JP2021515016A5 - - Google Patents

Info

Publication number
JP2021515016A5
JP2021515016A5 JP2020546409A JP2020546409A JP2021515016A5 JP 2021515016 A5 JP2021515016 A5 JP 2021515016A5 JP 2020546409 A JP2020546409 A JP 2020546409A JP 2020546409 A JP2020546409 A JP 2020546409A JP 2021515016 A5 JP2021515016 A5 JP 2021515016A5
Authority
JP
Japan
Prior art keywords
coor
substituted
halogen
independently
alkyl
Prior art date
Application number
JP2020546409A
Other languages
English (en)
Japanese (ja)
Other versions
JP2021515016A (ja
JPWO2019173587A5 (https=
JP7250808B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2019/021145 external-priority patent/WO2019173587A1/en
Publication of JP2021515016A publication Critical patent/JP2021515016A/ja
Publication of JP2021515016A5 publication Critical patent/JP2021515016A5/ja
Publication of JPWO2019173587A5 publication Critical patent/JPWO2019173587A5/ja
Application granted granted Critical
Publication of JP7250808B2 publication Critical patent/JP7250808B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2020546409A 2018-03-08 2019-03-07 抗がん剤としての環状ジヌクレオチド Active JP7250808B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862640325P 2018-03-08 2018-03-08
US62/640,325 2018-03-08
PCT/US2019/021145 WO2019173587A1 (en) 2018-03-08 2019-03-07 Cyclic dinucleotides as anticancer agents

Publications (4)

Publication Number Publication Date
JP2021515016A JP2021515016A (ja) 2021-06-17
JP2021515016A5 true JP2021515016A5 (https=) 2022-02-17
JPWO2019173587A5 JPWO2019173587A5 (https=) 2022-02-17
JP7250808B2 JP7250808B2 (ja) 2023-04-03

Family

ID=65818709

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2020546409A Active JP7250808B2 (ja) 2018-03-08 2019-03-07 抗がん剤としての環状ジヌクレオチド

Country Status (7)

Country Link
US (1) US11945834B2 (https=)
EP (1) EP3762397B1 (https=)
JP (1) JP7250808B2 (https=)
KR (2) KR20200130362A (https=)
CN (1) CN111801341B (https=)
ES (1) ES2980374T3 (https=)
WO (1) WO2019173587A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11660311B2 (en) 2017-10-10 2023-05-30 Bristol-Myers Squibb Company Cyclic dinucleotides as anticancer agents
WO2021206158A1 (ja) 2020-04-10 2021-10-14 小野薬品工業株式会社 がん治療方法

Family Cites Families (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI309240B (en) 2004-09-17 2009-05-01 Hoffmann La Roche Anti-ox40l antibodies
AU2006230099B2 (en) 2005-03-25 2012-04-19 Gitr, Inc. GITR binding molecules and uses therefor
PL1879573T3 (pl) 2005-05-10 2013-05-31 Incyte Holdings Corp Modulatory 2,3-dioksygenazy indoloaminy i sposoby ich zastosowania
CA2634198C (en) 2005-12-20 2014-06-03 Incyte Corporation N-hydroxyamidinoheterocycles as modulators of indoleamine 2,3-dioxygenase
CL2007002650A1 (es) 2006-09-19 2008-02-08 Incyte Corp Compuestos derivados de heterociclo n-hidroxiamino; composicion farmaceutica, util para tratar cancer, infecciones virales y desordenes neurodegenerativos entre otras.
ES2444574T3 (es) 2006-09-19 2014-02-25 Incyte Corporation N-hidroxiamidinoheterociclos como moduladores de la indolamina 2,3-dioxigenasa
EP1987839A1 (en) 2007-04-30 2008-11-05 I.N.S.E.R.M. Institut National de la Sante et de la Recherche Medicale Cytotoxic anti-LAG-3 monoclonal antibody and its use in the treatment or prevention of organ transplant rejection and autoimmune disease
ES2776406T3 (es) 2007-07-12 2020-07-30 Gitr Inc Terapias de combinación que emplean moléculas de enlazamiento a GITR
EP2044949A1 (en) 2007-10-05 2009-04-08 Immutep Use of recombinant lag-3 or the derivatives thereof for eliciting monocyte immune response
JP5583592B2 (ja) 2007-11-30 2014-09-03 ニューリンク ジェネティクス コーポレイション Ido阻害剤
AR072999A1 (es) 2008-08-11 2010-10-06 Medarex Inc Anticuerpos humanos que se unen al gen 3 de activacion linfocitaria (lag-3) y los usos de estos
EP2473531A4 (en) 2009-09-03 2013-05-01 Merck Sharp & Dohme Anti-gitr antibodies
US8722720B2 (en) 2009-10-28 2014-05-13 Newlink Genetics Corporation Imidazole derivatives as IDO inhibitors
PH12012500881A1 (en) 2009-12-10 2017-07-26 Hoffmann La Roche Antibodies binding preferentially human csf1r extracellular domain 4 and their use
CA2789076C (en) 2010-03-05 2017-11-21 F. Hoffmann-La Roche Ag Antibodies against human colony stimulating factor-1 receptor and uses thereof
CN102918061B (zh) 2010-03-05 2016-06-08 霍夫曼-拉罗奇有限公司 针对人csf-1r的抗体及其用途
MX378336B (es) 2010-05-04 2025-03-10 Five Prime Therapeutics Inc Anticuerpos que se unen a factor estimulante de colonias 1 (csf1r).
PT2614082T (pt) 2010-09-09 2018-12-03 Pfizer Moléculas de ligação a 4-1bb
NO2694640T3 (https=) 2011-04-15 2018-03-17
KR101970025B1 (ko) 2011-04-20 2019-04-17 메디뮨 엘엘씨 B7-h1 및 pd-1과 결합하는 항체 및 다른 분자들
BR112014012624A2 (pt) 2011-12-15 2018-10-09 F Hoffmann-La Roche Ag anticorpos, composição farmacêutica, ácido nucleico, vetores de expressão, célula hospedeira, método para a produção de um anticorpo recombinante e uso do anticorpo
RU2014136332A (ru) 2012-02-06 2016-03-27 Дженентек, Инк. Композиции и способы применения ингибиторов csf1r
AR090263A1 (es) 2012-03-08 2014-10-29 Hoffmann La Roche Terapia combinada de anticuerpos contra el csf-1r humano y las utilizaciones de la misma
EP2847220A1 (en) 2012-05-11 2015-03-18 Five Prime Therapeutics, Inc. Methods of treating conditions with antibodies that bind colony stimulating factor 1 receptor (csf1r)
HK1204557A1 (en) 2012-05-31 2015-11-27 Sorrento Therapeutics, Inc. Antigen binding proteins that bind pd-l1
AR091649A1 (es) 2012-07-02 2015-02-18 Bristol Myers Squibb Co Optimizacion de anticuerpos que se fijan al gen de activacion de linfocitos 3 (lag-3) y sus usos
CN107759690A (zh) 2012-08-31 2018-03-06 戊瑞治疗有限公司 用结合群落刺激因子1受体(csf1r)的抗体治疗病状的方法
JP6742903B2 (ja) 2013-05-02 2020-08-19 アナプティスバイオ インコーポレイティッド プログラム死−1(pd−1)に対する抗体
US9676853B2 (en) 2013-05-31 2017-06-13 Sorrento Therapeutics, Inc. Antigen binding proteins that bind PD-1
EA034666B1 (ru) 2013-09-13 2020-03-04 Бейджин Свитзерланд Гмбх Антитело против pd-1 и его применение для лечения рака или вирусной инфекции и фрагмент антитела
MY184154A (en) 2013-12-12 2021-03-23 Shanghai hengrui pharmaceutical co ltd Pd-1 antibody, antigen-binding fragment thereof, and medical application thereof
TWI681969B (zh) 2014-01-23 2020-01-11 美商再生元醫藥公司 針對pd-1的人類抗體
SG10201900002QA (en) 2014-01-24 2019-02-27 Dana Farber Cancer Institue Inc Antibody molecules to pd-1 and uses thereof
CN108112254B (zh) 2015-03-13 2022-01-28 西托姆克斯治疗公司 抗-pdl1抗体、可活化的抗-pdl1抗体、及其使用方法
CR20180101A (es) * 2015-08-13 2018-04-12 Merck Sharp & Dohme Compuestos di-nucleóticos cíclicos como agonistas de sting
RS67188B1 (sr) * 2016-01-11 2025-10-31 Innate Tumor Immunity Inc Ciklični dinukleotidi za lečenje stanja povezanih sa aktivnošću sting kao što je kancer
WO2017123657A1 (en) * 2016-01-11 2017-07-20 Gary Glick Cyclic dinucleotides for treating conditions associated with sting activity such as cancer
SG10201912074PA (en) * 2016-03-18 2020-02-27 Immune Sensor Llc Cyclic di-nucleotide compounds and methods of use
WO2019043634A2 (en) * 2017-08-30 2019-03-07 Beijing Xuanyi Pharmasciences Co., Ltd. CYCLIC DI-NUCLEOTIDES AS STIMULATORS OF INTERFERON GENE MODULATORS
ES2904317T3 (es) * 2017-08-31 2022-04-04 Bristol Myers Squibb Co Dinucleótidos cíclicos como agentes anticancerosos
US10947263B2 (en) * 2017-08-31 2021-03-16 Bristol-Myers Squibb Company Cyclic dinucleotides as anticancer agents
US11667663B2 (en) * 2017-08-31 2023-06-06 Bristol-Myers Squibb Company Cyclic dinucleotides as anticancer agents
US11660311B2 (en) * 2017-10-10 2023-05-30 Bristol-Myers Squibb Company Cyclic dinucleotides as anticancer agents
US11427610B2 (en) * 2017-10-16 2022-08-30 Bristol-Myers Squibb Company Cyclic dinucleotides as anticancer agents

Similar Documents

Publication Publication Date Title
JP2020536971A5 (https=)
JP2021513562A5 (https=)
JP7602272B2 (ja) Kras関連がんを治療する方法
CN101678029B (zh) 基于嘌呤的cdk抑制剂与酪氨酸激酶抑制剂的组合及其在治疗增生性疾病中的用途
AU2016213972B2 (en) Combinations of IRS/Stat3 dual modulators and anti-cancer agents for treating cancer
JP2019501204A5 (https=)
JP2020536897A5 (https=)
AU2009279771B2 (en) Antineoplastic combinations of 4-anilino-3-cyanoquinolines and capecitabine
JP2020532542A5 (https=)
JP2020532529A5 (https=)
HRP20220520T1 (hr) Ciklički dinukleotidi kao agensi protiv raka
JP2020529400A5 (https=)
JP2020532539A5 (https=)
KR20140025433A (ko) Akt 억제제 화합물 및 베무라페닙의 조합물, 및 사용 방법
RU2013132018A (ru) Применение производных пиримидина для лечения egfr-зависимых заболеваний или заболеваний с приобретенной резистентностью к агентам, направленным против членов семейства egfr
WO2013100014A1 (ja) 抗腫瘍剤の効果増強剤
JP2019048822A (ja) Egfr依存性疾患またはegfrファミリーメンバーを標的とする薬剤に対して獲得耐性を有する疾患の治療における2−カルボキサミドシクロアミノウレア誘導体の使用
US20100196365A1 (en) Use of imidazoquinolines for the treatment of egfr dependent diseases or diseases that have acquired resistance to agents that target egfr family members
WO2016104657A1 (ja) 癌治療剤
JP2021515016A5 (https=)
JPWO2019160884A5 (https=)
EP3324974B1 (en) Compounds, compositions, methods for treating diseases, and methods for preparing compounds
JPWO2019173587A5 (https=)
JP2021138693A5 (https=)
JP6553726B2 (ja) 腫瘍治療剤