JP2021155360A - Chewable tablet - Google Patents

Abstract

To provide a chewable tablet having saliva secretion promoting effect.SOLUTION: On a chewable tablet that contains an acidulant and is rather hard, irregularities of a specific depth are applied, thereby controlling an impulse to chew and allowing the tablet to be licked for a longer time to increase the intraoral momentum, so that saliva secretion is promoted.SELECTED DRAWING: Figure 2

Description

The present invention relates to a chewable lock containing an acidulant and having an uneven surface.

In the oral environment of prenatal and postnatal women, especially women during pregnancy, the quantity and quality of saliva changes due to changes in hormonal balance, and caries and periodontal disease are likely to progress. In addition, due to changes in taste, sweetness and acidity that cause caries are preferred, and the oral environment is more likely to deteriorate. It is known that when pregnant women suffer from periodontal disease, they are at increased risk of low birth weight and premature birth. However, oral care may not be sufficient due to poor physical condition such as morning sickness.

Attempts have already been made to use an orally soluble solid as a means of preventing caries, improving oral function and oral hygiene, and cleaning the oral cavity. For example, a tablet for suppressing halitosis containing an organic acid (see, for example, Patent Document 1), or assuming that this effect is short-term, by blending an organic acid and water and setting the tablet hardness to a specific value, There are orally disintegrating tablets in which the time for disintegrating such tablets is controlled to enhance the effect of removing tongue coating (see, for example, Patent Document 2). Further, there is a substance containing an acidulant, which has a good flavor and an orally soluble solid having an ability to promote saliva secretion (see, for example, Patent Document 3). However, these saliva-secreting effects could not be sufficiently obtained even with the above-mentioned techniques utilizing organic acids and acidulants.

Japanese Unexamined Patent Publication No. 2017-171610 Special Table 2019-182818 Japanese Unexamined Patent Publication No. 2018-24596

As a result of diligent studies, the present inventors have surprisingly found that by applying unevenness of a specific depth to a chewable tablet, the momentum in the oral cavity is increased when licking. Furthermore, we have developed a chewable tablet that promotes saliva secretion by adding an acidulant and menthol and lemon flavors.

Promotion of saliva secretion can be expected in orally soluble solids containing organic acids and acidulants. However, the saliva-secreting effect of such an orally-soluble solid substance is largely due to the saliva-secreting effect due to the acidity of the organic acid contained in the orally-soluble solid substance, which is caused by licking the orally-soluble solid substance itself. It was not a salivation effect due to increased movement.

The present invention includes, for example, the subjects described in the following sections.
Item 1. A chewable tablet for promoting saliva secretion that contains an acidulant and has an uneven surface.
Item 2. Item 2. The chewable tablet for promoting saliva secretion according to Item 1, which contains an acidulant and is subjected to uneven processing on only one side of the tablet.
Item 3. Item 2. The chewable lock for promoting saliva secretion according to Item 1 or 2, wherein the unevenness processing depth is 0.2 mm or more.
Item 4. The chewable tablet for promoting saliva secretion according to any one of Items 1 to 3, wherein the diameter of the circumscribed circle in a plan view is 10 to 20 mm.
Item 5. Item 2. The chewable tablet for promoting saliva secretion according to any one of Items 1 to 4, wherein the central portion of the chewable tablet has the thickest shape.
Item 6. Item 2. The chewable for promoting saliva secretion according to any one of Items 1 to 5, wherein the acidulant is one or more selected from citric acid, ascorbic acid, tartaric acid, fumaric acid, malic acid and salts thereof. Lock.
Item 7. Item 2. The chewable tablet for promoting saliva secretion according to any one of Items 1 to 6, further containing a calcium salt.
Item 8. Item 2. The chewable tablet for promoting saliva secretion according to any one of Items 1 to 7, further containing a sugar alcohol.
Item 9. The chewable tablet for promoting saliva secretion according to any one of Items 1 to 8, wherein the calcium salt is one or more selected from calcium carbonate and calcium stearate.
Item 10. The chewable tablet for promoting saliva secretion according to any one of Items 1 to 9, wherein the sugar alcohol is one or more selected from xylitol, lactitol, maltitol, erythritol, and sorbitol.

The chewable tablet of the present invention, which contains an acidulant and has an uneven surface on the surface of the tablet, has an effect of promoting saliva secretion in order to activate the movement of the tongue, and is expected to improve the oral environment.

It is a chart which measured the movement of the tongue of the subject when licking the chewable lock of Example and Comparative Example in Test Example 1 by myoelectricity. A front view (A), a left side view (B), and a back view (C) of the chewable lock, which is one aspect of the chewable lock of the present invention, in which a recess is provided on one side and the thickness of the pharmaceutical product increases toward the center. show. The right side view is the same as the left side view, so it is omitted.

Hereinafter, each embodiment of the present invention will be described in more detail.

The chewable tablet of the present invention is a tablet having an uneven surface and further containing an acidulant, a calcium salt and a sugar alcohol.

[Shape of chewable lock]
(form)
The form of the chewable tablet of the present invention can be arbitrarily set as long as the effect of the present invention is not impaired. The shape is not particularly limited, and examples thereof include a circular flat lock, a sumi round flat lock, an oval lock, and a substantially triangular lock. The shape that is thicker toward the center makes it easier to roll with the tongue, and the saliva secretion promoting effect can be further enhanced.
The size of the chewable lock is preferably 10 to 21 mm, more preferably 12 to 19 mm, and particularly preferably 14 to 17 mm in diameter of the circumscribed circle in a plan view. The chewable tablet may be a single layer tablet or a laminated tablet.
(Tablet hardness)
The tablet hardness of the chewable tablet of the present invention is preferably 7 kgf, more preferably 10 kgf. When the tablet hardness is 10 kgf or more, the chewable tablet tends to stay in the oral cavity, and the saliva secretion promoting effect is enhanced. The tablet hardness in the present specification is a value measured in the radial direction using a Kiya-type hardness tester (manufactured by Fujiwara Seisakusho).
(Concavo-convex processing)
The pattern of uneven processing of the present invention is not limited, but the pattern of FIG. 1 is desirable. The depth of the concave portion of the uneven processing is preferably 0.15 mm or more and 0.7 mm or less, but 0.2 mm or more is particularly preferable from the stimulating feeling to the tongue, and 0.6 mm or less is particularly preferable from the problem of manufacturing stability. ..

(Acidulant)
The acidulant in the present invention is not particularly limited as long as it is an inorganic acid, an organic acid and salts thereof which can be expected to stimulate saliva secretion in the human oral cavity and can be used as additives for foods and pharmaceuticals. Examples of acidulants include organic acids such as citric acid, lactic acid, acetic acid, tartaric acid, succinic acid, gluconic acid, fumaric acid, sodium acetate, ascorbic acid (vitamin C), malic acid and its salts, phosphoric acid and its salts. Can be mentioned. Citric acid and ascorbic acid are particularly desirable from the viewpoint of imparting a good flavor to the solid matter. The acidulant may be used alone or in combination of two or more.

The blending amount of the acidulant is preferably 10% or less from the viewpoint of palatability, and when it is 8% or less, it becomes more delicious, which is particularly desirable.

(Calcium salt)
The calcium salt in the present invention can be expected to have an effect of improving and preventing dental caries. Examples of the calcium salt include calcium carbonate, calcium hydrogencarbonate, calcium stearate, calcium citrate, calcium glycerophosphate, calcium gluconate, calcium glutamate, calcium silicate, calcium acetate, calcium hydroxide and the like. Examples of natural calcium include those derived from organisms such as eggshell calcium, scallop shell calcium, coral calcium, cow bone powder and fish bone powder, and those derived from minerals such as dolomite and limestone. Calcium carbonate, calcium stearate and calcium lactate are particularly desirable. The calcium salt may be used alone or in combination of two or more.

The amount of the calcium salt is preferably 10% or more from the viewpoint of the effect on the teeth, and 80% or less from the viewpoint of the shape-retaining property of the preparation.

(Sugar alcohol)
The sugar alcohol in the present invention serves as a base material for solidifying the powder. Examples of sugar alcohols include xylitol, sorbitol, mannitol, reduced maltose, lactitol, oligosaccharide alcohol, erythritol, maltitol (reduced maltose water candy), and reduced palatinose. Sorbitol, xylitol, erythritol and maltitol have low hygroscopicity and are more preferable in terms of storage stability of the preparation. The sugar alcohol may be used alone or in combination of two or more.

The content of the sugar alcohol is preferably 45 to 85% by mass, more preferably 50 to 80% by mass, because a smooth disintegration feeling can be obtained.

(Arbitrary ingredient)
The chewable tablet of the present invention may contain any component other than the above-mentioned acidulant, calcium salt and sugar alcohol as long as the physical properties and stability are not impaired.
(Sweetness excluding sugar alcohol)
Examples of the sweetener excluding sugar alcohol include aspartame, acesulfame potassium, saccharin, saccharin salt, sucralose, taumatin, steviol and the like. As the sweetener used in the present invention, a low cariogenic sweetener and a non-cariogenic sweetener are preferable.
(Fragrance)
As the fragrance, known fragrances can be widely used, and synthetic fragrances or natural fragrances may be appropriately used, and there is no particular limitation. Examples thereof include menthol, eugenol, methyl salicylate, methyl eugenol, limonene, citronella, osimene, apple fragrance, sugar honey flavor, vegetable essential oil (hakka oil, mint oil, lychee oil, orange oil, lemon oil, etc.).

[Packaging container]
The packaging container for accommodating the chewable lock is not particularly limited, and examples thereof include an aluminum pouch, a bottle, a plastic case, and a capsule. In order to prevent the chewable lock from absorbing moisture, a pouch containing aluminum having excellent sealing properties is desirable.

[Production method]
The method for producing a chewable tablet of the present invention is not particularly limited. That is, the chewable tablet of the present invention can be produced according to a known production method. For example, a chewable tablet can be obtained by sequentially mixing raw materials and tableting.

Hereinafter, the present invention will be described with reference to Examples, Comparative Examples, and the like, but the present invention is not limited thereto.

[Example 1]
(Preparation of chewable tablets)
The raw materials were mixed according to the composition shown in Table 1 and locked by direct hitting to obtain a chewable tablet having a recess of 0.25 mm on one side.

[Comparative Example 1]
(Preparation of chewable tablets)
The raw materials were mixed according to the composition shown in Table 1 and tableted by direct hitting to obtain a chewable tablet having no unevenness.

[Observation of tongue movement when licking chewable lock]
(Evaluation method)
Two types of chewable tablets shown in Table 1 were licked by three subjects, and the movement of the tongue was measured using myoelectricity for 30 seconds after being put in the mouth. The results are shown in FIG.
(result)
It was revealed that among the chewable tablets having the same composition, the chewable tablets with the engraving had a better tongue movement than the chewable tablets without the engraving.

[Evaluation of saliva secretion promoting effect]
(Evaluation method)
The two chewable tablets shown in Table 1 were licked by four subjects for 30 seconds, and the saliva secreted during the licking was collected and the amount was measured. The results are shown in Table 2. The numerical value is an average value for four people.
(result)
Among the chewable tablets having the same composition, the chewable tablets with the engraving produced more than twice as much saliva as the chewable tablets without the engraving.

As shown in Table 2, the engraved chewable tablets containing acidulants surprisingly increased saliva production compared to the unengraved ones, and as shown in FIG. 1, the movement of the tongue. Was also found to grow.

Claims (11)

A chewable tablet for promoting saliva secretion that contains an acidulant and has an uneven surface. A chewable tablet for promoting saliva secretion that contains an acidulant and has uneven processing on only one side of the agent. The chewable lock for promoting saliva secretion according to claim 1 or 2, wherein the engraving depth of the uneven processing is 0.2 m or more. The chewable tablet for promoting saliva secretion according to any one of claims 1 to 3, wherein the diameter of the circumscribed circle in a plan view is 10 to 20 mm. The chewable tablet for promoting saliva secretion according to any one of claims 1 to 4, wherein the central portion of the chewable tablet has the thickest shape. The chewable tablet for promoting salivation according to any one of claims 1 to 5, wherein the acidulant is selected from the group consisting of citric acid, ascorbic acid, tartaric acid, fumaric acid, malic acid and salts thereof. The chewable tablet for promoting saliva secretion according to any one of claims 1 to 6, further containing a calcium salt. The chewable tablet for promoting saliva secretion according to any one of claims 1 to 7, further containing a sugar alcohol. The chewable tablet for promoting saliva secretion according to any one of claims 1 to 8, wherein the calcium salt is selected from the group consisting of calcium charcoal and calcium stearate. The chewable tablet for promoting saliva secretion according to any one of claims 1 to 9, wherein the sugar alcohol is selected from the group consisting of xylitol, lactitol, maltitol, erythritol, and sorbitol. A saliva secretion method for licking a chewable lock according to any one of claims 1 to 10.

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