JP2021093932A - Skin condition improving composition - Google Patents

Abstract

To provide a composition for improving skin conditions that can be applied conveniently by oral ingestion or the like.SOLUTION: This skin condition improving composition contains whey protein. The composition is applied, preferably, by oral ingestion.SELECTED DRAWING: Figure 1

Description

The present invention relates to a composition for improving skin condition containing whey protein.

There is a high demand for beautiful, healthy or youthful skin. In general, the skin condition is likely to change significantly due to aging or external stimuli such as ultraviolet rays, and specifically, the skin condition is likely to become unfavorable, such as an increase in stains and wrinkles, and a decrease in firmness and elasticity. It has been proposed to deal with these changes in skin condition by using cosmetics or massages that can improve the skin condition such as skin-whitening effect, whitening effect, anti-wrinkle / anti-aging effect (Patent Document 1).

By the way, it has been reported that milk proteins such as whey and casein are not only used as a food material as a protein source, but also have functions such as an adrenal function decline suppressing effect and a sweating promoting effect in recent years (patented). Documents 2-3).

Japanese Unexamined Patent Publication No. 2016-210695 Japanese Unexamined Patent Publication No. 2019-1982272 International Publication No. 2018/123873

An object of the present invention is to provide a composition for improving skin condition, which can be easily applied by oral ingestion or the like.

As a result of diligent research to solve the above problems, the present inventors have found that ingestion of whey protein improves the skin condition, and have completed the present invention.

That is, the present invention is a composition for improving skin condition containing whey protein.
The compositions of the present invention are preferably taken orally.
The composition of the present invention is preferably ingested as an intake of whey protein of 2 to 80 g / day.
The composition of the present invention is preferably a food or drink.
The composition of the present invention is preferably a pharmaceutical product.

According to the present invention, it is possible to improve the general condition of the skin of the ingestor (administrator), specifically, the condition of moisturizing, texture, firmness / elasticity, pores and the like. In particular, the composition gives a feeling of improvement to the ingestor and is excellent in satisfaction. In addition, the composition of the present invention has few side effects and is excellent in safety, so that it can be continuously ingested.

A graph showing the average skin-related item scores before and after whey protein intake. A graph showing the average skin-related item scores before and after whey protein intake. A graph showing the average fatigue score before and after whey protein intake. A graph showing the average sleep score before and after whey protein intake. A graph showing the average menopausal symptom score before and after whey protein intake.

Next, the present invention will be described in detail. However, the present invention is not limited to the following embodiments, and can be freely changed within the scope of the present invention.

The composition of the present invention contains whey protein (also referred to as "whey protein").
Examples of whey protein include whey (for example, whey powder, desalted whey powder, etc.) separated from commercially available products, milk, defatted milk, etc. by a known method, or separated and purified whey protein concentrate (WPC), whey protein alone. Separation (WPI) and the like are preferred, or may be a mixture thereof in any proportion.
The whey protein may be derived from general milk or a plant such as soybean (so-called “soybean whey” or the like), but it is more preferably derived from milk, and more preferably cow milk. It is derived from.

When the composition of the present invention contains a protein other than whey protein, the protein is not particularly limited as long as it does not interfere with the effects of the present invention. For example, milk protein other than whey protein, for example, casein protein may be used.
Further, it may be a whey protein or a hydrolyzate (peptide or amino acid) of a protein other than whey protein.

The composition of the present invention can improve the skin condition. Improving the skin condition means making the skin healthier or better than before the application of the composition of the present invention.
In the present invention, the skin includes skin and surfaces such as the face, nails, fingers, arms, legs, legs, hair, and head.
More specifically, the composition of the present invention includes "skin moisturizing", "skin dryness", "skin texture", "skin gloss", "skin transparency", and "makeup paste". , "Skin smoothness", "Skin firmness", "Opening of pores", "Skin tarmi", "Wrinkles", "Stains", "Fatness", "Fingertip condition (cracking, hangnail) , "Cold, dry)", "Hand condition (pores, cracks, cold, dry)", "Claw condition (gloss, hangnail, crack, color, stretch)", "Skin condition (pores, swelling, "Sagging, itching)", "Heel condition (cracking, keratin, itching, moisture condition)", "Leg condition (cold, swelling, sagging, darkening)", "Hangnail condition (dry, split hair, cohesiveness, "Gloss, elongation)" and "skin condition (itch, hangnail, stickiness, dryness)" can be made healthy or good.
The improvement of the skin condition can be confirmed by the subjective evaluation of the subject (human, etc.) to which the composition of the present invention is applied, or by the evaluator subjectively or objectively evaluating the subject. it can. The objective evaluation includes measuring the amount of water retained in the skin, the amount of pigmentation, the viscoelasticity of the skin, and the like by a well-known method, but the evaluation is not particularly limited.

The composition of the present invention has a track record of use as food and is highly safe. Moreover, even if it is continuously ingested (administered) for a long period of time, there is little concern about side effects. Furthermore, it is highly safe when used in combination with other drugs.

The subject to which the composition of the present invention is administered (administrator) and the subject to be ingested (ingestor) are not particularly limited as long as they are animals, but are usually humans. In addition, it may be any of adults, children, infants, newborns (including low-weight babies), etc., but it is usually an adult. The gender is not particularly limited.

Another aspect of the invention is the use of whey protein in the manufacture of skin condition improving compositions.
Another aspect of the invention is the use of whey protein in improving skin condition.
Another aspect of the invention is whey protein, which is used to improve skin condition.
Another aspect of the invention is a method of improving skin condition, including administering whey protein to an animal.

In addition, in this specification, "administering whey protein to an animal" may be synonymous with "ingesting whey protein to an animal". Ingestion is usually voluntary (free ingestion), but may be compulsory (compulsory ingestion). That is, specifically, the administration step may be, for example, a step of blending whey protein with food or drink or feed and supplying it to a subject, thereby allowing the subject to freely ingest whey protein.

The ingestion (administration) timing of the composition of the present invention is not particularly limited, and can be appropriately selected according to the state of the ingestion (administration) target.

The ingestion (administration) amount of the composition of the present invention is appropriately selected depending on the age, gender, condition, other conditions, etc. of the ingestion (administration) subject.
The intake (administration) amount of the composition of the present invention is preferably in the range of 2 g / day to 80 g / day, and 5 g / day to 40 g / day, for example, as the intake (administration) amount of the whey protein according to the present invention. Is more preferable, and 10 g / day to 20 g / day is even more preferable.
The above-mentioned intake (administration) amount may be an amount to be ingested (administered) in addition to the amount of protein to be ingested (administered) in a normal diet or the like. That is, the composition of the present invention can be further ingested (administered) by a subject who normally ingests (administers) protein (or a reference amount) in a meal or the like. Then, as shown in Examples described later, since the skin condition improving effect can be obtained in such a subject, such a subject is suitable as an ingestor (administeree) of the composition of the present invention.
The composition of the present invention can be ingested (administered) once or in a plurality of times a day regardless of the amount and duration of ingestion (administration).

The ingestion (administration) period of the composition of the present invention is not particularly limited, but preferably 12 weeks or more, the effect is likely to be obtained. In addition, there is no particular upper limit on the intake (administration) period, and continuous and long-term intake (administration) is possible.

The route of ingestion (administration) of the composition of the present invention may be oral or parenteral, but oral is preferable. In addition, parenteral ingestion (administration) includes transdermal, intravenous injection, rectal administration, inhalation and the like.

When the composition of the present invention is to be orally ingested (administered), it is preferably in the form of food and drink.

As the food and drink, the form and properties are not particularly limited as long as it can be orally ingested (administered) without impairing the effect of the present invention, and raw materials usually used for food and drink are used except that whey protein is contained. Can be manufactured by the usual method.

Foods and drinks may be in the form of liquid, paste, gel solid, powder, etc., for example, nutritional supplements (supplements), tablets; liquid foods (nutrition foods for tube intake); bread, macaroni, spaghetti. , Mens, cake mix, fried flour, bread flour and other wheat flour products; instant noodles, cup noodles, retort / cooked foods, canned cooking, microwave foods, instant soups / stews, instant miso soups / soups, canned soups, freeze-dried foods , Other instant foods such as instant foods; canned agricultural products, canned fruits, jams and marmalades, pickles, boiled beans, dried agricultural products, processed agricultural products such as cereals (processed grain products); canned marine products, fish hams and sausages , Seafood paste products, fishery delicacies, boiled fish and other marine products; canned livestock and pastes, processed livestock products such as meat ham and sausage; processed milk, dairy beverages, yogurt, lactic acid bacteria beverages, cheese, ice cream , Prepared milk powder, cream, other dairy products such as dairy products; butter, margarines, vegetable oils and other fats and oils; soy sauce, miso, sauces, tomato processed seasonings, mirins, vinegars, etc. Ingredients: Combined seasonings / foods such as cooking mixes, curry ingredients, sauces, dressings, noodles, spices, and other complex seasonings; Ingredients Frozen foods, semi-cooked frozen foods, cooked frozen foods, etc. Frozen foods; caramel, candy, chewing gum, chocolate, cookies, biscuits, cakes, pies, snacks, crackers, Japanese sweets, rice sweets, bean sweets, dessert sweets, jelly, and other sweets; carbonated beverages, natural fruit juice , Fruit juice drinks, soft drinks with fruit juice, fruit meat drinks, fruit drinks with fruit grains, vegetable drinks, soy milk, soy milk drinks, coffee drinks, tea drinks, powder drinks, concentrated drinks, sports drinks, nutritional drinks, alcoholic drinks, etc. Favorite beverages such as favorite beverages, baby foods, sprinkles, other commercially available foods such as Ochazuke paste; prepared powdered milk for childcare; enteral nutritional foods; functional foods (foods for specified health use, nutritionally functional foods), etc. ..

It can also be used as feed as one aspect of food and drink. Examples of the feed include pet food, livestock feed, fish feed and the like.
The form of the feed is not particularly limited, and in addition to whey protein, for example, grains such as corn, wheat, barley, rye, and milo; vegetable oil cakes such as soybean oil cake, rapeseed oil cake, palm oil cake, and flaxseed oil cake; Bran such as wheat bran, rice bran and defatted rice bran; production cakes such as corn gluten meal and corn jam meal; animal feeds such as fish flour, defatted milk powder, casein, yellow grease and tallow; Yeasts; mineral feeds such as tertiary calcium phosphate and calcium carbonate; oils and fats; single amino acids; sugars and the like may be contained.

When the composition of the present invention is in the form of a food or drink (including feed), it is provided and sold as a food or drink labeled for use in improving skin condition, prevention of brain dysfunction, prevention of memory deterioration, etc. Is possible. In addition, the whey protein according to the present specification can be used for producing these foods and drinks.

Such "display" act includes all acts for informing the consumer of the use, and if it is an expression that can recall or analogize the use, the purpose of the display, the content of the display, etc. Regardless of the object or medium to be displayed, all of them fall under the act of "displaying" in the present invention.
Further, it is preferable that the "display" is performed by an expression that allows the consumer to directly recognize the above-mentioned use. Specifically, the act of transferring a product related to food and drink or the packaging of the product with the above-mentioned use, displaying it for delivery, transfer or delivery, and importing it, advertising on the product, price list or transaction documents Examples include the act of describing the above-mentioned use and displaying or distributing it, or describing the above-mentioned use in the information containing these and providing it by an electromagnetic (Internet, etc.) method.

On the other hand, as the display content, it is preferable that the display is approved by the government or the like (for example, a display obtained based on various systems established by the government and performed in a manner based on such approval). In addition, it is preferable to attach such display contents to packaging, containers, catalogs, pamphlets, promotional materials such as POPs at sales sites, and other documents.

In addition, "labeling" includes health foods, functional foods, enteric nutritional foods, special purpose foods, health functional foods, specified health foods, nutritional functional foods, functional foods, non-medicinal products, etc. The display is also mentioned. Among these, in particular, labeling approved by the Consumer Affairs Agency, for example, a system related to foods for specified health use, nutritionally functional foods, or functional foods, or labeling approved by a system similar to these can be mentioned. Specifically, labeling as a food for specified health use, labeling as a conditional food for specified health use, labeling to the effect that it affects the structure and function of the body, labeling for reducing the risk of illness, and functionality based on scientific evidence. Indications, etc. can be mentioned, and more specifically, Cabinet Office Ordinance on permission for special use indications stipulated in the Health Promotion Act (Cabinet Office Ordinance No. 57, August 31, 2001) Labeling as a food for specified health use (particularly labeling for health use) and similar labeling specified in the above are typical examples.

Such indications include, for example, "improving skin condition", "to moisturize skin", "to smooth skin", "for those who are concerned about dandruff and wrinkles", and "do not want to make pores stand out". Toward, "For firm and smooth skin", "For healthy nails", "For hair that is dry and cohesive and glossy", "For dandruff, itchiness and stickiness to keep the scalp healthy" , Etc. can be mentioned.

The composition of the present invention can also be in the form of a pharmaceutical product.
The route of ingestion (administration) of the drug may be oral or parenteral, but oral is preferable. In addition, parenteral ingestion (administration) includes transdermal, intravenous injection, rectal administration, inhalation and the like.
As the form of the drug, it can be appropriately formulated into a desired dosage form according to the ingestion (administration) method. For example, in the case of oral ingestion (administration), it can be formulated into a solid preparation such as a powder, a granule, a tablet or a capsule; a liquid preparation such as a solution, a syrup, a suspension or an emulsion. In the case of parenteral ingestion (administration), it can be formulated into a suppository, an ointment, an injection, or the like.
In the formulation, in addition to whey protein, components such as excipients, pH adjusters, colorants, and flavoring agents that are usually used in the formulation can be used. It is also possible to use other medicines such as other medicinal ingredients and ingredients having a known or future skin condition improving effect.
In addition, the formulation can be carried out by a known method as appropriate depending on the dosage form. At the time of formulation, a carrier usually used for formulation may be blended and formulated as appropriate. Examples of such carriers include excipients, binders, disintegrants, lubricants, stabilizers, flavoring agents and the like.

Examples of excipients include sugar derivatives such as lactose, sucrose, glucose, mannit, and sorbit; starch derivatives such as corn starch, potato starch, α-starch, dextrin, and carboxymethyl starch; crystalline cellulose, hydroxypropyl cellulose, etc. Cellulose derivatives such as hydroxypropylmethyl cellulose, carboxymethyl cellulose, carboxymethyl cellulose calcium; gum arabic; dextran; purulan; silicate derivatives such as light anhydrous silicic acid, synthetic aluminum silicate, magnesium aluminometasilicate; phosphate derivatives such as calcium phosphate; carbonic acid Carbonate derivatives such as calcium; Sulfate derivatives such as calcium sulfate can be mentioned.

Examples of the binder include gelatin; polyvinylpyrrolidone; macrogol and the like in addition to the above-mentioned excipients.

Examples of the disintegrant include, in addition to the above-mentioned excipients, chemically modified starch or cellulose derivatives such as croscarmellose sodium, carboxymethyl starch sodium, and crosslinked polyvinylpyrrolidone.

Examples of the lubricant include talc; stearic acid; metal stearate salts such as calcium stearate and magnesium stearate; colloidal silica; waxes such as pea gum and gay wax; boric acid; glycol; carboxylic acids such as fumaric acid and adipic acid. Sodium carboxylic acid salts such as sodium benzoate; sulfates such as sodium sulfate; leucine; lauryl sulfates such as sodium lauryl sulfate and magnesium lauryl sulfate; silicic acids such as silicic acid anhydride and silicic acid hydrate; starch derivatives and the like. Be done.

Examples of the stabilizer include paraoxybenzoic acid esters such as methylparaben and propylparaben; alcohols such as chlorobutanol, benzyl alcohol and phenylethyl alcohol; benzalkonium chloride; acetic acid anhydride; and sorbic acid.

Examples of the flavoring agent include sweeteners, acidulants, and flavors.
Examples of the carrier used in the case of a liquid preparation for oral ingestion (administration) include a solvent such as water.

The timing of ingesting (administering) the drug of the present invention is not particularly limited, for example, before meals, after meals, between meals, and before bedtime.

The present specification also discloses an embodiment in which a composition containing whey protein is used for another purpose. That is, the present specification also discloses the following inventions.
(1) A composition for improving fatigue, which contains whey protein.
(2) A composition for improving sleep quality, which contains whey protein.
(3) The composition according to (2) above, wherein the improvement in sleep quality is selected from improvement in sleepiness when waking up, improvement in dreams, and recovery from fatigue.
(4) A composition for improving menopausal symptoms, which contains whey protein.
(5) The composition according to (4) above, wherein the menopausal symptom is a neuropsychiatric symptom or a motor nervous system symptom.
(6) The composition according to any one of (1) to (5) above, which is orally ingested (administered).
(7) The composition according to any one of (1) to (6) above, wherein the whey protein is ingested (administered) at an amount of 2 to 80 g / day.
(8) The composition according to any one of (1) to (7) above, which is a food or drink.
(9) The composition according to any one of (1) to (8) above, which is a pharmaceutical product.
The description of whey protein, food and drink, pharmaceuticals, etc. in the invention relating to the composition used for these other uses is based on the above-mentioned description of the composition for improving skin condition of the present invention.

The composition containing whey protein can also be an embodiment of a fatigue-improving composition. Fatigue improvement means reducing physical or mental fatigue as compared to before the application of the composition.
More specifically, oral ingestion (administration) of the composition can reduce the degree to which physical or mental fatigue is felt, for example, the fatigue score evaluated by the Challenge scale.

The composition for improving fatigue is preferably taken orally (administered), and the intake (administration) amount thereof is, for example, 2 g / day to 80 g / day in an adult as the intake (administration) amount of the whey protein according to the present invention. The range is preferred, the range from 5 g / day to 40 g / day is more preferred, and the range from 10 g / day to 20 g / day is even more preferred.
The above-mentioned intake (administration) amount may be an amount to be ingested (administered) in addition to the amount of protein to be ingested (administered) in a normal diet or the like. That is, the composition of the present invention can be further ingested (administered) by a subject who normally ingests (administers) protein (or a reference amount) in a meal or the like. Then, as shown in Examples described later, since the fatigue improving effect can be obtained in such a subject, such a subject is suitable as an ingestor (administered person) of the fatigue improving composition.

The composition containing whey protein can also be an embodiment of a composition for improving sleep quality. Improving sleep quality means increasing the benefits obtained by sleep, improving drowsiness when waking up, reducing the number of dreams, or enhancing the fatigue recovery effect of sleep compared to before the application of the composition. Say that.
More specifically, oral ingestion (administration) of the composition improves the subjective evaluation of post-sleep impressions, such as "wake-up sleepiness", "dreaming", or "fatigue" in the OSA sleep questionnaire. You can increase the "recovery" score.

The composition for improving sleep quality is preferably taken orally (administered), and the intake (administration) amount thereof is, for example, 2 g / day to 80 g / g / day as the intake (administration) amount of the whey protein according to the present invention. The range of days is preferred, the range of 5 g / day to 40 g / day is more preferred, and the range of 10 g / day to 20 g / day is even more preferred.
The above-mentioned intake (administration) amount may be an amount to be ingested (administered) in addition to the amount of protein to be ingested (administered) in a normal diet or the like. That is, the composition of the present invention can be further ingested (administered) by a subject who normally ingests (administers) protein (or a reference amount) in a meal or the like. Then, as shown in Examples described later, since the sleep quality improving effect can be obtained in such a subject, such a subject is suitable as an ingestor (administered person) of the sleep quality improving composition.

The composition containing whey protein can also be an embodiment of a composition for improving menopausal symptoms. Improvement of menopausal symptoms means improvement of menopausal symptoms and / or menopause. Here, the climacteric symptom refers to a symptom that is not caused by organic changes among a wide variety of symptom that appears during the climacteric period (five years before and after menopause). Examples of such a symptom can be irritability, depression, headache, dizziness and the like. Furthermore, climacteric disorder refers to a pathological condition that interferes with daily life among climacteric symptoms.
More specifically, the degree to which climacteric symptoms are felt by oral ingestion (administration) of the composition, for example, "total" of simplified climacteric index (SMI), "psycho-nervous system symptoms" (sleeping, irritability, depression, headache) , Dizziness, etc.), or "motor nervous system symptoms" (tiredness, stiff shoulders, low back pain, limb pain, etc.) can be reduced.

The composition for improving menopausal symptoms is preferably taken orally (administered), and the intake (administration) amount thereof is, for example, 2 g / day to 80 g / day in an adult as the intake (administration) amount of the whey protein according to the present invention. Is preferably in the range of 5 g / day to 40 g / day, more preferably 10 g / day to 20 g / day.
The above-mentioned intake (administration) amount may be an amount to be ingested (administered) in addition to the amount of protein to be ingested (administered) in a normal diet or the like. That is, the composition of the present invention can be further ingested (administered) by a subject who normally ingests (administers) protein (or a reference amount) in a meal or the like. Then, as shown in Examples described later, since the effect of improving menopausal symptoms can be obtained in such a subject, such a subject is suitable as an ingestor (administered person) of the composition for improving menopausal symptoms.

Hereinafter, the present invention will be described in more detail with reference to Examples, but the present invention is not limited to these Examples.

[Test Example 1]
(1) Preparation of test sample A commercially available WPC (whey protein concentrate (whey protein content 80%), Milei80 (manufactured by Mirai)) mixed with a sweetener, etc. was prepared, and the obtained whey protein mixture was prepared. 20 g each was filled in individual packaging.
WPC (whey protein concentrate) contains α-lactalbumin 15 to 25%, β-lactoglobulin 50 to 65%, bovine serum albumin 5 to 10%, lactoferrin and the like.

(2) Ingestion test A nutritional survey using FFQg was conducted in advance, and 70 women with an average age of about 47 years who were ingesting a standard protein mass (about 65 g per day) were targeted. 20 g of a protein mixture dissolved in about 100 to 200 mL of drinking water was continuously ingested once a day for 12 weeks (whey protein intake per dose: 16 g). A questionnaire was given to the subjects regarding skin-related items, fatigue, sleep, and menopausal symptoms before and after the intake of the whey protein mixture.

For skin-related items, "skin moisturizing", "skin dryness", "skin texture", "skin gloss", "skin transparency", "makeup glue", "skin smoothness" , "Skin firmness", "Opening of pores", "Skin tarmi", "Wrinkles", "Stains", "Fatness", "Breakouts, acne", "Fingertip condition (cracking, swelling, "Cold, dry", "Hand condition (pores, cracks, cold, dry)", "Claw condition (gloss, swelling, cracking, color, elongation)", "Skin condition (pores, swelling, sagging)" , Itching) ”,“ Heel condition (cracking, keratin, itching, moisture condition) ”,“ Leg condition (cold, swelling, sagging, darkening) ”,“ Hair condition (dry, split hair, cohesiveness, gloss) , Elongation) ”and“ Skin condition (itch, dandruff, stickiness, dryness) ”were evaluated by the subjects in 7 stages (1: very bad to 7: very good).
For the feeling of fatigue, a Fatigue scale was used, and the subjects were evaluated to give a fatigue score (the lower the score, the lower the degree of fatigue).
For sleep, the OSA sleep questionnaire was used, and the subjects were given scores of "sleep onset", "sleep onset and sleep maintenance", "dreaming", "recovery from fatigue", and "sleep time" (the higher the score, the better the quality). The evaluation was carried out with (indicating good sleep).
For climacteric symptoms, the simplified climacteric index (SMI) was used, and the subjects were given scores of "total", "vasomotor nervous system symptoms", "psychoneurological symptoms", and "motor nervous system symptoms" (low scores). The symptom is weaker).
For the scores calculated for each questionnaire item, statistically significant differences were verified by a paired t-test.

(3) Results Scores for each questionnaire item before and after ingestion of the whey protein mixture are shown in Tables 1 to 5 and FIGS. 1 to 5.
As shown in Tables 1 and 2 and FIGS. 1 and 2, for skin-related items, "skin moisturizing", "skin dryness", and "skin texture" were compared with the pre-ingestion scores of the whey protein mixture. , "Skin gloss", "Skin transparency", "Makeup glue", "Skin smoothness", "Skin firmness", "Opening of pores", "Skin tarmi", "Wrinkles", ""Stain","greasy","fingertipcondition","handcondition","clawcondition","scalpcondition","heelcondition","legcondition","haircondition" Significant improvement was observed in the scores after the end of ingestion in "condition" and "condition of scalp".

As shown in Table 3 and FIG. 3, regarding the feeling of fatigue, a significant improvement (decrease) was observed in the fatigue score after the end of ingestion as compared with the score before ingestion of the whey protein mixture.
Regarding sleep, as shown in Table 4 and FIG. 4, the scores of "sleepiness when waking up", "dreaming", and "recovery from fatigue" on the OSA sleep questionnaire were also compared with the scores before ingestion of the whey protein mixture. There was a significant improvement (increase) in the score after the end of intake.
Furthermore, regarding the climacteric symptoms, as shown in Table 5 and FIG. 5, the whey protein mixture was used in each of the scores of the simplified climacteric index (SMI) of "total", "psycho-nervous system symptom", and "motor nervous system symptom". There was a significant improvement (decrease) in the score after the end of ingestion compared with the score before ingestion.

Claims (5)

A composition for improving skin condition containing whey protein. The composition according to claim 1, which is orally ingested. The composition according to claim 1 or 2, wherein the whey protein is ingested as an intake amount of 2 to 80 g / day. The composition according to any one of claims 1 to 3, which is a food or drink. The composition according to any one of claims 1 to 3, which is a pharmaceutical product.

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