JP2021500901A - Crofおよび機械学習を使用する画像ベースのアッセイのシステムおよび方法 - Google Patents

Crofおよび機械学習を使用する画像ベースのアッセイのシステムおよび方法 Download PDF

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JP2021500901A
JP2021500901A JP2020523785A JP2020523785A JP2021500901A JP 2021500901 A JP2021500901 A JP 2021500901A JP 2020523785 A JP2020523785 A JP 2020523785A JP 2020523785 A JP2020523785 A JP 2020523785A JP 2021500901 A JP2021500901 A JP 2021500901A
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スティーブン ワイ. チョウ
スティーブン ワイ. チョウ
ウェイ ディン
ウェイ ディン
ウー チョウ
ウー チョウ
ジュン ティアン
ジュン ティアン
ユエチェン チャン
ユエチェン チャン
ミンカン ウー
ミンカン ウー
リ リ
リ リ
マイケル レオニー
マイケル レオニー
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エッセンリックス コーポレーション
エッセンリックス コーポレーション
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JP2020523785A 2017-10-26 2018-10-26 Crofおよび機械学習を使用する画像ベースのアッセイのシステムおよび方法 Pending JP2021500901A (ja)

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US201762577481P 2017-10-26 2017-10-26
US62/577,481 2017-10-26
PCT/US2018/057877 WO2019084517A1 (en) 2017-10-26 2018-10-26 SYSTEM AND METHODS FOR IMAGE-BASED ANALYSIS USING MACHINE LEARNING AND CROF

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Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2021501322A (ja) * 2017-10-26 2021-01-14 エッセンリックス コーポレーション 血小板の高速測定法
US12089930B2 (en) 2018-03-05 2024-09-17 Marquette University Method and apparatus for non-invasive hemoglobin level prediction
EP3575813B1 (en) * 2018-05-30 2022-06-29 Siemens Healthcare GmbH Quantitative mapping of a magnetic resonance imaging parameter by data-driven signal-model learning
EP3837543A4 (en) * 2018-08-16 2022-11-16 Essenlix Corporation CELL ANALYSIS IN BODY FLUID, ESPECIALLY BLOOD
US11068694B2 (en) * 2019-01-23 2021-07-20 Molecular Devices, Llc Image analysis system and method of using the image analysis system
JP7314253B2 (ja) * 2019-03-19 2023-07-25 富士フイルム株式会社 情報処理装置、細胞培養システム、情報処理方法、及び情報処理プログラム
US11210554B2 (en) 2019-03-21 2021-12-28 Illumina, Inc. Artificial intelligence-based generation of sequencing metadata
US11783917B2 (en) 2019-03-21 2023-10-10 Illumina, Inc. Artificial intelligence-based base calling
US11423306B2 (en) 2019-05-16 2022-08-23 Illumina, Inc. Systems and devices for characterization and performance analysis of pixel-based sequencing
US11593649B2 (en) * 2019-05-16 2023-02-28 Illumina, Inc. Base calling using convolutions
CN110223279B (zh) * 2019-05-31 2021-10-08 上海商汤智能科技有限公司 一种图像处理方法和装置、电子设备
WO2020246753A1 (en) * 2019-06-03 2020-12-10 Samsung Electronics Co., Ltd. Electronic apparatus for object recognition and control method thereof
US20220276235A1 (en) * 2019-07-18 2022-09-01 Essenlix Corporation Imaging based homogeneous assay
GB2583149B (en) * 2019-07-19 2021-03-17 Forsite Diagnostics Ltd Assay reading method
US20230012125A1 (en) * 2019-11-27 2023-01-12 Corning Incorporated Sensing vessels for cell cultures
WO2021104410A1 (zh) * 2019-11-28 2021-06-03 北京小蝇科技有限责任公司 血涂片全视野智能分析方法血细胞分割模型及识别模型的构造方法
US12354008B2 (en) 2020-02-20 2025-07-08 Illumina, Inc. Knowledge distillation and gradient pruning-based compression of artificial intelligence-based base caller
WO2021168353A2 (en) 2020-02-20 2021-08-26 Illumina, Inc. Artificial intelligence-based many-to-many base calling
US20210265016A1 (en) 2020-02-20 2021-08-26 Illumina, Inc. Data Compression for Artificial Intelligence-Based Base Calling
US12055542B2 (en) 2020-05-29 2024-08-06 Quidel Corporation System and methods for remote assessment of a sample assay for disease diagnostics
US11783563B2 (en) * 2020-05-29 2023-10-10 Quidel Corporation Software and algorithms for use in remote assessment of disease diagnostics
WO2022204611A1 (en) * 2021-03-26 2022-09-29 Essenlix Corporation Cells and other bio-entity analysis and counting
US20220336057A1 (en) 2021-04-15 2022-10-20 Illumina, Inc. Efficient voxelization for deep learning
US12217829B2 (en) 2021-04-15 2025-02-04 Illumina, Inc. Artificial intelligence-based analysis of protein three-dimensional (3D) structures
WO2023287831A2 (en) * 2021-07-12 2023-01-19 Essenlix Corporation Apparatus for multiple sample analysis
CN114266731B (zh) * 2021-11-29 2025-05-27 安徽中科本元信息科技有限公司 一种融合牙弓二维图像的咬合检测分析系统及实现方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013516999A (ja) * 2010-01-20 2013-05-16 イー・エム・デイー・ミリポア・コーポレイシヨン 細胞画像取得および遠隔モニタリングシステム
WO2015195609A1 (en) * 2014-06-16 2015-12-23 Siemens Healthcare Diagnostics Inc. Analyzing digital holographic microscopy data for hematology applications
WO2017027643A1 (en) * 2015-08-10 2017-02-16 Essenlix Corp. Bio/chemical assay devices and methods for simplified steps, small samples, accelerated speed, and ease-of-use
JP2017516992A (ja) * 2014-05-23 2017-06-22 ベンタナ メディカル システムズ, インコーポレイテッド 画像内の生物学的構造及び/又はパターンの検出のためのシステム及び方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5656499A (en) * 1994-08-01 1997-08-12 Abbott Laboratories Method for performing automated hematology and cytometry analysis
CN101578520B (zh) * 2006-10-18 2015-09-16 哈佛学院院长等 基于形成图案的多孔介质的横向流动和穿过生物测定装置、及其制备方法和使用方法
US8691509B2 (en) * 2009-04-02 2014-04-08 Fluidigm Corporation Multi-primer amplification method for barcoding of target nucleic acids
WO2014040184A1 (en) * 2012-09-13 2014-03-20 The Governing Council Of The University Of Toronto System and method for fetal and maternal red blood cell counting
JP6192747B2 (ja) * 2013-03-15 2017-09-06 ベンタナ メディカル システムズ, インコーポレイテッド デジタル・ホール・スライドの自動採点のための組織物体に基づく機械学習システム
US9836839B2 (en) * 2015-05-28 2017-12-05 Tokitae Llc Image analysis systems and related methods
MY194887A (en) * 2015-09-14 2022-12-21 Essenlix Corp Device and System for Analyzing a Sample, Particularly Blood, as Well as Methods of Using The Same
CN105260730A (zh) * 2015-11-24 2016-01-20 严媚 基于机器学习的接触式成像微流细胞计数器及其图像处理方法
JP6750033B2 (ja) * 2016-04-08 2020-09-02 アレンティック マイクロサイエンス インコーポレイテッド 顕微鏡検査のための試料処理
CN106202997B (zh) * 2016-06-29 2018-10-30 四川大学 一种基于深度学习的细胞分裂检测方法

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013516999A (ja) * 2010-01-20 2013-05-16 イー・エム・デイー・ミリポア・コーポレイシヨン 細胞画像取得および遠隔モニタリングシステム
JP2017516992A (ja) * 2014-05-23 2017-06-22 ベンタナ メディカル システムズ, インコーポレイテッド 画像内の生物学的構造及び/又はパターンの検出のためのシステム及び方法
WO2015195609A1 (en) * 2014-06-16 2015-12-23 Siemens Healthcare Diagnostics Inc. Analyzing digital holographic microscopy data for hematology applications
JP2017519985A (ja) * 2014-06-16 2017-07-20 シーメンス・ヘルスケア・ダイアグノスティックス・インコーポレーテッドSiemens Healthcare Diagnostics Inc. 血液学用デジタルホログラフィ顕微鏡検査データ分析
WO2017027643A1 (en) * 2015-08-10 2017-02-16 Essenlix Corp. Bio/chemical assay devices and methods for simplified steps, small samples, accelerated speed, and ease-of-use

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US20200256856A1 (en) 2020-08-13
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EP3701260A1 (en) 2020-09-02

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