JP2021503448A - Ｌｓｚ１０２及びリボシクリブを含む医薬組合せ - Google Patents

Ｌｓｚ１０２及びリボシクリブを含む医薬組合せ Download PDF

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JP2021503448A
JP2021503448A JP2020526417A JP2020526417A JP2021503448A JP 2021503448 A JP2021503448 A JP 2021503448A JP 2020526417 A JP2020526417 A JP 2020526417A JP 2020526417 A JP2020526417 A JP 2020526417A JP 2021503448 A JP2021503448 A JP 2021503448A
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Prior art keywords
lsz102
day
pharmaceutically acceptable
breast cancer
mcf
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Japanese (ja)
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JP2021503448A5 (https=
Inventor
アブラムス，ティンヤ
ガイサー，ラリー
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ノバルティス アーゲー
ノバルティス アーゲー
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Publication of JP2021503448A5 publication Critical patent/JP2021503448A5/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2020526417A 2017-11-16 2018-11-14 Ｌｓｚ１０２及びリボシクリブを含む医薬組合せ Pending JP2021503448A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762587239P 2017-11-16 2017-11-16
US62/587,239 2017-11-16
US201862758835P 2018-11-12 2018-11-12
US62/758,835 2018-11-12
PCT/IB2018/058963 WO2019097426A1 (en) 2017-11-16 2018-11-14 Pharmaceutical combination comprising lsz102 and ribociclib

Publications (2)

Publication Number Publication Date
JP2021503448A true JP2021503448A (ja) 2021-02-12
JP2021503448A5 JP2021503448A5 (https=) 2021-12-23

Family

ID=64572406

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2020526417A Pending JP2021503448A (ja) 2017-11-16 2018-11-14 Ｌｓｚ１０２及びリボシクリブを含む医薬組合せ

Country Status (6)

Country Link
US (2) US11179365B2 (https=)
EP (1) EP3709997A1 (https=)
JP (1) JP2021503448A (https=)
CN (1) CN111315378A (https=)
TW (1) TW201922238A (https=)
WO (1) WO2019097426A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102529049B1 (ko) * 2013-08-14 2023-05-08 노파르티스 아게 암의 치료를 위한 조합 요법
WO2019106604A1 (en) * 2017-12-01 2019-06-06 Novartis Ag Pharmaceutical combination comprising lsz102 and alpelisib
WO2023284790A1 (zh) * 2021-07-13 2023-01-19 江苏恒瑞医药股份有限公司 选择性雌激素受体共价拮抗剂与cdk4/6抑制剂联合在制备治疗乳腺癌药物中的用途

Citations (5)

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JP2015003909A (ja) * 2013-06-19 2015-01-08 オレマ ファーマシューティカルズ インク． ベンゾピラン化合物の組合せ、その組成物および使用
JP2016509022A (ja) * 2013-02-19 2016-03-24 ノバルティス アーゲー 選択的エストロゲン受容体ディグレーダーとしてのベンゾチオフェン誘導体およびその組成物
JP2016516005A (ja) * 2013-02-25 2016-06-02 ノバルティス アーゲー 新規のアンドロゲンレセプター変異
WO2017172957A1 (en) * 2016-04-01 2017-10-05 Kalyra Pharmaceuticals, Inc. Estrogen receptor modulators
WO2017174757A1 (en) * 2016-04-08 2017-10-12 F. Hoffmann-La Roche Ag Tetrahydroisoquinoline estrogen receptor modulators and uses thereof

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US20080306057A1 (en) 2005-10-11 2008-12-11 Laboratories Serono Sa P13K Inhibitors for the Treatment of Endometriosis
ES2522346T3 (es) 2008-08-22 2014-11-14 Novartis Ag Compuestos de pirrolopirimidina como inhibidores de CDK
EP2650401A1 (de) 2012-04-10 2013-10-16 Siemens Aktiengesellschaft Kraftwerk basiertes Methanisierungssystem
EA031077B1 (ru) 2013-06-19 2018-11-30 Серагон Фармасьютикалз, Инк. Модулятор рецептора эстрогена и его применения
KR102529049B1 (ko) 2013-08-14 2023-05-08 노파르티스 아게 암의 치료를 위한 조합 요법
WO2015028409A1 (de) 2013-08-27 2015-03-05 Bayer Pharma Aktiengesellschaft 6,7-dihydro-5h-benzo[7]annulen-derivate, verfahren zu ihrer herstellung, pharmazeutische präparate die diese enthalten, sowie deren verwendung zur herstellung von arzneimitteln
JP6223154B2 (ja) 2013-11-29 2017-11-01 ロッテ アドバンスト マテリアルズ カンパニー リミテッド ポリアミド樹脂およびその製造方法
JP2017507964A (ja) 2014-03-13 2017-03-23 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト エストロゲン受容体モジュレーターを用いた治療的組合せ
JP7019422B2 (ja) 2015-04-29 2022-02-15 ラジウス ファーマシューティカルズ，インコーポレイテッド 癌を治療するための方法
HK1249866A1 (zh) 2015-06-29 2018-11-16 豪夫迈‧罗氏有限公司 用他塞利昔布进行治疗的方法
JP7084875B2 (ja) 2016-03-29 2022-06-15 ノバルティス アーゲー 水－界面活性剤混合物を含む反応媒体
EP3565558B1 (en) 2017-01-06 2023-12-06 G1 Therapeutics, Inc. Combination therapy with a serd compound and a cdk4/6 inhibitor for the treatment of cancer
WO2019106604A1 (en) 2017-12-01 2019-06-06 Novartis Ag Pharmaceutical combination comprising lsz102 and alpelisib

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016509022A (ja) * 2013-02-19 2016-03-24 ノバルティス アーゲー 選択的エストロゲン受容体ディグレーダーとしてのベンゾチオフェン誘導体およびその組成物
JP2016516005A (ja) * 2013-02-25 2016-06-02 ノバルティス アーゲー 新規のアンドロゲンレセプター変異
JP2015003909A (ja) * 2013-06-19 2015-01-08 オレマ ファーマシューティカルズ インク． ベンゾピラン化合物の組合せ、その組成物および使用
WO2017172957A1 (en) * 2016-04-01 2017-10-05 Kalyra Pharmaceuticals, Inc. Estrogen receptor modulators
WO2017174757A1 (en) * 2016-04-08 2017-10-12 F. Hoffmann-La Roche Ag Tetrahydroisoquinoline estrogen receptor modulators and uses thereof

Non-Patent Citations (6)

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Title
"(E)-3-(4-((2-(2-(1,1-difluoroethyl)-4-fluorophenyl)-6-hydroxybenzo[b]thiophen-3-yl)oxy)phenyl)acryli", PUBCHEM, JPN6022040968, 23 February 2016 (2016-02-23), ISSN: 0005044947 *
CANCER RESEARCH, vol. Vol.77, No.4 supplement, JPN6022040972, February 2017 (2017-02-01), pages 4 - 22, ISSN: 0004888253 *
CLINICAL CANCER RESERCH, vol. 21, no. 22, JPN6022040973, 2015, pages 5121 - 5130, ISSN: 0004888254 *
LANCET, vol. Vol.389-2403-2414, JPN6022040975, 2016, ISSN: 0004888255 *
MEDICAL ONCOLOGY, vol. 34, no. 119, JPN6022040967, 19 May 2017 (2017-05-19), pages 1 - 16, ISSN: 0005044946 *
TRANSLATIONAL ONCOLOGY, vol. 10, no. 5, JPN6022040970, October 2017 (2017-10-01), pages 766 - 771, ISSN: 0005044948 *

Also Published As

Publication number Publication date
EP3709997A1 (en) 2020-09-23
TW201922238A (zh) 2019-06-16
CN111315378A (zh) 2020-06-19
US11179365B2 (en) 2021-11-23
WO2019097426A1 (en) 2019-05-23
US20220031657A1 (en) 2022-02-03
US20190142796A1 (en) 2019-05-16

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