JP7037881B2 - Orally soluble solids - Google Patents

Description

The present invention relates to an orally soluble solid consisting of at least two layers, a layer containing an acidulant and exhibiting acidity and a layer containing a pH adjuster and exhibiting alkalinity.

In recent years, the number of elderly people who have dry mouth due to decreased saliva secretion is increasing. Xerostomia includes oral discomfort such as dry mouth and sticky saliva, pain in the tongue and oral mucosa, incompatibility and pain of artificial teeth, artificial tooth ulcer, aphthous stomatitis, mucosal ulcer, masticatory disorder, dysphagia, May cause symptoms such as taste disorders.

Xerostomia often lick candy to stimulate saliva production and moisturize the mouth. However, since the amount of saliva secreted is small, the pH buffering action by saliva is unlikely to occur, so that there is a problem that the acidulant contained in the candy itself lowers the pH in the oral cavity and causes caries.

Attempts have been reported to regulate the pH of the oral cavity using foods such as candy and chewing gum to prevent caries and plaque. For example, as an oral composition useful for preventing dental caries, an oral composition for preventing a decrease in saliva pH, which comprises histidine and the like and calcium carbonate, has been reported (for example, Patent Document 1). reference). Such a composition is provided in the form of chewing gum, candy, etc., has a buffering ability to maintain the pH at 5.5 or higher by adding a small amount of a pH buffering agent that does not affect the flavor, and is expected to have a caries-preventing effect. To. Further, as an active ingredient for neutralizing an acid, a candy having a plaque neutralizing action containing ammonium phosphate and / or sodium hydrogen carbonate and the like has been reported (see, for example, Patent Document 2). By ingesting such candy after ingesting food, coffee, etc., it is expected to promote the neutralization of acid in tooth plaque and prevent or suppress the formation of dental caries in the presence of plaque. Further, dental training gums having an effect of preventing caries as well as improving masticatory function have been reported (see, for example, Patent Document 3). Such gum is characterized by containing a saliva secretion promoting agent such as citric acid and a saliva buffering ability improving agent such as sodium hydrogen carbonate, and by chewing the training gum as if it were a luxury item, the chewing function is improved. It is expected to have a caries-preventing effect due to the oral cleaning action by improving the saliva secretion function and the oral pH buffering action.

Japanese Unexamined Patent Publication No. 8-301742 Special Table 9-511912 Gazette Japanese Patent Application Laid-Open No. 2002-220332

By adding a basic buffer component or the like, it is possible to prevent a decrease in pH in the oral cavity and expect a caries-preventing effect. However, such orally soluble solids such as candy and troches have no sour taste and are not only unsatisfactory in terms of flavor, and the promotion of saliva secretion by the sour taste cannot be expected. Therefore, the present invention is an orally soluble solid substance having a good flavor due to acidity, an ability to promote saliva secretion, and an oral pH that can be maintained at 5.0 or higher, which has a low risk of dental caries. The purpose is to provide.

As a result of diligent studies to solve the above-mentioned problems, the present inventors have made an orally soluble solid substance into a layer containing an acidulant and exhibiting acidity and a layer containing a pH adjuster and exhibiting alkalinity. By being composed of at least two layers, it has a good flavor due to acidity in the oral cavity and a saliva secretion promoting action, and the pH in the oral cavity is set to 5.0 or more, which has a low risk of caries. We have found that it can be maintained and completed the present invention.
The present invention is as follows.

[1] An orally soluble solid consisting of at least two layers, a layer (a) containing an acidulant and exhibiting acidity, and a layer (b) containing a pH adjuster and exhibiting alkalinity.
[2] The solid substance according to [1], wherein the acidulant is selected from the group consisting of citric acid, tartaric acid, fumaric acid, malic acid, ascorbic acid and salts thereof.
[3] The pH adjuster is selected from the group consisting of carbonic acid, hydrogen carbonate, citric acid, lactic acid, phosphoric acid and ammonium salts of hydrogen phosphate, alkali metal salts and alkaline earth metal salts, [1] or [ 2] The solid substance according to.
[4] The solid according to any one of [1] to [3], wherein the pH when 20 g of the solid is dissolved in 100 mL of water is 5.0 to 8.0.
[5] The solid matter according to any one of [1] to [4], wherein the solid matter is a hard candy, a soft candy, a gummy candy, or a tablet.
[6] The solid matter according to any one of [1] to [5], wherein the solid matter has a substantially cylindrical shape having a thickness of 2 to 20 mm and a diameter of 5 to 30 mm, and has at least one protrusion on the surface.

The orally soluble solid of the present invention is composed of at least two layers, a layer (a) containing an acidulant and exhibiting acidity, and a layer (b) containing a pH adjuster and exhibiting alkalinity. When this solid substance is contained in the oral cavity, the acidulant of the layer (a) gives a good flavor in the oral cavity and saliva secretion is promoted, and at the same time, the pH adjuster of the layer (b) adjusts the pH of the oral cavity. The lowering is hindered and the risk of caries can be kept below 5.0, which is low.

It is a graph which showed the saliva secretion increase rate of the subject (Y) at the time of licking the candy of an Example and a comparative example in Test Example 2. It is a graph which showed the saliva secretion increase rate of the subject (Z) at the time of licking the candy of an Example and a comparative example in Test Example 2. A front view (a), a plan view (b), and a right side view (c) of a donut-shaped candy having three hemispherical protrusions on one side, which is one aspect of the orally soluble solid substance of the present invention. ) And the cross-sectional view taken along the line A (d). Since the bottom view is the same as the plan view, it is omitted. The left side view is the same as the right side view, so it is omitted. The rear view is the same as the front view, so it is omitted. A front view (a), a plan view (b), and a right side view (c) of a donut-shaped candy having four hemispherical protrusions on one side, which is one aspect of the orally soluble solid substance of the present invention. ) And the cross-sectional view taken along the line A (d). Since the bottom view is the same as the plan view, it is omitted. The left side view is the same as the right side view, so it is omitted. The rear view is the same as the front view, so it is omitted. A front view (a), a cross-sectional view (b), and a plan view of a donut-shaped candy having 5 hemispherical protrusions on one side, which is one aspect of the orally soluble solid substance of the present invention. c), right side view (d) and rear view (e) are shown. Since the bottom view is the same as the plan view, it is omitted. The left side view is the same as the right side view, so it is omitted. A front view (a), a plan view (b), and a right side view (c) of a donut-shaped candy having 6 hemispherical protrusions on one side, which is one aspect of the orally soluble solid substance of the present invention. ) And the cross-sectional view taken along the line A (d). Since the bottom view is the same as the plan view, it is omitted. The left side view is the same as the right side view, so it is omitted. The rear view is the same as the front view, so it is omitted. A front view (a), a plan view (b), a right side view (c), and a sectional view taken along the line A of a four-petaled flower-shaped candy having a donut hole, which is one aspect of the orally soluble solid substance of the present invention. d) is shown. Since the bottom view is the same as the plan view, it is omitted. The left side view is the same as the right side view, so it is omitted. The rear view is the same as the front view, so it is omitted. A front view (a), a sectional view (b), a plan view (c), and a right side view of a five-petaled flower-shaped candy having a donut hole, which is one aspect of the orally soluble solid substance of the present invention. d) and a rear view (e) are shown. Since the bottom view is the same as the plan view, it is omitted. The left side view is the same as the right side view, so it is omitted. A front view (a), a plan view (b), a right side view (c), and a sectional view taken along the line A of a 6-petaled flower-shaped candy having a donut hole, which is one aspect of the orally soluble solid substance of the present invention. d) is shown. Since the bottom view is the same as the plan view, it is omitted. The left side view is the same as the right side view, so it is omitted. The rear view is the same as the front view, so it is omitted. A front view (a), a plan view (b), a right side view (c), and a cross-sectional view taken along the line A (d) of a donut-shaped candy, which is one aspect of the orally soluble solid substance of the present invention, are shown. Since the bottom view is the same as the plan view, it is omitted. The left side view is the same as the right side view, so it is omitted. The rear view is the same as the front view, so it is omitted.

The present invention relates to an orally soluble solid. In the embodiment of the present invention, the orally soluble solid matter means a solid matter that is mainly dissolved by saliva in the oral cavity, and is in the form of known confectionery such as hard candy, soft candy, gummy candy, and tablet. It may be in the form of a known pharmaceutical preparation such as a troche, a film, or an orally fast-dissolving tablet. From the viewpoint of application to dry mouth, the form of confectionery is preferable, and the form of hard candy is more preferable.

In an embodiment of the present invention, the acidulant in layer (a) can stimulate saliva secretion in the human oral cavity by stimulating sourness, and can be used as an additive for foods or pharmaceuticals. It is not particularly limited as long as it is an inorganic acid, an organic acid and salts thereof. Examples of acidulants include adipic acid, citric acid, gluconic acid, succinic acid, acetic acid (glacial acetic acid), tartaric acid, lactic acid, fumaric acid, malic acid, phosphoric acid, ascorbic acid and salts thereof. Tartrate acid, fumaric acid, malic acid, ascorbic acid and salts thereof are preferable, and citric acid or phosphoric acid is more preferable. Citric acid is particularly preferred because it gives the solid a good flavor. The acidulant may be used alone or in combination of two or more. The blending amount of the acidulant may be appropriately set so that the layer (a) exhibits acidity (pH less than 5.0) according to the type of acidulant, the type and blending amount of the pH adjuster, but the total amount of solid matter is total. It is 0.05 to 2.0% by mass, preferably 0.1 to 1.0% by mass, and more preferably 0.15 to 0.5% by mass with respect to the weight.

In an embodiment of the present invention, the pH adjuster in layer (b) has a buffering ability to maintain the pH in the human oral cavity at 5.0 or higher in the presence of the orally soluble composition of the present invention. , Basic inorganic acids and organic acid salts that can be used as additives for foods or pharmaceuticals are not particularly limited. Examples of pH regulators include carbonic acid, hydrogen carbonate, citric acid, lactic acid, phosphoric acid and ammonium salts of hydrogen phosphate, alkali metal salts and alkaline earth metal salts, and hydrogen phosphate disodium dihydrate. , Hydrogen phosphate disodium 12 hydrate, Citrate trisodium dihydrate, and sodium lactate are preferred. Disodium hydrogen phosphate dihydrate is more preferred because it gives the solid a good flavor and solubility. The pH adjuster may be used alone or in combination of two or more. The blending amount of the pH adjusting agent may be appropriately set so that the layer (b) exhibits basicity (pH over 8.0) according to the type and blending amount of the acidulant and the type of the pH adjusting agent. It is 0.1 to 10.0% by mass, preferably 0.2 to 5.0% by mass, and more preferably 0.5 to 3.0% by mass with respect to the total weight of the above.

In a preferred embodiment of the present invention, the blending amount of the acidulant and the pH adjuster is such that the pH when 20 g of the orally soluble solid of the present invention is dissolved in 100 mL of water is 5.0 to 8.0. Is set to.

In a preferred embodiment of the present invention, a pH adjuster containing a component other than the acidulant and a pH adjuster constituting the acidulant-containing layer (a) and constituting the basic layer (b). Ingredients other than the agent are appropriately selected depending on the form of the orally soluble solid substance. For example, when the orally soluble solid is hard candy, the bases of layers (a) and (b) are those commonly used as bases for hard candy, such as sugar, starch syrup, or sugar. Examples include alcohols (maltitol, reduced palatinose, xylitol, reduced starch syrup, etc.). In addition, flavors, sweeteners, coloring agents, emulsifiers, edible oils and fats, vitamins and the like can be appropriately added to the base as long as the object of the present invention is not impaired.

Further, for example, when the orally soluble solid substance is a tablet, the base of the layer (a) and the layer (b) is not particularly limited as long as it is usually used as a base of the tablet, but sugar. , Glucose, sorbitol, saccharides such as lactose, polysaccharides such as starch, methyl cellulose, crystalline cellulose, and silicic acids such as silicic anhydride. In addition, flavors, sweeteners, coloring agents, binders, vitamins and the like can be appropriately added to the base as long as the object of the present invention is not impaired.

In an embodiment of the present invention, the orally soluble solid is composed of at least two layers, a layer (a) containing an acidulant and exhibiting acidity, and a layer (b) containing a pH adjuster and exhibiting alkalinity. It is composed. It is preferably composed of two layers, a layer (a) and a layer (b). The orally soluble solid may be configured such that each layer is present on the surface of the solid so that when it is contained in the oral cavity, it comes into contact with saliva and the acidulant and the pH adjuster are released from each layer. ..

In the embodiment of the present invention, the shape of the orally soluble solid substance is not particularly limited, and may be any shape and size suitable for dissolution in the oral cavity. Such shapes include a substantially spherical shape with a diameter of 5 to 25 mm; a substantially cylindrical shape with a maximum thickness of 2 to 20 mm and a diameter of 5 to 30 mm; a substantially donut with a maximum thickness of 2 to 20 mm, a diameter of 5 to 30 mm, and an inner diameter of 2 to 10 mm. Shape; Approximately cubic body with a side of 5 to 20 mm long; Approximately rectangular parallelepiped with a maximum thickness of 2 to 15 mm, a major axis of 5 to 25 mm, and a minor axis of 2 to 25 mm; or a three-dimensional shape with motifs of flowers, plants, animals, vehicles, etc. It may be any shape used in known confectionery or pharmaceutical formulations. In a preferred embodiment of the present invention, the orally soluble solid is a substantially cylindrical solid having a maximum thickness of 5 to 15 mm and a diameter of 15 to 25 mm, and has at least one protrusion on the surface. good. Examples of such solids are shown in FIGS. 2-9. For example, FIG. 5 has 6 hemispherical protrusions on one side and 12 hemispherical protrusions on both sides. The protrusions can stimulate the oral cavity and promote further saliva production. The number of protrusions present per solid substance is not particularly limited, but is, for example, 1 or more, preferably 2 to 12. The orally soluble solid is substantially donut-shaped with a maximum thickness of 5 to 15 mm, a diameter of 15 to 25 mm, and an inner diameter (or the diameter of the donut hole) of 2 to 10 mm, and has at least one protrusion on the surface. May be. Even if the orally soluble solid is aspirated and the solid is clogged in the throat, the donut hole can secure the airway and avoid suffocation.

The method for producing an orally soluble solid substance of the present invention is not particularly limited. That is, the orally soluble solid of the present invention can be produced according to a known production method. For example, when the orally soluble solid is hard candy, an acidic candy raw material prepared by adding an acidulant to a base prepared with sugar, starch syrup, etc., and a basic base prepared by adding a pH adjuster to the same base. It can be obtained by laminating the candy raw material at a weight ratio of about 1: 1, roping, cutting into a desired shape with a molding machine, and cooling. Alternatively, a basic candy raw material is poured into a mold, and after cooling, the same amount of acidic candy raw material is poured and cooled to produce an orally soluble solid product of the present invention, which is a hard candy composed of two layers. can do. Further, for example, when the orally soluble solid is a tablet, acidic granules granulated by adding an acidulant to a base prepared with sugar, a binder, etc., and granules by adding a pH adjuster to the same base. The basic granules obtained can be obtained as a double-layer tablet by sequentially compression-packing according to a known method for forming a multi-layer tablet.

Hereinafter, the present invention will be described with reference to Examples, Comparative Examples, and the like, but the present invention is not limited thereto.

[Example 1]
(A) Preparation of acidic candy raw material 41.878 g of reduced palatinose, 57.013 g of reduced starch syrup and 30 g of water were placed in a pan and dissolved by heating, and then heated to 175 ° C. with stirring. This was transferred to a tray and air-cooled to use as a base.
0.700 g of citric acid (anhydrous) as an acidulant, 0.020 g of aspartame as a sweetener, 0.014 g of acesulfame K and 0.005 g of sucralose were mixed in advance, and the base obtained above was added to the one obtained by heating and dissolving in an oven. rice field. Further, 0.370 g of a fragrance was added and kneaded to obtain an acidic candy raw material.
(B) Preparation of basic candy raw material 41.241 g of reduced palatinose, 56.850 g of reduced starch syrup and 30 g of water were placed in a pan and dissolved by heating, and then heated to 175 ° C. with stirring. This was transferred to a tray and air-cooled to use as a base.
1.500 g of disodium hydrogen phosphate dihydrate as a pH adjuster, 0.020 g of aspartame as a sweetener, 0.014 g of acesulfame K and 0.005 g of sucralose are mixed in advance, and the base obtained above is heated in an oven. Added to the dissolved one. Further, 0.370 g of a fragrance was added and kneaded to obtain a basic candy raw material.
(C) Preparation of hard candy Each candy raw material obtained in (a) and (b) was bonded at a ratio of 1: 1 (weight ratio) and roped until an appropriate thickness was obtained. Next, the pasted candy raw materials were put into a molding machine, stamped, and then taken out from the mold to obtain 50 hard candy (about 3.8 g) consisting of two layers of substantially cylindrical shape having a maximum thickness of 12 mm and a diameter of 20 mm. rice field.

[Example 2]
Hard candy (about 3.8 g) consisting of two layers of substantially cylindrical shape with a maximum thickness of 12 mm and a diameter of 20 mm in the same manner as in Example 1 except that the formulations of each component are the formulations shown in Table 1 below. I got a piece.

[Example 3]
Hard candy (about 3.8 g) consisting of two layers of substantially cylindrical shape with a maximum thickness of 12 mm and a diameter of 20 mm in the same manner as in Example 1 except that the formulations of each component are the formulations shown in Table 1 below. I got a piece.

[Example 4]
Except that a mixture of citric acid (anhydride) and tartaric acid was used as an acidulant, disodium hydrogen phosphate dodecahydrate was used as a pH adjuster, and the formulations of each component were the formulations shown in Table 1 below. By the same method as in Example 1, 50 hard candies (about 3.8 g) composed of two layers having a maximum thickness of 12 mm and a diameter of 20 mm and having a substantially cylindrical shape were obtained.

[Example 5]
A substantially cylindrical cylinder having a maximum thickness of 12 mm and a diameter of 20 mm in the same manner as in Example 1 except that sodium citrate dihydrate was used as a pH adjuster and the formulations of each component were the formulations shown in Table 1 below. Fifty hard candies (about 3.8 g) consisting of two layers of shape were obtained.

[Comparative Example 1]
42.127 g of reduced palatinose, 57.464 g of reduced starch syrup and 30 g of water were placed in a pan and dissolved by heating, and then heated to 175 ° C. with stirring. This was transferred to a tray and air-cooled to use as a base.
Aspartame 0.020 g, acesulfame K 0.014 g and sucralose 0.005 g were mixed in advance as sweeteners, and the base obtained above was added to the mixture heated and dissolved in an oven. Further, 0.370 g of a fragrance was added and kneaded to obtain a candy raw material. The obtained candy raw material was roped to an appropriate thickness. Next, the candy raw material was put into a molding machine and stamped, and then taken out from the mold to obtain 25 substantially cylindrical hard candy (about 3.8 g) having a maximum thickness of 12 mm and a diameter of 20 mm.

[Comparative Example 2]
65.980 g of reduced palatinose, 31.600 g of reduced starch syrup and 30 g of water were placed in a pan and dissolved by heating, and then heated to 175 ° C. with stirring. This was transferred to a tray and air-cooled to use as a base. 2.100 g of citric acid (anhydride) as an acidulant, 0.050 g of acesulfame K and 0.020 g of sucralose as sweeteners were mixed in advance, and the base obtained above was added to the one heated and dissolved in an oven. Further, 0.250 g of a fragrance was added and kneaded to obtain a candy raw material. The obtained candy raw material was roped to an appropriate thickness. Next, the candy raw material was put into a molding machine and stamped, and then taken out from the mold to obtain 25 substantially cylindrical hard candy (about 3.8 g) having a maximum thickness of 12 mm and a diameter of 20 mm.

[Comparative Example 3]
A substantially cylindrical hard candy with a maximum thickness of 12 mm and a diameter of 20 mm in the same manner as in Comparative Example 2 except that aspartame was further used as a sweetener and the composition of each component was as shown in Table 2 below. 3.8 g) Twenty-five pieces were obtained.

[Comparative Example 4]
41.21 g of reduced palatinose, 56.910 g of reduced starch syrup and 30 g of water were placed in a pan and dissolved by heating, and then heated to 175 ° C. with stirring. This was transferred to a tray and air-cooled to use as a base. 1.470 g of disodium hydrogen phosphate dihydrate as a pH adjuster, 0.020 g of aspartame as a sweetener, 0.014 g of acesulfame K and 0.005 g of sucralose are mixed in advance, and the base obtained above is heated in an oven. Added to the dissolved one. Further, 0.370 g of a fragrance was added and kneaded to obtain a candy raw material. The obtained candy raw material was roped to an appropriate thickness. Next, the candy raw material was put into a molding machine and stamped, and then taken out from the mold to obtain 25 substantially cylindrical hard candy (about 3.8 g) having a maximum thickness of 12 mm and a diameter of 20 mm.

[Comparative Example 5]
41.100 g of reduced palatinose, 56.291 g of reduced starch syrup and 30 g of water were placed in a pan and dissolved by heating, and then heated to 175 ° C. with stirring. This was transferred to a tray and air-cooled to use as a base.
0.700 g of citric acid (anhydrous) as an acidulant, 1.500 g of disodium hydrogen phosphate dihydrate as a pH adjuster, 0.020 g of aspartame as a sweetener, 0.014 g of Acesulfam K and 0.005 g of sucralose are mixed in advance. , The base obtained above was added to the heat-dissolved one using an oven. Further, 0.370 g of a fragrance was added and kneaded to obtain a candy raw material. The obtained candy raw material was roped to an appropriate thickness. Next, the candy raw material was put into a molding machine and stamped, and then taken out from the mold to obtain 25 substantially cylindrical hard candy (about 3.8 g) having a maximum thickness of 12 mm and a diameter of 20 mm.

[Comparative Example 6]
Hard candy (about 3.8 g) consisting of two layers of substantially cylindrical shape with a maximum thickness of 12 mm and a diameter of 20 mm in the same manner as in Example 1 except that the formulations of each component are the formulations shown in Table 3 below. I got a piece.

[Comparative Example 7]
Hard candy (about 3.8 g) consisting of two layers of substantially cylindrical shape with a maximum thickness of 12 mm and a diameter of 20 mm in the same manner as in Example 1 except that the formulations of each component are the formulations shown in Table 3 below. I got a piece.

[Test Example 1: Sensory evaluation]
The flavor of each hard candy obtained in Examples 1 to 5 and Comparative Examples 1 to 7 was evaluated by three inspectors (X, Y and Z). Moreover, the pH when 20 g of each hard candy obtained in Examples 1 to 5 and Comparative Examples 1 to 7 was dissolved in 100 mL of water was measured. The results are shown in Tables 4 and 5.
The evaluation was carried out by a method of sensually evaluating the flavor (sour and salty taste) contained in the mouth. The evaluation criteria are as follows:
Acidity: Feel acidity (○); Slightly acidity (△); Do not feel acidity (×);
Salty taste: No salty taste (○); Slightly salty taste (△); Strongly salty taste (×).

Each of the hard candy obtained in Examples 1 to 5 had a good flavor. The pH was also over 5.5, which was a low risk range of caries. On the other hand, each of the hard candy obtained in Comparative Examples 2 and 3 contained an acidulant but did not contain a pH adjuster, and all had a good flavor, but the pH was 3.1 or less. It was extremely low and there was a risk of caries. Further, each of the hard candy obtained in Comparative Examples 1 and 4 did not contain an acidulant, and the evaluation of the flavor was poor in any of the inspectors. Further, the hard candy obtained in Comparative Example 5 contains an acidulant and a pH adjuster, but like the hard candy obtained in the example, the acidulant and the pH adjuster are separately added to each of the two layers. The evaluation of the flavor was poor because it did not contain the acidulant and the pH adjuster in one layer. Furthermore, each of the hard candy obtained in Comparative Examples 6 and 7 was produced by the same method as in Example, but in Comparative Example 6, the amount of the acidulant was small and the layer (a) was made acidic. However, no evaluation of acidity was obtained because it was not sufficient. On the other hand, in Comparative Example 7, the amount of the acidulant compounded was excessive, the balance with the layer (b) was impaired, the evaluation of saltiness was low, the pH was as low as 3.9, and there was a risk of caries. rice field.

[Test Example 2: Saliva secretion promoting effect]
Two subjects (Y and Z) were subjected to a saliva secretion promoting effect test according to the following procedure.
(procedure)
While maintaining a resting state, store saliva in the oral cavity so as not to swallow it, and spit it into a pre-weighted cup every minute.
Weigh the cup and calculate the amount of saliva secreted.
Perform every 1 minute for 5 minutes. The saliva obtained at this time is referred to as "front".
Lick 3.8 g of hard candy, store it in the oral cavity so as not to swallow saliva, and spit it into a cup every minute.
Perform every 1 minute for 5 minutes. The saliva obtained at this time is referred to as "medium".
After 5 minutes, spit out the hard candy, and then spit it out into a cup every minute to keep it in a resting state and keep it in the oral cavity so as not to swallow saliva.
Perform every 1 minute for 5 minutes. The saliva obtained at this time is referred to as "after".
(result)
Table 6 shows the average value of saliva volume (average saliva volume (mL) per minute) measured every minute for 5 minutes before, during, and after licking the hard candy. Further, the change when the average saliva volume (mL) per minute for 5 minutes before licking the hard candy is 1, is shown in FIGS. 1A and 1B as the rate of increase in saliva secretion. From these results, it was clarified that saliva secretion increased when the hard candy of Example 1 was licked rather than the hard candy of Comparative Examples 1 and 4 to 6.

Claims (5)

A pH adjuster selected from the group consisting of a layer (a) containing an acidulant and exhibiting acidity, and an ammonium salt of citric acid, lactic acid, phosphoric acid and hydrogen phosphate, an alkali metal salt and an alkaline earth metal salt. It is an orally soluble solid consisting of at least two layers of the layer (b) containing and exhibiting alkalinity, and the amount of the acidulant blended is 0.15 to 1 with respect to the total weight of the orally soluble solid. .0% by mass of orally soluble solids (except when containing calcium salts) . The solid according to claim 1, wherein the acidulant is selected from the group consisting of citric acid, tartaric acid, fumaric acid, malic acid, ascorbic acid and salts thereof. The solid according to claim 1 or 2, wherein the pH when 20 g of the solid is dissolved in 100 mL of water is 5.0 to 8.0. The solid matter according to any one of claims 1 to 3, wherein the solid matter is a hard candy, a soft candy, a gummy candy or a tablet. The solid matter according to any one of claims 1 to 4, wherein the solid matter has a substantially cylindrical shape having a thickness of 2 to 20 mm and a diameter of 5 to 30 mm, and has at least one protrusion on the surface.

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