JP2021522783A5 - - Google Patents
Info
- Publication number
- JP2021522783A5 JP2021522783A5 JP2020560827A JP2020560827A JP2021522783A5 JP 2021522783 A5 JP2021522783 A5 JP 2021522783A5 JP 2020560827 A JP2020560827 A JP 2020560827A JP 2020560827 A JP2020560827 A JP 2020560827A JP 2021522783 A5 JP2021522783 A5 JP 2021522783A5
- Authority
- JP
- Japan
- Prior art keywords
- sequence
- protein
- nonviral
- abp
- aptamer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024093050A JP7832700B2 (ja) | 2018-05-01 | 2024-06-07 | 真核生物の遺伝子編集のためのレンチウイルスベースのベクターならびに関連システムおよび方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862665080P | 2018-05-01 | 2018-05-01 | |
| US62/665,080 | 2018-05-01 | ||
| PCT/US2019/030198 WO2019213257A1 (en) | 2018-05-01 | 2019-05-01 | Lentiviral-based vectors and related systems and methods for eukaryotic gene editing |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024093050A Division JP7832700B2 (ja) | 2018-05-01 | 2024-06-07 | 真核生物の遺伝子編集のためのレンチウイルスベースのベクターならびに関連システムおよび方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021522783A JP2021522783A (ja) | 2021-09-02 |
| JP2021522783A5 true JP2021522783A5 (https=) | 2022-04-01 |
| JP7506405B2 JP7506405B2 (ja) | 2024-06-26 |
Family
ID=66676890
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020560827A Active JP7506405B2 (ja) | 2018-05-01 | 2019-05-01 | 真核生物の遺伝子編集のためのレンチウイルスベースのベクターならびに関連システムおよび方法 |
| JP2024093050A Active JP7832700B2 (ja) | 2018-05-01 | 2024-06-07 | 真核生物の遺伝子編集のためのレンチウイルスベースのベクターならびに関連システムおよび方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024093050A Active JP7832700B2 (ja) | 2018-05-01 | 2024-06-07 | 真核生物の遺伝子編集のためのレンチウイルスベースのベクターならびに関連システムおよび方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US12398182B2 (https=) |
| EP (1) | EP3788155A1 (https=) |
| JP (2) | JP7506405B2 (https=) |
| AU (2) | AU2019262029B2 (https=) |
| CA (1) | CA3098137A1 (https=) |
| WO (1) | WO2019213257A1 (https=) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9228207B2 (en) | 2013-09-06 | 2016-01-05 | President And Fellows Of Harvard College | Switchable gRNAs comprising aptamers |
| US12390514B2 (en) | 2017-03-09 | 2025-08-19 | President And Fellows Of Harvard College | Cancer vaccine |
| EP3592853A1 (en) | 2017-03-09 | 2020-01-15 | President and Fellows of Harvard College | Suppression of pain by gene editing |
| CN111801345A (zh) | 2017-07-28 | 2020-10-20 | 哈佛大学的校长及成员们 | 使用噬菌体辅助连续进化(pace)的进化碱基编辑器的方法和组合物 |
| EP3788155A1 (en) | 2018-05-01 | 2021-03-10 | Wake Forest University Health Sciences | Lentiviral-based vectors and related systems and methods for eukaryotic gene editing |
| US12522807B2 (en) | 2018-07-09 | 2026-01-13 | The Broad Institute, Inc. | RNA programmable epigenetic RNA modifiers and uses thereof |
| AU2019343045A1 (en) | 2018-09-18 | 2021-05-13 | Vnv Newco Inc. | ARC-based capsids and uses thereof |
| US12351837B2 (en) | 2019-01-23 | 2025-07-08 | The Broad Institute, Inc. | Supernegatively charged proteins and uses thereof |
| WO2020191233A1 (en) | 2019-03-19 | 2020-09-24 | The Broad Institute, Inc. | Methods and compositions for editing nucleotide sequences |
| US12473543B2 (en) | 2019-04-17 | 2025-11-18 | The Broad Institute, Inc. | Adenine base editors with reduced off-target effects |
| WO2020252455A1 (en) | 2019-06-13 | 2020-12-17 | The General Hospital Corporation | Engineered human-endogenous virus-like particles and methods of use thereof for delivery to cells |
| CN110819707B (zh) * | 2019-11-24 | 2023-07-18 | 中南大学湘雅医院 | 一种针对多种来源细胞样本中内部核糖体结合位点元件的高通量鉴定方法 |
| WO2021142343A1 (en) * | 2020-01-09 | 2021-07-15 | The Regents Of The University Of California | Targeting transfer rna for the suppression of nonsense mutations in messenger rna |
| CA3189601A1 (en) | 2020-07-24 | 2022-01-27 | The General Hospital Corporation | Enhanced virus-like particles and methods of use thereof for delivery to cells |
| WO2022109275A2 (en) * | 2020-11-19 | 2022-05-27 | Wake Forest University Health Sciences | Vectors, systems and methods for eukaryotic gene editing |
| WO2022155239A1 (en) * | 2021-01-12 | 2022-07-21 | University Of Massachusetts | Allele-specific inactivation of mutant htt via gene editing at coding region single nucleotide polymorphisms |
| US20240084330A1 (en) * | 2021-01-28 | 2024-03-14 | The Broad Institute, Inc. | Compositions and methods for delivering cargo to a target cell |
| WO2022174004A1 (en) * | 2021-02-12 | 2022-08-18 | Wake Forest University Health Sciences | Engineered extracellular vesicles and their uses |
| WO2022216536A1 (en) * | 2021-04-06 | 2022-10-13 | Animatus Biosciences, Inc. | Selective expression of mrnas in cardiomyocytes without cardiac fibroblast stimulation |
| EP4341404A1 (en) * | 2021-05-21 | 2024-03-27 | Aarhus Universitet | Lentivirus-derived nanoparticles comprising crispr/cas9 ribonucleoprotein complexes |
| JP7125727B1 (ja) | 2021-09-07 | 2022-08-25 | 国立大学法人千葉大学 | 核酸配列改変用組成物および核酸配列の標的部位を改変する方法 |
| EP4489772A4 (en) * | 2022-03-08 | 2026-03-25 | Univ Wake Forest Health Sciences | EUKARYOTIC GENE EDITING COMPOSITIONS, SYSTEMS AND METHODS |
| CN116218906A (zh) * | 2023-01-31 | 2023-06-06 | 安可来(重庆)生物医药科技有限公司 | 一种rna编辑器表达质粒、外泌体适配子融合表达质粒以及一种靶向基因rna编辑方法 |
| WO2025242168A1 (en) * | 2024-05-22 | 2025-11-27 | Nanjing Legend Biotech Co., Ltd. | Methods of making cells expressing an engineered receptor |
| CN118903442A (zh) * | 2024-07-19 | 2024-11-08 | 上海佰炼生物医药科技有限公司 | 基于PP7 RNA茎环结构的高效VLP载体及其用于递送mRNA |
| CN119662735A (zh) * | 2024-10-10 | 2025-03-21 | 上海佰炼生物医药科技有限公司 | 一种基于核定位信号和pp7 rna茎环结构的重组质粒及其载体系统和应用 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2004225520A1 (en) | 2003-03-25 | 2004-10-14 | Stratagene | DNA polymerase fusions and uses thereof |
| GB0526210D0 (en) * | 2005-12-22 | 2006-02-01 | Oxford Biomedica Ltd | Vectors |
| US20120202276A1 (en) | 2010-02-26 | 2012-08-09 | Life Technologies Corporation | Modified Proteins and Methods of Making and Using Same |
| WO2015002956A1 (en) | 2013-07-01 | 2015-01-08 | Ohio State Innovation Foundation | Exosome delivery system |
| EP3080259B1 (en) * | 2013-12-12 | 2023-02-01 | The Broad Institute, Inc. | Engineering of systems, methods and optimized guide compositions with new architectures for sequence manipulation |
| US9580727B1 (en) * | 2015-08-07 | 2017-02-28 | Caribou Biosciences, Inc. | Compositions and methods of engineered CRISPR-Cas9 systems using split-nexus Cas9-associated polynucleotides |
| US10624849B2 (en) | 2015-09-28 | 2020-04-21 | Northwestern University | Targeted extracellular vesicles comprising membrane proteins with engineered glycosylation sites |
| WO2017059902A1 (en) * | 2015-10-07 | 2017-04-13 | Biontech Rna Pharmaceuticals Gmbh | 3' utr sequences for stabilization of rna |
| CN105861485B (zh) * | 2016-04-20 | 2021-08-17 | 上海伊丽萨生物科技有限公司 | 一种提高基因置换效率的方法 |
| JP6982001B2 (ja) * | 2016-05-13 | 2021-12-17 | フラッシュ セラピューティクス | ゲノム工学システムのカプシド形成のための粒子 |
| US11866697B2 (en) | 2017-05-18 | 2024-01-09 | The Broad Institute, Inc. | Systems, methods, and compositions for targeted nucleic acid editing |
| KR102761791B1 (ko) | 2017-06-26 | 2025-02-05 | 더 브로드 인스티튜트, 인코퍼레이티드 | 표적화된 핵산 편집을 위한 crispr/cas-아데닌 데아미나아제 기반 조성물, 시스템 및 방법 |
| EP3788155A1 (en) | 2018-05-01 | 2021-03-10 | Wake Forest University Health Sciences | Lentiviral-based vectors and related systems and methods for eukaryotic gene editing |
| US11946040B2 (en) | 2019-02-04 | 2024-04-02 | The General Hospital Corporation | Adenine DNA base editor variants with reduced off-target RNA editing |
| AU2020466994A1 (en) | 2019-09-17 | 2022-04-21 | Rutgers, The State University Of New Jersey | Highly efficient DNA base editors mediated by RNA-aptamer recruitment for targeted genome modification and uses thereof |
-
2019
- 2019-05-01 EP EP19727544.9A patent/EP3788155A1/en active Pending
- 2019-05-01 WO PCT/US2019/030198 patent/WO2019213257A1/en not_active Ceased
- 2019-05-01 CA CA3098137A patent/CA3098137A1/en active Pending
- 2019-05-01 US US17/051,296 patent/US12398182B2/en active Active
- 2019-05-01 AU AU2019262029A patent/AU2019262029B2/en active Active
- 2019-05-01 JP JP2020560827A patent/JP7506405B2/ja active Active
-
2024
- 2024-06-07 JP JP2024093050A patent/JP7832700B2/ja active Active
-
2025
- 2025-07-15 US US19/270,184 patent/US20250340600A1/en active Pending
-
2026
- 2026-02-18 AU AU2026201197A patent/AU2026201197A1/en active Pending
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