|
US6624142B2
(en)
|
1997-12-30 |
2003-09-23 |
Enzon, Inc. |
Trimethyl lock based tetrapartate prodrugs
|
|
US6833358B1
(en)
|
1998-09-28 |
2004-12-21 |
Santen Pharmaceutical Co., Ltd. |
Lacrimal secretion promoters or eye drops for treating keratoconjunctival failure containing as the active ingredient natriuretic peptides
|
|
DK1578771T3
(da)
|
2001-10-10 |
2013-06-10 |
Novo Nordisk As |
Remodellering og glycokonjugering af peptider
|
|
US8596542B2
(en)
*
|
2002-06-04 |
2013-12-03 |
Hand Held Products, Inc. |
Apparatus operative for capture of image data
|
|
US7122189B2
(en)
|
2002-08-13 |
2006-10-17 |
Enzon, Inc. |
Releasable polymeric conjugates based on aliphatic biodegradable linkers
|
|
WO2004047871A2
(en)
*
|
2002-11-26 |
2004-06-10 |
Nobex Corporation |
Modified naturetic compounds, conjugates, and uses thereof
|
|
US7332164B2
(en)
|
2003-03-21 |
2008-02-19 |
Enzon Pharmaceuticals, Inc. |
Heterobifunctional polymeric bioconjugates
|
|
DK1620118T3
(da)
|
2003-04-08 |
2014-09-29 |
Yeda Res & Dev |
Reversible pegylerede lægemidler
|
|
CA2786794C
(en)
|
2004-03-23 |
2017-09-12 |
Complex Biosystems Gmbh |
Aromatic polymeric cascade prodrug linker reagent
|
|
GB2427360A
(en)
|
2005-06-22 |
2006-12-27 |
Complex Biosystems Gmbh |
Aliphatic prodrug linker
|
|
CU23556A1
(es)
*
|
2005-11-30 |
2010-07-20 |
Ct Ingenieria Genetica Biotech |
Estructura polimérica semejante a dendrímero para la obtención de conjugados de interés farmacéutico
|
|
US8450269B2
(en)
|
2006-02-03 |
2013-05-28 |
Prolor Biotech Ltd. |
Long-acting growth hormone and methods of producing same
|
|
CN101600731A
(zh)
|
2006-09-08 |
2009-12-09 |
梅约医学教育与研究基金会 |
不具备血管舒张活性的促排水和利尿钠多肽
|
|
CN101534643A
(zh)
|
2006-09-15 |
2009-09-16 |
安佐制药股份有限公司 |
用于递送寡核苷酸的基于位阻酯的生物可降解连接体
|
|
KR20140032505A
(ko)
|
2006-11-09 |
2014-03-14 |
알콘 리서치, 리미티드 |
약물 전달용 수불용성 폴리머 매트릭스
|
|
AU2008242797B2
(en)
*
|
2007-04-20 |
2011-07-14 |
Shell Internationale Research Maatschappij B.V. |
In situ recovery from residually heated sections in a hydrocarbon containing formation
|
|
KR20080098216A
(ko)
|
2007-05-04 |
2008-11-07 |
한미약품 주식회사 |
캐리어 물질을 이용한 나트륨 배설 펩타이드 약물 결합체
|
|
SI2173890T1
(sl)
|
2007-06-21 |
2011-06-30 |
Univ Muenchen Tech |
Biološko aktivni proteini, ki imajo povečano in vivo in/ali in vitro stabilnost
|
|
CA2693616A1
(en)
|
2007-07-11 |
2009-01-15 |
Enzon Pharmaceuticals, Inc. |
Polymeric drug delivery system containing a multi-substituted aromatic moiety
|
|
TWI367213B
(en)
|
2007-11-21 |
2012-07-01 |
Biomarin Pharm Inc |
Variants of c-type natriuretic peptide
|
|
US8906847B2
(en)
|
2008-02-01 |
2014-12-09 |
Ascendis Pharma A/S |
Prodrug comprising a drug linker conjugate
|
|
JP2011520983A
(ja)
|
2008-05-23 |
2011-07-21 |
エンゾン ファーマシューティカルズ，インコーポレーテッド |
オリゴヌクレオチドの送達のための細胞内遊離可能ジスルフィドリンカーを含有するポリマーシステム
|
|
WO2009156481A1
(en)
|
2008-06-25 |
2009-12-30 |
Ascendis Pharma As |
Pegylated bnp
|
|
WO2010033217A1
(en)
|
2008-09-19 |
2010-03-25 |
Nektar Therapeutics |
Polymer conjugates of cd-np peptides
|
|
MX362028B
(es)
|
2009-02-03 |
2019-01-04 |
Amunix Pharmaceuticals Inc |
Polipeptidos recombinantes extendidos y composiciones que comprenden los mismos.
|
|
AR078044A1
(es)
*
|
2009-05-20 |
2011-10-12 |
Biomarin Pharm Inc |
Variantes de peptidos natriureticos de tipo c
|
|
EP2459227B1
(en)
|
2009-07-31 |
2021-03-17 |
Ascendis Pharma A/S |
Prodrugs containing an aromatic amine connected by an amide bond to a carrier
|
|
WO2011031441A1
(en)
*
|
2009-08-28 |
2011-03-17 |
The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
Therapy with a chimeric molecule and a pro-apoptotic agent
|
|
WO2011075471A2
(en)
|
2009-12-18 |
2011-06-23 |
Alcon Research, Ltd. |
Novel npr-b agonists and methods of use for the treatment of c-type natriuretic peptide-mediated disorders
|
|
CN102724967A
(zh)
|
2009-12-31 |
2012-10-10 |
安龙制药公司 |
包括可释放的脲连接体的含芳香胺化合物的聚合缀合物
|
|
US9561285B2
(en)
|
2010-01-22 |
2017-02-07 |
Ascendis Pharma As |
Carrier-linked carbamate prodrug linkers
|
|
EP2525829A1
(en)
|
2010-01-22 |
2012-11-28 |
Ascendis Pharma A/S |
Dipeptide-based prodrug linkers for aromatic amine-containing drugs
|
|
US9062094B2
(en)
|
2010-01-22 |
2015-06-23 |
Ascendis Pharma As |
Dipeptide-based prodrug linkers for aliphatic amine-containing drugs
|
|
EP2552967A4
(en)
|
2010-04-02 |
2014-10-08 |
Amunix Operating Inc |
BINDING FUSION PROTEINS, BINDING FUSION PROTEIN MEDICINAL CONJUGATES, XTEN MEDICAMENT CONJUGATES, AND METHOD FOR THEIR PREPARATION AND USE
|
|
US8946405B2
(en)
|
2010-05-05 |
2015-02-03 |
Prolynx Llc |
Controlled release from solid supports
|
|
US8754190B2
(en)
|
2010-05-05 |
2014-06-17 |
Prolynx Llc |
Controlled release from macromolecular conjugates
|
|
EA024755B1
(ru)
|
2010-05-21 |
2016-10-31 |
ИксЭль-ПРОТЕИН ГМБХ |
Биосинтетические нерегулярные спиральные полипептиды пролина/аланина и их применения
|
|
WO2013024052A1
(en)
|
2011-08-12 |
2013-02-21 |
Ascendis Pharma A/S |
Carrier-linked treprostinil prodrugs
|
|
US20140323402A1
(en)
|
2011-08-12 |
2014-10-30 |
Ascendis Phama A/S |
Protein Carrier-Linked Prodrugs
|
|
WO2013024053A1
(en)
|
2011-08-12 |
2013-02-21 |
Ascendis Pharma A/S |
Carrier-linked prodrugs having reversible carboxylic ester linkages
|
|
US20140296257A1
(en)
|
2011-08-12 |
2014-10-02 |
Ascendis Pharma A/S |
High-Loading Water-Soluable Carrier-Linked Prodrugs
|
|
AU2012296950B2
(en)
|
2011-08-12 |
2016-09-22 |
Ascendis Pharma A/S |
Polymeric hyperbranched carrier-linked prodrugs
|
|
WO2013036857A1
(en)
|
2011-09-07 |
2013-03-14 |
Prolynx Llc |
Sulfone linkers
|
|
US20150087688A1
(en)
|
2012-04-25 |
2015-03-26 |
Ascendis Pharma A/S |
Prodrugs of hydroxyl-comprising drugs
|
|
CN104379171A
(zh)
|
2012-04-25 |
2015-02-25 |
第一三共株式会社 |
骨修复促进剂
|
|
US10052366B2
(en)
|
2012-05-21 |
2018-08-21 |
Alexion Pharmaceuticsl, Inc. |
Compositions comprising alkaline phosphatase and/or natriuretic peptide and methods of use thereof
|
|
CN106232141A
(zh)
|
2014-02-27 |
2016-12-14 |
第三共株式会社 |
针对由给予类固醇诱发的生长不足的药物
|
|
CA2955569C
(en)
|
2014-08-06 |
2023-02-14 |
Ascendis Pharma A/S |
Prodrugs comprising an aminoalkyl glycine linker
|
|
BR112017014560A2
(pt)
|
2015-01-09 |
2018-01-02 |
Ascendis Pharma Growth Disorders As |
profármacos de cnp
|
|
DK3386531T3
(da)
|
2015-12-08 |
2022-01-03 |
Biomarin Pharm Inc |
Anvendelse af c-type natriuretiske peptidvarianter til behandling af osteoarthritis
|
|
CA3007976C
(en)
|
2016-01-08 |
2023-09-26 |
Ascendis Pharma Growth Disorders A/S |
Cnp prodrugs with large carrier moieties
|
|
WO2017118707A1
(en)
|
2016-01-08 |
2017-07-13 |
Ascendis Pharma Growth Disorders A/S |
Controlled-release cnp agonists with reduced side-effects
|
|
CN114306629B
(zh)
|
2016-01-08 |
2023-11-10 |
阿森迪斯药物生长障碍股份有限公司 |
具有增加的nep稳定性的控制释放cnp激动剂
|
|
EP3400022A1
(en)
|
2016-01-08 |
2018-11-14 |
Ascendis Pharma Growth Disorders A/S |
Controlled-release cnp agonists with low initial npr-b activity
|
|
DK3400019T3
(da)
|
2016-01-08 |
2022-10-24 |
Ascendis Pharma Growth Disorders As |
CNP-prodrugs med bærerbinding ved ringenheden
|
|
WO2017118704A1
(en)
|
2016-01-08 |
2017-07-13 |
Ascendis Pharma Growth Disorders A/S |
Controlled-release cnp agonists with low npr-c binding
|
|
PL3518930T3
(pl)
*
|
2016-09-29 |
2023-09-11 |
Ascendis Pharma Growth Disorders A/S |
Terapia skojarzona z zastosowaniem agonistów cnp o kontrolowanym uwalnianiu
|
|
CA3129352A1
(en)
|
2019-02-11 |
2020-08-20 |
Ascendis Pharma Growth Disorders A/S |
Dry pharmaceutical formulations of cnp conjugates
|
