JP2021069714A - Fundus photography device and eye disease inspection device - Google Patents

Abstract

To provide a technique that makes it possible to photograph a fundus with a wide angle of view.SOLUTION: A fundus photography device (1) has a target present part for presenting a target into a field of view of one eye of a subject, an irradiation part for irradiating the other eye of the subject with near infrared rays, and a photography part for photographing the fundus of the other eye. The near infrared rays have a wavelength of 780 nm or more and 1450 nm or less.SELECTED DRAWING: Figure 1

Description

The present invention relates to a fundus imaging device and an ophthalmologic examination device.

Three major causes of blindness in Japanese are known: diabetic retinopathy, age-related macular degeneration and glaucoma. Fundus examination is effective for early detection of these diseases. As a device for fundus examination, an excellent device for fixing the line of sight of a subject when imaging the fundus is known (see, for example, Patent Document 1).

Japanese Patent Application Laid-Open No. 2011-502015

In general, a device that images the fundus of the eye has a configuration in which the eye of the subject to be photographed sees an optotype at a specific position in order to fix the orientation of the eyeball at the time of photographing. However, in order to see the target, the pupil of the eyeball to be imaged may be narrowed, and the range in which the fundus can be imaged may be narrowed. As described above, the conventional technique of viewing the optotype with the eye to be imaged has room for examination from the viewpoint of imaging the fundus with a wide angle of view.

One aspect of the present invention is to provide a technique capable of imaging the fundus with a wide angle of view.

In order to solve the above problems, the fundus imaging device according to one aspect of the present invention includes an optotype presenting unit for presenting an optotype within the visual field of one eye of the subject and the other eye of the subject. It has an irradiation unit for irradiating near infrared rays and an imaging unit for imaging the fundus of the other eye. The wavelength of the near infrared rays is 780 nm or more and 1450 nm or less.

Further, in order to solve the above-mentioned problems, the ophthalmoscopic examination apparatus according to one aspect of the present invention is based on the above-mentioned fundus imaging apparatus and one or more images captured by the imaging unit, and the other eye of the subject. It is provided with a determination unit for determining an ophthalmologic disease.

According to one aspect of the present invention, it is possible to provide a technique capable of imaging the fundus with a wide angle of view.

It is a figure which shows typically the appearance of an example of the fundus imaging apparatus which concerns on Embodiment 1 of this invention. It is a figure which shows typically the appearance of another example in the fundus imaging apparatus which concerns on Embodiment 1 of this invention. It is a block diagram which shows an example of the functional structure of the fundus imaging apparatus which concerns on Embodiment 1 of this invention. It is a figure which shows typically an example of the optotype image used in Embodiment 1 of this invention. It is a figure which shows the other example of the optotype image used in Embodiment 1 of this invention schematically. It is a figure which shows typically an example of the optical system in the fundus imaging apparatus which concerns on Embodiment 1 of this invention. It is a figure which shows the other example of the optical system in the fundus imaging apparatus which concerns on Embodiment 1 of this invention schematically. It is a flowchart which shows an example of the flow of the fundus imaging process by the fundus imaging apparatus which concerns on Embodiment 1 of this invention. It is a figure which shows an example of the image of the fundus image taken by the fundus imaging apparatus which concerns on Embodiment 1 of this invention. It is a block diagram which shows an example of the functional structure of the fundus imaging apparatus which concerns on Embodiment 2 of this invention. It is a flowchart which shows an example of the flow of the fundus imaging process by the fundus imaging apparatus which concerns on Embodiment 2 of this invention. It is a figure which shows an example of the image which combined the image data of the fundus by the fundus imaging apparatus which concerns on Embodiment 2 of this invention. It is a block diagram which shows an example of the functional structure of the ophthalmologic examination apparatus which concerns on Embodiment 3 of this invention. It is a flowchart which shows an example of the flow of the image | imaging process of the fundus by the ophthalmoscopic examination apparatus which concerns on Embodiment 3 of this invention.

The fundus imaging device according to the present embodiment includes an optotype presenting unit for presenting an optotype in the visual field of one eye of the subject, an irradiation unit for irradiating near infrared rays to the other eye of the subject, and the other. It has an imaging unit for imaging the fundus of the eye. When the subject moves the eyeball of one eye, the other eye of the subject also moves. For example, when a subject only moves his or her eyes and looks up with one eye, the other eye also moves upward. Therefore, even if the other eye of the imaging target does not see the optotype, the orientation of the other eye of the imaging target is fixed by seeing the optotype with one eye. Therefore, it is possible to image the fundus of the other eye with the other eye facing the desired direction without showing the optotype to the other eye, and it is possible to image the fundus of the fundus with a wide angle of view. It becomes.

In the present specification, the “field of view” refers to a range in which the subject can be seen by the eyeball when the eyeball is looking at a predetermined point such as the front, unless otherwise specified.

In the present embodiment, the optotypes placed in the visual field of one eye of the subject are not limited in shape, color and number as long as they can be seen by one eye for an arbitrary period. The optotype is preferably a visual acuity vote. It is preferable that the visual acuity target is a visual acuity card from the viewpoint that the existing devices and tools for the visual acuity test can be used in the fundus imaging in the present embodiment, and the visual acuity test can be performed in parallel.

The optotypes are preferably arranged in each of the plurality of compartments set in the visual field in one eye of the subject. It is preferable that the optotypes are arranged in each of the sections, because the orientation of the eyeball is specified for each section, and therefore, the eyeball is moved and fixed in a sufficient amount and in a desired direction.

Further, in the present embodiment, the wavelength of the near infrared ray irradiated to the other eye of the imaging target is preferably 780 nm or more and 1450 nm or less. In the present embodiment, the other eye to be imaged is near infrared rays that deviate from visible light. Therefore, the contraction of the pupil of the other eye due to the light emitted at the time of imaging is suppressed. Therefore, it is possible to capture an image of the fundus with a wider angle of view as compared with the case where visible light is applied to the eye to be imaged.

The wavelength of the near infrared rays is more preferably 840 nm or more and 1450 nm or less. It is preferable that the wavelength of the near-infrared ray is 840 nm or more from the viewpoint that the irradiation of the near-infrared ray is not detected by the other eye even if the wavelength is dispersed in the light source of the near-infrared ray. It is preferable that the wavelength of the near infrared ray is 1450 nm or less from the viewpoint of irradiating the fundus without being absorbed by the eyeball.

The peak wavelength of near infrared rays may be one or more. For example, the peak wavelength of near infrared rays may be a single wavelength in the range of 780 to 1450 nm, may change continuously within the range, or may exist in a plurality of wavelengths within the range. May be good. Near infrared rays preferably have a plurality of different peak wavelengths. For example, the peak wavelength of near infrared rays may be discretely two or more wavelengths. Further, when the image obtained by imaging is displayed by pseudo color display, it is preferably 3 wavelengths or more. Pseudo-color display with light of different wavelengths can be carried out by applying a known technique.

In addition, in this specification, "~" represents the above-mentioned range unless otherwise specified.

In the present embodiment, it is preferable that the optical system constituting the optotype presenting unit, the irradiation unit, and the imaging unit further includes a reflection mirror. As shown later, the above-mentioned optical system including a reflection mirror can bend the optical axis in the middle of the optical system. Therefore, it is preferable from the viewpoint of shortening the total length of the optical system and downsizing the fundus imaging device.

Further, in the present embodiment, the fundus imaging device has an autofocus unit for automatically focusing the return light from the retina of the subject to a camera for imaging the fundus of the other eye of the subject, and the other eye. It is preferable that one or both of the auto-alignment unit and the auto-alignment unit for automatically adjusting the relative positional relationship between the image and the optical system for imaging the image are provided. It is preferable to further include one or both of the autofocus unit and the autoalignment unit from the viewpoint of easily capturing a sufficiently clear image of the fundus. Autofocus and autoalignment in the captured image of the fundus can be performed using known techniques.

In the present embodiment, it is preferable to further include an image synthesizing unit for creating an image by joining a plurality of images captured by the imaging unit from the viewpoint of obtaining a fundus image having a wide angle of view. As will be described in detail later, such image synthesis can be carried out using known techniques.

In the present embodiment, it is preferable that the imaging unit images the fundus of the other eye while performing the examination of one eye of the subject using the optotype presented by the optotype presenting unit. It is more effective for the imaging unit to image the fundus of the other eye in parallel with the examination of one eye from the viewpoint of efficiently performing the examination of the subject's eye.

Further, in the present embodiment, the visual acuity is a visual acuity slip, and includes a voice guidance unit for guiding the subject to work for examining the visual acuity of one eye of the subject by voice, and a visual acuity to be presented to the subject. It is preferable to further include an optotype changing unit for changing the optotype image according to the work of the visual acuity test. As described above, it is possible to have the subject perform a visual acuity test to guide the line of sight of one eye and then fix the eyeball in a predetermined direction. Therefore, the visual acuity test in one eye and the fundus imaging in the other eye can be performed in parallel, which is more effective from the viewpoint of efficiently performing the eye test of the subject.

Further, the present embodiment is a determination for determining the ophthalmoscope of the other eye of the subject based on the fundus imaging device according to the above-described embodiment and one or more images captured by the imaging unit of the fundus imaging device. It is an ophthalmologic examination device provided with a part. The ophthalmologic examination apparatus can capture an image of the fundus with a wide angle of view sufficiently clearly as compared with the conventional technique of showing an optotype to the eye to be imaged. In addition, the ophthalmologic examination device can be used in parallel with the visual acuity examination, during which the fundus can be imaged. Therefore, as compared with the prior art, it is advantageous from the viewpoint of performing an accurate ophthalmologic examination more easily.

Hereinafter, embodiments of the present invention will be described in more detail with reference to the drawings.

[Embodiment 1]
(Device configuration)
FIG. 1 is a diagram schematically showing the appearance of an example of a fundus imaging device according to a first embodiment of the present invention. As shown in FIG. 1, the fundus imaging device 1 has a table 2, a device main body 3, and eyepiece tubes 4 and 5. The base 2 supports the apparatus main body 3. The device main body 3 is, for example, a housing including an optotype presenting unit, an irradiation unit, and an imaging unit, which will be described later. The eyepiece tubes 4 and 5 are tube portions that can be viewed by the subject with both eyes at the same time.

The table 2 has a movable function of facing each of the eyepiece tubes 4 and 5 to any of the eyes of the subject. That is, the table 2 rotatably supports the device main body 3 in a horizontal plane. Therefore, the orientation of the device main body 3 is adjusted so that the subject can look into each of the eyepiece tubes 4 and 5 with one eye (or the other eye). Further, the table 2 rotatably supports the device main body 3 with respect to one axis in the horizontal plane. Therefore, the position of the device main body 3 is adjusted so that the subject can look into the eyepiece tubes 4 and 5.

The device main body 3 has a configuration in which an optotype is presented to the eye looking into the eyepiece cylinder 4, and has a configuration in which the fundus of the eye looking into the eyepiece cylinder 5 is imaged. These configurations in the apparatus main body 3 will be described later. The device main body 3 has a function of adjusting the optical centers of the eyepiece tubes 4 and 5 between 55 and 75 mm.

The subject first looks into the eyepiece tube 4 with his right eye, and at the same time looks into the eyepiece tube 5 with his left eye. Next, by reversing the orientation of the device body 3 and adjusting the angle, the eyepiece tube 5 is viewed with the right eye, and the eyepiece tube 4 is viewed with the left eye. As described above, the fundus imaging device 1 is configured so that the subject can look into each of the eyepiece tubes with the right eye and the left eye, respectively.

The eyepiece tubes 4 and 5 surround the eyes of the subject looking into these eyepiece tubes. Therefore, the eyes of the subject looking into the eyepiece tubes 4 and 5 are shielded from the surroundings. Therefore, it is prevented that the pupil of the subject is contracted by the ambient light.

The fundus imaging device according to the present embodiment may be configured as shown in FIG. FIG. 2 is a diagram schematically showing the appearance of another example of the fundus imaging device according to the present embodiment. As shown in FIG. 2, the fundus imaging device 1a has a base 2a, a device main body 3a, and eyepiece tubes 4, 5a, and 5b. The fundus imaging device 1a is different from the fundus imaging device 1 in the following points.

The base 2a rotatably supports the apparatus main body 3a with respect to one axis of the horizontal plane. The device main body 3a has a configuration in which the fundus of the eye is imaged for each of the eyepiece tubes 5a and 5b. In the fundus imaging device 1a, the subject looks into the eyepiece tube 5a and the eyepiece tube 4 to image the fundus, and then looks into the eyepiece tube 4 and the eyepiece tube 5b to image the fundus. It is possible to image the fundus. The apparatus main body 3 may have two configurations for fundus imaging corresponding to each of the eyepiece tubes 5a and 5b, or for one fundus imaging applicable to each of the eyepiece tubes 5a and 5b. It may have the structure of.

(Functional configuration)
Next, the functional configuration of the fundus imaging device according to the present embodiment will be described. FIG. 3 is a block diagram showing an example of a functional configuration of the fundus imaging device according to the present embodiment. As shown in FIG. 3, the fundus imaging device 1 includes a control unit 100, an input unit 101, an optotype presenting device 102, a near infrared (NIR) light source 10, a CCD sensor 20, a storage unit 103, and an output unit 104. ing.

The control unit 100 controls the fundus imaging process in the fundus imaging device 1. The control unit 100 is, for example, a processor that executes instructions of a program that is software that realizes each function described later. As the processor, for example, a CPU (Central Processing Unit) can be used.

The input unit 101 inputs a signal to the control unit 100. The input unit 101 may be, for example, a keyboard operated by a subject or an operator of the fundus imaging device 1 (hereinafter, the subject and the operator are also collectively referred to as “subjects and the like”). Alternatively, the input unit 101 may be a button operated by the subject or the like, may be a touch panel, or may be a voice input device in which the subject or the like inputs the operation content by voice.

The optotype presenting device 102 presents an optotype according to the visual acuity of the subject to the eyes of the subject in contact with the eyepiece tube 4. The optotype presenting device 102 may have a configuration capable of presenting an optotype at a desired position in the visual field of one eye of the subject. It is possible to apply a configuration for presenting an optotype in a visual acuity test, which will be described later, to the optotype presenting device 102. The optotype presenting device 102 may be a device in which a subject looking into the eyepiece tube 4 displays an optotype image having a visual acuity tag with one of the eyes. The optotype image will be described later.

The NIR light source 10 irradiates the eyes of the subject in contact with the eyepiece tube 5 with near infrared rays. The NIR light source 10 is, for example, a near infrared LED. Near-infrared LEDs are advantageous from the viewpoint of compactness and weight reduction. In addition to this, the NIR light source 10 may be composed of a halogen lamp and a Fabry-Perot type bandpass filter that transmits near infrared rays of a specific wavelength, or a metasurface structure that efficiently extracts heat radiant light is applied. It may be a thermal radiation ceramic heater. The NIR light source 10 outputs near infrared rays having an arbitrary wavelength in the range of 780 to 1450 nm. The wavelength of the near infrared rays is more preferably 840 to 1450 nm.

The CCD sensor 20 is an example of an image pickup device. The CCD sensor 20 converts an image of light reflected by the retina of the other eye of the subject and backscattered light into image data through an optical system described later. In the present specification, imaging of the fundus means that, of the return light from the eyeball, the focus of the return light from the retina is focused on the image sensor to form an image. The return light from the retina is, for example, the light reflected by the retina and the light backscattered by the retina, as described above. In addition to the CCD sensor 20, a CMOS sensor or an InGaAs sensor can be used as the image pickup device in this embodiment.

The storage unit 103 is a recording medium that can be read by the control unit 100. The control unit 100 reads, for example, a program in the storage unit 103 from the storage unit 103 and executes it to perform imaging of the fundus of the eye in the present embodiment. The storage unit 103 is, for example, a non-temporary tangible medium, and more specifically, a ROM (Read Only Memory) or the like, a tape, a disk, a card, a semiconductor memory, a programmable logic circuit, or the like.

The output unit 104 acquires the imaged image data of the fundus from the control unit 100 (imaging control unit 130 described later). The output unit 104 may be, for example, a display device that displays the image data, or may be a transmission device that transmits the image data to another device.

The control unit 100 includes an optotype control unit 110, an irradiation control unit 120, and an imaging control unit 130.

The optotype control unit 110 causes, for example, the optotype presenting device 102 present an optotype within the visual field of one eye of the subject via an optical system described later. In this way, the optotype control unit 110 and the optotype presenting device 102 form an optotype presenting unit for presenting an optotype within the visual field of one eye of the subject.

The irradiation control unit 120 controls, for example, the NIR light source 10 to irradiate the NIR light source 10 with near infrared rays to the other eye of the subject via an optical system described later. As described above, the irradiation control unit 120 and the NIR light source 10 form an irradiation unit for irradiating the other eye of the subject with near infrared rays.

The image pickup control unit 130 controls, for example, the CCD sensor 20, and outputs image data indicating an image of the fundus of the other eye of the subject who is irradiated with near infrared rays to the CCD sensor 20 via an optical system described later. Let me create it. In this way, the image pickup control unit 130 and the CCD sensor 20 form an image pickup unit for imaging the fundus of the other eye of the subject.

(Optimal image)
Next, an optotype image for presenting an optotype to one eye of a subject in the present embodiment will be described. FIG. 4 is a diagram schematically showing an example of an optotype image used in the present embodiment. The optotype image 50 includes a plurality of visual acuity slips 51 and a frame 52. As shown in FIG. 4, the optotype image 50 is an image of a table for a visual acuity test in which a plurality of visual acuity slips are displayed. In this embodiment, a Randall ring is used as a visual acuity vote. However, the available sight cards are not limited to the Randall ring. For example, letters can be used as a visual acuity vote.

In the table, the visual acuity slips 51 are vertically arranged in five columns. In the table, the vertical axis represents visual acuity, the upper one is 0.2, the lower one is 2.0, and the lower one has higher visual acuity. In each column of the table, the visual acuity slip 51 has a size corresponding to the visual acuity, and the lower the visual acuity, that is, the higher the size, the larger the size. In the table, the visual acuity slip 51 is arranged so that its opening end faces in any of eight directions, four directions of up, down, left and right, and four diagonal directions. However, the orientation of the opening end of any of the plurality of visual acuity slips 51 in the table is irregular.

The frame 52 is an object that can be moved on the target screen so as to surround any of the visual acuity votes 51 in the table. The movement of the frame 52 may be executed based on the program in the storage unit 103 by the optotype control unit 110, or may be executed in response to a signal input by the operator via the input unit 101. In this way, in the optotype image 50, by designating any of the visual acuity slips in the table in the frame 52, the subject fixes the direction of one eye toward a specific position in the visual field of one eye. It is configured to be possible.

Alternatively, the optotype image used in this embodiment may be configured as shown in FIG. FIG. 5 is a diagram schematically showing another example of the optotype image used in the present embodiment. As shown in FIG. 5, the optotype image 50a includes a plurality of visual acuity slips 51 and a frame 52. The plurality of visual acuity cards 51 have the same size as each other, and a total of nine visual acuity cards 51 are arranged in the visual acuity image 50a, three vertically and three horizontally. The orientation of the open end of these visual acuity votes 51 is irregular. In this way, the optotype image 50a displays a large visual acuity vote 51 arranged over the entire visual field of one eye of the subject. The frame 52 is displayed at a position surrounding any of the visual acuity slips 51. The subject fixes one eye to visually recognize the visual acuity slip 51 surrounded by the frame 52 and the orientation of its open end.

In the visual acuity image 50a, since the visual acuity vote 51 is displayed in a large size, it is possible to prevent the subject from changing the state of one eye, such as squinting one eye in order to see the visual acuity vote 51 more clearly. it can. Therefore, the other eye of the subject is opened as usual as the other eye. Therefore, it is advantageous from the viewpoint of suppressing the influence of the degree of eye opening of the subject on the fundus imaging.

(Optical system related to fundus imaging)
Next, an optical configuration related to imaging of the fundus in the present embodiment will be described. FIG. 6 is a diagram schematically showing an example of an optical system in the fundus imaging device according to the first embodiment. The optical system includes a NIR light source 10, a CCD sensor 20, and a polarization beam splitter 34, as shown in FIG. Reference numeral E is the eyeball of the other eye of the subject looking into the eyepiece tube 5.

A polarizing beam splitter 34 is arranged on the optical axis of the NIR light source 10, and a CCD sensor 20 is arranged on an axis orthogonal to the optical axis of the polarizing beam splitter 34. The eyeball E is arranged at a position facing the NIR light source 10. Lenses 31, 32 and a linear polarizing plate 33 are arranged in this order on the NIR light source 10 side of the polarizing beam splitter 34 from the NIR light source 10 side. Lenses 35, 36 and a quarter wave plate 37 are arranged in this order on the eyeball E side of the polarizing beam splitter 34 from the polarizing beam splitter 34 side. A lens 38 is arranged between the polarizing beam splitter 34 and the CCD sensor 20.

The polarization beam splitter 34 has, for example, a derivative film tilted at a predetermined angle in a transparent body, and has optical characteristics of passing only linearly polarized light oscillating in the longitudinal direction and reflecting light oscillating in the other direction. Have. Further, the lenses 31, 32, 35, 36, and 38 are arranged so as to appropriately widen and narrow the light flux of the near infrared rays from the NIR light source 10 or the light flux of the return light from the eyeball E. In FIG. 6, the optical path of the incident light to the eyeball E is shown by a broken line, and the optical path of the return light from the eyeball E is shown by a solid line.

The near-infrared rays emitted from the NIR light source 10 pass through the lenses 31 and 32, pass through the linear polarizing plate 33, and become linearly polarized light that vibrates in the vertical direction, for example. The longitudinally linearly polarized near-infrared rays pass through the polarization beam splitter 34, pass through the lenses 35 and 36, and pass through the quarter wave plate 37. Near-infrared rays are circularly polarized by the 1/4 wave plate 37, pass through the pupil of the eyeball E, and enter the eyeball E. Near-infrared rays incident on the eyeball E are reflected by the retina of the fundus of the eyeball E and diffuse backward to become return light.

The return light from the eyeball E passes through the pupil, passes through the quarter wave plate 37, and becomes linearly polarized light that oscillates in the lateral direction, for example. The laterally linearly polarized light enters the polarizing beam splitter 34 through the lenses 36 and 35, is reflected by the dielectric film thereof, and is emitted from the polarizing beam splitter 34 in a direction orthogonal to the optical axis of the incident light. The emitted laterally polarized light reaches the CCD sensor 20 through the lens 38. In this way, image data of the fundus of the eye irradiated with near infrared rays can be obtained.

Alternatively, the optical system in this embodiment may be configured as shown in FIG. FIG. 7 is a diagram schematically showing another example of the optical system in the fundus imaging device according to the present embodiment. The optical system shown in FIG. 7 has optical characteristics that allow the polarization beam splitter 34a to pass only laterally linearly polarized light, further has a reflection mirror 40 between the lens 35 and the lens 36, and has an optical path shape. It is configured in the same manner as the optical system shown in FIG. 6, except that it is different. The lens 35 is arranged on an axis orthogonal to the optical axis of the NIR light source 10. The reflection mirror 40 is arranged at an angle of 45 ° with respect to the axis, and the lens 36 and the quarter wave plate 37 are arranged on an axis parallel to the optical axis of the NIR light source 10.

In the optical system shown in FIG. 7, the distance from the NIR light source 10 to the eyeball E in the optical axis direction of the NIR light source 10 is shorter than that of the optical system shown in FIG. Further, when the optical system becomes large for reasons such as further expanding the imaging range of the fundus, the size of the optical system shown in FIG. 6 is the maximum value of the distance between the two eyepiece tubes 4 and 5 described above (the above-mentioned maximum value of the distance between the eyepiece tubes 4 and 5). It may not fit in 75 mm). The optical system shown in FIG. 7 is advantageous from the viewpoint of downsizing the optical system as compared with the optical system shown in FIG.

(Fundus imaging process)
Next, the fundus imaging process by the fundus imaging device 1 will be described. FIG. 8 is a flowchart showing an example of the flow of the fundus imaging process by the fundus imaging device according to the present embodiment.

In step S101, the optotype control unit 110 receives, for example, a signal of an imaging instruction from the input unit 101 by a subject or the like. Next, the control unit 100 parallels steps S102, S103 and S104.

In step S102, the optotype control unit 110 presents the optotype to one eye of the subject. For example, the optotype control unit 110 causes the optotype presenting device 102 to present the above-mentioned optotype image to one eye of the subject, and displays the frame 52 at a position surrounding the specific visual acuity slip 51. The subject moves the eyeball of one eye looking into the eyepiece tube 4 to fix the direction of the eyeball in order to see the visual acuity slip 51 surrounded by the frame 52. At this time, the other eye looking into the eyepiece tube 5 of the subject cannot see the visual acuity slip 51 and the frame 52, but the eyeball of the other eye is also the eyeball of the other eye due to the movement of the eyeball in one eye. Works the same as. Therefore, the orientation of the eyeball of the other eye that is not looking at the optotype is fixed in substantially the same direction as the eyeball of one eye that is fixed by the optotype.

In step S103, the irradiation control unit 120 turns on the NIR light source 10 and irradiates the other eye of the subject with near infrared rays. As a result, the other eye of the subject is illuminated with near infrared rays. Since near-infrared light is not visible light, the subject does not feel dazzling when the other eye is illuminated by near-infrared light. Therefore, even if the other eye is illuminated by near infrared rays, the pupil of the other eye is sufficiently open.

In step S104, the imaging control unit 130 operates the CCD sensor 20 to image the fundus of the other eye of the subject irradiated with near infrared rays. For example, the CCD sensor 20 detects the return light from the other eye that is irradiated with near infrared rays. The imaging control unit 130 has described above so that the near infrared rays reach the fundus through the pupil of the other eye and the return light from the fundus is appropriately imaged by the CCD sensor 20 as necessary. The position of one or more of the lenses arranged in the optical system is moved along the optical axis. In this way, the CCD sensor 20 generates image data of the fundus of the eye in the other eye of the subject. The generated image data is output from the CCD sensor 20 to the control unit 100. For example, the image pickup control unit 130 acquires the image data.

The presentation of the optotype and the irradiation of the near-infrared ray may or may not be synchronized, but while the optotype is presented to one eye of the subject in step S102. , It is preferable that the other eye of the subject is irradiated with near infrared rays in step S103. When the optotype is presented multiple times, the subject's eyeballs move up, down, left, and right during that time, and the orientation of the eyeballs is fixed each time. During that time, by continuing to irradiate the other eye with near infrared rays, it is possible to continue imaging the fundus of the other eye. As a result, a wide range of fundus can be imaged, and image data of a wide range of fundus can be generated.

In step S105, the image pickup control unit 130 outputs the image data generated by the CCD sensor 20 to the output unit 104. The output unit 104 displays the image data acquired by the image pickup control unit 130 on a display device such as a liquid crystal display. FIG. 9 is a diagram showing an example of an image obtained by the CCD sensor 20.

As shown in FIG. 9, the image taken by the CCD sensor 20 clearly shows the state of the fundus. For example, a bright, substantially elliptical optic disc is projected in part A in FIG. In addition, blood vessels are projected in part B in FIG.

As described above, according to the present embodiment, a sufficiently clear image of the fundus can be obtained. The image data may be captured by the CCD sensor 20 at a predetermined time, or may be image data of a still image taken out from the image data of the moving image by generating the image data as a moving image by the CCD sensor 20. You may.

(Action effect)
This embodiment has at least the following effects.

(1) As described above, in the present embodiment, the fundus of the eyeball of the subject is imaged in a state of irradiating the eyeball of the subject with near infrared rays. Therefore, since the subject does not feel glare, it is possible to image the fundus of the eye with the pupils sufficiently open in the eyeball.

Here, since the subject is observing the visual acuity tag in the bright optotype image with one eye, the pupil in one eye is narrowed. However, the pupils of each eye in both eyes move somewhat independently. Therefore, for example, even if the right eye is gazing at the visual acuity vote, if the visual field of the left eye is kept dark, the pupil of the left eye is sufficiently widened according to the darkness of the visual field.

Some conventional fundus imaging devices illuminate the fundus with visible light, and in that case, the eye to be imaged may be illuminated with visible light having a larger amount of light and brightness when imaging the fundus. As described above, in the conventional fundus imaging device, the pupil of the eye to be imaged at the time of imaging tends to be narrowed.

In this embodiment, near infrared rays are used instead of visible light for illuminating the eyes at the time of imaging. Therefore, the subject is substantially unaffected by illumination when imaging the fundus. Therefore, in the present embodiment, it is possible to image the fundus more widely than in the conventional technique of irradiating the eye to be imaged with visible light.

(2) While the pupils move substantially independently in the left and right eyes, the movements of the eyeballs are linked in the left and right eyes. Therefore, while the subject is visually recognizing the optotype with one eye, the other eye moves in accordance with the movement of one eye. Therefore, by imaging the fundus of the other eye during this period, it is possible to image the fundus of the other eye that is oriented in substantially the same direction as that of one eye. Therefore, it is possible to image the fundus when the other eye is facing not only the front but also up, down, left, right, and diagonally. As described above, in the present embodiment, it is not necessary to guide the line of sight of the subject by presenting the optotype to the other eye of the imaging target. Therefore, in the present embodiment, it is possible to image a wide range of fundus very easily.

For imaging of the fundus, a technique of expanding the pupil with eye drops is known. This technology has adverse effects such as the inability to drive a car after instillation, which is one of the factors that hinder the spread of fundus imaging. In the present embodiment, since the pupil is naturally widened at the time of imaging, the ability of the eye does not deteriorate after imaging. As described above, this embodiment is also excellent from the viewpoint of not causing side effects in imaging of the fundus.

[Embodiment 2]
Other embodiments of the present invention will be described below. For convenience of explanation, the same reference numerals will be added to the members having the same functions as the members described in the above embodiment, and the description will not be repeated.

(Device configuration and functional configuration)
The fundus imaging device of the present embodiment is configured in the same manner as the fundus imaging device 1 of the first embodiment, except that the target presenting unit also serves as a visual acuity test executing unit and further includes an auto-alignment function, an auto-focus function, and a speaker. .. The visual acuity test performing unit may have a configuration capable of performing a visual acuity test, and such a configuration can be realized by a known technique. For example, the configuration of the visual acuity test device described in Japanese Patent No. 4970122 can be adopted for the configuration.

FIG. 10 is a block diagram showing an example of a functional configuration of the fundus imaging device according to the second embodiment of the present invention. As shown in FIG. 10, the control unit 200 in the present embodiment is the control unit 100 in the first embodiment except that the image processing unit 240, the alignment control unit 250, the focus control unit 260, and the guidance control unit 270 are further provided. It is virtually the same.

Further, the optotype control unit 210 in the present embodiment is substantially the same as the optotype control unit 110 in the first embodiment except that the optotype image changing unit 211 is further provided. The irradiation control unit 220 in the present embodiment is substantially the same as the irradiation control unit 120 in the first embodiment except that it receives an input signal from the input unit 101. The image pickup control unit 230 in the present embodiment is substantially the same as the image pickup control unit 130 in the first embodiment except that a signal instructing the CCD sensor 20 to perform imaging is also output to the focus control unit 260.

The image processing unit 240 processes the image data generated by the CCD sensor 20 so that the image data is suitable for the examination of the fundus of the eye or the diagnosis of ophthalmic disease. The image processing unit 240 includes an image determination unit 241 and an image composition unit 242. The image determination unit 241 determines, for example, the suitability of the image data acquired by the image pickup control unit 130 with reference to the image determination model stored in the storage unit 103. The image synthesizing unit 242 connects a plurality of image data determined to be appropriate and synthesizes image data showing a wider range of fundus than one image data.

The alignment control unit 250 refers to the input signal to the optotype control unit 210 to perform an alignment process that at least aligns the optical system for photographing the fundus with the eye of the subject to be imaged.

The focus control unit 260 receives the signal from the image pickup control unit 230 and adjusts at least the optical system 30 for fundus imaging so that at least the focus of the return light from the fundus is appropriately focused on the CCD sensor 20.

The guidance control unit 270 receives the signal from the input unit 101 and outputs information for guiding the operation for the visual acuity test and the fundus imaging based on the program stored in the storage unit 103. The information is output from the guidance control unit 270 to the speaker 205, and is notified to the subject or the operator as voice information.

(About the image judgment model)
The image determination model referred to by the image determination unit 241 may output information regarding the suitability of the image data in response to the input of information regarding a specific portion in the image data. The image determination model may be one kind or more.

The image determination model can be trained by referring to the teacher data. The teacher data includes image data of the fundus of the subject and at least one piece of information about a part in the image corresponding to the image data.

The learning of the image determination model can be carried out, for example, as follows. That is, a sufficient number of image data of the fundus is prepared, and the state (for example, size) of a specific part (for example, optic nerve head, venous blood vessel, etc.) in the image is measured. A sufficient number of data from the measurement are acquired, the neural network is trained, and the path weight is determined for each image data. In this way, the image determination model is created.

The image judgment model and the method for training the image judgment model can be appropriately selected as long as the desired result can be obtained. Examples of image determination models include neural networks and support vector machines. Examples of neural networks include convolutional neural networks (CNNs), recurrent neural networks (RNNs) and fully coupled neural networks. Examples of algorithms for training the image determination model include backpropagation and ID3.

The image determination model may be other than the model by machine learning. For example, the image determination model may be a regression model in which the above image data is used as an objective variable and information regarding the suitability of the image data is used as an explanatory variable.

(Fundus imaging process)
Next, a processing example of fundus imaging in the present embodiment will be described. FIG. 11 is a flowchart showing an example of the flow of the fundus imaging process by the fundus imaging device according to the present embodiment.

In step S101, the optotype control unit 210 receives the imaging instruction signal input to the input unit 101 by the subject or the like. The optotype control unit 210, for example, refers to a program stored in the storage unit 103 to perform a visual acuity test on one eye of the subject. In addition, the optotype image changing unit 211 appropriately changes the optotype image according to the progress of the visual acuity test.

In step S202, the irradiation control unit 220 determines the wavelength of the near infrared rays to be irradiated from the NIR light source 10 with reference to the imaging instruction signal from the input unit 101. For example, when the irradiation control unit 220 includes information on the near-infrared wavelength in the above-mentioned imaging instruction signal, the irradiation control unit 220 determines the near-infrared wavelength according to the information.

The information regarding the wavelength of the near-infrared ray is, for example, the numerical value of the wavelength of the near-infrared ray to be irradiated, or information for instructing a pseudo-color display in the output unit 104, which will be described later. In the latter case, the irradiation control unit 220 determines a plurality of near-infrared wavelengths that enable pseudo-color display, for example, based on the table data stored in the storage unit 103.

In step S203, the guidance control unit 270 outputs the operation information for the visual acuity test to the speaker 205 with reference to the signal output from the optotype control unit 210. The information includes, for example, an instruction of the target to be seen by the subject, an instruction to keep looking at the target, and the like. The speaker 205 outputs the information by voice.

In step S204, the alignment control unit 250 executes auto-alignment in response to the optotype control unit 210 receiving the imaging instruction signal. For example, the alignment control unit 250 moves at least one of the NIR light source 10, the CCD sensor 20, and the optical system 30 relative to the position of the other eye in the subject. As a result, the relative positional relationship between the eye to be imaged and the optical system for imaging is optimized. Next, the control unit 200 parallels the following steps S102, S103 and S205 and S104.

In step S102, the optotype control unit 210 outputs information for designating the optotype to the visual acuity test device 202, and presents the optotype to one eye of the subject.

In step S103, the irradiation control unit 220 turns on the NIR light source 10 and irradiates the other eye of the subject with near infrared rays.

In step S205, the focus control unit 260 executes autofocus. For example, the focus control unit 260 appropriately shifts at least one lens in the optical system 30 in the optical axis direction in response to the image pickup control unit 230 outputting a signal instructing the imaging of the fundus to the CCD sensor 20. Move. Thereby, the focal length of the return light is optimized so that the focus of the return light from the fundus is located on the CCD sensor 20 while the near infrared rays are emitted from the NIR light source 10.

In step S104, the imaging control unit 230 acquires image data obtained by imaging the fundus of the other eye of the subject. For example, the CCD sensor 20 receives the return light from the retina of the other eye to generate image data of the fundus, and the imaging control unit 230 acquires the image data. The image pickup control unit 230 outputs the acquired image data to the image processing unit 240.

In step S206, the image determination unit 241 determines whether or not the acquired image data is appropriate. For example, the image determination unit 241 determines whether or not the acquired image data satisfies the desired requirements by referring to the above-mentioned image determination model stored in the storage unit 103.

When the image data acquired in step S206 satisfies the desired requirements, the image synthesizing unit 242 synthesizes the determined image data in step S207. For example, among the image data determined by the image compositing unit 242 to satisfy the desired requirements, when the other eye is facing the front, facing each of the top, bottom, left, and right, there are four diagonal directions. If it is suitable for each, the image data of the composite image is created by connecting the image data of each. The image processing unit 204 outputs the image data of the composite image to the output unit 104.

If the acquired image data does not satisfy the desired conditions in step S206, the control unit 200 returns to step S203, and repeats the subsequent steps from the guidance of the visual acuity test work by voice.

In step S208, the output unit 104 outputs the combined image data. For example, the output unit 104 displays the image data output by the image processing unit 204 on a display device such as a liquid crystal display. FIG. 12 is a diagram showing an example of an image of image data synthesized by the image processing unit 240.

FIG. 12 shows an image synthesized by superimposing overlapping portions of the second image I2 on the first image I1. By synthesizing such images, the structure of the fundus as shown by the broken line in FIG. 12 is clearly shown.

In the present embodiment, an image as shown in FIG. 12 is displayed on the display device. As described above, according to the present embodiment, it is possible to obtain a sufficiently clear image showing the state of the fundus observed from the eyeballs directed in various directions.

(Action effect)
In addition to the above-described effects of the first embodiment, the present embodiment further exerts the following effects.

(1) In the present embodiment, it is possible to perform imaging of the fundus in the other eye in parallel with the visual acuity test of one eye. Visual acuity test devices are used for medical examinations and are widely used in various medical institutions, including general hospitals and hospitals specializing in ophthalmology, as well as medical examination centers and general practitioners. The fundus imaging device of the present embodiment can be configured in combination with such a widely used visual acuity test device. Therefore, it is advantageous from the viewpoint of widespread use of fundus imaging for the prevention of ophthalmology.

(2) In the present embodiment, since the image of the fundus of the other eye can be performed in parallel with the visual acuity test of one eye, the visual acuity test and the image of the fundus can be performed at the same time. It is possible to carry out an efficient examination of the eyeball.

(3) In the conventional fundus imaging device, an autofocus or autoalignment technique has been developed so that the fundus can be imaged with a simple operation. However, the conventional fundus imaging device has a configuration that requires an operator. For example, in the conventional fundus imaging device, it is necessary for the operator to explain the imaging method to the subject, guide the subject, and perform a button operation. For this reason, an operator is required for imaging the fundus, and there is a cost for keeping the operator on standby and training. Such a cost is one of the obstacles to the widespread use of fundus imaging to the extent that it is performed in a medical examination. Therefore, the fundus imaging device is arranged only in a specific medical institution, and its operating rate is naturally low. Such a situation is one of the reasons why it is difficult for the medical institution to recover the investment in the fundus imaging device.

In this embodiment, the fundus is imaged in parallel with the visual acuity test by the visual acuity test device. Therefore, it is possible to image the fundus of the other eye while the subject is performing the visual acuity test of one eye by using the guidance function of the visual acuity test device. Further, the visual acuity test device is configured so that the subject himself / herself can perform a visual acuity test by a guidance function such as a voice guide. Therefore, it is possible to eliminate the need for an operator for imaging the fundus, and it is expected that the cost for operating the fundus imaging device can be significantly reduced. Therefore, according to the present embodiment, it is expected that fundus imaging will become widespread, prevention of ophthalmology will be further promoted, and as a result, the number of patients who lose their eyesight due to ophthalmology will be reduced.

(4) Further, since the present embodiment has an autofocus function for the CCD sensor 20, it is possible to image the fundus of the eye from eyeballs in different directions, and it is possible to create an image in which these are joined together. Therefore, according to the present embodiment, it is possible to form an image of the fundus in a wider range, which is advantageous from the viewpoint of accurately diagnosing the ophthalmoscope based on the image of the fundus.

[Embodiment 3]
Other embodiments of the present invention will be described below. For convenience of explanation, the same reference numerals will be added to the members having the same functions as the members described in the above embodiment, and the description will not be repeated.

(Configuration of ophthalmic examination device and its functional configuration)
The ophthalmoscopic examination apparatus according to the present embodiment has substantially the same configuration as the fundus imaging apparatus of the second embodiment described above.

FIG. 13 is a block diagram showing an example of a functional configuration of the ophthalmologic examination apparatus according to the present embodiment. As shown in FIG. 13, the ophthalmologic examination apparatus of the present embodiment is functionally described above, except that it further includes an ophthalmologic determination unit 370 that determines ophthalmology from image data synthesized by the image processing unit 240. It has substantially the same configuration as the fundus imaging device of the second embodiment. That is, the control unit 300 is configured to be substantially the same as the control unit 220 of the second embodiment except that the ophthalmologic determination unit 370 is further provided.

The ophthalmologic determination unit 370 acquires the processed image data output by the image processing unit 240, and determines the presence or absence and degree of ophthalmology from the state of the fundus indicated by the image data. For example, the ophthalmologic determination unit 370 determines the suitability of the image data acquired by the imaging control unit 130 with reference to the ophthalmologic determination model stored in the storage unit 103, for example. The ophthalmologic determination unit 370 outputs the acquired image data and information representing the ophthalmologic determination result to the output unit 104.

(About the eye disease judgment model)
The ophthalmologic determination model referred to by the ophthalmologic determination unit 370 may be any one that outputs information on the ophthalmologic disease in response to the input of image data of the fundus. The ophthalmologic determination model may be one type or more.

Similar to the image determination model, the eye disease determination model can also be trained by referring to the teacher data. The teacher data includes image data of the fundus of the subject and at least one piece of information about the ophthalmology corresponding to the image data. Examples of such information include the type and degree of ophthalmology.

The ophthalmologic determination model prepares, for example, a sufficient number of image data of the fundus and measures information on the type and degree of ophthalmologic disease corresponding thereto. A sufficient number of data from the measurement are acquired, the neural network is trained, and the path weight is determined for each image data. In this way, an ophthalmologic determination model is created.

The ophthalmologic determination model and the method for training it may be the same as those of the image determination model, or may be different. The ophthalmologic determination model may be other than the model by machine learning. For example, the ophthalmology determination model can be a regression model in which the above image data is used as an objective variable and information about ophthalmology such as the type and degree of ophthalmology is used as an explanatory variable.

(Ophthalmology judgment processing)
FIG. 14 is a flowchart showing an example of the flow of the ophthalmologic determination process by the ophthalmologic examination apparatus according to the present embodiment. As shown in FIG. 14, the determination process in the present embodiment can be carried out in the same manner as the process example of fundus imaging in the second embodiment, except that step S308 and step S309 are further included in place of step S208. That is, the ophthalmologic determination process in the present embodiment is executed in the same manner as the fundus imaging process in the second embodiment from step S101 to step S207.

In step S309, the ophthalmologic determination unit 370 determines the ophthalmology based on the synthesized image data. For example, the ophthalmologic determination unit 370 acquires the processed image data output by the image processing unit 240, refers to the above-mentioned ophthalmologic determination model stored in the storage unit 103, and obtains the state of the fundus indicated by the image data. , Determine the presence and degree of ophthalmology.

In step S310, the output unit 104 outputs the image data acquired by the ophthalmology determination unit 370 and the ophthalmology determination result acquired by the ophthalmology determination unit 370. For example, the output unit 104 displays the image of the image data and the determination result on a display device such as a liquid crystal display. According to this embodiment, it is possible to obtain a sufficiently clear image showing the state of the fundus observed from the eyeballs oriented in various directions.

(Action effect)
In addition to the effects of the second embodiment described above, the present embodiment further exerts the effect that the determination result of ophthalmologic disease can be obtained from the image of the fundus. This embodiment is suitable from the viewpoint of assisting the diagnosis of a doctor, and is advantageous for increasing the accuracy and speed in the diagnosis of ophthalmology.

[Modification example]
The present invention is not limited to the above-described embodiments, and various modifications can be made within the scope of the claims, and the embodiments obtained by appropriately combining the technical means disclosed in the different embodiments. Is also included in the technical scope of the present invention.

In the above-described embodiment, the optotype may be a visual acuity vote as long as it is possible to move and fix one eye of the subject. For example, the optotype may be an arrow, a letter, or a point of light that lights or flashes. Further, a plurality of optotypes may not be arranged in the optotype image. For example, the optotype may be one object that can be moved and stopped in the optotype image.

In the above-described embodiment, the optotype presenting unit is not limited to the optotype presenting device or the visual acuity test device as long as it can appropriately present the optotype. For example, when the subject is in a predetermined position and the fundus can be imaged, various objects at a position away from the subject can be used as optotypes. One example is a visual acuity card in the table for visual acuity test on a wall surface located away from the subject.

In the above-described embodiment, the fundus imaging device may have a configuration including an optotype presenting unit according to the optotype. For example, when an object away from the subject is used as an optotype, the fundus imaging device is composed of an integral structure of an irradiation unit and an imaging unit arranged to face one eye of the subject and goggles holding the irradiation unit. It may be in a goggle-like manner. Alternatively, the fundus imaging device may be an integrated structure (handy type structure) of an irradiation unit and an imaging unit that can be held by the subject by touching one eye of the subject. The fundus imaging device of these embodiments is excellent in portability.

In the above-described embodiment, laser scanning technology may be applied to the optical system for fundus imaging. For example, a near-infrared laser may be used as the NIR light source 10, and the optical system may be an optical system that scans the fundus of the eye with the laser and forms an image of return light from the fundus on the CCD sensor 20.

In the above-described embodiment, the optotype may also be presented to the other eye of the subject, that is, the eye that images the fundus, as long as the effects of the above-described embodiment can be obtained. However, in the case where the image of the fundus and the visual acuity test are performed in parallel, when the optotype is presented to the other eye that images the fundus, the visual acuity test in one eye may be hindered.

In the above-described embodiment, the control unit (100, 200, 300) may further include a RAM (Random Access Memory) for developing the program or the like. Further, the program may be supplied to the computer via an arbitrary transmission medium (communication network, broadcast wave, etc.) capable of transmitting the program. It should be noted that one aspect of the present invention can also be realized in the form of a data signal embedded in a carrier wave, in which the above program is embodied by electronic transmission. Alternatively, the control unit (100, 200, 300) may be realized by a logic circuit (hardware) formed in an integrated circuit (IC chip) or the like.

1, 1a fundus imaging device 3, 3a Device body 4, 5, 5a, 5b Eyepiece tube 10 NIR light source 20 CCD sensor 30 Optical system 31, 32, 35, 36, 38 Lens 33 Linear polarizing plate 34, 34a Polarized beam splitter 37 Wave plate 40 Reflective mirror 50, 50a Eyepiece image 51 Eyepiece 100, 200, 220, 300 Control unit 101 Input unit 102 Eyepiece presentation device 103 Storage unit 104 Output unit 110, 210 Eyepiece control unit 120, 220 Irradiation control unit 130, 230 Image control unit 202 Visual acuity test device 204, 240 Image processing unit 205 Speaker 211 Eyepiece image change unit 241 Image judgment unit 242 Image synthesis unit 250 Alignment control unit 260 Focus control unit 270 Guidance control unit 370 Eyepiece judgment unit

Claims (11)

An optotype presenting unit for presenting an optotype within the visual field of one eye of the subject,
An irradiation unit for irradiating the other eye of the subject with near infrared rays,
It has an imaging unit for imaging the fundus of the other eye, and has an imaging unit.
A fundus imaging device in which the wavelength of the near infrared rays is 780 nm or more and 1450 nm or less. The fundus imaging device according to claim 1, wherein the near-infrared wavelength is 840 nm or more and 1450 nm or less. The fundus imaging device according to claim 1 or 2, wherein the optotype is a visual acuity card. The fundus imaging device according to any one of claims 1 to 3, wherein the optotype is arranged in each of a plurality of sections set in the field of view. The fundus imaging device according to any one of claims 1 to 4, wherein the near infrared rays have a plurality of different peak wavelengths. The fundus imaging apparatus according to any one of claims 1 to 5, further comprising a reflection mirror in the optical system constituting the optotype presenting unit, the irradiation unit, and the imaging unit. An autofocus unit for automatically focusing the return light from the retina of the subject to a camera for imaging the fundus of the other eye of the subject, and optics for imaging the other eye. The fundus imaging apparatus according to any one of claims 1 to 6, further comprising one or both of an auto-alignment unit for automatically adjusting the relative positional relationship with the system. The fundus imaging apparatus according to any one of claims 1 to 7, further comprising an image synthesizing unit for creating an image obtained by joining a plurality of images captured by the imaging unit. Claims 1 to 8, wherein the imaging unit images the fundus of the other eye while performing an examination of the one eye of the subject using the optotype presented by the optotype presenting unit. The fundus imaging apparatus according to any one of the following items. The target is a visual acuity card,
A voice guidance unit for guiding the subject to the work for inspecting the visual acuity of the one eye by voice, and an optotype image including the optotype presented to the subject are used to inspect the visual acuity. The fundus imaging device according to any one of claims 1 to 9, further comprising an optotype image changing unit for changing according to the work for the purpose. The fundus imaging device according to any one of claims 1 to 10, and a determination unit for determining an ophthalmoscope of the other eye of the subject based on one or more images captured by the imaging unit. Equipped with an ophthalmologic examination device.

Images