JP2021520355A5 - - Google Patents
Info
- Publication number
- JP2021520355A5 JP2021520355A5 JP2020554092A JP2020554092A JP2021520355A5 JP 2021520355 A5 JP2021520355 A5 JP 2021520355A5 JP 2020554092 A JP2020554092 A JP 2020554092A JP 2020554092 A JP2020554092 A JP 2020554092A JP 2021520355 A5 JP2021520355 A5 JP 2021520355A5
- Authority
- JP
- Japan
- Prior art keywords
- double
- nucleic acid
- stranded nucleic
- acid inhibitor
- inhibitor molecule
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862657428P | 2018-04-13 | 2018-04-13 | |
| US62/657,428 | 2018-04-13 | ||
| US201862778755P | 2018-12-12 | 2018-12-12 | |
| US62/778,755 | 2018-12-12 | ||
| PCT/US2019/027021 WO2019200124A1 (en) | 2018-04-13 | 2019-04-11 | Double-stranded nucleic acid inhibitor molecules modified with tm-increasing nucleotides |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2021520355A JP2021520355A (ja) | 2021-08-19 |
| JP2021520355A5 true JP2021520355A5 (enExample) | 2022-04-14 |
Family
ID=68161339
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020554092A Withdrawn JP2021520355A (ja) | 2018-04-13 | 2019-04-11 | Ｔｍ上昇ヌクレオチドで修飾された二本鎖核酸阻害剤分子 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US11873488B2 (enExample) |
| EP (1) | EP3773609A4 (enExample) |
| JP (1) | JP2021520355A (enExample) |
| KR (1) | KR20200144100A (enExample) |
| CN (1) | CN111971051A (enExample) |
| AU (1) | AU2019252529A1 (enExample) |
| CA (1) | CA3094008A1 (enExample) |
| IL (1) | IL277813A (enExample) |
| MX (1) | MX2020010802A (enExample) |
| WO (1) | WO2019200124A1 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2020123083A1 (en) * | 2018-12-12 | 2020-06-18 | Dicerna Pharmaceuticals, Inc. | Double-stranded nucleic acid inhibitor molecules containing a triloop |
| AU2020268798A1 (en) * | 2019-05-03 | 2021-11-04 | Dicerna Pharmaceuticals, Inc. | Double-stranded nucleic acid inhibitor molecules with shortened sense strands |
| TW202308662A (zh) * | 2021-05-11 | 2023-03-01 | 美商黛瑟納製藥公司 | 用於靶定中樞神經系統的神經元之脂質結合物 |
| WO2023069707A2 (en) * | 2021-10-22 | 2023-04-27 | Sirnaomics, Inc. | Products and compositions |
| US20250188477A1 (en) * | 2022-03-16 | 2025-06-12 | Daiichi Sankyo Company, Limited | CHEMICALLY MODIFIED OLIGONUCLEOTIDE HAVING RNAi ACTIVITY |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8273866B2 (en) * | 2002-02-20 | 2012-09-25 | Merck Sharp & Dohme Corp. | RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (SINA) |
| WO2009117589A1 (en) | 2008-03-21 | 2009-09-24 | Isis Pharmaceuticals, Inc. | Oligomeric compounds comprising tricyclic nucleosides and methods for their use |
| DK2341943T3 (en) * | 2008-09-22 | 2019-02-25 | Dicerna Pharmaceuticals Inc | COMPOSITIONS AND METHODS OF SPECIFIC INHIBITION OF DSRNA REPRINT WITH MODIFICATIONS |
| US20110288147A1 (en) * | 2008-09-22 | 2011-11-24 | Bob Dale Brown | Compositions and methods for the specific inhibition of gene expression by DSRNA containing a tetraloop |
| KR101728655B1 (ko) * | 2008-12-18 | 2017-04-19 | 다이서나 파마수이티컬, 인크. | 유전자 발현의 특이적 억제를 위한 연장된 다이서 기질 제제 및 방법 |
| CN103555722B (zh) * | 2009-04-03 | 2016-08-31 | 戴瑟纳制药公司 | 利用不对称双链rna特异性抑制kras的方法和组合物 |
| WO2012027033A1 (en) | 2010-07-19 | 2012-03-01 | Isis Pharmaceuticals, Inc. | Compounds and methods for modulating target nuclear and sub-nuclear nucleic acid molecules in cells and animals |
| EP2850092B1 (en) | 2012-04-09 | 2017-03-01 | Ionis Pharmaceuticals, Inc. | Tricyclic nucleic acid analogs |
| DK2970968T3 (en) * | 2013-03-15 | 2018-03-05 | Miragen Therapeutics Inc | CONNECTED BICYCLIC Nucleosides |
| US9862742B2 (en) | 2013-03-15 | 2018-01-09 | Universität Bern | Tricyclic nucleosides and oligomeric compounds prepared therefrom |
| US9458457B2 (en) * | 2013-07-03 | 2016-10-04 | Dicerna Pharmaceuticals, Inc. | Methods and compositions for the specific inhibition of alpha-1 antitrypsin by double-stranded RNA |
| US10150965B2 (en) * | 2013-12-06 | 2018-12-11 | Dicerna Pharmaceuticals, Inc. | Methods and compositions for the specific inhibition of transthyretin (TTR) by double-stranded RNA |
| EP3119789B1 (en) | 2014-03-17 | 2020-04-22 | Ionis Pharmaceuticals, Inc. | Bicyclic carbocyclic nucleosides and oligomeric compounds prepared therefrom |
| AU2015330670B2 (en) * | 2014-10-10 | 2022-01-06 | Novo Nordisk Health Care Ag | Therapeutic inhibition of lactate dehydrogenase and agents therefor |
| DK3569711T3 (da) * | 2014-12-15 | 2021-02-22 | Dicerna Pharmaceuticals Inc | Ligandmodificerede dobbeltstrengede nukleinsyrer |
| US10036017B2 (en) * | 2015-02-17 | 2018-07-31 | Dicerna Pharmaceuticals, Inc. | Methods and compositions for the specific inhibition of complement component 5(C5) by double-stranded RNA |
| HUE059718T2 (hu) * | 2016-09-02 | 2022-12-28 | Dicerna Pharmaceuticals Inc | 4'-foszfát analógok és azokat tartalmazó oligonukleotidok |
| IL271680B (en) * | 2017-06-29 | 2022-09-01 | Dicerna Pharmaceuticals Inc | Compositions and methods for inhibiting hmgb1 expression |
-
2019
- 2019-04-11 JP JP2020554092A patent/JP2021520355A/ja not_active Withdrawn
- 2019-04-11 AU AU2019252529A patent/AU2019252529A1/en not_active Abandoned
- 2019-04-11 CA CA3094008A patent/CA3094008A1/en active Pending
- 2019-04-11 WO PCT/US2019/027021 patent/WO2019200124A1/en not_active Ceased
- 2019-04-11 KR KR1020207029911A patent/KR20200144100A/ko not_active Ceased
- 2019-04-11 CN CN201980025615.0A patent/CN111971051A/zh active Pending
- 2019-04-11 US US16/381,931 patent/US11873488B2/en active Active
- 2019-04-11 MX MX2020010802A patent/MX2020010802A/es unknown
- 2019-04-11 EP EP19784831.0A patent/EP3773609A4/en active Pending
-
2020
- 2020-10-05 IL IL277813A patent/IL277813A/en unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2021520355A5 (enExample) | ||
| JP7535047B2 (ja) | トリループを含む二本鎖核酸インヒビター分子 | |
| JP2022525208A5 (enExample) | ||
| JP2025000693A (ja) | Ａｐｐの発現を低減するための化合物及び方法 | |
| JP7446443B2 (ja) | Ｓｍｎ２を調節するための化合物及び方法 | |
| WO2016040748A1 (en) | Compositions and methods for detection of smn protein in a subject and treatment of a subject | |
| US11873488B2 (en) | Double-stranded nucleic acid inhibitor molecules modified with Tm-increasing nucleotides | |
| EP4323518A2 (en) | Compositions and methods for inhibiting ketohexokinase (khk) | |
| CA3190481A1 (en) | Compositions and methods for inhibiting plp1 expression | |
| JP2022521877A5 (enExample) | ||
| US20230416742A1 (en) | Compositions and methods for inhibiting mapt expression | |
| JP2024528503A5 (enExample) | ||
| CN119403927A (zh) | 用于抑制跨膜丝氨酸蛋白酶6（tmprss6）表达的组合物和方法 | |
| JP2022530678A5 (enExample) | ||
| US12529053B2 (en) | Double-stranded nucleic acid inhibitor molecules with shortened sense strands | |
| JP2023530072A (ja) | Ｐｍｐ２２を調節するための化合物及び方法 | |
| JP2022523065A (ja) | Ｎｒ２ｅ３発現抑制オリゴヌクレオチド、それを含む組成物、及びそれらの使用方法 | |
| CN118979036A (zh) | 抑制APP基因表达的siRNA及其缀合物和应用 | |
| CA3250061A1 (en) | Compositions and methods for inhibiting the expression of SNCA | |
| CN115279904A (zh) | 抑制asah1基因表达的组合物和方法 | |
| HK40083632A (en) | Compositions and methods for inhibiting asah1 gene expression | |
| KR20260049590A (ko) | Tubb4a 발현을 감소시키기 위한 화합물 및 방법 | |
| CN121718537A (zh) | 用于血脂异常等相关疾病的siRNA及其缀合物和应用 | |
| JP2024528417A5 (enExample) |