JP2021185817A - バイオマーカー及びインターフェロンγ関連遺伝子のバイオマーカーとしての使用 - Google Patents
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Abstract
Description
インターフェロンγは活性化されたT細胞で産生され免疫系と炎症反応に対して調節作用を有する。IFN-γには抗ウイルス作用と抗腫瘍作用があるが弱く、その代わりIFN-αとβの効果を増強する作用がある。IFN-γはTh1細胞から分泌され、白血球を感染局所にリクルートして炎症を強化する作用がある。またマクロファージを刺激して細菌を貪食殺菌させる。Th1細胞から分泌されたIFN-γはTh2反応を調節する作用でも重要である。免疫応答の調節にも関わっており、過剰な産生は自己免疫疾患につながる可能性がある。
大腸癌切除標本6例(control 1〜6)の非病変部と、治療抵抗性のため手術となった潰瘍性大腸炎7例(Ulcerative colitis:UC)の腸管全層部と、から下記表1に示すように細胞サンプルを取得した。
クラスター解析の結果、図1に示すように、発現の低い部分と発現の高い部分とのコントラストが強い場所は、A2M、CXCL9-CXCR3 Axis(CXCR3、及び、CXCR3に対するligandであるCXCL9)、STAT1、GBP1、MMP3、PTPRC、及び、MAFであり、これによりインターフェロンγ(INF-γ)関連遺伝子が、潰瘍性大腸炎の発症と有意な相関があることが判明した。
実施例2では、実際に潰瘍性大腸炎患者から採取した細胞において、本発明にかかるバイオマーカーの発現を確認した。
Claims (6)
- インターフェロンγ関連遺伝子の、発現量の増加に基づく潰瘍性大腸炎の診断を補助するための、バイオマーカーとしての使用。
- 前記インターフェロンγ関連遺伝子は、A2M、CXCL9-CXCR3 Axis、STAT1、GBP1、MMP3、PTPRC、又は、MAFであることを特徴とする請求項1に記載のバイオマーカーとしての使用。
- 潰瘍性大腸炎の診断のためのバイオマーカーであって、
インターフェロンγ関連遺伝子であることを特徴とするバイオマーカー。 - 前記インターフェロンγ関連遺伝子は、A2M、CXCL9-CXCR3 Axis、STAT1、GBP1、MMP3、PTPRC、又は、MAFであることを特徴とする請求項3に記載のバイオマーカー。
- 潰瘍性大腸炎を診断するための診断キットであって、被検者から得られた生物学的試料におけるインターフェロンγ関連遺伝子を検出又は定量する手段を含む診断キット。
- 前記生物学的試料は、被検者の血清、血液、唾液、腹水、尿、糞便、胃洗浄液、又は、生検組織の何れかであることを特徴とする請求項5に記載の診断キット。
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