JP2021515032A - 好中球調節物質と免疫チェックポイントの調節物質の組み合わせを使用したがん処置 - Google Patents

好中球調節物質と免疫チェックポイントの調節物質の組み合わせを使用したがん処置 Download PDF

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JP2021515032A
JP2021515032A JP2020566524A JP2020566524A JP2021515032A JP 2021515032 A JP2021515032 A JP 2021515032A JP 2020566524 A JP2020566524 A JP 2020566524A JP 2020566524 A JP2020566524 A JP 2020566524A JP 2021515032 A JP2021515032 A JP 2021515032A
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cancer
antibody
met
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biomarker
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JPWO2019161320A5 (https=
JP2021515032A5 (https=
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レドゥカ，サンジーヴ
レディ，マンマサ
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アポロミクス インコーポレイテッド
アポロミクス インコーポレイテッド
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP2020566524A 2018-02-17 2019-02-17 好中球調節物質と免疫チェックポイントの調節物質の組み合わせを使用したがん処置 Pending JP2021515032A (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2023173684A JP2024009886A (ja) 2018-02-17 2023-10-05 好中球調節物質と免疫チェックポイントの調節物質の組み合わせを使用したがん処置

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201862631771P 2018-02-17 2018-02-17
US62/631,771 2018-02-17
US201862757729P 2018-11-08 2018-11-08
US62/757,729 2018-11-08
PCT/US2019/018377 WO2019161320A1 (en) 2018-02-17 2019-02-17 Cancer treatment using combination of neutrophil modulator with modulator of immune checkpoint

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JP2023173684A Division JP2024009886A (ja) 2018-02-17 2023-10-05 好中球調節物質と免疫チェックポイントの調節物質の組み合わせを使用したがん処置

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JP2021515032A true JP2021515032A (ja) 2021-06-17
JPWO2019161320A5 JPWO2019161320A5 (https=) 2022-03-09
JP2021515032A5 JP2021515032A5 (https=) 2022-03-09

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JP2023173684A Pending JP2024009886A (ja) 2018-02-17 2023-10-05 好中球調節物質と免疫チェックポイントの調節物質の組み合わせを使用したがん処置

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US (1) US20200405719A1 (https=)
EP (1) EP3752528A4 (https=)
JP (2) JP2021515032A (https=)
CN (1) CN112424222A (https=)
CA (1) CA3091373A1 (https=)
WO (1) WO2019161320A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2024009886A (ja) * 2018-02-17 2024-01-23 アポロミクス インコーポレイテッド 好中球調節物質と免疫チェックポイントの調節物質の組み合わせを使用したがん処置

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2023523295A (ja) * 2020-04-26 2023-06-02 アポロミクス インコーポレイテッド Ｃ－ｍｅｔ阻害剤のための新規医薬製剤
EP4159238A4 (en) * 2020-06-02 2024-08-07 Chia Tai Tianqing Pharmaceutical Group Co., Ltd. COMBINED PHARMACEUTICAL COMPOSITION OF C-MET KINASE INHIBITOR AND ANTI-PD-L1 ANTIBODY
CN113105436B (zh) * 2021-04-20 2022-07-01 西格莱(苏州)生物医药有限公司 吡唑类化合物的制备方法及其中间体
WO2023172629A2 (en) * 2022-03-08 2023-09-14 Brown University Anticancer maleimide derivatives for use with immune checkpoint blockade
WO2025129332A1 (en) * 2023-12-21 2025-06-26 11949098 Canada Inc. (Nuredco) C/O Jean I. Tchervenkov Method of prognosis and monitoring of cancer patient and of determining immunological status of a subject

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015526486A (ja) * 2012-09-03 2015-09-10 クラウン バイオサイエンス インコーポレイテッド（台湾） 抗がん剤としての高選択性ｃ−Ｍｅｔ阻害剤
WO2017058780A1 (en) * 2015-09-30 2017-04-06 Merck Patent Gmbh Combination of a pd-1 axis binding antagonist and an alk inhibitor for treating alk-negative cancer
JP2017523786A (ja) * 2014-08-05 2017-08-24 シービー セラピューティックス インコーポレイテッド 抗ｐｄ−ｌ１抗体
JP2017530722A (ja) * 2014-07-22 2017-10-19 シービー セラピューティックス インコーポレイテッド 抗ｐｄ−１抗体
JP2017537112A (ja) * 2014-12-04 2017-12-14 ヤンセン ファーマシューティカ エンヴェー キナーゼモジュレーターとしての重水素化トリアゾロピリダジン

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101050829B1 (ko) * 2008-10-02 2011-07-20 서울대학교산학협력단 항 ｐｄ-1 항체 또는 항 ｐｄ-ｌ1 항체를 포함하는 항암제
EP3122900A1 (en) * 2014-03-24 2017-02-01 F. Hoffmann-La Roche AG Cancer treatment with c-met antagonists and correlation of the latter with hgf expression
AU2015327868A1 (en) * 2014-10-03 2017-04-20 Novartis Ag Combination therapies
RS61152B2 (sr) * 2015-05-12 2024-06-28 Hoffmann La Roche Terapeutski i dijagnostički postupci za lečenje raka
HK1254635A1 (zh) * 2015-12-17 2019-07-26 Novartis Ag C-met抑制剂与pd-1抗体分子的组合及其用途
CA3091373A1 (en) * 2018-02-17 2019-08-22 Apollomics Inc. Cancer treatment using combination of neutrophil modulator with modulator of immune checkpoint
EP4159238A4 (en) * 2020-06-02 2024-08-07 Chia Tai Tianqing Pharmaceutical Group Co., Ltd. COMBINED PHARMACEUTICAL COMPOSITION OF C-MET KINASE INHIBITOR AND ANTI-PD-L1 ANTIBODY

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015526486A (ja) * 2012-09-03 2015-09-10 クラウン バイオサイエンス インコーポレイテッド（台湾） 抗がん剤としての高選択性ｃ−Ｍｅｔ阻害剤
JP2017530722A (ja) * 2014-07-22 2017-10-19 シービー セラピューティックス インコーポレイテッド 抗ｐｄ−１抗体
JP2017523786A (ja) * 2014-08-05 2017-08-24 シービー セラピューティックス インコーポレイテッド 抗ｐｄ−ｌ１抗体
JP2017537112A (ja) * 2014-12-04 2017-12-14 ヤンセン ファーマシューティカ エンヴェー キナーゼモジュレーターとしての重水素化トリアゾロピリダジン
WO2017058780A1 (en) * 2015-09-30 2017-04-06 Merck Patent Gmbh Combination of a pd-1 axis binding antagonist and an alk inhibitor for treating alk-negative cancer

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
IMMUNITY, vol. 47, JPN6023002158, 2017, pages 789 - 802, ISSN: 0005209406 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2024009886A (ja) * 2018-02-17 2024-01-23 アポロミクス インコーポレイテッド 好中球調節物質と免疫チェックポイントの調節物質の組み合わせを使用したがん処置

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US20200405719A1 (en) 2020-12-31
EP3752528A1 (en) 2020-12-23
WO2019161320A1 (en) 2019-08-22
CA3091373A1 (en) 2019-08-22
CN112424222A (zh) 2021-02-26
EP3752528A4 (en) 2021-11-03
JP2024009886A (ja) 2024-01-23

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