JP2021524765A - バイオセンサ・パッケージ - Google Patents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/372—Arrangements in connection with the implantation of stimulators
- A61N1/375—Constructional arrangements, e.g. casings
- A61N1/3758—Packaging of the components within the casing
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- A—HUMAN NECESSITIES
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- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/372—Arrangements in connection with the implantation of stimulators
- A61N1/375—Constructional arrangements, e.g. casings
- A61N1/37514—Brain implants
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- A—HUMAN NECESSITIES
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- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
- A61N1/36064—Epilepsy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
- A61N1/36067—Movement disorders, e.g. tremor or Parkinson disease
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
- A61N1/36071—Pain
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/36125—Details of circuitry or electric components
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/372—Arrangements in connection with the implantation of stimulators
- A61N1/375—Constructional arrangements, e.g. casings
- A61N1/3756—Casings with electrodes thereon, e.g. leadless stimulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2560/00—Constructional details of operational features of apparatus; Accessories for medical measuring apparatus
- A61B2560/04—Constructional details of apparatus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2560/00—Constructional details of operational features of apparatus; Accessories for medical measuring apparatus
- A61B2560/04—Constructional details of apparatus
- A61B2560/0462—Apparatus with built-in sensors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/01—Measuring temperature of body parts ; Diagnostic temperature sensing, e.g. for malignant or inflamed tissue
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
- A61B5/053—Measuring electrical impedance or conductance of a portion of the body
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
- A61N1/36082—Cognitive or psychiatric applications, e.g. dementia or Alzheimer's disease
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/36128—Control systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/065—Light sources therefor
- A61N2005/0651—Diodes
- A61N2005/0652—Arrays of diodes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/0658—Radiation therapy using light characterised by the wavelength of light used
- A61N2005/0662—Visible light
- A61N2005/0663—Coloured light
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0613—Apparatus adapted for a specific treatment
- A61N5/062—Photodynamic therapy, i.e. excitation of an agent
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/28—Electrolytic cell components
- G01N27/30—Electrodes, e.g. test electrodes; Half-cells
- G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
- G01N27/3275—Sensing specific biomolecules, e.g. nucleic acid strands, based on an electrode surface reaction
- G01N27/3277—Sensing specific biomolecules, e.g. nucleic acid strands, based on an electrode surface reaction being a redox reaction, e.g. detection by cyclic voltammetry
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/403—Cells and electrode assemblies
- G01N27/414—Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS
- G01N27/4145—Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS specially adapted for biomolecules, e.g. gate electrode with immobilised receptors
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- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Radiology & Medical Imaging (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Pathology (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
- Measuring And Recording Apparatus For Diagnosis (AREA)
Abstract
Description
Claims (20)
- 半導体基板とプロセッサとを含むバイオセンサ・モジュールであって、前記半導体基板は、前記プロセッサに動作可能に結合したセンサ及び組込み刺激デバイスのうちの1つ又は複数を有する、バイオセンサ・モジュールと、
ポリマー層と、を含む装置であって、前記バイオセンサ・モジュールは、前記ポリマー層内に、前記ポリマー層が前記バイオセンサ・モジュールの複数の側面に設けられるように埋め込まれた、
装置。 - 前記半導体基板は、窒化ガリウム、シリコン、サファイア、及び酸化シリコンからなる群から選択される、請求項1に記載の装置。
- 前記ポリマー層はエラストマーである、請求項1に記載の装置。
- 前記ポリマー層は、ポリジメチルシロキサン、キチン、セルロース、及びポリウレタンからなる第2の群から選択されるポリマーを含む、請求項3に記載の装置。
- 前記半導体基板は、前記センサを有する、請求項1から請求項4のいずれかに記載の装置。
- 前記バイオセンサ・モジュールは、前記プロセッサに動作可能に結合した発光ダイオードをさらに含む、請求項5に記載の装置。
- 前記ポリマー層は、前記センサに隣接した化学送達システムを含み、前記化学送達システムは、前記バイオセンサ・モジュールに隣接して前記ポリマー層の部分内に配置されたマイクロ流体チャネルを含む、請求項5に記載の装置。
- 前記バイオセンサ・モジュールは、キャパシタ及びバッテリからなる第3の群から選択される動力デバイスをさらに含む、請求項5に記載の装置。
- 前記半導体基板は透明であり、前記発光ダイオードは前記半導体基板に組み込まれる、請求項6に記載の装置。
- 前記バイオセンサ・モジュールは、光遺伝学的刺激デバイスである、請求項5に記載の装置。
- 前記バイオセンサ・モジュールは、前記プロセッサに動作可能に結合した発光ダイオードをさらに含み、前記センサ及び前記発光ダイオードは、前記半導体基板に組み込まれる、請求項5に記載の装置。
- 第2のバイオセンサ・モジュールをさらに含み、前記第2のバイオセンサ・モジュールは、前記ポリマー層内に、前記ポリマー層が前記第2のバイオセンサ・モジュールの複数の側面に設けられるように埋め込まれ、前記第2のバイオセンサ・モジュールは、第2の半導体基板と第2のプロセッサとを含み、前記第2の半導体基板は、前記第2のプロセッサに動作可能に結合した第2のセンサを有する、請求項5に記載の装置。
- 前記半導体基板は、前記組込み刺激デバイスを含む、請求項1から請求項4のいずれかに記載の装置。
- 前記バイオセンサ・モジュールは、センサ及び動力デバイスをさらに含み、前記センサ及び前記動力デバイスは、前記プロセッサに動作可能に結合し、前記動力デバイスは、キャパシタ及びバッテリからなる第3の群から選択される、請求項13に記載の装置。
- 前記ポリマー層は、前記バイオセンサ・モジュールに隣接して配置されたマイクロ流体チャネルを含み、前記マイクロ流体チャネルは、たんぱく質発現のための遺伝物質、神経伝達物質、成長因子、成長抑制物質、及び医薬からなる群から選択される化学物質を含むヒドロゲルを含む、請求項12に記載の装置。
- 前記組込み刺激デバイスは、発光ダイオード、ヒータ、及び電極からなる群から選択される、請求項12に記載の装置。
- 第2のバイオセンサ・モジュールをさらに含み、前記第2のバイオセンサ・モジュールは、前記ポリマー層内に、前記ポリマー層が前記第2のバイオセンサ・モジュールの複数の側面に設けられるように埋め込まれ、前記第2のバイオセンサ・モジュールは、第2の半導体基板と第2のプロセッサとを含み、前記第2の半導体基板は、前記第2のプロセッサに動作可能に結合した第2の組込み発光ダイオードを含む、請求項12に記載の装置。
- ポリマーをモールドに注入してポリマー層を生成することと、
バイオセンサ・モジュールを、前記ポリマー層に、前記ポリマー層が前記バイオセンサ・モジュールの複数の側面に設けられるように取り付けることと、を含む方法であって、前記バイオセンサ・モジュールは、半導体基板とプロセッサとを含み、前記半導体基板は、前記プロセッサに動作可能に結合したセンサを有する、方法 - 前記注入することは、前記ポリマー層内にマイクロ流体チャネルを生成することをさらに含み、前記方法は、前記マイクロ流体チャネル内にヒドロゲルを堆積させることをさらに含み、前記ヒドロゲルは、たんぱく質発現のための遺伝物質、神経伝達物質、成長因子、成長抑制物質、及び医薬からなる群から選択される化学物質を含む、請求項18に記載の方法。
- 前記半導体基板は、窒化ガリウム、シリコン、サファイア、及び酸化シリコンからなる第1の群から選択され、前記ポリマーは、ポリジメチルシロキサン及びポリウレタンからなる第2の群から選択される、請求項18に記載の方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US15/991,254 US11083902B2 (en) | 2018-05-29 | 2018-05-29 | Biosensor package |
US15/991,254 | 2018-05-29 | ||
PCT/IB2019/054165 WO2019229582A1 (en) | 2018-05-29 | 2019-05-21 | Biosensor package |
Publications (2)
Publication Number | Publication Date |
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JP2021524765A true JP2021524765A (ja) | 2021-09-16 |
JP7289178B2 JP7289178B2 (ja) | 2023-06-09 |
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JP2020561804A Active JP7289178B2 (ja) | 2018-05-29 | 2019-05-21 | バイオセンサ・パッケージ |
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US (1) | US11083902B2 (ja) |
JP (1) | JP7289178B2 (ja) |
CN (1) | CN112105935B (ja) |
DE (1) | DE112019002691T5 (ja) |
WO (1) | WO2019229582A1 (ja) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
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KR102414417B1 (ko) * | 2021-01-06 | 2022-06-28 | 가천대학교 산학협력단 | 다공성 실리콘 및 금속 나노입자를 포함하는 다공성 실리콘 나노센서 및 그의 제조방법 |
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Publication number | Priority date | Publication date | Assignee | Title |
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US11988625B2 (en) * | 2020-12-23 | 2024-05-21 | Vanguard International Semiconductor Corporation | Capacitive biosensor and fabricating method thereof |
CN113937900B (zh) * | 2021-10-11 | 2024-02-23 | 北京翌光医疗科技研究院有限公司 | 一种可穿戴的光医疗器件及其制备方法 |
CN115112743B (zh) * | 2022-07-06 | 2023-08-25 | 上海交通大学 | 一种基于有机晶体管微阵列的气体和生物分子传感芯片 |
CN116297762A (zh) * | 2023-03-07 | 2023-06-23 | 复旦大学 | 一种基于微流控平台的光电联合病原体检测装置及方法 |
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