JP2021520200A5 - - Google Patents

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Publication number
JP2021520200A5
JP2021520200A5 JP2020554154A JP2020554154A JP2021520200A5 JP 2021520200 A5 JP2021520200 A5 JP 2021520200A5 JP 2020554154 A JP2020554154 A JP 2020554154A JP 2020554154 A JP2020554154 A JP 2020554154A JP 2021520200 A5 JP2021520200 A5 JP 2021520200A5
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JP
Japan
Prior art keywords
cells
composition according
neuronal cells
expression level
contact
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Pending
Application number
JP2020554154A
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English (en)
Japanese (ja)
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JP2021520200A (ja
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Priority claimed from PCT/US2019/027027 external-priority patent/WO2019200129A1/en
Publication of JP2021520200A publication Critical patent/JP2021520200A/ja
Publication of JP2021520200A5 publication Critical patent/JP2021520200A5/ja
Pending legal-status Critical Current

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JP2020554154A 2018-04-11 2019-04-11 非神経細胞のニューロンへの再プログラミング、及び神経変性疾患または障害を治療するための方法と組成物 Pending JP2021520200A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201862656322P 2018-04-11 2018-04-11
US62/656,322 2018-04-11
US201862718774P 2018-08-14 2018-08-14
US62/718,774 2018-08-14
PCT/US2019/027027 WO2019200129A1 (en) 2018-04-11 2019-04-11 Reprogramming of non-neuronal cells into neurons and methods and compositions to treat neurodegenerative diseases and disorders

Publications (2)

Publication Number Publication Date
JP2021520200A JP2021520200A (ja) 2021-08-19
JP2021520200A5 true JP2021520200A5 (enExample) 2022-03-22

Family

ID=68164570

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2020554154A Pending JP2021520200A (ja) 2018-04-11 2019-04-11 非神経細胞のニューロンへの再プログラミング、及び神経変性疾患または障害を治療するための方法と組成物

Country Status (9)

Country Link
US (2) US11702656B2 (enExample)
EP (1) EP3773749A4 (enExample)
JP (1) JP2021520200A (enExample)
KR (1) KR20200142537A (enExample)
CN (1) CN112312928A (enExample)
AU (1) AU2019252534A1 (enExample)
CA (1) CA3096691A1 (enExample)
GB (2) GB2588307B (enExample)
WO (1) WO2019200129A1 (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021031565A1 (en) * 2019-08-16 2021-02-25 Center For Excellence In Brain Science And Intelligence Technology, Chinese Academy Of Sciences Treatment of Neuronal Diseases
EP4039801A4 (en) * 2019-08-16 2023-10-18 Center For Excellence In Brain Science And Intelligence Technology, Chinese Academy Of Sciences USE OF PTBP1 INHIBITORS TO PREVENT AND/OR TREAT NERVOUS SYSTEM DISEASES ASSOCIATED WITH FUNCTIONAL NEURONAL DEATH
WO2021232062A1 (en) * 2020-05-13 2021-11-18 Figene, Llc Fibroblast based therapy for treatment of parkinson's disease
EP4267196A4 (en) * 2020-12-25 2024-03-20 Shanghai Genemagic Biosciences Co., Ltd. TREATMENT OF NEUROLOGICAL DISEASES
CN112661828B (zh) * 2021-01-15 2022-04-01 武汉大学 一种突触素的抗原肽及其抗体与应用
CN117279668A (zh) * 2021-02-10 2023-12-22 上海鲸奇生物科技有限公司 胶质细胞向神经元转分化用于预防或治疗神经元功能缺失或死亡相关疾病
CN112941019B (zh) * 2021-03-18 2023-01-06 浙江大学 一种促进体细胞重编程的方法
CN116218774A (zh) * 2021-03-26 2023-06-06 广西大学 一种体外高效诱导人体细胞重编程为神经元细胞的方法
CN113171369A (zh) * 2021-04-16 2021-07-27 南通大学 多聚嘧啶序列结合蛋白在制备脊髓损伤的修复药物中的应用
US20240207324A1 (en) * 2021-04-21 2024-06-27 Shanghai Unixell Biotechnology Co., Ltd. Method for quality control and enrichment of human dopaminergic neural precursor cells
CN115887655B (zh) * 2021-09-30 2025-06-17 上海鲸奇生物科技有限公司 直接转分化治疗神经系统疾病
KR102712694B1 (ko) * 2021-10-20 2024-10-02 서울시립대학교 산학협력단 자가조립된 rna 구조체를 포함하는 직접교차분화 유도용 조성물

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011091048A1 (en) 2010-01-19 2011-07-28 The Board Of Trustees Of The Leland Stanford Junior University Direct conversion of cells to cells of other lineages
EP2542267A4 (en) * 2010-03-05 2014-09-17 Univ Columbia THE RNA BINDEPROTEIN HNRNPA1, HNRNPA2 AND PTB-INHIBITING RNAS AND USES THEREOF
WO2012118988A1 (en) 2011-03-01 2012-09-07 The Scripps Research Institute Direct reprogramming of human fibroblasts to functional neurons under defined conditions
WO2014015261A1 (en) * 2012-07-19 2014-01-23 The Penn State Research Foundation Regenerating functional neurons for treatment of disease and injury in the nervous system
WO2014071157A1 (en) * 2012-11-01 2014-05-08 The Regents Of The University Of California Methods for engineering non-neuronal cells into neurons and using newly engineered neurons to treat neurodegenerative diseases
WO2016086092A1 (en) * 2014-11-25 2016-06-02 The Penn State Research Foundation Chemical reprogramming of human glial cells into neurons for brain and spinal cord repair
US9481864B1 (en) * 2015-06-30 2016-11-01 University Of South Florida Conversion of non-neuronal cells into neurons
US20180318260A1 (en) * 2015-11-04 2018-11-08 The Scripps Research Institute Compositions and methods for treating cystic fibrosis
CN105950557B (zh) * 2016-04-22 2019-10-25 中国科学院生物物理研究所 一种控制人神经细胞重编程的信号通路及其应用

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