JP2021186105A - Optical fiber probe and medical device - Google Patents

Abstract

To provide an optical fiber probe and a medical device capable of executing photodynamic treatment and diagnosis with low invasiveness on the depth of a tissue.SOLUTION: The optical fiber probe comprises: an optical fiber having a core part and a clad part surrounding the circumference of the core part; and a puncture needle which internally houses the tip of the optical fiber. The optical fiber has an optical input and output part to input and output light between the part and the outer region of the puncture needle, in at least a part of the tip.SELECTED DRAWING: Figure 1

Description

The present invention relates to optical fiber probes and medical devices.

As known techniques, photodynamic therapy (PDT), diagnostic method (Photodynamic Diagnosis: PDD), and photoimmuno therapy (PIT) are known. PDTs and PDDs take advantage of the fact that specific light-sensitive agents have specific agglomeration for specific biological tissues such as tumors and new blood vessels. In addition, the biological tissue may be simply abbreviated as a tissue below.

In PDT and PIT, after administering a specific drug to a patient, the drug accumulated in the tissue is irradiated with light having a therapeutic wavelength in the range of 400 nm to 800 nm to photoexcite it. For example, in PDT, singlet oxygen (a type of active oxygen) is used. ) Is generated, and the cells of the tissue are denatured or necrotic by the singlet oxygen, and in PIT, the photoexcited drug causes a chemical reaction with the cells of the tissue to cause necrosis. On the other hand, in PDD, after administering a specific drug to a patient, the photosensitizer accumulated in the tissue is irradiated with excitation light to be photoexcited, and the diagnosis is made by observing the fluorescence emitted by the photosensitizer during relaxation.

When performing PDT or PDD, a method using an optical fiber probe or an endoscopic camera is known. For example, in the case of PDT or PIT, a configuration is known in which therapeutic light is spot-irradiated from the tip of the optical fiber of the optical fiber probe, or light is diffused and irradiated from the outer peripheral surface of the optical fiber (Patent Document 1). , 2).

Japanese Unexamined Patent Publication No. 2018-624 U.S. Pat. No. 10295719

With known techniques, therapeutic light is emitted from the surface of the tissue and fluorescence from the surface of the tissue is observed. Therefore, if there is a lesion such as a tumor in the deep part of the tissue, the treatment or treatment is performed. Difficult to diagnose. For example, when the wavelength of the therapeutic light is 630 nm to 670 nm, the depth of penetration into the tissue is about 5 mm from the surface layer. However, excision of a part of the tissue to expose the deep part for deep treatment or diagnosis is problematic in terms of invasiveness.

The present invention has been made in view of the above, and an object thereof is to provide an optical fiber probe and a medical device capable of performing photodynamic treatment and diagnosis with minimal invasiveness to a deep part of a tissue. To do.

In order to solve the above-mentioned problems and achieve the object, one aspect of the present invention includes an optical fiber and a piercing needle that internally accommodates the tip of the optical fiber, and the optical fiber is the tip of the optical fiber. An optical fiber probe having an optical input / output unit that inputs / outputs light to / from the outer region of the puncture needle in at least a part of the unit.

The optical fiber may have a core portion, a clad portion that surrounds the outer periphery of the core portion, and a covering portion that surrounds the outer periphery of the clad portion.

The puncture needle may have an opening that communicates with the inside and the outside region, and the optical input / output portion may face the opening.

The optical input / output portion is the tip surface of the optical fiber, and the opening may be provided at the tip of the puncture needle.

The optical input / output portion may be located on the outer peripheral surface of the optical fiber, and the opening may be provided on the outer peripheral surface of the puncture needle.

The plurality of openings may be provided on the outer periphery of the puncture needle.

The plurality of openings may have different positions around the axis of the puncture needle.

The puncture needle may be made of a material transparent to the light.

The optical fiber has a plurality of core portions, and the optical input / output portions corresponding to each of the plurality of core portions may be positioned differently from each other in the longitudinal direction of the optical fiber.

The optical fiber may be a multi-core optical fiber.

The optical fiber may be a bundle type optical fiber.

The optical fiber may be a double clad type optical fiber.

The tip surface of the optical fiber may be inclined with respect to the optical axis.

The gauge size of the puncture needle may be 21 G or less.

The outer diameter of the optical fiber may be 480 μm or less in the portion accommodated inside the puncture needle.

One aspect of the present invention is a medical device including the optical fiber probe and a photoelectric portion optically coupled to the core portion on the proximal end side of the optical fiber.

The photoelectric portion may have at least one of a light emitting device and a light receiving device.

The present invention has the effect of being able to perform photodynamic treatment and diagnosis with minimal invasiveness to the deep part of the tissue.

FIG. 1 is a schematic configuration diagram of the medical device according to the first embodiment. FIG. 2 is a schematic diagram illustrating the operation of the medical device shown in FIG. FIG. 3 is a schematic view of a first modification of the optical fiber probe. FIG. 4 is a schematic view of a second modification of the optical fiber probe. FIG. 5 is a schematic configuration diagram of the medical device according to the second embodiment. FIG. 6 is a schematic diagram of the optical fiber probe shown in FIG. FIG. 7 is a schematic diagram illustrating the operation of the medical device shown in FIG. FIG. 8 is a schematic view of a third modification of the optical fiber probe. FIG. 9 is a schematic view of a fourth modification of the optical fiber probe. FIG. 10 is a schematic view of a fifth modification of the optical fiber probe. FIG. 11 is a schematic diagram of a sixth modification of the optical fiber probe. FIG. 12 is a schematic diagram of a seventh modification of the optical fiber probe. FIG. 13 is a schematic configuration diagram of the medical device according to the third embodiment. FIG. 14 is a schematic diagram illustrating the operation of the medical device shown in FIG. FIG. 15 is a schematic configuration diagram of the medical device according to the fourth embodiment. FIG. 16 is a schematic diagram illustrating the configuration of the optical fiber probe shown in FIG. 15 and the operation of the medical device. FIG. 17 is a schematic configuration diagram of the medical device according to the fifth embodiment. FIG. 18 is a schematic diagram illustrating the operation of the medical device shown in FIG. FIG. 19 is a schematic configuration diagram of the medical device according to the sixth embodiment.

Hereinafter, embodiments of the present invention will be described in detail with reference to the drawings. The present invention is not limited to the embodiments described below. Further, in each drawing, the same or corresponding components are appropriately designated with the same reference numerals.

(Embodiment 1)
FIG. 1 is a schematic configuration diagram of the medical device according to the first embodiment. The medical device 100 is, for example, a device that executes PDT or PDD, and includes an optical fiber probe 10, a connecting optical fiber 20, and a photoelectric device 30.

The optical fiber probe 10 includes an optical fiber 11 and a puncture needle 12. The puncture needle 12 is shown transparently for the sake of explanation. The optical fiber 11 is a so-called single-core optical fiber having one core portion, a clad portion surrounding the outer periphery of the core portion, and a covering portion surrounding the outer periphery of the clad portion. The optical fiber 11 is, for example, a multimode optical fiber, but may be a single mode optical fiber. Further, the material of the core portion and the clad portion of the optical fiber 11 may be glass, resin such as plastic, a part of glass, and the other part may be resin. The material of the covering portion may be resin.

The puncture needle 12 has a hollow cylindrical shape and a blade-shaped tip so that it can be pierced into a tissue. The size of the puncture needle 12 is not particularly limited, but it is preferable that the gauge size is 21 G or less, for example. The size of the 21G puncture needle has an outer diameter of 0.81 ± 0.02 mm and an inner diameter of 0.51 ± 0.03 mm. The material of the puncture needle 12 may be metal or resin. Examples of the metal include stainless steel, titanium alloys, cobalt-molybdenum-containing alloys, and the like. The resins include transparent polypropylene, transparent ABS resin, polycarbonate, PMMA (polymethylmethacrylate resin), PSU (polysulfone), PES (polyethersulfone), PPSU (polyphenylsulfone), and PMP (polymethylpentene). ), COP (cycloolefin polymer) and the like.

The hollow cylindrical puncture needle 12 accommodates the tip of the optical fiber 11 inside. Therefore, the outer diameter of the optical fiber 11 is smaller than the inner diameter of the puncture needle 12, for example, 480 μm or less, at least in the portion accommodated inside the puncture needle 12. The puncture needle 12 is fixed to the optical fiber 11 with, for example, an adhesive. The tip of the optical fiber 11 is a portion having a predetermined length from the tip surface at one end of the optical fiber 11 in the longitudinal direction. Further, the core portion and the clad portion are exposed on the tip surface of the optical fiber 11. The covering portion of the optical fiber 11 is provided at least in a portion other than the portion housed inside the puncture needle 12, for example, from the base end of the optical fiber 11 to a part of the portion housed in the puncture needle 12. It protects the core portion and the clad portion of the optical fiber 11.

The connection optical fiber 20 is an optical fiber that connects the optical fiber probe 10 and the photoelectric device 30. The connected optical fiber 20 is optically connected to the proximal end portion, which is the other end portion in the longitudinal direction of the optical fiber probe 10, by a connector or the like. The connected optical fiber 20 is, for example, an optical fiber of the same type as the optical fiber 11.

The photoelectric device 30 includes a photoelectric unit 31, an optical coupling unit 32, and a control unit 33. The photoelectric unit 31 has a function of mutually converting light energy and electric energy. The photoelectric unit 31 includes, for example, at least one of a light emitting device that outputs light and a light receiving device that receives light. The light emitting device includes, for example, a laser device. The laser device can be appropriately selected from a solid-state laser device, a dye laser device, a semiconductor laser device, and the like. The light receiving device can be appropriately selected from a photodiode, a photodiode array, a CCD, a CMOS, and the like. The optical coupling unit 32 has a function of optically coupling the connecting optical fiber 20 and the photoelectric unit 31. The optical coupling portion 32 includes a spatial optical system, an optical fiber, and the like. The control unit 33 includes, for example, a microcomputer, and performs arithmetic processing for controlling the operation of light emission or light reception of the photoelectric unit 31, receiving a current signal generated by light reception, and obtaining information on the light reception state. Or do. The photoelectric device 30 may include an input device for the operator to operate the operation of the photoelectric device 30, and a display device for displaying the operating state of the photoelectric device 30.

Next, the operation when the medical device 100 is a device that executes PDT will be described with reference to FIG. When the medical device 100 is a device that executes PDT, the photoelectric unit 31 includes a light emitting device.

First, patients subject to PDT are intravenously administered with a photosensitizing agent, such as porphymer sodium or talaporfin sodium. The drug accumulates, for example, in malignant tumors.

Subsequently, during the period when the drug is stagnant in the malignant tumor, as shown in FIG. 2, the optical fiber probe 10 is invaded into the patient from a luminal organ such as a bronchus to reach the site P and puncture. The needle 12 is punctured at the site P. Malignant tumor C is deeply present as a lesion at the site P. If a guide wire is used, the optical fiber probe 10 can easily enter, reach, or puncture.

Subsequently, while the drug is stagnant in the malignant tumor C, the control unit 33 of the medical device 100 operates the photoelectric unit 31 to emit the therapeutic light. The wavelength of the therapeutic light is selected depending on the type of the drug, and is, for example, red light having a wavelength of 600 nm to 800 nm. The optical coupling portion 32 couples the therapeutic light to the connecting optical fiber 20. The connected optical fiber 20 outputs the therapeutic light to the optical fiber 11 of the optical fiber probe 10.

When the therapeutic light indicated by the arrow in FIG. 2 is input from the proximal end side in the longitudinal direction of the optical fiber 11, the optical fiber 11 propagates the therapeutic light to the distal end side and outputs it from the distal end surface. The puncture needle 12 has a hollow cylindrical shape and has an opening at the tip. This opening is an example of an opening that communicates with the inner and outer regions of the puncture needle. The therapeutic light is output from this opening to the outer region of the puncture needle 12 to reach the malignant tumor C and degenerate or necrotize the cells of the malignant tumor C. The tip surface of the optical fiber 11 is a part of the tip portion, and is an example of an optical input / output portion facing the opening portion. That is, in the optical fiber probe 10, the tip surface of the optical fiber 11 housed inside the puncture needle 12 is an optical input / output unit that inputs / outputs light to / from the outer region of the puncture needle 12.

In the medical device 100 including the optical fiber probe 10 configured as described above, in the optical fiber probe 10, the optical fiber 11 has an optical input / output unit that inputs / outputs light to / from the outer region of the puncture needle 12. Have. As a result, the puncture needle 12 can be punctured into the site P to irradiate the malignant tumor C in the deep part with therapeutic light. As a result, the treatment can be performed without excising a part of the site P, which is good from the viewpoint of minimal invasiveness. Further, since the optical fiber 11 is protected by being housed in the puncture needle 12, the puncture can be performed while suppressing the breakage of the optical fiber 11 as compared with the case where the optical fiber 11 is directly punctured at the site P. It can be done and puncture can be performed smoothly.

Further, in the optical fiber probe 10, the puncture needle 12 has an opening, and the optical input / output portion of the optical fiber 11 faces the opening. As a result, even if the puncture needle 12 is made of an opaque material, the treatment light can be irradiated, so that the degree of freedom in selecting the material is high. Further, since the optical input / output portion is the tip surface of the optical fiber 11 and the opening is provided at the tip of the puncture needle 12, the optical fiber probe 10 can be easily manufactured.

(First modification)
Next, a modified example of the optical fiber probe that can be used in place of the optical fiber probe 10 in the medical device 100 will be described. FIG. 3 is a schematic view of a first modification of the optical fiber probe. The optical fiber probe 10A according to the first modification includes an optical fiber 11A and a puncture needle 12A. For the sake of explanation, the puncture needle 12A is shown transparently.

The optical fiber 11A is a single-core optical fiber having one core portion, a clad portion surrounding the outer periphery of the core portion, and a covering portion surrounding the outer periphery of the clad portion. Further, the optical fiber 11A is a type of optical fiber called a diffused optical fiber. That is, the optical fiber 11A has a diffusion portion 11Aa as a tip portion. The diffusion portion 11Aa is a portion where the covering portion is removed and the clad portion is exposed, and the light propagating through the core portion gradually leaks and is diffused and radiated from the clad portion. The outer peripheral surface of the diffusion unit 11Aa is an example of an optical input / output unit on the outer peripheral surface of the optical fiber. The optical fiber 11A is, for example, a multimode optical fiber, but may be a single mode optical fiber. Further, the material of the core portion, the clad portion and the covering portion of the optical fiber 11A may be the same as that of the optical fiber 11.

The puncture needle 12A has a hollow cylindrical shape, has a blade-shaped tip so that it can be pierced into a tissue, and has an opening 12Aa on the outer periphery. The opening 12Aa is provided in a slit shape along the longitudinal direction of the puncture needle 12A. The opening 12Aa may be located at a position different from the position shown in the drawing. The puncture needle 12A houses the diffusion portion 11Aa as the tip end portion of the optical fiber 11A inside. The size of the puncture needle 12A is not particularly limited, but it is preferable that the gauge size is 21G or less, for example. The material of the puncture needle 12A may be the same as that of the puncture needle 12.

According to this optical fiber probe 10A, the puncture needle 12A can be punctured into the site PA, and the malignant tumors CA1 and CA2 located in front of and to the side of the puncture needle 12A can be irradiated with the therapeutic light indicated by the arrow. .. Further, according to the optical fiber probe 10A, as in the case of using the optical fiber probe 10, it is good from the viewpoint of minimal invasiveness, puncture can be performed while extremely suppressing breakage of the optical fiber 11A, and puncture is smooth. Can be done.

(Second modification)
FIG. 4 is a schematic view of a second modification of the optical fiber probe. The optical fiber probe 10B according to the second modification has a configuration in which the puncture needle 12A is replaced with the puncture needle 12B in the optical fiber probe 10A. For the sake of explanation, the puncture needle 12B is shown transparently. FIG. 4A shows the overall configuration of the optical fiber probe 10B, and FIG. 4B shows a side view of the puncture needle 12B.

The puncture needle 12B has a hollow cylindrical shape, has a blade-shaped tip so as to pierce the tissue, and is provided with a plurality of openings 12Ba, 12Bb, 12Bc, and 12Bd on the outer periphery. The positions of the openings 12Ba, 12Bb, 12Bc, and 12Bd around the axis of the puncture needle 12B are different from each other. The puncture needle 12B houses the diffusion portion 11Aa as the tip end portion of the optical fiber 11A inside. The size of the puncture needle 12B is not particularly limited, but it is preferable that the gauge size is 21 G or less, for example. The material of the puncture needle 12B may be the same as that of the puncture needle 12.

According to this optical fiber probe 10B, the puncture needle 12B can be punctured into the site PB, and the therapeutic light indicated by the arrow can be output in various directions in front of and to the side of the puncture needle 12B. Although the treatment light output from the openings 12Ba and 12Bc is shown in FIG. 4 on the side, the treatment light is also output from the openings 12Bb and 12Bd. This makes it possible to irradiate the malignant tumors such as malignant tumors CB1, CB2, and CB3 located in various directions in front of and lateral to the puncture needle 12B with therapeutic light. Further, according to the optical fiber probe 10B, as in the case of using the optical fiber probe 10, it is good from the viewpoint of minimal invasiveness, puncture can be performed while extremely suppressing breakage of the optical fiber 11A, and puncture is smooth. Can be done.

The medical device 100 may be a device that executes PDD. When the medical device 100 is a device that executes PDD, the photoelectric unit 31 includes a light emitting device and a light receiving device. Further, the optical coupling unit 32 is configured so that the light emitted from the light emitting device can be coupled to the connecting optical fiber 20 and the fluorescence from the connecting optical fiber 20 can be coupled to the light receiving device. Patients who are the target of PDD are administered a drug such as 5-aminolevulinic acid. The drug is biosynthesized into protoporphyrin IX (PpIX) in the patient's body. PpIX is a photosensitizer that accumulates in malignant tumors, for example.

Subsequently, during the period when PpIX is stagnant in the malignant tumor, the puncture needle 12 of the optical fiber probe 10 is punctured at the site where the malignant tumor is considered to be present, as in FIG. If a guide wire is used at this time, it is easy to invade, reach, and puncture.

Subsequently, while PpIX is stagnant in the malignant tumor, the control unit 33 of the medical device 100 operates the photoelectric unit 31 to emit excitation light. The wavelength of the excitation light is selected depending on the type of the light-sensitive substance, but in PpIX, it is, for example, blue light having a wavelength of 375 nm to 445 nm. The optical coupling unit 32 couples the excitation light to the connecting optical fiber 20. The connected optical fiber 20 outputs the excitation light to the optical fiber 11 of the optical fiber probe 10.

The excitation light propagates through the optical fiber 11 and is output from the opening of the puncture needle 12 to the outer region of the puncture needle 12 to reach the malignant tumor and photoexcitate PpIX. Then PpIX fluoresces. The wavelength of fluorescence of PpIX is 600 nm to 740 nm. The fluorescence is input to the optical fiber 11 from the opening of the puncture needle 12 and propagates, and is received by the light receiving device of the photoelectric unit 31. The control unit 33 receives the current signal generated by the light reception, performs arithmetic processing for obtaining information on the light reception state such as the presence / absence of light reception, and displays the light reception state on the display device. This allows the operator to diagnose the presence or absence of a malignant tumor according to the light receiving state. That is, in the optical fiber probe 10, the tip surface of the optical fiber 11 whose tip is housed inside the puncture needle 12 inputs and outputs light (excitation light and fluorescence) to and from the outer region of the puncture needle 12. It is an input / output unit.

The medical device 100 that executes PDD can also obtain the same effects as those of the device that executes PDT, such as smooth puncture while being minimally invasive and extremely suppressing breakage of the optical fiber 11. Further, the same effect can be obtained by replacing the optical fiber probe 10 with the optical fiber probes 10A and 10B.

Further, the medical device 100 may be configured so that both PDD and PDT can be executed. In this case, PDD can be performed first to make a diagnosis, and then PDT can be performed to perform treatment. In addition, PDD may be further executed after PDT execution to confirm the result of treatment.

(Embodiment 2)
FIG. 5 is a schematic configuration diagram of the medical device according to the second embodiment. The medical device 100C is a device for executing PDT or PDD, for example, and includes an optical fiber probe 10C, a connecting optical fiber 20C, and a photoelectric device 30C. The optical fiber probe 10C includes an optical fiber 11C and a puncture needle 12C. For the sake of explanation, the puncture needle 12C is shown transparently.

6A and 6B are schematic views of the optical fiber probe 10C, FIG. 6A is an enlarged view of the tip side, and FIG. 6B is a sectional view taken along line XX of FIG. 6A. Is. The optical fiber 11C is a bundle type optical fiber in which seven single-core type unit optical fibers are bundled so as to form a triangular lattice in a cross section perpendicular to the longitudinal direction. Of the seven unit optical fibers, three unit optical fibers arranged in a direction perpendicular to the longitudinal direction are referred to as unit optical fibers 11Ca, 11Cb, 11Cc, and in FIG. 6A, only unit optical fibers 11Ca, 11Cb, 11Cc are used. Is illustrated.

The unit optical fiber 11Ca has one core portion 11Caa, a clad portion 11Cab that surrounds the outer periphery of the core portion 11Caa, and a covering portion that surrounds the outer periphery of the clad portion 11Cab. In the portion shown in FIG. 6, the covering portion is removed. Other unit optical fibers also have a core portion, a clad portion, and a covering portion. Therefore, the optical fiber 11C has a plurality of core portions. Each unit optical fiber is, for example, a multimode optical fiber, but may be a single mode optical fiber. Further, the material of the core portion and the clad portion of each unit optical fiber may be glass, a resin such as plastic, a part thereof may be glass, and the other part may be a resin. The material of the covering portion may be resin. Each unit optical fiber may have the same configuration or may have different configurations from each other.

The puncture needle 12C has a hollow cylindrical shape having an inner diameter D2, and has a blade-shaped tip so that it can be pierced into a tissue. The size of the puncture needle 12C is not particularly limited, but it is preferable that the gauge size is 21 G or less, for example. The material of the puncture needle 12C may be the same as that of the puncture needle 12.

The hollow cylindrical puncture needle 12C accommodates the tip of the optical fiber 11C inside. Therefore, the outer diameter D1 of the optical fiber 11 is smaller than the inner diameter of the puncture needle 12C in the portion accommodated inside the puncture needle 12C, and is, for example, 480 μm or less. The puncture needle 12C is fixed to the optical fiber 11C with, for example, an adhesive. Further, the tip surface of each unit optical fiber is inclined with respect to the optical axis. For example, the unit optical fibers 11Ca, 11Cb, and 11Cc have tip surfaces 11Cac, 11Cbc, and 11Ccc inclined with respect to the optical axis, respectively. The core portion and the clad portion are exposed on each tip surface. The tip surface of each unit optical fiber is an example of an optical input / output unit. The slope of the tip surface can be formed by diagonal cutting, mechanical polishing, or chemical polishing of each unit optical fiber. Further, the optical input / output portions (tip surfaces) corresponding to each of the plurality of core portions are located at different positions in the longitudinal direction of the optical fiber 11C. For example, the distal end surfaces 11Cac, 11Cbc, and 11Ccc of the unit optical fibers 11Ca, 11Cb, and 11Cc are arranged in this order in the longitudinal direction from the distal end side to the proximal end side, respectively. The tip surface of the other unit optical fiber is located between the tip surface 11Cac and the tip surface 11Ccc in the longitudinal direction.

Further, the covering portion of each unit optical fiber is provided at least in a portion other than the portion housed inside the puncture needle 12C, for example, from the base end of the optical fiber 11C to a part of the portion housed in the puncture needle 12C. It protects the core and clad of each unit optical fiber.

The connected optical fiber 20C is an optical fiber that connects the optical fiber probe 10C and the photoelectric device 30C. The connected optical fiber 20C is optically connected to a base end portion which is the other end portion in the longitudinal direction of the optical fiber probe 10 by a connector or the like. The connected optical fiber 20C is, for example, a bundle type optical fiber of the same type as the optical fiber 11C.

The photoelectric device 30C includes a photoelectric unit 31C, an optical coupling unit 32C, and a control unit 33C. The photoelectric unit 31C includes, for example, at least one of a light emitting device and a light receiving device. The optical coupling unit 32C has a function of optically coupling the connecting optical fiber 20C and the photoelectric unit 31C. The photoelectric unit 31C may include a plurality of light emitting devices that individually output light to each unit optical fiber of the optical fiber 11C, or one light emitting device that collectively outputs light to each unit optical fiber. May include. Alternatively, the photoelectric unit 31C may include a one-dimensional or two-dimensional light receiving device such as a photodiode array, a CCD, or a CMOS, which individually receives light from each unit optical fiber of the optical fiber 11C. It may include a one-dimensional or two-dimensional light receiving device that collectively receives light from each unit optical fiber. The optical coupling unit 32C is configured to be able to perform the above-mentioned individual or collective light receiving and emitting light. The control unit 33C includes, for example, a microcomputer, and controls the operation of light emission or light reception of the photoelectric unit 31C. The photoelectric device 30C may include an input device and a display device.

Next, the operation when the medical device 100C is a device that executes PDD will be described with reference to FIG. 7. When the medical device 100C is a device that executes PDD, the photoelectric unit 31C includes a light emitting device and a light receiving device.

First, a drug such as 5-aminolevulinic acid is administered to a patient who is the target of PDT. The drug is biosynthesized into PpIX in the patient's body. PpIX accumulates, for example, in malignant tumors.

Subsequently, during the period when the drug is stagnant in the malignant tumor, as shown in FIG. 7, the optical fiber probe 10C is invaded into the patient's body from a luminal organ such as a bronchus, and the malignant tumor CC1 which is a lesion is formed. The CC2 is made to reach the site PC that seems to be present in the deep part, and the puncture needle 12C is punctured into the site PC. If a guide wire is used at this time, it is easy to invade, reach, and puncture.

Subsequently, during the period when the drug is stagnant in the malignant tumor, the photoelectric unit 31C is operated by the control unit 33C of the medical device 100C to emit the excitation light. The optical coupling portion 32C couples the excitation light to the connecting optical fiber 20C. The connected optical fiber 20C outputs the excitation light to each unit optical fiber of the optical fiber 11C of the optical fiber probe 10C.

The excitation light propagates through each unit optical fiber of the optical fiber 11C and is output from the opening of the puncture needle 12C to the outer region of the puncture needle 12C. At this time, the excitation light irradiates the regions Aa1, Ab1, and Ac1 by the unit optical fibers 11Ca, 11Cb, and 11Cc, respectively. These regions Aa1, Ab1, and Ac1 are located at different positions in the depth direction in the site PC. Here, in FIG. 7, since malignant tumors CC1 and CC2 are present in the regions Aa1 and Ab1, respectively, the excitation light photoexcites PpIX accumulated in the malignant tumors CC1 and CC2. Then PpIX fluoresces. The fluorescent LC1 and LC2 are input to the unit optical fibers 11Ca and 11Cb from the opening of the puncture needle 12C, propagate, and are received by the light receiving device of the photoelectric unit 31C, respectively. The control unit 33C processes the current signal generated by the light reception, and displays the light reception state on, for example, a display device. As a result, the operator can not only diagnose the presence or absence of a malignant tumor according to the light receiving state, but also know that the malignant tumor is present in the regions Aa1 and Ab1.

The medical device 100C provided with the optical fiber probe 10C configured as described above is good from the viewpoint of minimal invasiveness because diagnosis can be performed without excising a part of the site PC. Further, the optical fiber 11C can be punctured while the breakage of the optical fiber 11C is extremely suppressed, and the puncture can be smoothly performed.

Further, in the optical fiber probe 10C, even if the puncture needle 12C is made of an opaque material, it is possible to irradiate the excitation light and acquire the light emission, so that the material can be easily selected with a high degree of freedom. can.

Further, in the medical device 100C provided with the optical fiber probe 10C, the presence or absence of a malignant tumor and the distribution of the presence of the malignant tumor in the depth direction of the site PC can be known, so that a more advanced diagnosis can be made.

In the above example, the excitation light is irradiated to the regions Aa1, Ab1, and Ac1 that do not overlap each other by the unit optical fibers 11Ca, 11Cb, and 11Cc, respectively. However, the region to be irradiated with the excitation light may be irradiated to the overlapping regions such as the regions Aa2, Ab2, and Ac2 shown in FIG. 7, depending on the wavelength and power of the excitation light, the type of portion, and the like. .. In this case, the control unit 33C performs arithmetic processing such as adding or subtracting the amount of light received from each of the unit optical fibers 11Ca, 11Cb, and 11Cc, so that the presence or absence of a malignant tumor and the distribution of the presence of the malignant tumor are more accurate. Since it is possible to obtain various information, it is possible to make a more advanced diagnosis.

Further, the region irradiated with the excitation light by each unit optical fiber can be changed, for example, by adjusting the inclination angle of the tip surface.

Further, the medical device 100C may be configured to be able to execute PDT, or may be configured to be able to execute both PDD and PDT.

(Third modification example)
FIG. 8 is a schematic view of a third modification of the optical fiber probe. The optical fiber probe 10D according to the third modification has a configuration in which the puncture needle 12C is replaced with the puncture needle 12D in the optical fiber probe 10C.

The puncture needle 12D has a bottomed hollow cylindrical shape and has a blade-shaped tip so that it can be pierced into a tissue. Further, the puncture needle 12D is made of a material transparent to excitation light and fluorescence, or therapeutic light. Therefore, even if the puncture needle 12D has no opening, the optical fiber 11 can input / output light to / from the outer region of the puncture needle 12D. The size of the puncture needle 12D is not particularly limited, but it is preferable that the gauge size is 21 G or less, for example.

According to this optical fiber probe 10D, with the puncture needle 12D punctured into the site PC as shown in FIG. 8, the excitation light is output from the unit optical fibers 11Ca, 11Cb, 11Cc and then transmitted through the side wall of the puncture needle 12D. Then, the regions Aa3, Ab3, and Ac3 are irradiated, respectively. In FIG. 8, since the malignant tumors CC1 and CC2 are present in the regions Aa3 and Ab3, respectively, the light-sensitive substances accumulated in the malignant tumors CC1 and CC2 fluoresce. The fluorescent LC1 and LC2 pass through the side wall of the puncture needle 12D, are input to the unit optical fibers 11Ca and 11Cb, propagate, and are received by the light receiving device of the photoelectric unit 31C, respectively. The control unit 33C processes the current signal generated by the light reception, and displays the light reception state on, for example, a display device. As a result, the operator can not only diagnose the presence or absence of a malignant tumor according to the light receiving state, but also know that the malignant tumor is present in the regions Aa3 and Ab3.

(Fourth modification)
FIG. 9 is a schematic view of a fourth modification of the optical fiber probe. The optical fiber probe 10E according to the fourth modification has a configuration in which the optical fiber 11C is replaced with the optical fiber 11C1 in the optical fiber probe 10C or 10D. Although the puncture needle is not shown, the optical fiber probe 10E includes a puncture needle such as a puncture needle 12C or 12D.

Similar to the optical fiber 11C, the optical fiber 11C1 is a bundled optical fiber composed of seven single-core type unit optical fibers bundled together, but the optical corresponding to each of the core portions of the unit optical fiber. All of the input / output portions (tip surfaces) are positioned differently from each other in the longitudinal direction of the optical fiber 11C1. For example, the tip surfaces of the six unit optical fibers arranged on the outer peripheral side of the optical fiber 11C1 are arranged in a spiral shape extending in the longitudinal direction.

According to the fiber optic probe 10E, PDD examination and / or PDT treatment can be performed at 7 levels in the depth direction.

(Fifth modification)
FIG. 10 is a schematic view of a fifth modification of the optical fiber probe. The optical fiber probe 10F according to the fifth modification has a configuration in which the optical fiber 11C is replaced with the optical fiber 11F in the optical fiber probe 10C or 10D. Although the puncture needle is not shown, the optical fiber probe 10F includes a puncture needle such as a puncture needle 12C or 12D.

The optical fiber 11F is a so-called multi-core optical fiber having seven core portions 11F, which are a plurality of core portions, a clad portion 11Fb surrounding the outer periphery of the seven core portions 11F, and a covering portion surrounding the outer periphery of the clad portion 11Fb. be. The seven core portions 11Fa are arranged so as to form a triangular lattice in a cross section perpendicular to the longitudinal direction. Further, the tip surface 11Fc of the optical fiber 11F is inclined with respect to the optical axis. On the tip surface 11Fc, the core portion 11Fa and the clad portion 11Fb are exposed. The positions of the exposed core portions 11F on the tip surface 11Fc in the longitudinal direction may differ from each other. The inclination of the tip surface 11Fc can be formed by diagonal cutting or polishing. The position of each exposed core portion 11F on the tip surface 11Fc in the longitudinal direction changes depending on the inclination angle of the tip surface 11Fc. The covering portion is provided at least from a portion other than the portion housed inside the puncture needle, for example, from the base end of the optical fiber 11F to a part of the portion housed in the puncture needle, and the core portion 11Fa and the clad portion. Protect 11Fb.

According to the optical fiber probe 10E, one multi-core fiber can perform PDD examination and / or PDT treatment at three or more stages in the depth direction.

Although the optical fiber 11F has seven core portions, the number of core portions of the multi-core fiber is not particularly limited and may be 2 or more, but may be 19, for example.

(6th modification)
FIG. 11 is a schematic diagram of a sixth modification of the optical fiber probe. The optical fiber probe 10G according to the sixth modification has a configuration in which the optical fiber 11C is replaced with the optical fiber 11G in the optical fiber probe 10D. Although the puncture needle is not shown, the optical fiber probe 10G includes, for example, a puncture needle 12D.

The optical fiber 11G has a configuration in which the tip portion of the same multi-core fiber as the optical fiber 11F is processed into an oblique conical shape. That is, the optical fiber 11G is a so-called multi-core optical fiber having seven core portions, which are a plurality of core portions, a clad portion surrounding the outer periphery of the seven core portions, and a covering portion surrounding the outer periphery of the clad portion. The seven cores are arranged to form a triangular grid in a cross section perpendicular to the longitudinal direction. FIG. 11 shows the core portions 11Ga, 11Gb, 11Gc and the clad portion 11Gd out of the seven core portions. Further, the tip surface 11Ge having an oblique conical shape is an example of an optical output unit. The exposed surfaces 11Gaa, 11Gba, and 11Gca, which are the surfaces on which the core portions 11Ga, 11Gb, and 11Gc are exposed on the tip surface 11Ge, are positioned differently from each other in the longitudinal direction.

According to this optical fiber probe 10G, one multi-core fiber can perform PDD examination and / or PDT treatment at three or more stages in the depth direction.

Although the optical fiber 11G has seven core portions, the number of core portions of the multi-core fiber is not particularly limited and may be 2 or more, but may be 19, for example.

(7th modification)
FIG. 12 is a schematic diagram of a seventh modification of the optical fiber probe. The optical fiber probe 10H according to the seventh modification has a configuration in which the optical fiber 11C is replaced with the optical fiber 11H in the optical fiber probe 10D. Although the puncture needle is not shown, the optical fiber probe 10H includes, for example, a puncture needle 12D.

Similar to the optical fiber 11C, the optical fiber 11H is a bundle type optical fiber composed of seven single-core type unit optical fibers 11H1 bundled together, but the notch 11H1a is formed on the outer peripheral surface of each unit optical fiber 11H1. Is formed. Each notch 11H1a is formed so that light propagating in the core portion is output or light input from the outside of the unit optical fiber 11H1 is coupled to the core portion and propagated. The notch 11H1a is an example of an optical input / output unit. Further, the notches 11H1a are different from each other in the longitudinal direction of the optical fiber 11H.

According to the fiber optic probe 10H, the notch 11H1a allows the PDD examination and / or PDT treatment to be performed at 7 levels in the depth direction.

Although the optical fiber 11G has seven core portions, the number of core portions of the multi-core fiber is not particularly limited and may be 2 or more, but may be 19, for example.

When the puncture needle of the optical fiber probe 10H is made of a transparent material, for example, the fluorescence that has reached the side wall of the puncture needle from a malignant tumor is distributed on the side wall as evanescent light, and propagates by binding to the core portion from the notch 11H1a. The medical device can be configured to receive light from the light receiving device. In such cases, more sensitive or extensive examination is possible.

(Embodiment 3)
FIG. 13 is a schematic configuration diagram of the medical device according to the third embodiment. The medical device 100I has a configuration in which the photoelectric device 30C is replaced with the photoelectric device 30I in the medical device 100C according to the second embodiment.

The photoelectric device 30I includes a photoelectric unit 31I, an optical coupling unit 32I, and a control unit 33I. The photoelectric unit 31I includes a light emitting unit 31Ia and a light receiving unit 31Ib. The light emitting unit 31Ia includes a light emitting device that outputs excitation light and a light emitting device that outputs therapeutic light. The light receiving unit 31Ib includes a light receiving device that receives fluorescence. The optical coupling unit 32I has a function of optically coupling the connecting optical fiber 20C and the photoelectric unit 31I. The light emitting unit 31Ia of the photoelectric unit 31I may include a light emitting device that individually outputs excitation light or therapeutic light to each unit optical fiber of the optical fiber 11C, or collectively excites light to each unit optical fiber. Or a light emitting device that outputs therapeutic light may be included. Further, the light receiving unit 31Ib may include a one-dimensional or two-dimensional light receiving device such as a photodiode array, CCD, or CMOS that individually receives light from each unit optical fiber of the optical fiber 11C. It may include a one-dimensional or two-dimensional light receiving device that collectively receives light from a unit optical fiber. The optical coupling unit 32I is configured to be able to perform the above-mentioned individual or collective light receiving and emitting light. The control unit 33I includes, for example, a microcomputer, and controls the operation of light emission or light reception of the photoelectric unit 31I. The photoelectric device 30I may include an input device and a display device.

Next, the operation of the medical device 100I to execute PDD and PDT will be described with reference to FIG.

First, the patient is administered a drug such as 5-aminolevulinic acid. The drug is biosynthesized into PpIX in the patient's body. PpIX accumulates, for example, in malignant tumors.

Subsequently, during the period when PpIX is stagnant in the malignant tumor, as shown in FIG. 14 (a), the optical fiber probe 10C is invaded into the patient's body, and the malignant tumors CI1 and CI2 are present in the deep part PI. And puncture the puncture needle 12C into the site PI. If a guide wire is used at this time, it is easy to invade, reach, and puncture.

Subsequently, while PpIX is stagnant in the malignant tumor, the control unit 33I of the medical device 100I operates the photoelectric unit 31I to emit the excitation light. The optical coupling unit 32I couples the excitation light to the connecting optical fiber 20C. The connected optical fiber 20C outputs the excitation light to each unit optical fiber of the optical fiber 11C of the optical fiber probe 10C.

The excitation light propagates through each unit optical fiber of the optical fiber 11C and is output from the opening of the puncture needle 12C to the outer region of the puncture needle 12C. In FIG. 14, the excitation light photoexcites PpIX accumulated in the malignant tumors CI1 and CI2. Then PpIX fluoresces. The fluorescent LI1 and LI2 are input to the unit optical fibers 11Ca and 11Cc from the opening of the puncture needle 12C and propagate, respectively, and are received by the light receiving portion 31Ib of the photoelectric portion 31I. The control unit 33I processes the current signal generated by the light reception, and displays the light reception state on, for example, a display device. As a result, the operator can not only diagnose the presence or absence of a malignant tumor according to the light receiving state, but also know that the malignant tumor is in the region irradiated with the excitation light by the unit optical fibers 11Ca and 11Cc. can.

Then, when performing PDT, the patient is intravenously administered with a light-sensitive agent, such as porphymer sodium or talaporfin sodium. The drug accumulates, for example, in malignant tumors.

Subsequently, as shown in FIG. 14B, the photoelectric unit 31I is operated by the control unit 33I of the medical device 100I to emit the therapeutic light while the drug is stagnant in the malignant tumor. The therapeutic light LI3 and LI4 propagate through the unit optical fibers 11Ca and 11Cc, respectively, and are output to the outer region of the puncture needle 12C to reach the malignant tumors CI1 and CI2, and degenerate or necrotize the cells of the malignant tumors CI1 and CI2.

In the medical device 100I configured as described above, PDD and PDT can be executed.

(Embodiment 4)
FIG. 15 is a schematic configuration diagram of the medical device according to the fourth embodiment. The medical device 100J is, for example, a device for executing PDT or PDD, and includes an optical fiber probe 10J, a connecting optical fiber 20J, and a photoelectric device 30J. The optical fiber probe 10J includes an optical fiber 11J and a puncture needle 12J.

FIG. 16 is a schematic diagram illustrating the configuration of the optical fiber probe 10J and the operation of the medical device 100J. The optical fiber 11J is a bundle type optical fiber in which seven double-clad type optical fibers, unit optical fibers, are bundled so as to form a triangular lattice in a cross section perpendicular to the longitudinal direction. Of the seven unit optical fibers, three unit optical fibers arranged in a direction perpendicular to the longitudinal direction are referred to as unit optical fibers 11Ja, 11Jb, 11Jc, and in FIG. 16, only unit optical fibers 11Ja, 11Jb, 11Jc are shown. ing.

The unit optical fiber 11Ja has one core portion 11Jaa, an inner clad portion 11Jab that surrounds the outer periphery of the core portion 11Jaa, an outer clad portion 11Jac that surrounds the outer periphery of the inner clad portion 11Jab, and a tip surface 11Jad. Other unit optical fibers also have a core portion, an inner clad portion, and an outer clad portion. The material of each unit optical fiber may be glass, a resin such as plastic, a part thereof may be glass, and the other part may be a resin. The material of the outer clad portion may be resin. Each unit optical fiber may have the same configuration or may have different configurations from each other.

Like the puncture needle 12C, the puncture needle 12J has a hollow cylindrical shape and has a blade-shaped tip so that it can be pierced into a tissue. The size of the puncture needle 12J is not particularly limited, but it is preferable that the gauge size is 21G or less, for example. The material of the puncture needle 12J may be the same as that of the puncture needle 12C.

The puncture needle 12J accommodates the tip of the optical fiber 11J inside. The puncture needle 12J is fixed to the optical fiber 11J with, for example, an adhesive. Further, the tip surface of each unit optical fiber is inclined with respect to the optical axis. The core portion, the inner clad portion and the outer clad portion are exposed on each tip surface. The tip surface of each unit optical fiber is an example of an optical input / output unit. The inclination of the tip surface can be formed by cutting or polishing each unit optical fiber. Further, the optical input / output portions (tip surfaces) corresponding to each of the plurality of core portions are located at different positions in the longitudinal direction of the optical fiber 11J.

The connected optical fiber 20J is an optical fiber that connects the optical fiber probe 10J and the photoelectric device 30J. The connected optical fiber 20J is optically connected to a base end portion which is the other end portion in the longitudinal direction of the optical fiber probe 10J by a connector or the like. The connected optical fiber 20J is, for example, a double clad type and bundle type optical fiber of the same type as the optical fiber 11J.

The photoelectric device 30J has a configuration in which the optical coupling portion 32I in the photoelectric device 30J of FIG. 13 is replaced with the optical coupling portion 32J. The optical coupling unit 32I has a function of optically coupling the connecting optical fiber 20J and the photoelectric unit 31I. For example, the optical coupling unit 32I is configured to couple the therapeutic light and the excitation light from the light emitting unit 31Ia to the core portion of each unit optical fiber of the connecting optical fiber 20J and the optical fiber probe 10J, and the connecting optical fiber. It is configured to bind the fluorescence from the inner clad portion of each unit optical fiber of 20J or the optical fiber probe 10J to the light receiving portion 31Ib.

Next, the operation of the medical device 100J to execute PDD and PDT will be described with reference to FIG.

First, the patient is administered a drug such as 5-aminolevulinic acid. The drug is biosynthesized into PpIX in the patient's body. PpIX accumulates, for example, in malignant tumors.

Subsequently, during the period when PpIX is stagnant in the malignant tumor, as shown in FIG. 16, the optical fiber probe 10J is invaded into the patient's body to reach the site PJ where the malignant tumor CJ1 which is the lesion is deeply present. Then, the puncture needle 12J is punctured into the site PJ. If a guide wire is used at this time, it is easy to invade, reach, and puncture.

Subsequently, during the period when the drug is stagnant in the malignant tumor, the photoelectric unit 31I is operated by the control unit 33I of the medical device 100J to emit the excitation light. The optical coupling portion 32J couples the excitation light to the core portion of the connecting optical fiber 20J. The connected optical fiber 20J outputs the excitation light to the core portion of each unit optical fiber of the optical fiber 11J of the optical fiber probe 10J.

The excitation light propagates through the core portion of each unit optical fiber of the optical fiber 11J, is output from the tip surface, and is output from the opening of the puncture needle 12J to the outer region of the puncture needle 12J. In FIG. 16, the excitation light photoexcites PpIX accumulated in the malignant tumor CJ1. Then PpIX fluoresces. The fluorescent LJ1 is input from the opening of the puncture needle 12C to the inner clad portion 11Jab of the unit optical fiber 11Ja, propagates, is coupled to the light receiving portion 31Ib of the photoelectric portion 31I by the optical coupling portion 32I, and receives light there. The control unit 33I processes the current signal generated by the light reception, and displays the light reception state on, for example, a display device. As a result, the operator can not only diagnose the presence or absence of the malignant tumor according to the light receiving state, but also know that the malignant tumor is in the region irradiated with the excitation light by the unit optical fiber 11Ja.

Then, when performing PDT, the patient is intravenously administered with a light-sensitive agent, such as porphymer sodium or talaporfin sodium. The drug accumulates, for example, in malignant tumors.

Subsequently, during the period when the drug is stagnant in the malignant tumor, the photoelectric unit 31I is operated by the control unit 33I of the medical device 100J to emit the therapeutic light. The therapeutic optical LJ2 propagates through the core portion of the unit optical fiber 11Ja, is output to the outer region of the puncture needle 12J, reaches the malignant tumor CJ1, and degenerates or necroses the cells of the malignant tumor CJ1.

In the medical device 100I configured as described above, PDD and PDT can be executed. Further, since the double clad type optical fiber is used for the optical fiber 11J of the optical fiber probe, for example, the propagation region of the excitation light and the fluorescence in the optical fiber 11J can be spatially separated to some extent. As a result, it becomes easy for the optical coupling unit 32J to separate the excitation light and the fluorescence into the light emitting unit 31Ia and the light receiving unit 31Ib, respectively.

(Embodiment 5)
FIG. 17 is a schematic configuration diagram of the medical device according to the fifth embodiment. The medical device 100K has a configuration in which the photoelectric device 30I is replaced with the photoelectric device 30K in the medical device 100I according to the third embodiment shown in FIG. The photoelectric device 30K has a configuration in which the photoelectric unit 31I, the optical coupling unit 32I, and the control unit 33I of the photoelectric device 30I are replaced with the photoelectric unit 31K, the optical coupling unit 32K, and the control unit 33K, respectively.

The photoelectric unit 31K has a configuration in which a light emitting unit 31Kc is further added to the photoelectric unit 31I. The light emitting unit 31Kc has a light emitting device such as a laser device that emits test light. The test light is light having a wavelength having a higher depth of penetration into the tissue than the therapeutic light or the excitation light, and is, for example, near-infrared light.

The optical coupling unit 32K has a function of optically coupling the connecting optical fiber 20C and the photoelectric unit 31K. Further, the control unit 33K controls the operation of light emission or light reception of the photoelectric unit 31K.

FIG. 18 is a schematic diagram illustrating the operation of the medical device 100K. In this medical device 100K, the internal state of the site PK to be examined or treated can be examined with a test light before the execution of PDD or PDT.

For example, as shown in FIG. 18, with the puncture needle 12C punctured into the site PK, the photoelectric unit 31K is operated by the control unit 33K of the medical device 100K to emit the test light. The optical coupling unit 32K couples the test light to the connecting optical fiber 20C. The connected optical fiber 20C outputs the test light to the unit optical fiber 11Cb of the optical fiber 11C of the optical fiber probe 10C.

The unit optical fiber 11Cb outputs the test light LK1 into the site PK. The test light LK1 reaches a relatively wide range of the region Ab4, but when the test light LK1 is scattered in the region Ab4, for example, the scattered lights LK2 and LK3 are input to the unit optical fibers 11Ca and 11Cb and propagate. These scattered lights LK2 and LK3 are received by the light receiving unit 31Ib of the photoelectric unit 31I of the photoelectric device 30K. The control unit 33K processes the current signal generated by the light reception, and displays the light reception state on a display device, for example. Thereby, the operator can know the internal state of the portion PK according to the light receiving state. The information about this internal state becomes useful information when executing PDD or PDT after that.

(Embodiment 6)
FIG. 19 is a schematic configuration diagram of the medical device according to the sixth embodiment. The medical device 100L has a configuration in which the photoelectric device 30K is replaced with the photoelectric device 30L in the medical device 100K according to the fifth embodiment shown in FIG. 17, and a connecting optical fiber 40L and an optical head 50L are added. The photoelectric device 30L has a configuration in which the optical coupling unit 32K and the control unit 33K of the photoelectric device 30K are replaced with the optical coupling unit 32L and the control unit 33L, respectively.

The optical coupling unit 32L is different from the optical coupling unit 32K in that the test light from the light emitting unit 31Kc is output to the connecting optical fiber 40L. The control unit 33L controls the operation of light emission or light reception of the photoelectric unit 31K. The connected optical fiber 40L is a single-mode optical fiber or a multi-mode optical fiber, but the material thereof is not particularly limited. The optical head 50L irradiates the surface of the site PL with the test light propagating through the connecting optical fiber 40L as the test light LL1.

When the test light LL1 is irradiated on the surface of the site PL with the puncture needle 12C punctured in the site PL, a part of the test light LL1 passes through the site PL, reaches the optical fiber probe 10C, and binds to the optical fiber 11C. Propagate. Such transmitted light is received by the light receiving unit 31Ib of the photoelectric unit 31K of the photoelectric device 30L. The control unit 33L processes the current signal generated by the light reception, and displays the light reception state on a display device, for example. Thereby, the operator can know the internal state of the site PL according to the light receiving state. The information about this internal state becomes useful information when executing PDD or PDT after that.

The present invention is not limited to the above embodiments. Although the above-described embodiment describes PDD and PDT, it can also be applied to PIT. Further, the present invention also includes those configured by appropriately combining the above-mentioned components. Further, further effects and modifications can be easily derived by those skilled in the art. Therefore, the broader aspect of the present invention is not limited to the above embodiment, and various modifications can be made.

10, 10A, 10B, 10C, 10D, 10E, 10F, 10G, 10H, 10J: Optical fiber probe 11, 11A, 11C, 11C1, 11F, 11G, 11H, 11J: Optical fiber 11Aa: Diffusion part 11Ca, 11Cb, 11Cc , 11H1, 11Ja, 11Jb, 11Jc: Unit optical fiber 11Caa, 11Fa, 11Ga, 11Gb, 11Gc, 11Jaa: Core part 11Cab, 11Fb, 11Gd: Clad part 11Cac, 11Cbc, 11Ccc, 11Fc, 11Gaa, 11Gba, 11Gca Tip surface 11H1a: Notch 11Jab: Inner clad portion 11Jac: Outer clad portion 12, 12A, 12B, 12C, 12D, 12J: Penetration needle 12Aa, 12Ba, 12Bb, 12Bc, 12Bd: Opening 20, 20C, 20J: Connecting optical fiber 30, 30C, 30I, 30J, 30K, 30L: Optical device 31, 31C, 31I, 31K: Optical fiber 31Ia, 31Kc: Light emitting unit 31Ib: Light receiving unit 32, 32C, 32I, 32J, 32K, 32L: Optical coupling unit 33 , 33C, 33I, 33K, 33L: Control unit 40L: Connected optical fiber 50L: Optical head 100, 100C, 100I, 100J, 100K, 100L: Medical device ABS: Transparency Aa1, Aa2, Aa3, Ab4: Area C, CA1 , CA2, CB1, CB2, CB3, CC1, CC2, CI1, CI2, CJ1: Malignant tumor LC1, LC2, LI1, LI2, LJ1: Fluorescent LI3, LI4: Treatment light LJ2: Treatment light LK1, LL1: Test light LK2, LK3: Scattered light P, PA, PB, PC, PI, PJ, PK, PL: Site

Claims (17)

With optical fiber
A puncture needle that houses the tip of the optical fiber inside,
Equipped with
The optical fiber is an optical fiber probe having an optical input / output unit that inputs / outputs light to / from the outer region of the puncture needle at least a part of the tip portion. The optical fiber probe according to claim 1, wherein the optical fiber has a core portion, a clad portion surrounding the outer periphery of the core portion, and a covering portion surrounding the outer periphery of the clad portion. The puncture needle has an opening communicating with the inside and the outside region.
The optical fiber probe according to claim 1 or 2, wherein the optical input / output unit faces the opening. The optical input / output unit is the front end surface of the optical fiber.
The optical fiber probe according to claim 3, wherein the opening is provided at the tip of the puncture needle. The optical input / output unit is located on the outer peripheral surface of the optical fiber.
The optical fiber probe according to claim 3, wherein the opening is provided on the outer periphery of the puncture needle. The optical fiber probe according to claim 5, wherein the plurality of openings are provided on the outer periphery of the puncture needle. The optical fiber probe according to claim 6, wherein the plurality of openings have different positions around the axis of the puncture needle. The optical fiber probe according to any one of claims 1 to 7, wherein the puncture needle is made of a material transparent to light. The optical fiber has a plurality of core portions and has a plurality of core portions.
The optical fiber probe according to any one of claims 1 to 8, wherein the optical input / output unit corresponding to each of the plurality of core units is located at a position different from each other in the longitudinal direction of the optical fiber. The optical fiber probe according to claim 9, wherein the optical fiber is a multi-core optical fiber. The optical fiber probe according to claim 9, wherein the optical fiber is a bundle type optical fiber. The optical fiber probe according to any one of claims 1 to 11, wherein the optical fiber is a double clad type optical fiber. The optical fiber probe according to any one of claims 1 to 12, wherein the tip surface of the optical fiber is inclined with respect to the optical axis. The optical fiber probe according to any one of claims 1 to 13, wherein the gauge size of the puncture needle is 21 G or less. The optical fiber probe according to any one of claims 1 to 14, wherein the outer diameter of the optical fiber is 480 μm or less in a portion housed inside the puncture needle. The optical fiber probe according to any one of claims 1 to 15,
A photoelectric portion that optically couples with the core portion on the base end side of the optical fiber,
A medical device equipped with. The medical device according to claim 16, wherein the photoelectric portion has at least one of a light emitting device and a light receiving device.

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