JP2021519307A - マイクロカプセル化されたプロバイオティック及びそれを含有する低水分活性組成物 - Google Patents
マイクロカプセル化されたプロバイオティック及びそれを含有する低水分活性組成物 Download PDFInfo
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- JP2021519307A JP2021519307A JP2020551921A JP2020551921A JP2021519307A JP 2021519307 A JP2021519307 A JP 2021519307A JP 2020551921 A JP2020551921 A JP 2020551921A JP 2020551921 A JP2020551921 A JP 2020551921A JP 2021519307 A JP2021519307 A JP 2021519307A
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- probiotic
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Abstract
Description
プロバイオティックマイクロカプセルの製剤及び使用が以下に論じられることになる。説明されるマイクロカプセル化されたプロバイオティクスは、低水分活性組成物に特に有用である。低水分活性スキンケアローションの実施例が、以下の表4〜7に記載される。ハンドクリーナ、ハンドソープ、及びシャンプーの実施例が、それぞれ、表8、9、及び10に見出され得る。
説明されるカプセル化されたプロバイオティック製品は、食物源の中又はその表面へのカプセル化されたプロバイオティックの組み込みよって、ユーザの腸に送達され得る。この実施例によると、マイクロカプセル化されたプロバイオティックは、パン又はペストリなどの食品に振りかけられ、ユーザによって消費される。マイクロカプセルは、それが放出され、ユーザに利益を提供し得るまで、プロバイオティックを保護するべきである。
Claims (43)
- 凍結乾燥プロバイオティック及び低水分活性担体を含む、複合体。
- 前記低水分活性担体が、油又はポリマーから選択される、請求項1に記載の複合体。
- 前記低水分活性担体が、ローション、日焼け止め剤、又は消臭剤用の担体組成物である、請求項1に記載の複合体。
- 前記担体組成物が、放射線照射されている、請求項3に記載の複合体。
- 前記プロバイオティックが、ビフィドバクテリウム、ペディオコッカス、ロイコノストック、ミクロコッカス、大腸菌、スタフィロコッカス、ストレプトコッカス、キャディダ、及びバチルスのうちの1つ以上から選択される、請求項4に記載の複合体。
- 前記低水分活性担体及び凍結乾燥プロバイオティックが、カプセル化されている、請求項2に記載の複合体。
- マイクロカプセル化されたプロバイオティックであって、
凍結乾燥プロバイオティック及びポリマーを含むコアと、
前記コアと関連付けられた栄養組成物と、
前記コア及び栄養組成物を取り囲む保護層と、を含む、マイクロカプセル化されたプロバイオティック。 - 前記プロバイオティックが、ビフィドバクテリウム、ペディオコッカス、ロイコノストック、ミクロコッカス、大腸菌、スタフィロコッカス、ストレプトコッカス、キャディダ、及びバチルスのうちの1つ以上から選択される、請求項7に記載のマイクロカプセル化されたプロバイオティック。
- 前記コアの前記ポリマーが、ポリエチレングリコール(PEG)、ポリビニルピロリドン((PVP)、好ましくは、約40,000〜約360,0000の分子量を有する)、ポリビニルアルコール(PVA)、ポリアクリルアミド、N−(2−ヒドロキシプロピル)メタクリルアミド(HPMA)、キサンタンガム、グアーガム、ペクチン、デキストラン、カラギーナン、カルボキシエチルセルロースナトリウム、ポリアクリル酸ポリマー、ヒアルロン酸、カルボキシビニルポリマー、ヒドロキシエチルセルロース、セルロース、ヒドロキシプロピルメチルセルロース、カルボキシビニルポリマーから選択される、請求項7に記載のマイクロカプセル化されたプロバイオティック。
- 前記ポリマーが、ポリアクリル酸ポリマーである、請求項7に記載のマイクロカプセル化されたプロバイオティック。
- 前記栄養組成物が、プレバイオティック糖である、請求項7に記載のマイクロカプセル化されたプロバイオティック。
- 前記栄養組成物が、前記コアの前記ポリマー中に分散されている、請求項11に記載のマイクロカプセル化されたプロバイオティック。
- 前記栄養組成物が、前記ポリマーコアを取り囲む、請求項11に記載のマイクロカプセル化されたプロバイオティック。
- 前記カプセル化コーティングが、ワックス、ポリマー材料、架橋ポリマー材料、金属、セラミック、又はそれらの組み合わせから選択される、請求項7に記載のマイクロカプセル化されたプロバイオティック。
- 前記カプセル化コーティングが、植物油、グリセリルトリステアレート、グリセリルジステアレート、キャノーラワックス、コーン油、水素添加綿実油、水素添加大豆油、ヒマシワックス、ナタネワックス、蜜蝋、カマウバワックス、キャンデリラワックス、マイクロワックス、ポリエチレン、ポリプロピレン、エポキシ、長鎖アルコール、長鎖エステル、ステアリン酸及びベヘン酸などの長鎖脂肪酸、水素添加植物、魚油及び獣脂油などの動物油、大豆油、微結晶ワックス、金属ステアレート、並びに金属脂肪酸から選択されるワックスである、請求項14に記載のマイクロカプセル化されたプロバイオティック。
- 前記カプセル化化合物が、架橋アルギン酸ナトリウム、アニオン性分散ラテックスエマルション、架橋ポリアクリル酸、架橋ポリビニルアルコール、架橋ポリ酢酸ビニル、ケイ酸塩、炭酸塩、硫酸塩、リン酸塩、ホウ酸塩、ポリビニルピロリドン、PLA/PGA、熱電子ゲル、尿素ホルムアルデヒド、メラミンホルムアルデヒド、ポリメラミン、架橋デンプン、ナイロン、尿素、ヒドロコロイドから選択されるポリマーである、請求項7に記載のマイクロカプセル化されたプロバイオティック。
- 前記ポリマー化合物が、前記コア中に分散された1つ以上の活性化剤又は架橋剤によって活性化される、請求項16に記載のマイクロカプセル化されたプロバイオティック。
- 前記活性化剤が、カルシウムの多価イオン、銅の多価イオン、バリウムの多価イオン、シラン、アルミニウム、チタネート、キレート剤、酸のうちの1つ以上から選択される、請求項17に記載のマイクロカプセル化されたプロバイオティクス。
- 耐湿層を更に含む、請求項7に記載のマイクロカプセル化されたプロバイオティック。
- 前記耐湿層が、イソシアン酸塩、スチレン−アクリレート、ビニルトルエンアクリレート、スチレン−ブタジエン、ビニル−アクリレート、ポリビニルブチラール、ポリ酢酸ビニル、ポリエチレンテレフタレート、ポリプロピレン、ポリスチレン、ポリメタクリル酸メチル、ポリ乳酸、ポリ塩化ビニリデン、ポリビニルジクロリド、ポリエチレン、アルキドポリエステル、カルナバワックス、水素添加植物油、水素添加動物油、ヒュームドシリカ、シリコンワックス、二酸化チタン、二酸化ケイ素、金属、金属炭酸塩、金属硫酸塩、セラミック、金属リン酸塩、及び微結晶ワックスと組み合わせられたポリオールのうちの1つ以上から選択される、請求項19に記載のマイクロカプセル化されたプロバイオティック。
- 一過性層を更に含む、請求項7に記載のマイクロカプセル化されたプロバイオティック。
- 前記一過性層が、ポリ乳酸、デキストロースのポリマー、ヒドロコロイド、アルギン酸塩、及びゼインのうちの1つ以上から選択され得る、請求項21に記載のマイクロカプセル化されたプロバイオティック。
- プロバイオティックを宿主に送達するための組成物であって、
ポリマーコア内に懸濁され、かつプロバイオティック栄養を更に含む、凍結乾燥プロバイオティックと、
0.3以下の水分活性を有する担体組成物と、含む、組成物。 - 前記低水分活性担体組成物が、ローション組成物、日焼け止め剤組成物、又は消臭剤組成物である、請求項23に記載の組成物。
- 前記プロバイオティックが、ビフィドバクテリウム、ペディオコッカス、ロイコノストック、ミクロコッカス、大腸菌、スタフィロコッカス、ストレプトコッカス、キャディダ、及びバチルスのうちの1つ以上から選択される、請求項23に記載の組成物。
- 前記低水分活性担体及び凍結乾燥プロバイオティックが、カプセル化されている、請求項23に記載の組成物。
- 前記コアの前記ポリマーが、ポリエチレングリコール(PEG)、ポリビニルピロリドン((PVP)、好ましくは、約40,000〜約360,0000の分子量を有する)、ポリビニルアルコール(PVA)、ポリアクリルアミド、N−(2−ヒドロキシプロピル)メタクリルアミド(HPMA)、キサンタンガム、グアーガム、ペクチン、デキストラン、カラギーナン、カルボキシエチルセルロースナトリウム、ポリアクリル酸ポリマー、ヒアルロン酸、カルボキシビニルポリマー、ヒドロキシエチルセルロース、セルロース、ヒドロキシプロピルメチルセルロース、カルボキシビニルポリマーから選択される、請求項23に記載の組成物。
- 前記ポリマーが、ポリアクリル酸ポリマーである、請求項23に記載のマイクロカプセル化されたプロバイオティック。
- 前記栄養組成物が、プレバイオティック糖である、請求項23に記載のマイクロカプセル化されたプロバイオティック。
- 前記栄養組成物が、前記コアの前記ポリマー中に分散されている、請求項29に記載のマイクロカプセル化されたプロバイオティック。
- 前記栄養組成物が、前記ポリマーコアを取り囲む、請求項29に記載のマイクロカプセル化されたプロバイオティック。
- 前記カプセル化コーティングが、ワックス、ポリマー材料、架橋ポリマー材料、金属、セラミック、又はそれらの組み合わせから選択される、請求項23に記載のマイクロカプセル化されたプロバイオティック。
- 前記カプセル化コーティングが、グリセリルトリステアレート、グリセリルジステアレート、コーン油、キャノーラワックス、水素添加綿実油、水素添加大豆油などの植物油、ヒマシワックス、ナタネワックス、蜜蝋、カマウバワックス、キャンデリラワックス、マイクロワックス、ポリエチレン、ポリプロピレン、エポキシ、長鎖アルコール、長鎖エステル、ステアリン酸及びベヘン酸などの長鎖脂肪酸、水素添加植物、魚油及び獣脂油などの動物油、大豆油、微結晶ワックス、金属ステアレート、白色グリース、黄色グリース、及び茶色グリース、並びに金属脂肪酸から選択されるワックスである、請求項32に記載のマイクロカプセル化されたプロバイオティック。
- 前記カプセル化化合物が、架橋アルギン酸ナトリウム、アニオン性分散ラテックスエマルション、架橋ポリアクリル酸、架橋ポリビニルアルコール、架橋ポリ酢酸ビニル、ケイ酸塩、炭酸塩、硫酸塩、リン酸塩、ホウ酸塩、ポリビニルピロリドン、PLA/PGA、熱電子ゲル、尿素ホルムアルデヒド、メラミンホルムアルデヒド、ポリメラミン、架橋デンプン、ナイロン、尿素、ヒドロコロイドから選択されるポリマーである、請求項23に記載のマイクロカプセル化されたプロバイオティック。
- 前記ポリマー化合物が、前記コア中に分散された1つ以上の活性化剤又は架橋剤によって活性化される、請求項34に記載のマイクロカプセル化されたプロバイオティック。
- 前記活性化剤が、カルシウムの多価イオン、銅の多価イオン、バリウムの多価イオン、シラン、アルミニウム、チタネート、キレート剤、酸のうちの1つ以上から選択される、請求項35に記載のマイクロカプセル化されたプロバイオティクス。
- 耐湿層を更に含む、請求項23に記載のマイクロカプセル化されたプロバイオティック。
- 前記耐湿層が、イソシアン酸塩、スチレン−アクリレート、ビニルトルエンアクリレート、スチレン−ブタジエン、ビニル−アクリレート、ポリビニルブチラール、ポリ酢酸ビニル、ポリエチレンテレフタレート、ポリプロピレン、ポリスチレン、ポリメタクリル酸メチル、ポリ乳酸、ポリ塩化ビニリデン、ポリビニルジクロリド、ポリエチレン、アルキドポリエステル、カルナバワックス、水素添加植物油、水素添加動物油、ヒュームドシリカ、シリコンワックス、二酸化チタン、二酸化ケイ素、金属、金属炭酸塩、金属硫酸塩、セラミック、金属リン酸塩、及び微結晶ワックスと組み合わせられたポリオールのうちの1つ以上から選択される、請求項37に記載のマイクロカプセル化されたプロバイオティック。
- 一過性層を更に含む、請求項23に記載のマイクロカプセル化されたプロバイオティック。
- 前記一過性層が、ポリ乳酸、デキストロースのポリマー、ヒドロコロイド、アルギン酸塩、及びゼインのうちの1つ以上から選択され得る、請求項39に記載のマイクロカプセル化されたプロバイオティック。
- カプセル化されたプロバイオティックを製造するための方法であって、
プロバイオティックを凍結乾燥することと、
前記凍結乾燥プロバイオティック及びプレバイオティック糖をポリマーと混合して、複合体を生成することと、
前記複合体を保護コーティング内にカプセル化することと、を含む、方法。 - 前記一過性層が、ポリ乳酸、デキストロースのポリマー、ヒドロコロイド、アルギン酸塩、及びゼインのうちの1つ以上から選択され得る、請求項39に記載の方法。
- 凍結乾燥プロバイオティックを生成する方法であって、
プロバイオティックを凍結乾燥することと、
前記凍結乾燥プロバイオティックを少なくとも1つの油中に分散させることと、
前記分散体をカプセル化して、マイクロカプセルを形成することと、を含む、方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201862648553P | 2018-03-27 | 2018-03-27 | |
US62/648,553 | 2018-03-27 | ||
PCT/US2019/024422 WO2019191325A1 (en) | 2018-03-27 | 2019-03-27 | Microencapsulated probiotic and low-water-activity compositions containing the same |
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JP2021519307A true JP2021519307A (ja) | 2021-08-10 |
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JP (1) | JP2021519307A (ja) |
BR (1) | BR112020019480A2 (ja) |
WO (1) | WO2019191325A1 (ja) |
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BR112022002044A2 (pt) * | 2019-09-24 | 2022-03-29 | Gpcp Ip Holdings Llc | Probiótico microencapsulado e composições contendo o mesmo |
EP3871653A1 (en) * | 2020-02-27 | 2021-09-01 | MicroCen Trans s.r.o | A composition containing a vital probiotic culture for human or veterinary use as a deodorant |
CN112094419B (zh) * | 2020-09-16 | 2022-08-19 | 青岛迦南美地家居用品有限公司 | 一种玻尿酸微胶囊、包含其的纤维、制备方法及应用 |
CN112890202A (zh) * | 2021-02-01 | 2021-06-04 | 绍兴同创生物科技有限公司 | 一种益生菌微囊及其制备方法 |
FR3136672A1 (fr) * | 2022-06-15 | 2023-12-22 | Basf Beauty Care Solutions France Sas | Nouvelle composition cosmétique ou dermatologique contenant une souche de bactérie vivante probiotique. |
WO2024115675A1 (en) * | 2022-12-01 | 2024-06-06 | Mello Aps | Encapsulated core material |
CN116283418B (zh) * | 2023-05-25 | 2023-08-11 | 地康食安(北京)农业科技有限公司 | 一种固载微生物的植物生长促进剂及其制备方法 |
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EP1344458A1 (en) | 2002-03-12 | 2003-09-17 | Société des Produits Nestlé S.A. | Probiotic delivery system |
US20050266069A1 (en) * | 2002-09-06 | 2005-12-01 | Simmons Donald L | Stable probiotic microsphere compositions and their methods of preparation |
US20080102163A1 (en) * | 2004-07-01 | 2008-05-01 | General Mills, Inc. | Cultures Encapsulated With Chocolate Food Products Coated With Chocolate And Method Of Preparation |
WO2008046625A2 (en) | 2006-10-18 | 2008-04-24 | Dsm Ip Assets B.V. | Encapsulation of heat and moisture sensitive substances |
US9210945B2 (en) | 2009-07-31 | 2015-12-15 | The Iams Company | Animal food having low water activity |
US20140065210A1 (en) | 2012-08-29 | 2014-03-06 | David W. Koenig | Protein stabilized probiotics and personal care products |
CN106011024A (zh) | 2016-07-11 | 2016-10-12 | 广州丹奇日用化工厂有限公司 | 一种微球菌微胶囊及其在祛痘化妆品中的应用 |
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- 2019-03-27 BR BR112020019480-8A patent/BR112020019480A2/pt not_active Application Discontinuation
- 2019-03-27 JP JP2020551921A patent/JP2021519307A/ja active Pending
- 2019-03-27 EP EP19777860.8A patent/EP3772986A4/en not_active Withdrawn
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BR112020019480A2 (pt) | 2020-12-29 |
WO2019191325A1 (en) | 2019-10-03 |
EP3772986A4 (en) | 2022-01-05 |
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