JP2021504479A - 非アルコール性脂肪性肝炎の処置のための方法および医薬組成物 - Google Patents

非アルコール性脂肪性肝炎の処置のための方法および医薬組成物 Download PDF

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Publication number
JP2021504479A
JP2021504479A JP2020546307A JP2020546307A JP2021504479A JP 2021504479 A JP2021504479 A JP 2021504479A JP 2020546307 A JP2020546307 A JP 2020546307A JP 2020546307 A JP2020546307 A JP 2020546307A JP 2021504479 A JP2021504479 A JP 2021504479A
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pirfenidone
administered
ubenimex
dose
nash
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JP2020546307A
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JP2021504479A5 (enExample
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デイビッド・コリー
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Eiger Biopharmaceuticals Inc
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Eiger Biopharmaceuticals Inc
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Publication of JP2021504479A publication Critical patent/JP2021504479A/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4418—Non condensed pyridines; Hydrogenated derivatives thereof having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/05—Dipeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2020546307A 2017-11-28 2018-11-27 非アルコール性脂肪性肝炎の処置のための方法および医薬組成物 Pending JP2021504479A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762591667P 2017-11-28 2017-11-28
US62/591,667 2017-11-28
PCT/US2018/062645 WO2019108551A1 (en) 2017-11-28 2018-11-27 Methods and pharmaceutical compositions for the treatment of non-alcoholic steatohepatitis

Publications (2)

Publication Number Publication Date
JP2021504479A true JP2021504479A (ja) 2021-02-15
JP2021504479A5 JP2021504479A5 (enExample) 2022-01-06

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JP2020546307A Pending JP2021504479A (ja) 2017-11-28 2018-11-27 非アルコール性脂肪性肝炎の処置のための方法および医薬組成物

Country Status (7)

Country Link
US (1) US20210369693A1 (enExample)
EP (1) EP3716975A4 (enExample)
JP (1) JP2021504479A (enExample)
CN (1) CN111386115A (enExample)
AU (1) AU2018375298A1 (enExample)
CA (1) CA3082178A1 (enExample)
WO (1) WO2019108551A1 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102399254B1 (ko) 2016-09-28 2022-05-17 아이거 바이오파마슈티컬스 인코포레이티드 비-알코올성 지방간염의 치료를 위한 방법 및 약제학적 조성물
WO2023220003A1 (en) * 2022-05-10 2023-11-16 Opko Pharmaceuticals, Llc Topical ophthalmic pirfenidone-loaded liposomes to increase the therapeutic activity of the drug in cornea and useful for prevention or therapy of corneal haze
CN118680879A (zh) * 2024-06-03 2024-09-24 贵州医科大学 一种用于负载吡非尼酮的口服肝靶向纳米乳剂及其制备方法和应用

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH11508247A (ja) * 1995-06-21 1999-07-21 シチュアン インダストリアル インスティテュート オブ アンティバイオティクス，ザ ステート ファーマシューティカル アドミニストレイション オブ チャイナ ウベニメクス及びウベニメクスを含む医薬組成物のウイルス性肝炎の治療薬としての用途
WO2001058448A1 (fr) * 2000-02-09 2001-08-16 Shionogi & Co., Ltd. Inhibiteur d'apoptose
US20080025986A1 (en) * 2003-06-06 2008-01-31 Ozes Osman N Methods of Treating Tnf-Mediated Disorders
JP2019535822A (ja) * 2016-11-11 2019-12-12 セル セラピー アンド テクノロジー，エス．エー． デーイー シー．ヴィ． ヒト脂肪性肝炎（ｎａｆｌｄ／ｎａｓｈ）の治療及び回復に対するピルフェニドンを含む持続放出性の組成物の薬学的使用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2827849A4 (en) * 2012-03-23 2015-11-18 Univ Leland Stanford Junior TREATMENT OF PULMONARY HYPERTONIA WITH LEUKOTRIENHEMMERN
CA2819967C (en) * 2012-08-31 2016-03-22 Intermune, Inc. Use of pirfenidone concomitantly with ciprofloxacin
JP2018536710A (ja) * 2015-11-06 2018-12-13 ジェンファイア・セラピューティクス・インコーポレイテッドＧｅｍｐｈｉｒｅ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｉｎｃ． 混合型脂質異常症の治療
WO2017108744A1 (de) * 2015-12-22 2017-06-29 Bayer Pharma Aktiengesellschaft Neue substituierte indazole, verfahren zu ihrer herstellung, pharmazeutische präparate die diese enthalten, sowie deren verwendung zur herstellung von arzneimitteln
KR102399254B1 (ko) * 2016-09-28 2022-05-17 아이거 바이오파마슈티컬스 인코포레이티드 비-알코올성 지방간염의 치료를 위한 방법 및 약제학적 조성물

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH11508247A (ja) * 1995-06-21 1999-07-21 シチュアン インダストリアル インスティテュート オブ アンティバイオティクス，ザ ステート ファーマシューティカル アドミニストレイション オブ チャイナ ウベニメクス及びウベニメクスを含む医薬組成物のウイルス性肝炎の治療薬としての用途
WO2001058448A1 (fr) * 2000-02-09 2001-08-16 Shionogi & Co., Ltd. Inhibiteur d'apoptose
US20080025986A1 (en) * 2003-06-06 2008-01-31 Ozes Osman N Methods of Treating Tnf-Mediated Disorders
JP2019535822A (ja) * 2016-11-11 2019-12-12 セル セラピー アンド テクノロジー，エス．エー． デーイー シー．ヴィ． ヒト脂肪性肝炎（ｎａｆｌｄ／ｎａｓｈ）の治療及び回復に対するピルフェニドンを含む持続放出性の組成物の薬学的使用

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
SCIENTIFIC REPORTS, vol. 7:44754, JPN6022042700, March 2017 (2017-03-01), pages 1 - 12, ISSN: 0005058668 *

Also Published As

Publication number Publication date
EP3716975A4 (en) 2022-01-12
CA3082178A1 (en) 2019-06-06
CN111386115A (zh) 2020-07-07
WO2019108551A1 (en) 2019-06-06
EP3716975A1 (en) 2020-10-07
US20210369693A1 (en) 2021-12-02
AU2018375298A1 (en) 2020-05-28

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