を考慮に入れる場合がある。有効な投与量及び投与計画は、例えば安全性及び用量漸増試験、インビボ試験(例えば動物モデル)、及び当業者に知られている他の方法から容易に決定することができる。
本発明はまた、本明細書に記載の化合物及びその医薬組成物を含むキットを企図する。キットは、一般に、以下に説明するように、様々な成分を収容する物理的構造物の形態であり、例えば上記の方法を実施する際に利用することができる。
以下の実施例は、当業者に、本発明の製造及び使用方法の完全な開示及び説明を提供するために提示されており、本発明者らが本発明者らの発明であると考える範囲を限定することを意図するものではなく、それらは、以下の実験が実行されたこと、又は実行され得るすべての実験であることを示すことを意図するものでもない。現在形で書かれた例示的な記述は、必ずしも実行されたわけではなく、記述は、本明細書に記述された性質のデータなどを生成するために実行され得ることを、理解されたい。使用される数値(量、温度など)に関して正確さを確保するための努力が払われているが、いくつかの実験誤差と偏差は考慮しなければならない。
示された場合には、以下の一般的な材料及び方法が使用されたか、又は以下の実施例で使用され得る:
当業者は、特許請求の範囲に示される分子を調製するために種々の方法が利用可能であることを認識するであろう。一般に、特許請求の範囲に示される化合物を合成するための有用な方法は4つの部分からなり、これらは任意の順序で行うことができる:
実施例1
3−{[4−(2−アミノ−8−メトキシ−4−キナゾリニル)−1H−1,2,3−トリアゾール−1−イル]メチル}−1−イソプロピル−1H−ピリジン−2−オン
実施例2
3−{[4−(2−アミノ−8−メトキシ−4−キナゾリニル)−1H−1,2,3−トリアゾール−1−イル]メチル}−1−メチル−1H−ピリジン−2−オン
実施例3
3−{[4−(2−アミノ−8−メトキシ−4−キナゾリニル)−1H−1,2,3−トリアゾール−1−イル]メチル}−1−エチル−1H−ピリジン−2−オン
実施例4
3−{[4−(2−アミノ−8−メトキシ−4−キナゾリニル)−1H−1,2,3−トリアゾール−1−イル]メチル}−1−(シクロプロピルメチル)−1H−ピリジン− 2−オン
実施例5
3−{[4−(2−アミノ−8−メトキシ−4−キナゾリニル)−1H−1,2,3−トリアゾール−1−イル]メチル}−1−(2−ヒドロキシ−2−メチルプロピル)−1H−ピリジン−2−オン
実施例6
3−{[4−(2−アミノ−8−メトキシ−4−キナゾリニル)−1H−1,2,3−トリアゾール−1−イル]メチル}−1−(2−メトキシ−1−メチルエチル)−1H−ピリジン−2−オン
実施例7
3−{[4−(2−アミノ−8−メトキシ−4−キナゾリニル)−1H−1,2,3−トリアゾール−1−イル]メチル}−1−(2−ヒドロキシ−1,2−ジメチルプロピル)−1H−ピリジン−2−オン
実施例8
3−{[4−(2−アミノ−8−メトキシ−4−キナゾリニル)−1H−1,2,3−トリアゾール−1−イル]メチル}−1−シクロプロピル−1H−ピリジン−2−オン
実施例9
3−{[4−(2−アミノ−8−メトキシ−4−キナゾリニル)−1H−1,2,3−トリアゾール−1−イル]メチル}−1−(テトラヒドロ−2H−ピラン−4−イル)−1H−ピリジン−2−オン
実施例10
3−{[4−(2−アミノ−8−メトキシ−4−キナゾリニル)−1H−1,2,3−トリアゾール−1−イル]メチル}−1−(2−メトキシエチル)−1H−ピリジン−2−オン
実施例11
3−{[4−(2−アミノ−8−メトキシ−4−キナゾリニル)−1H−1,2,3−トリアゾール−1−イル]メチル}−1−[(テトラヒドロ−2H−ピラン−4−イル)メチル]−1H−ピリジン−2−オン
実施例12
3−{[4−(2−アミノ−8−エトキシ−4−キナゾリニル)−1H−1,2,3−トリアゾール−1−イル]メチル}−1−イソプロピル−1H−ピリジン−2−オン
実施例13
3−{[4−(2−アミノ−8−メチル−4−キナゾリニル)−1H−1,2,3−トリアゾール−1−イル]メチル}−1−イソプロピル−1H−ピリジン−2−オン
実施例14
3−{[4−(2−アミノ−8−フルオロ−4−キナゾリニル)−1H−1,2,3−トリアゾール−1−イル]メチル}−1−イソプロピル−1H−ピリジン−2−オン
実施例15
3−{[4−(2−アミノ−8−クロロ−4−キナゾリニル)−1H−1,2,3−トリアゾール−1−イル]メチル}−1−イソプロピル−1H−ピリジン−2−オン
実施例16
3−{[4−(2−アミノ−7−メトキシ−4−キナゾリニル)−1H−1,2,3−トリアゾール−1−イル]メチル}−1−イソプロピル−1H−ピリジン−2−オン
実施例17
3−{[4−(2−アミノ−7−フルオロ−8−メトキシ−4−キナゾリニル)−1H−1,2,3−トリアゾール−1−イル]メチル}−1−イソプロピル−1H−ピリジン−2−オン
実施例18
3−{[4−(2−アミノ−6−フルオロ−8−メトキシ−4−キナゾリニル)−1H−1,2,3−トリアゾール−1−イル]メチル}−1−イソプロピル−1H−ピリジン−2−オン
実施例19
1−[(R)−1−(テトラヒドロ−2H−ピラン−4−イル)エチル]−3−{[4−(2−アミノ−8−メトキシ−4−キナゾリニル)−1H−1,2,3−トリアゾール−1−イル]メチル}−1H−ピリジン−2−オン
実施例20
1−[(S)−1−(テトラヒドロ−2H−ピラン−4−イル)エチル]−3−{[4−(2−アミノ−8−メトキシ−4−キナゾリニル)−1H−1,2,3−トリアゾール−1−イル]メチル}−1H−ピリジン−2−オン
実施例21
3−{[4−(2−アミノ−8−メトキシ−4−キナゾリニル)−1H−1,2,3−トリアゾール−1−イル]メチル}−1−(シス−4−ヒドロキシシクロヘキシル)−1H−ピリジン−2−オン
実施例22
3−{[4−(2−アミノ−8−メトキシ−4−キナゾリニル)−1H−1,2,3−トリアゾール−1−イル]メチル}−1−(トランス−4−ヒドロキシシクロヘキシル)−1H−ピリジン−2−オン
実施例23
1−[(R)−2−メトキシ−1−メチルエチル]−3−{[4−(2−アミノ−8−メトキシ−4−キナゾリニル)−1H−1,2,3−トリアゾール−1−イル]メチル}−1H−ピリジン−2−オン
実施例24
3−{[4−(2−アミノ−8−メトキシ−4−キナゾリニル)−1H−1,2,3−トリアゾール−1−イル]メチル}−1−シクロペンチル−1H−ピリジン−2−オン
実施例25
1−[(S)−2−ヒドロキシ−1,2−ジメチルプロピル]−3−{[4−(2−アミノ−6−フルオロ−8−メトキシ−4−キナゾリニル)−1H−1,2,3−トリアゾール−1−イル]メチル}−1H−ピリジン−2−オン
実施例26
1−[(S)−2−ヒドロキシ−1,2−ジメチルプロピル]−3−{[4−(2−アミノ−8−メトキシ−4−キナゾリニル)−1H−1,2,3−トリアゾール−1−イル]メチル}−1H−ピリジン−2−オン
実施例27
1−[(R)−2−ヒドロキシ−1,2−ジメチルプロピル]−3−{[4−(2−アミノ−8−メトキシ−4−キナゾリニル)−1H−1,2,3−トリアゾール−1−イル]メチル}−1H−ピリジン−2−オン
実施例28
1−[(S)−1−シクロプロピルエチル]−3−{[4−(2−アミノ−8−メトキシ−4−キナゾリニル)−1H−1,2,3−トリアゾール−1−イル]メチル}−1H−ピリジン−2−オン
実施例29
1−[(R)−テトラヒドロフル−3−イル]−3−{[4−(2−アミノ−8−メトキシ−4−キナゾリニル)−1H−1,2,3−トリアゾール−1−イル]メチル}−1H−ピリジン−2−オン
実施例30
1−[(S)−2−メトキシ−1−メチルエチル]−3−{[4−(2−アミノ−8−メトキシ−4−キナゾリニル)−1H−1,2,3−トリアゾール−1−イル]メチル}−1H−ピリジン−2−オン
実施例31
1−[(R)−1−(テトラヒドロ−2H−ピラン−4−イル)エチル]−3−{[4−(2−アミノ−6−フルオロ−8−メトキシ−4−キナゾリニル)−1H−1,2,3−トリアゾール−1−イル]メチル}−1H−ピリジン−2−オン
実施例32
1−[(S)−テトラヒドロ−2H−ピラン−3−イル]−3−{[4−(2−アミノ−8−メトキシ−4−キナゾリニル)−1H−1,2,3−トリアゾール−1−イル]メチル}−1H−ピリジン−2−オン
実施例33
1−[(R)−テトラヒドロ−2H−ピラン−3−イル]−3−{[4−(2−アミノ−8−メトキシ−4−キナゾリニル)−1H−1,2,3−トリアゾール−1−イル]メチル}−1H−ピリジン−2−オン
実施例34
1−[(R)−1−(2−ヒドロキシ−2−メチルプロピオニル)−3−ピロリジニル]−3−{[4−(2−アミノ−8−メトキシ−4−キナゾリニル)−1H−1,2,3−トリアゾール−1−イル]メチル}−1H−ピリジン−2−オン
実施例35
1−[(S)−テトラヒドロフル−3−イル]−3−{[4−(2−アミノ−8−メトキシ−4−キナゾリニル}−1H−1,2,3−トリアゾール−1−イル]メチル}−1H−ピリジン−2−オン
実施例36
1−[(S)−1−(1−ヒドロキシシクロプロピル)エチル]−3−{[4−(2−アミノ−8−メトキシ−4−キナゾリニル)−1H−1,2,3−トリアゾール−1−イル]メチル}−1H−ピリジン−2−オン
実施例37
1−[(S)−1−(2−ヒドロキシ−2−メチルプロピオニル)−3−ピロリジニル]−3−{[4−(2−アミノ−8−メトキシ−4−キナゾリニル)−1H−1,2,3−トリアゾール−1−イル]メチル}−1H−ピリジン−2−オン
実施例38
3−{[4−(2−アミノ−8−フルオロ−4−キノリル)−1H−1,2,3−トリアゾール−1−イル]メチル}−1−イソプロピル−1H−ピリジン−2−オン
実施例39
3−{[4−(2−アミノ−8−メトキシ−4−キナゾリニル)−1H−ピラゾール−1−イル]メチル}−1−イソプロピル−1H−ピリジン−2−オン
実施例40
3−{[4−(2−アミノ−8−メトキシ−4−キナゾリニル)−1H−ピラゾール−1−イル]メチル}−1−エチル−1H−ピリジン−2−オン
実施例41
3−{[4−(2−アミノ−8−メトキシ−4−キナゾリニル)−1H−ピラゾール−1−イル]メチル}−1−シクロプロピル−1H−ピリジン−2−オン
実施例42
1−[(R)−1−(テトラヒドロ−2H−ピラン−4−イル)エチル]−3−{[4−(2−アミノ−8−メトキシ−4−キナゾリニル)−1H−ピラゾール−1−イル]メチル}−1H−ピリジン−2−オン
実施例43
3−{[4−(2−アミノ−8−メトキシ−4−キノリル)−1H−1,2,3−トリアゾール−1−イル]メチル}−1−イソプロピル−1H−ピリジン−2−オン
LC:Agilent 1100シリーズ;質量分析計:Agilent G6120BA、シングルクワッド
ヒト2Aアデノシン受容体(A2aR)CHO−TREx cAMP機能アッセイを使用する化合物のアデノシン受容体活性の測定
cAMPアンタゴニスト機能アッセイ(Perkin Elmer)を、ヒトA2ARを発現するように誘導されたCHO−T−REx細胞で実施した。細胞を白色の384ウェルOptiプレートに、ウェルあたり1,000〜2,500細胞の密度で接種した後、さまざまな濃度の化合物(1μM〜0μMの範囲)と37℃で1時間インキュベートした。
ヒトアデノシン2B受容体(A2BR:カタログ番号M000329、GenScript)を安定して発現するCHO−K1細胞を、GenScript Inc., Piscataway, NJ 08854, USA から購入した。
Claims (39)
- 式(I)で表される化合物
G1は、N又はCR3aであり;
G2は、N又はCR3bであり;
R3aとR3bは、それぞれ独立してH又はC1-3アルキルであり;
R1aとR1bは、それぞれ独立して、
i)H、
ii)1〜3個のR5置換基で任意選択的に置換されたC1-8アルキル、
iii)1〜3個のR5置換基で任意選択的に置換された−X1−O−C1-8アルキル、
iv)−C(O)−R6、
v)1〜3個のR7置換基で任意選択的に置換されたY、
vi)1〜3個のR7置換基で任意選択的に置換された−X1−Yから成る群から選択され;かつ
vii)R1aとR1bは、それらが結合している窒素とともに、1〜3個のR8置換基で任意選択的に置換された5〜6員のヘテロシクロアルキル環を形成し、ここで前記ヘテロシクロアルキルは、O、N、及びSからなる群から選択される0〜2個の追加のヘテロ原子環頂点を有し;
各Yは、C3-8シクロアルキル、又はO、N、及びSからなる群から選択される1〜3個のヘテロ原子環頂点を有する4〜6員のヘテロシクロアルキルであり:
R2とR4は、それぞれ独立してH又はC1-3アルキルであり;
各X1は、C1-6アルキレンであり;
各R5は、ヒドロキシル、C3-8シクロアルキル、フェニル、−O−フェニル、−C(O)ORa、及びオキソからなる群から独立して選択され;
各R6は、C1-8アルキル又はYであり、その各々は、ヒドロキシル、−O−フェニル、フェニル、及び−O−C1-8アルキルからなる群から選択される1〜3個の置換基で任意選択的に置換されており;
各R7は、C1-8アルキル、ヒドロキシル、−O−C1-8アルキル、オキソ、及びC(O)ORaからなる群から独立して選択され;
各R8は、C1-8アルキル、ヒドロキシル、及びオキソからなるから独立して選択され;
下付き文字nは、0、1、2、又は3であり;
各R9は、C1-8アルキル、−O−C1-8アルキル、−X1−O−C1-8アルキル、−O−X1−O−C1-8アルキル、−X1−O−X1−O−C1-8アルキル、−C(O)ORa、ハロゲン、シアノ、−NRbRc、Y、−X1−C3-8シクロアルキル、及び−X2−Zからなる群から独立して選択され、ここで、X2は、C1-6アルキレン、−C1-6アルキレン−O−、−C1-4アルキレン−O−C1-4アルキレン、−C(O)−、及び−S(O)2−からなる群から選択され、Zは、O、N、及びSからなる群から選択される1〜3個のヘテロ原子環頂点を有する4〜6員のヘテロシクロアルキルであり、ここで、前記R9置換基の各々は、1〜3個のR11で任意選択的に置換され;
R10a、R10b、R10c、及びR10dの各々は、H、C1-8アルキル、ハロ、シアノ、−O−C1-8アルキル、−X1−O−C1-8アルキル、−O−X1−O−C1-8アルキル、−S(O)2−C1-6アルキル、−C(O)NRdRe、及びO、N、及びSからなる群から選択される1〜3個のヘテロ原子環頂点を有する4〜6員のヘテロアリールからなる群から独立して選択され、ここで、前記R10a~d置換基の各々は、1〜3個のR12で任意選択的に置換されるか、又は隣接する環頂点上のR10a、R10b、R10c、及びR10dのうちの2つは、任意選択的に組み合わさって、1〜2個のハロゲンで任意選択的に置換された5員複素環を形成し;
各R11は、ヒドロキシル、オキソ、ハロ、シアノ、−NRdRe、−C(O)ORa、フェニル、C3-8シクロアルキル、及びC(O)ORaで任意選択に置換されたC1-4アルキルからなる群から独立して選択され;
各R12は、ハロ、シアノ、ヒドロキシ、−C(O)ORaからなる群から独立して選択され;そして
各Raは、H又はC1-6アルキルであり;
各RbとRcは、H、C1-8アルキル、−S(O)2−C1-6アルキル、−C(O)ORa、及び−X1−C(O)ORaからなる群から独立して選択され;そして
各Rd及びReは、H、C1-8アルキル、−S(O)2−C1-6アルキルからなる群から独立して選択される]。 - R10a、R10b、及びR10cのうちの少なくとも1つがメトキシである、請求項1〜3のいずれか1項に記載の化合物。
- 各R9が、C1-8アルキル、−O−C1-8アルキル、−X1−O−C1-8アルキル、−O−X1−O−C1-8アルキル、−X1−O−X1−O−C1-8アルキルからなる群から独立して選択され、ここで、前記R9置換基の各々は、1〜3個のR11で任意選択的に置換されている、請求項1〜6のいずれか1項に記載の化合物、又はその医薬的に許容し得る塩、水和物、若しくは溶媒和物。
- 各R9が、−C(O)ORa、−NRbRc、Y、−X1−C3-8シクロアルキル、及び−X2−Zからなる群から独立して選択され、ここで、X2は、C1-6アルキレン、−C1-6アルキレン−O−、−C(O)−、及び−S(O)2−からなる群から選択され、Zは、O、N、及びSからなる群から選択される1〜3個のヘテロ原子環頂点を有する4〜6員のヘテロシクロアルキルであり、ここで前記R9置換基の各々は、1〜3個のR11で任意選択的に置換されている、請求項1〜6のいずれか1項に記載の化合物、又はその医薬的に許容し得る塩、水和物、若しくは溶媒和物。
- 表1の化合物から選択される、請求項1に記載の化合物。
- 請求項1〜15のいずれか1項に記載の化合物と医薬的に許容し得る賦形剤とを含む医薬組成物。
- 少なくとも一部はアデノシンA2A受容体(A2AR)及び/又はアデノシンA2B受容体(A2BR)により媒介される疾患、障害、又は状態を治療する方法であって、請求項1〜15のいずれか1項に記載の化合物の治療有効量を、それを必要とする被験体に投与することを含む上記方法。
- 前記疾患、障害、又は状態が、少なくとも一部はA2ARにより媒介される、請求項17に記載の方法。
- 前記疾患、障害、又は状態が、少なくとも一部はA2BRにより媒介される、請求項17に記載の方法。
- 前記疾患、障害、又は状態が、少なくとも一部はA2AR及びA2BRにより媒介される、請求項17に記載の方法。
- 前記化合物が、A2AR媒介免疫抑制の進行を逆転又は停止するのに有効な量で投与される、請求項18に記載の方法。
- 前記疾患、障害、又は状態が癌である、請求項17〜21のいずれか1項に記載の方法。
- 請求項22に記載の方法であって、前記癌が、前立腺癌、結腸癌、直腸癌、膵臓癌、子宮頚癌、胃癌、子宮内膜癌、脳癌、肝臓癌、膀胱癌、卵巣癌、精巣癌、頭部癌、頸部癌、皮膚癌(黒色腫及び基底細胞癌を含む)、中皮内層癌、白血球の癌(リンパ腫及び白血病を含む)、食道癌、乳癌、筋肉癌、結合組織癌、肺癌(小細胞肺癌及び非小細胞肺癌を含む)、副腎癌、甲状腺癌、腎臓癌、又は骨癌;神経膠芽腫、中皮腫、腎細胞癌、胃癌、肉腫(カポジ肉腫を含む)、絨毛癌、皮膚基底細胞癌、及び精巣セミノーマである、上記方法。
- 請求項22に記載の方法であって、前記癌が、黒色腫、結腸直腸癌、膵臓癌、乳癌、前立腺癌、肺癌、白血病、脳腫瘍、リンパ腫、卵巣癌、カポシ肉腫、頭頸部の扁平上皮癌、膀胱癌、子宮内膜癌、メルケル細胞癌、又は胃食道癌からなる群から選択される、上記方法。
- 前記疾患、障害、又は状態が、免疫関連の疾患、障害、又は状態である、請求項17〜21のいずれか1項に記載の方法。
- 請求項25に記載の方法であって、前記免疫関連疾患、障害、又は状態が、関節リウマチ、腎不全、狼瘡、喘息、乾癬、大腸炎、膵臓炎、アレルギー、線維症、貧血線維筋痛、アルツハイマー病、うっ血性心不全、脳卒中、大動脈弁狭窄症、動脈硬化症、骨粗鬆症、パーキンソン病、感染症、クローン病、潰瘍性大腸炎、アレルギー性接触皮膚炎及びその他の湿疹、全身性硬化症、並びに多発性硬化症からなる群から選択される、上記方法。
- 請求項1〜15のいずれか1項に記載の化合物と少なくとも1種の追加の治療薬とを含む組み合わせ。
- 前記少なくとも1種の追加の治療薬が、化学療法剤、免疫及び/又は炎症調節剤、抗高コレステロール血症剤、抗感染剤、又は放射線である、請求項27に記載の組み合わせ。
- 前記少なくとも1種の追加の治療薬が免疫チェックポイント阻害剤である、請求項27に記載の組み合わせ。
- 前記免疫チェックポイント阻害剤が、PD1、PDL1、BTLA、LAG3、TIM−3、TIGIT、B7ファミリーメンバー、又はCTLA4の少なくとも1つの活性を阻止する、請求項29に記載の組み合わせ。
- 被験体の癌を治療する方法であって、前記被験体に、請求項1〜15のいずれか1項に記載の化合物と少なくとも1種の追加の治療薬との有効量を投与することを含む、上記方法。
- 前記少なくとも1種の追加の治療薬が、化学療法剤、免疫及び/又は炎症調節剤、抗高コレステロール血症剤、抗感染剤、又は放射線である、請求項31に記載の方法。
- 前記少なくとも1種の追加の治療薬が免疫チェックポイント阻害剤である、請求項32に記載の方法。
- 前記免疫チェックポイント阻害剤が、PD1、PDL1、BTLA、LAG3、TIM−3、TIGIT、B7ファミリーメンバー、又はCTLA4のうちの少なくとも1つの活性を阻止する、請求項33に記載の方法。
- 化学療法剤をさらに含む、請求項31〜34のいずれか1項に記載の方法。
- 前記化学療法剤が、シスプラチン、カルボプラチン、オキサリプラチン、ドキソルビシン、及びペメトレキセドからなる群から選択される、請求項35に記載の方法。
- 前記化合物及び前記少なくとも1種の追加の治療薬が組み合わせて投与される、請求項31〜36のいずれか1項に記載の方法。
- 前記化合物及び前記少なくとも1種の追加の治療薬が、同時に、しかし別々に投与される、請求項31〜36のいずれか1項に記載の方法。
- 前記化合物及び前記少なくとも1種の追加の治療薬が連続して投与される、請求項31〜36のいずれか1項に記載の方法。
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