JP2021045052A - Lipin-1 gene expression enhancer - Google Patents
Lipin-1 gene expression enhancer Download PDFInfo
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- JP2021045052A JP2021045052A JP2019168352A JP2019168352A JP2021045052A JP 2021045052 A JP2021045052 A JP 2021045052A JP 2019168352 A JP2019168352 A JP 2019168352A JP 2019168352 A JP2019168352 A JP 2019168352A JP 2021045052 A JP2021045052 A JP 2021045052A
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- Prior art keywords
- extract
- acid
- oil
- cacao
- gene expression
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Abstract
Description
本発明は,カカオのlipin1遺伝子発現促進剤に関するもので,例えば,飲食品,薬品,医薬部外品,化粧品等の素材として適用されるものである。 The present invention relates to a cacao lipin1 gene expression promoter, and is applied as a material for, for example, foods and drinks, drugs, quasi-drugs, and cosmetics.
カカオは,チョコレートやココアの原料として古くから世界中で親しまれてきた。含有成分として,テオブロミンやポリフェノールを豊富に含有することから,近年カカオの機能性に関する研究が盛んに行われている。例えば,特許文献では,抗アレルギー剤(特開2000−169383),抗炎症食品(特開平11−318387),血流改善外用剤(特開2004−123622),持久力向上用食品組成物(特開2003−334022),集中力向上食品(特開2005−13127),発ガン予防物質を含有する健康飲食品(特開平9−224606),ストレスの予防および適応形成を促進させる飲食品(特開平9−206026),胃潰瘍予防飲食品(特開平7−274894),歯垢形成抑制剤(特開平7−238028),更年期障害を改善する飲食品(特開2001−69946),嚥下障害改善剤(特開2004−107285),脳の老化抑制剤(特開2005−8606),創傷治癒促進剤(特開2001−233779),癌転移抑制剤(特開2002−128685)および免疫賦活剤(特開2000−86526)などがある。 Cacao has long been popular around the world as a raw material for chocolate and cocoa. Since it contains abundant theobromine and polyphenols as ingredients, research on the functionality of cacao has been actively conducted in recent years. For example, in the patent documents, an antiallergic agent (Japanese Patent Laid-Open No. 2000-169383), an anti-inflammatory food (Japanese Patent Laid-Open No. 11-318387), an external preparation for improving blood flow (Japanese Patent Laid-Open No. 2004-123622), and a food composition for improving endurance (specification). Kai 2003-334022), Concentration-enhancing foods (Japanese Patent Laid-Open No. 2005-13427), Healthy foods and drinks containing carcinogenic preventive substances (Japanese Patent Laid-Open No. 9-224606), Foods and drinks that promote stress prevention and adaptation formation (Japanese Patent Laid-Open No. 9-224606) 9-20602), gastric ulcer preventive food and drink (Japanese Patent Laid-Open No. 7-274894), dentin formation inhibitor (Japanese Patent Laid-Open No. 7-238028), food and drink for improving menopausal disorders (Japanese Patent Laid-Open No. 2001-69946), swallowing disorder improving agent (Japanese Patent Laid-Open No. 7-28028) Japanese Patent Application Laid-Open No. 2004-107285), brain aging inhibitor (Japanese Patent Laid-Open No. 2005-8606), wound healing promoter (Japanese Patent Laid-Open No. 2001-233779), cancer metastasis inhibitor (Japanese Patent Laid-Open No. 2002-128685) and immunostimulatory agent (Japanese Patent Laid-Open No. 2004-128685). 2000-86526) and the like.
一方,ダイエットに用いられる成分を機能別に分類すると,脂肪吸収抑制素材ではキトサン,食物繊維,低分子アルギン酸ナトリウム,ローズマリーエキス,オーリスタットが,糖吸収抑制素材では,月見草エキス,プロアントシアニジン,ペンタガロイルグルコース,黒米エキス,サラシア,サラシノール,白インゲン豆エキス,フォセオラミン,桑葉エキス,デオキシノジリマイシン,アカルボース,ボグリボースがある。また蓄積した体脂肪の分解促進作用をもつ素材として,カフェイン,コーヒー生豆エキス,カプサイシン,トウガラシ抽出物,シネフリン,シトラス抽出物,フォルスコリン,コレウス・フォルスコリが,さらに分解遊離した脂肪酸の燃焼を促進する素材として,緑茶カテキン,クロロゲン酸類,ラズベリーケトン,セサミン,ガンマ−リノレン酸がある。これらのダイエット素材は,主に経口的に摂取することで用いられるが,外用剤として用いられることもある。 On the other hand, when the ingredients used in the diet are classified by function, chitosan, dietary fiber, low-molecular-weight sodium alginate, rosemary extract, and auristat are used as fat absorption-suppressing materials, and evening primrose extract, proanthocyanidin, and pentagallo are used as sugar absorption-suppressing materials. There are ylglucose, black rice extract, salasia, salacinol, navy bean extract, foseolamine, mulberry leaf extract, deoxynodirimycin, acarbose, and bogribose. In addition, caffeine, green coffee bean extract, capsaicin, capsicum extract, synephrine, citrus extract, forskolin, and Coleus barbatus are further decomposed and liberated fatty acids are burned as materials that promote the decomposition of accumulated body fat. Materials to promote include green tea catechin, chlorogenic acids, raspberry ketone, sesamine, and gamma-linolenic acid. These diet materials are mainly used by ingestion orally, but they may also be used as external preparations.
一方,lipin1は肝臓や脂肪組織,骨格筋などの脂質代謝が盛んな臓器で発現する。lipin1は二つの役割が知られている。1つ目として,Lipin1は,小胞体膜上においてホスファチジン酸ホスファターゼ活性を有する。2つ目として,Lipin1は,核内においてPPARα/PGC−1α調節経路のコアクチベーターとしても作用し,脂肪酸の酸化的代謝を正方向に調節する。即ち,lipin1は,トリグリセリドの合成促進と脂肪酸酸化という対局した2つの機能を有しており,生体内にこれらの機能を使い分けるシステムが存在すると考えられている(WO2013/111909)。したがって,lipin1の発現を促進することにより,脂質代謝をコントロールする機能が向上する。 On the other hand, lipin1 is expressed in organs with active lipid metabolism such as liver, adipose tissue, and skeletal muscle. lipin1 is known to have two roles. First, Lipin1 has phosphatidic acid phosphatase activity on the endoplasmic reticulum membrane. Second, Lipin1 also acts as a coactivator of the PPARα / PGC-1α regulatory pathway in the nucleus, regulating the oxidative metabolism of fatty acids in the positive direction. That is, lipin1 has two opposing functions of promoting triglyceride synthesis and fatty acid oxidation, and it is considered that there is a system that properly uses these functions in the living body (WO2013 / 111909). Therefore, by promoting the expression of lipin1, the function of controlling lipid metabolism is improved.
上記背景の下,本発明者は,高脂肪食飼育マウスを用いて評価した結果カカオ抽出物にlipin1遺伝子の発現を促進する作用,体重抑制作用,内臓脂肪蓄積抑制作用を有することを見出し,本発明を完成させた。
即ち,本発明は,新規なlipin1遺伝子発現促進剤を提供することを目的とする。
Against the above background, the present inventor found that the cacao extract has an action of promoting the expression of the lipin1 gene, a body weight suppressing action, and a visceral fat accumulation suppressing action as a result of evaluation using high-fat diet-fed mice. Completed the invention.
That is, an object of the present invention is to provide a novel lipin1 gene expression promoter.
上記課題を解決するための本発明の技術的特徴は以下のとおりである。
1.カカオ抽出物を有効成分とするlipin1遺伝子発現促進剤。
2.上記1.の剤を有効成分とする体重増加抑制剤。
3.上記1.又は上記2.の剤を有効成分とする内臓脂肪蓄積抑制剤。
The technical features of the present invention for solving the above problems are as follows.
1. 1. A lipin1 gene expression promoter containing a cacao extract as an active ingredient.
2. Above 1. A weight gain inhibitor containing the active ingredient of.
3. 3. Above 1. Or the above 2. A visceral fat accumulation inhibitor containing the above agent as an active ingredient.
本発明はカカオの抽出物を有効成分とすることを特徴とする。
本発明の原料となるカカオは,生のままあるいは発酵・焙煎した果実の果皮,ハスク,種子,胚乳,カカオマスなど加工方法および部位を限定しない。種々の方法で処理した各部位を粉砕し,粉末のままあるいは賦形剤とともに混合し,散剤,顆粒剤,錠剤,カプセル剤などの形態で経口用途のダイエット素材として使用できる。また,他のダイエット素材や健康食品素材と混合して使用することができる。
The present invention is characterized in that an extract of cacao is used as an active ingredient.
The cacao used as a raw material of the present invention does not limit the processing method and site such as raw or fermented / roasted fruit skin, husk, seed, endosperm, and cacao mass. Each part treated by various methods is crushed and mixed as a powder or with an excipient, and can be used as a diet material for oral use in the form of powders, granules, tablets, capsules and the like. In addition, it can be mixed with other diet materials and health food materials.
また,より服用しやすい形態にするため,抽出物の形で使用することもできる。抽出溶媒としては,メタノール,エタノール,イソプロピルアルコール,ブタノール,1,3−ブチレングリコール,エチレングリコール,プロピレングリコール,グリセリン,アセトン,水などの高極性溶媒があげられる。これら溶媒を単独あるいは2種以上の溶媒を混合して使用することができるが,好ましくは70%エタノールを用いる。これらに加え必要に応じて,界面活性剤として,グリセリン脂肪酸エステル,ショ糖脂肪酸エステル,縮合レシノレート,ソルビタン脂肪酸エステル,プロピレングリコール脂肪酸エステル,サポニン,及びステロールから成る群より選ばれる1種以上を適宜使用することができる。 It can also be used in the form of an extract to make it easier to take. Examples of the extraction solvent include highly polar solvents such as methanol, ethanol, isopropyl alcohol, butanol, 1,3-butylene glycol, ethylene glycol, propylene glycol, glycerin, acetone, and water. These solvents can be used alone or in combination of two or more kinds of solvents, but 70% ethanol is preferably used. In addition to these, if necessary, at least one selected from the group consisting of glycerin fatty acid ester, sucrose fatty acid ester, condensed lesinolate, sorbitan fatty acid ester, propylene glycol fatty acid ester, saponin, and sterol is appropriately used as a surfactant. can do.
抽出時の温度としては,20℃〜100℃が好ましい。この範囲以下だと抽出効率が低下し,逆にこの範囲を超えるとポリフェノールの重合がおこり,成分が変質しやすいので好ましくない。特に好ましい温度は60℃〜90℃である。抽出に用いる溶媒量は,カカオ1重量に対して,1から10重量比の範囲で添加することができるが,好ましくは3〜5倍量である。得られた抽出液は,減圧濃縮,真空乾燥,凍結乾燥などの手法を用いて,濃縮・粉末化してダイエット組成物として用いる。このダイエット組成物は,粉末のままあるいは賦形剤とともに混合し,散剤,顆粒剤,錠剤,カプセル剤などの形態で経口用途のダイエット素材として使用できるが,水やエタノールあるいは油脂類に分散後,液剤,軟カプセル剤などの形態で使用できる。また,他のダイエット素材や健康食品素材と混合して使用することができる。 The temperature at the time of extraction is preferably 20 ° C to 100 ° C. If it is below this range, the extraction efficiency will decrease, and if it exceeds this range, polyphenols will polymerize and the components will easily deteriorate, which is not preferable. A particularly preferable temperature is 60 ° C to 90 ° C. The amount of the solvent used for extraction can be added in the range of 1 to 10% by weight with respect to 1 weight of cacao, but is preferably 3 to 5 times the amount. The obtained extract is concentrated and powdered by methods such as vacuum concentration, vacuum drying, and freeze-drying, and used as a diet composition. This diet composition can be used as a diet material for oral use in the form of powders, granules, tablets, capsules, etc. in the form of powder or mixed with excipients, but after being dispersed in water, ethanol or fats and oils, It can be used in the form of liquids, soft capsules, etc. In addition, it can be mixed with other diet materials and health food materials.
濃縮・粉末化して得られたカカオ抽出物は,lipin1遺伝子発現促進作用を有するが,必要に応じて有効成分であるテオブロミンやポリフェノール濃度を高めることができる。
これらを濃縮する手法としては,例えば,次の方法がある。即ち,超臨界二酸化炭素抽出,カラムを用いた吸着剤,シリカゲル,逆相シリカゲル処理などがあげられるが,好ましくは合成吸着剤を用いたカラム処理である。
The cacao extract obtained by concentration and powdering has a lipin1 gene expression promoting action, and can increase the concentration of theobromine and polyphenols, which are active ingredients, as needed.
As a method for concentrating these, for example, there are the following methods. That is, supercritical carbon dioxide extraction, adsorbent using a column, silica gel, reverse phase silica gel treatment, etc. can be mentioned, but column treatment using a synthetic adsorbent is preferable.
以上の方法で得られる本発明のlipin1遺伝子発現促進剤(カカオ抽出物)は,各種飲食品の素材として使用することができる。飲食品としては,例えば,食用油(サラダ油),菓子類(ガム,キャンディー,キャラメル,チョコレート,クッキー,スナック,ゼリー,グミ,錠菓等),麺類(そば,うどん,ラーメン等),乳製品(ミルク,アイスクリーム,ヨーグルト等),調味料(味噌,醤油等),スープ類,飲料(ジュース,コーヒー,紅茶,茶,炭酸飲料,スポーツ飲料等)をはじめとする一般食品や,健康食品(錠剤,カプセル等),栄養補助食品(栄養ドリンク等)が挙げられる。これらの飲食品に本発明のダイエット組成物を適宜配合するとよい。 The lipin1 gene expression promoter (cacao extract) of the present invention obtained by the above method can be used as a material for various foods and drinks. Foods and drinks include, for example, edible oil (salad oil), confectionery (gum, candy, caramel, chocolate, cookies, snacks, jelly, gummy, tablet confectionery, etc.), noodles (soba, udon, ramen, etc.), dairy products (soba, udon, ramen, etc.) General foods such as milk, ice cream, yogurt, etc.), seasonings (miso, soy sauce, etc.), soups, beverages (juice, coffee, tea, tea, carbonated beverages, sports beverages, etc.) and health foods (tablets) , Capsules, etc.), nutritional supplements (nutrition drinks, etc.). The diet composition of the present invention may be appropriately added to these foods and drinks.
これら飲食品には,その種類に応じて種々の成分を配合することができ,例えば,ブドウ糖,果糖,ショ糖,マルトース,ソルビトール,ステビオサイド,コーンシロップ,乳糖,クエン酸,酒石酸,リンゴ酸,コハク酸,乳酸,L−アスコルビン酸,dl−α−トコフェロール,エリソルビン酸ナトリウム,グリセリン,プロピレングリコール,グリセリン脂肪酸エステル,ポリグリセリン脂肪酸エステル,ショ糖脂肪酸エステル,ソルビタン脂肪酸エステル,プロピレングリコール脂肪酸エステル,アラビアガム,カラギーナン,カゼイン,ゼラチン,ペクチン,寒天,ビタミンB類,ニコチン酸アミド,パントテン酸カルシウム,アミノ酸類,カルシウム塩類,色素,香料,保存剤等の食品素材を使用することができる。さらに,健康維持機能をもった本lipin1遺伝子発現促進剤には,他の抗酸化物質や健康食品素材などの配剤,例えば,抗酸化物質)還元型アスコルビン酸(ビタミンC),ビタミンE,還元型グルタチン,トコトリエノール,ビタミンA誘導体,リコピン,β−クリプトキサンチン,アスタキサンチン,ゼアキサンチン,フコキサンチン,尿酸,アルファリポ酸,ユビキノン,コエンザイムQ10,葉酸,ニンニクエキス,アリシン,セザミン,リグナン類,カテキン,イソフラボン,カルコン,タンニン類,フラボノイド類,クマリン,イソクマリン類,ブルーベリーエキス,アルブチン,タンニン,アントシアニン,リンゴポリフェノール,ブドウ種子エキス,エラジ酸,コウジ酸,サージ抽出物,V.(ビタミン)A,V.B1,V.B2,V.B6,V.B12,V.C,V.D,V.E,V.P,コリン,ナイアシン,パントテン酸,葉酸カルシウム,EPA,オリゴ糖,食物繊維,スクアレン,大豆レシチン,タウリン,ドナリエラ,プロテイン,オクタコサノール,DHA,卵黄レシチン,リノール酸,ラクトフェリン,マグネシウム,亜鉛,クロム,セレン,カリウム,ヘム鉄,カキ肉エキス,キトサン,キチンオリゴ糖,コラーゲン,コンドロイチン,ウコン,カンゾウ,クコシ,ケイヒ,サンザシ,生姜,霊芝,シジミエキス,スッポン,カンゾウ,クコシ,ケイヒ,サンザシ,生姜,霊芝,オオバコ,カミツレ,カモミール,セイヨウタンポポ,ハイビスカス,ハチミツ,ボーレン,ローヤルゼリー,ライム,ラベンダー,ローズヒップ,ローズマリー,セージ,ビフィズス菌,フェーカリス菌,ラクリス,小麦胚芽油,ゴマ油,シソ油,大豆油,中鎖脂肪酸,アガリクス,イチョウ葉エキス,ウコン,コンドロイチン,玄米胚芽エキス,レイシ,タマネギ,DHA,EPA,DPA,甜茶,冬虫夏草,ニンニク,蜂の子,パパイヤ,プーアル,プロポリス,メグスリの木,ヤブシタケ,ロイヤルゼリー,ノコギリヤシ,ヒアルロン酸,コラーゲン,ギャバ,ハープシールオイル,サメ軟骨,グルコサミン,レシチン,ホスファチジルセリン,田七ニンジン,桑葉,大豆抽出物,エキナセア,エゾウコギ,大麦抽出物,オリーブ葉,オリーブ実,ギムネマ,バナバ,サラシア,ガルシニア,キトサン,セントジョーンズワート,ナツメ,ニンジン,パッションフラワー,ブロッコリー,プラセンタ,ハトムギ,ブドウ種子,ピーナッツ種皮,ビルベリー,ブラックコホシュ,マリアアザミ,月桂樹,セージ,ラフマ,黒酢,ゴーヤー,マカ,紅花,亜麻,ウーロン茶,花棘,カフェイン,カプサイシン,キシロオリゴ糖,グルコサミン,ソバ,シトラス,食物繊維,プロテイン,プルーン,スピルリナ,大麦若葉,核酸,酵母,椎茸,梅肉,アミノ酸,深海鮫抽出物,ノニ,カキ肉,スッポン,シャンピニオン,オオバコ,アセロラ,パイナップル,バナナ,モモ,アンズ,メロン,イチゴ,ラズベリー,オレンジ,フコイダン,メシマコブ,クランベリー,コンドロイチン硫酸,亜鉛,鉄,セラミド,シルクペプチド,グリシン,ナイアシン,チェストツリー,セラミド,L−システイン,L−カルニチン,赤ワイン葉,ミレット,ホーステール,ビオチン,センテラアジアティカ,ハスカップ,ピクノジェノール,フキ,ルバーブ,クローブ,カテキン,プーアル,クエン酸,ビール酵母,メリロート,ブラックジンガー,ショウガ,ガジュツ,ナットウキナーゼ,ベニコウジ,トコトリエノール,ラクトフェリン,シナモン,韃靼ソバ,生コーヒー豆エキスなども配合することができる。 Various ingredients can be added to these foods and drinks according to their types. For example, glucose, fructose, sucrose, maltose, sorbitol, stebioside, corn syrup, lactate, citric acid, tartrate acid, malic acid, and succinic acid. Acid, lactic acid, L-ascorbic acid, dl-α-tocopherol, sodium erythorbicate, glycerin, propylene glycol, glycerin fatty acid ester, polyglycerin fatty acid ester, sucrose fatty acid ester, sorbitan fatty acid ester, propylene glycol fatty acid ester, Arabic gum, Food materials such as carrageenan, casein, gelatin, pectin, agar, vitamin Bs, nicotinic acid amide, calcium pantothenate, amino acids, calcium salts, pigments, fragrances, and preservatives can be used. Furthermore, this lipin1 gene expression promoter having a health-maintaining function includes other antioxidants and distributions such as health food materials, for example, antioxidant) reduced ascorbic acid (vitamin C), vitamin E, and reduced type. Glutatin, tocotrienol, vitamin A derivative, lycopene, β-cryptoxanthin, astaxanthin, zeaxanthin, fucoxanthin, uric acid, alpha lipoic acid, ubiquinone, coenzyme Q10, folic acid, garlic extract, alicin, sezamine, lignans, catechin, isoflavone, chalcone , Tannins, flavonoids, coumarin, isocmarins, blueberry extract, astaxanthin, tannin, anthocyanin, apple polyphenol, grape seed extract, elladic acid, ascorbic acid, surge extract, V.I. (Vitamin) A, V. B1, V. B2, V. B6, V. B12, V.I. C, V. D, V. E, V. P, choline, niacin, pantothenic acid, calcium folic acid, EPA, oligosaccharide, dietary fiber, squalane, soybean lecithin, taurine, donariella, protein, octacosanol, DHA, egg yolk lecithin, linoleic acid, lactoferrin, magnesium, zinc, chromium, selenium , Potassium, Hem Iron, Shaved Meat Extract, Chitosan, Chitin Oligosaccharide, Collagen, Chondroitin, Ukon, Kanzo, Kukoshi, Keihi, Sanzashi, Ginger, Reishi, Shijimi Extract, Suppon, Kanzo, Kukoshi, Keihi, Sanzashi, Ginger, Reishi, Obako, Chamomile, Chamomile, Seiyo Dandelion, Hibiscus, Honey, Bohlen, Royal Jelly, Lime, Lavender, Rosehip, Rosemary, Sage, Bifizus, Faecalis, Lacris, Wheat germ oil, Sesame oil, Perilla oil, Soybean oil , Medium chain fatty acid, Agaricus, Ginkgo biloba extract, Ukon, Chondroitin, Brown rice germ extract, Reishi, Onion, DHA, EPA, DPA, Jellyfish, Winter worm summer grass, Garlic, Bee cub, Papaya, Poor, Propolis, Megusuri tree, Yabushitake , Royal jelly, sawtooth palm, hyaluronic acid, collagen, gaba, harp seal oil, shark cartilage, glucosamine, lecithin, phosphatidylserine, Tanana carrot, mulberry leaf, soybean extract, echinacea, eleuthero, barley extract, olive leaf, olive Fruit, Gymnema, Banaba, Saracia, Garsina, Chitosan, St. Jones wort, Natsume, Carrot, Passion flower, Broccoli, Placenta, Hatomugi, Grape seed, Peanut seed coat, Bilberry, Black kohosh, Maria thistle, Laurel, Sage, Rafuma, Black vinegar, Bitter gourd, maca, red flower, flax, oolong tea, flower spine, caffeine, capsaicin, xylooligosaccharide, glucosamine, buckwheat, citrus, dietary fiber, protein, prune, spirulina, young barley leaf, nucleic acid, yeast, shiitake mushroom, plum meat, amino acid, Deep sea shark extract, noni, oyster meat, suppon, champignon, obaco, acerola, pineapple, banana, peach, apricot, melon, strawberry, raspberry, orange, fucoidan, mesimacob, cranberry, chondroitin sulfate, zinc, iron, ceramide, silk Peptide, glycine, niacin, chest tree, ceramide, L-cysteine, L-carnitine, red wine leaf, millet, royal jelly, biotin, centera asiatica, hascup, pi Knogenol, butterbur, rhubarb, clove, catechin, puer, citric acid, brewer's yeast, melilot, black zinger, ginger, gajutsu, nuttokinase, benikoji, tocotrienol, lactoferrin, cinnamon, buckwheat, raw coffee bean extract, etc. may also be added. it can.
具体的な製法としては,本発明のlipin1遺伝子発現促進剤と他の健康維持素材をそのまま,もしくは粉末セルロースとともにスプレードライまたは凍結乾燥し,これを粉末,顆粒,打錠または溶液にすることで容易に食品(インスタント食品等)に含有させることができる。また必要に応じてアラビアガム,デキストリン等のバインダーと混合して粉末状あるいは顆粒状にし,固形食品に添加することも可能である。また,本ダイエット組成物の液剤はそのまま,もしくは例えば,水,エタノール,グリセリンあるいはこれらの混合物に分散溶解して,飲料にすることが可能である。 As a specific manufacturing method, it is easy to spray-dry or freeze-dry the lipin1 gene expression promoter of the present invention and other health-maintaining materials as they are or with powdered cellulose to make powder, granules, tableting or solution. Can be contained in foods (instant foods, etc.). If necessary, it can be mixed with a binder such as gum arabic or dextrin to form a powder or granules, which can be added to solid foods. In addition, the liquid preparation of this diet composition can be used as it is, or, for example, it can be dispersed and dissolved in water, ethanol, glycerin or a mixture thereof to make a beverage.
本発明のlipin1遺伝子発現促進剤を飲食品に適用する場合の添加量としては,病気予防や健康維持が主な目的であるので,飲食品に対して有効成分の含量が合計0.01〜10wt%であるのが好ましい。 When the lipin1 gene expression promoter of the present invention is applied to foods and drinks, the content of the active ingredient in the foods and drinks is 0.01 to 10 wt in total because the main purpose is to prevent diseases and maintain health. It is preferably%.
本発明のlipin1遺伝子発現促進剤は,薬品(医薬品および医薬部外品を含む。)の素材として用いてもよい。薬品製剤用の原料に,本発明のlipin1遺伝子発現促進剤を適宜配合して製造することができる。本発明のlipin1遺伝子発現促進剤に配合しうる製剤原料としては,例えば,賦形剤(ブドウ糖,乳糖,白糖,塩化ナトリウム,デンプン,炭酸カルシウム,カオリン,結晶セルロース,カカオ脂,硬化植物油,カオリン,タルク等),結合剤(蒸留水,生理食塩水,エタノール水,単シロップ,ブドウ糖液,デンプン液,ゼラチン溶液,カルボキシメチルセルロース,リン酸カリウム,ポリビニルピロリドン等),崩壊剤(アルギン酸ナトリウム,カンテン,炭酸水素ナトリウム,炭酸カルシウム,ラウリル硫酸ナトリウム,ステアリン酸モノグリセリド,デンプン,乳糖,アラビアゴム末,ゼラチン,エタノール等),崩壊抑制剤(白糖,ステアリン,カカオ脂,水素添加油等),吸収促進剤(第四級アンモニウム塩基,ラウリル硫酸ナトリウム等),吸着剤(グリセリン,デンプン,乳糖,カオリン,ベントナイト,硅酸等),滑沢剤(精製タルク,ステアリン酸塩,ポリエチレングリコール等)などが挙げられる。 The lipin1 gene expression promoter of the present invention may be used as a material for drugs (including pharmaceuticals and quasi-drugs). It can be produced by appropriately blending the lipin1 gene expression promoter of the present invention with a raw material for drug preparation. Examples of the preparation raw material that can be blended in the lipin1 gene expression promoter of the present invention include excipients (glucose, lactose, sucrose, sodium chloride, starch, calcium carbonate, kaolin, crystalline cellulose, cacao butter, hardened vegetable oil, kaolin, etc. Talk, etc.), binders (distilled water, physiological saline, ethanol water, simple syrup, glucose solution, starch solution, gelatin solution, carboxymethyl cellulose, potassium phosphate, polyvinylpyrrolidone, etc.), disintegrants (sodium alginate, canten, carbonic acid, etc.) Sodium hydrogen hydrogen, calcium carbonate, sodium lauryl sulfate, stearic acid monoglyceride, starch, lactose, gum arabic powder, gelatin, ethanol, etc.), disintegration inhibitor (sucrose, stear, cacao butter, hydrogenated oil, etc.), absorption enhancer (No. 1) Tertiary ammonium bases, sodium lauryl sulfate, etc.), excipients (glycerin, starch, lactose, kaolin, bentonite, silicic acid, etc.), lubricants (purified talc, stearic acid, polyethylene glycol, etc.), etc.
本発明によるlipin1遺伝子発現促進剤の投与方法は,一般的には,錠剤,丸剤,軟・硬カプセル剤,細粒剤,散剤,顆粒剤等の形態で経口投与することができる。また,水溶性製剤は,液剤として経口的に投与することができる。さらに非経口投与であってもよい。非経口剤として投与する場合は,本lipin1遺伝子発現促進剤をエタノールや適当な可溶化剤に分散させた後,パップ剤,ローション剤,軟膏剤,チンキ剤,クリーム剤などの剤形で適用することができる。また本lipin1遺伝子発現促進剤の液剤は,そのままで,あるいは分散剤,懸濁剤,安定剤などを添加した状態で,パップ剤,ローション剤,軟膏剤,チンキ剤,クリーム剤などの剤形で適用することができる。 The method for administering the lipin1 gene expression promoter according to the present invention can generally be orally administered in the form of tablets, pills, soft / hard capsules, fine granules, powders, granules and the like. In addition, the water-soluble preparation can be orally administered as a liquid preparation. Further, it may be administered parenterally. When administered as a parenteral agent, the lipin1 gene expression promoter is dispersed in ethanol or an appropriate solubilizer, and then applied in the form of a poultice, lotion, ointment, tincture, cream, etc. be able to. In addition, the liquid preparation of this lipin1 gene expression promoter may be used as it is, or in the form of a poultice, lotion, ointment, tincture, cream, etc. with a dispersant, suspension, stabilizer, etc. added. Can be applied.
投与量は,投与方法,病状,患者の年齢等によって変化し得るが,大人では,通常,1日当たり有効成分として5〜500mg,子供では通常0.5〜100mg程度投与することができる。 The dose may vary depending on the administration method, medical condition, age of the patient, etc., but in adults, usually 5 to 500 mg of the active ingredient per day can be administered, and in children, usually about 0.5 to 100 mg can be administered.
本発明のlipin1遺伝子発現促進剤を薬品として使用する際の配合比は,剤型によって適宜変更することが可能であるが,通常,経口または粘膜吸収により投与される場合は約0.01〜10wt%,非経口投与による場合は,0.01〜20wt%程度にするとよい。なお,投与量は種々の条件で異なるので,前記投与量より少ない量で十分な場合もあるし,また,範囲を超えて投与する必要のある場合もある。 The compounding ratio when the lipin1 gene expression promoter of the present invention is used as a drug can be appropriately changed depending on the dosage form, but is usually about 0.01 to 10 wt when administered orally or by mucosal absorption. %, In the case of parenteral administration, it should be about 0.01 to 20 wt%. Since the dose varies depending on various conditions, a dose smaller than the above dose may be sufficient, or it may be necessary to administer beyond the range.
本発明のlipin1遺伝子発現促進剤は,化粧品の素材として用いてもよい。本発明のダイエット組成物を配合しうる皮膚外用材の形態としては,例えば,乳液,石鹸,洗顔料,入浴剤,クリーム,乳液,化粧水,オーデコロン,ひげ剃り用クリーム,ひげ剃り用ローション,化粧油,日焼け・日焼け止めローション,おしろいパウダー,ファンデーション,香水,パック,爪クリーム,エナメル,エナメル除去液,眉墨,ほお紅,アイクリーム,アイシャドー,マスカラ,アイライナー,口紅,リップクリーム,シャンプー,リンス,染毛料,分散液,洗浄料等が挙げられる。 The lipin1 gene expression promoter of the present invention may be used as a material for cosmetics. Examples of the form of the external skin material to which the diet composition of the present invention can be blended include milky lotion, soap, washing pigment, bathing agent, cream, milky lotion, lotion, odecolon, shaving cream, shaving lotion, and makeup. Oil, sunscreen / sunscreen lotion, white powder, foundation, perfume, pack, nail cream, enamel, enamel remover, eyebrow, blush, eye cream, eye shadow, mascara, eyeliner, lipstick, lip balm, shampoo, rinse, Examples include hair dyes, dispersions, and cleaning agents.
上記形態の皮膚外用剤には,本発明によるlipin1遺伝子発現促進剤の他に,そのlipin1遺伝子発現促進剤発現促進作用を損なわない範囲で化粧品,医薬部外品などの皮膚外用剤に配合される成分,油分,高級アルコール,脂肪酸,紫外線吸収剤,粉体,顔料,界面活性剤,多価アルコール・糖,高分子,生理活性成分,溶媒,酸化防止剤,香料,防腐剤等を配合することができる。
例を以下に羅列するが,本発明はこれらの例に限定されるものではない。
(1)油分の例
エステル系の油相成分:トリ2−エチルヘキサン酸グリセリル,2−エチルヘキサン酸セチル,ミリスチン酸イソプロピル,ミリスチン酸ブチル,パルミチン酸イソプロピル,ステアリン酸エチル,パルミチン酸オクチル,イソステアリン酸イソセチル,ステアリン酸ブチル,ミリスチン酸ブチル,リノール酸エチル,リノール酸イソプロピル,オレイン酸エチル,ミリスチン酸イソセチル,ミリスチン酸イソステアリル,パルミチン酸イソステアリル,ミリスチン酸オクチルドデシル,イソステアリン酸イソセチル,セバシン酸ジエチル,アジピン酸ジイソプロピル,ネオペンタン酸イソアラキル,トリ(カプリル・カプリン酸)グリセリル,トリ2−エチルヘキサン酸トリメチロールプロパン,トリイソステアリン酸トリメチロールプロパン,テトラ2−エチルヘキサン酸ペンタエリスリトール,カプリル酸セチル,ラウリン酸デシル,ラウリン酸ヘキシル,ミリスチン酸デシル,ミリスチン酸ミリスチル,ミリスチン酸セチル,ステアリン酸ステアリル,オレイン酸デシル,リシノレイン酸セチル,ラウリン酸イソステアリル,ミリスチン酸イソトリデシル,ミリスチン酸イソセチル,ミリスチン酸イソステアリル,パルミチン酸イソセチル,パルミチン酸イソステアリル,ステアリン酸オクチル,ステアリン酸イソセチル,オレイン酸イソデシル,オレイン酸オクチルドデシル,リノール酸オクチルドデシル,イソステアリン酸イソプロピル,2−エチルヘキサン酸セトステアリル,2−エチルヘキサン酸ステアリル,イソステアリン酸ヘキシル,ジオクタン酸エチレングリコール,ジオレイン酸エチレングリコール,ジカプリン酸プロピレングリコール,ジ(カプリル・カプリン酸)プロピレングリコール,ジカプリル酸プロピレングリコール,ジカプリン酸ネオペンチルグリコール,ジオクタン酸ネオペンチルグリコール,トリカプリル酸グリセリル,トリウンデシル酸グリセリル,トリイソパルミチン酸グリセリル,トリイソステアリン酸グリセリル,ネオペンタン酸オクチルドデシル,オクタン酸イソステアリル,イソノナン酸オクチル,ネオデカン酸ヘキシルデシル,ネオデカン酸オクチルドデシル,イソステアリン酸イソセチル,イソステアリン酸イソステアリル,イソステアリン酸オクチルデシル,ポリグリセリンオレイン酸エステル,ポリグリセリンイソステアリン酸エステル,炭酸ジプロピル,炭酸ジアルキル(C12−18),クエン酸トリイソセチル,クエン酸トリイソアラキル,クエン酸トリイソオクチル,乳酸ラウリル,乳酸ミリスチル,乳酸セチル,乳酸オクチルデシル,クエン酸トリエチル,クエン酸アセチルトリエチル,クエン酸アセチルトリブ
チル,クエン酸トリオクチル,リンゴ酸ジイソステアリル,ヒドロキシステアリン酸2−エチルヘキシル,コハク酸ジ2−エチルヘキシル,アジピン酸ジイソブチル,セバシン酸ジイソプロピル,セバシン酸ジオクチル,ステアリン酸コレステリル,イソステアリン酸コレステリル,ヒドロキシステアリン酸コレステリル,オレイン酸コレステリル,オレイン酸ジヒドロコレステリル,イソステアリン酸フィトステリル,オレイン酸フィトステリル,12−ステアロイルヒドロキシステアリン酸イソセチル,12−ステアロイルヒドロキシステアリン酸ステアリル,12−ステアロイルヒドロキシステアリン酸イソステアリル等が挙げられる。
炭化水素系の油相成分:スクワラン,流動パラフィン,α−オレフィンオリゴマー,イソパラフィン,セレシン,パラフィン,流動イソパラフィン,ポリブテン,マイクロクリスタリンワックス,ワセリン等が挙げられる。
動植物油とその硬化油,および天然由来のロウ:牛脂,硬化牛脂,豚脂,硬化豚脂,馬油,硬化馬油,ミンク油,オレンジラフィー油,魚油,硬化魚油,卵黄油等の動物油およびその硬化油,アボカド油,アルモンド油,オリーブ油,カカオ脂,杏仁油,ククイナッツ油,ゴマ油,小麦胚芽油,コメ胚芽油,コメヌカ油,サフラワー油,シアバター,大豆油,月見草油,シソ油,茶実油,ツバキ油,トウモロコシ油,ナタネ油,硬化ナタネ油,パーム核油,硬化パーム核油,パーム油,硬化パーム油,ピーナッツ油,硬化ピーナッツ油,ヒマシ油,硬化ヒマシ油,ヒマワリ油,ブドウ種子油,ホホバ油,硬化ホホバ油,マカデミアナッツ油,メドホーム油,綿実油,硬化綿実油,ヤシ油,硬化ヤシ油等の植物油およびその硬化油,ミツロウ,高酸価ミツロウ,ラノリン,還元ラノリン,硬化ラノリン,液状ラノリン,カルナバロウ,モンタンロウ等のロウ等が挙げられる。
シリコーン系の油相成分:ジメチルポリシロキサン,メチルフェニルポリシロキサン,メチルシクロポリシロキサン,オクタメチルポリシロキサン,デカメチルポリシロキサン,ドデカメチルシクロシロキサン,メチルハイドロジェンポリシロキサン,ボリエーテル変性オルガノポリシロキサン,ジメチルシロキサン・メチルセチルオキシシロキサン共重合体,ジメチルシロキサン・メチルステアロキシシロキサン共重合体,アルキル変性オルガノポリシロキサン,末端変性オルガノポリシロキサン,アミノ変性シリコーン油,アミノ変性オルガノポリシロキサン,ジメチコノール,シリコーンゲル,アクリルシリコーン,トリメチルシロキシケイ酸,シリコーンRTVゴム等が挙げられる。
フッ素系の油相成分:パーフルオロポリエーテル,フッ素変性オルガノポリシロキサン,フッ化ピッチ,フルオロカーボン,フルオロアルコール,フルオロアルキル・ポリオキシアルキレン共変性オルガノポリシロキサン等が挙げられる。
(2)高級アルコールの例
ラウリルアルコール,ミリスチルアルコール,セチルアルコール,ステアリルアルコール,イソステアリルアルコール,オレイルアルコール,ベヘニルアルコール,2−エチルヘキサノール,ヘキサデシルアルコール,オクチルドデカノール等が挙げられる。
(3)脂肪酸の例
カプリル酸,カプリン酸,ウンデシレン酸,ラウリン酸,ミリスチン酸,パルミチン酸,パルミトレイン酸,ステアリン酸,イソステアリン酸,オレイン酸,リノール酸,リノレン酸,アラキン酸,アラキドン酸,ベヘン酸,エルカ酸,2−エチルヘキサン酸等が挙げられる。
(4)紫外線吸収剤の例
パラアミノ安息香酸,パラアミノ安息香酸アミル,パラアミノ安息香酸エチルジヒドロキシプロピル,パラアミノ安息香酸グリセリル,パラアミノ安息香酸エチル,パラアミノ安息香酸オクチル,パラアミノ安息香酸オクチルジメチル,サリチル酸エチレングリコール,サリチル酸オクチル,サリチル酸トリエタノールアミン,サリチル酸フェニル,サリチル酸ブチルフェニル,サリチル酸ベンジル,サリチル酸ホモメンチル,ケイ皮酸ベンジル,パラメトキシケイ皮酸オクチル,パラメトキシケイ皮酸2−エチルヘキシル,ジパラメトキシケイ皮酸モノ2−エチルヘキサン酸グリセリル,パラメトキシケイ皮酸イソプロピル,パラメトキシヒドロケイ皮酸ジエタノールアミン塩,ジイソプロピル・ジイソプロ
ピルケイ皮酸エステル混合物,ウロカニン酸,ウロカニン酸エチル,ヒドロキシメトキシベンゾフェノン,ヒドロキシメトキシベンゾフェノンスルホン酸及びその塩,ジヒドロキシメトキシベンゾフェノン,ジヒドロキシメトキシベンゾフェノンジスルホン酸ナトリウム,ジヒドロキシベンゾフェノン,ジヒドロキシジメトキシベンゾフェノン,ヒドロキシオクトキシベンゾフェノン,テトラヒドロキシベンゾフェノン,ブチルメトキシジベンゾイルメタン,2,4,6−トリアニリノ−p−(カルボ−2−エチルヘキシル−1−オキシ)−1,3,5−トリアジン,2−(2−ヒドロキシ−5−メチルフェニル)ベンゾトリアゾール,メチル−O−アミノベンゾエート,2−エチルヘキシル−2−シアノ−3,3−ジフェニルアクリレート,フェニルベンゾイミダゾール硫酸,3−(4−メチルベンジリデン)カンフル,イソプロピルジベンゾイルメタン,4−(3,4−ジメトキシフェニルメチレン)−2,5−ジオキソ−1−イミダゾリジンプロピオン酸2−エチルヘキシル等,およびこれらの高分子誘導体やシラン誘導体等が挙げられる。
(5)粉体・顔料の例
赤色104号,赤色201号,黄色4号,青色1号,黒色401号等の色素,黄色4号ALレーキ,黄色203号BAレーキ等のレーキ色素,ナイロンパウダー,シルクパウダー,ウレタンパウダー,テフロン(登録商標)パウダー,シリコーンパウダー,ポリメタクリル酸メチルパウダー,セルロースパウダー,デンプン,シリコーンエラストマー球状粉体,ポリエチレン末等の高分子,黄酸化鉄,赤色酸化鉄,黒酸化鉄,酸化クロム,カーボンブラック,群青,紺青等の有色顔料,酸化亜鉛,酸化チタン,酸化セリウム等の白色顔料,タルク,マイカ,セリサイト,カオリン,板状硫酸バリウム等の体質顔料,雲母チタン等のパール顔料,硫酸バリウム,炭酸カルシウム,炭酸マグネシウム,珪酸アルミニウム,珪酸マグネシウム等の金属塩,シリカ,アルミナ等の無機粉体,ステアリン酸アルミニウム,ステアリン酸マグネシウム,パルミチン酸亜鉛,ミリスチン酸亜鉛,ミリスチン酸マグネシウム,ラウリン酸亜鉛,ウンデシレン酸亜鉛等の金属セッケン,ベントナイト,スメクタイト,窒化ホウ素等が挙げられる。これらの粉体の形状(球状,棒状,針状,板状,不定形状,燐片状,紡錘状等)および粒子径に特に制限はない。なおこれらの粉体は,従来公知の表面処理,例えばフッ素化合物処理,シリコーン処理,シリコーン樹脂処理,ペンダント処理,シランカップリング剤処理,チタンカップリング剤処理,油剤処理,N−アシル化リジン処理,ポリアクリル酸処理,金属セッケン処理,アミノ酸処理,レシチン処理,無機化合物処理,プラズマ処理,メカノケミカル処理等によって事前に表面処理されていてもいなくても構わない。
(6)界面活性剤の例
アニオン性界面活性剤:脂肪酸セッケン,α−アシルスルホン酸塩,アルキルスルホン酸塩,アルキルアリルスルホン酸塩,アルキルナフタレンスルホン酸塩,アルキル硫酸塩,POEアルキルエーテル硫酸塩,アルキルアミド硫酸塩,アルキルリン酸塩,POEアルキルリン酸塩,アルキルアミドリン酸塩,アルキロイルアルキルタウリン塩,N−アシルアミノ酸塩,POEアルキルエーテルカルボン酸塩,アルキルスルホコハク酸塩,アルキルスルホ酢酸ナトリウム,アシル化加水分解コラーゲンペプチド塩,パーフルオロアルキルリン酸エステル等が挙げられる。
カチオン性界面活性剤:塩化アルキルトリメチルアンモニウム,塩化ステアリルトリメチルアンモニウム,臭化ステアリルトリメチルアンモニウム,塩化セトステアリルトリメチルアンモニウム,塩化ジステアリルジメチルアンモニウム,塩化ステアリルジメチルベンジルアンモニウム,臭化ベヘニルトリメチルアンモニウム,塩化ベンザルコニウム,塩化ベヘニン酸アミドプロピルジメチルヒドロキシプロピルアンモニウム,ステアリン酸ジエチルアミノエチルアミド,ステアリン酸ジメチルアミノプロピルアミド,ラノリン誘導体第四級アンモニウム塩等が挙げられる。
両性界面活性剤:カルボキシベタイン型,アミドベタイン型,スルホベタイン型,ヒドロキシスルホベタイン型,アミドスルホベタイン型,ホスホベタイン型,アミノカルボン酸塩型,イミダゾリン誘導体型,アミドアミン型等が挙げられる。
ノニオン性界面活性剤:プロピレングリコール脂肪酸エステル,グリセリン脂肪酸エステ
ル,ポリグリセリン脂肪酸エステル,ソルビタン脂肪酸エステル,POEソルビタン脂肪酸エステル,POEソルビット脂肪酸エステル,POEグリセリン脂肪酸エステル,POEアルキルエーテル,POE脂肪酸エステル,POE硬化ヒマシ油,POEヒマシ油,POE・POP共重合体,POE・POPアルキルエーテル,ポリエーテル変性シリコーンラウリン酸アルカノールアミド,アルキルアミンオキシド,水素添加大豆リン脂質等が挙げられる。
天然系界面活性剤:レシチン,サポニン,糖系界面活性剤等が挙げられる。
(7)多価アルコール,糖の例
エチレングリコール,ジエチレングリコール,ポリエチレングリコール,プロピレングリコール,ジプロピレングリコール,ポリプロピレングリコール,グリセリン,ジグリセリン,ポリグリセリン,3−メチル−1,3−ブタンジオール,1,3−ブチレングリコール,ソルビトール,マンニトール,ラフィノース,エリスリトール,グルコース,ショ糖,果糖,キシリトール,ラクトース,マルトース,マルチトール,トレハロース,アルキル化トレハロース,混合異性化糖,硫酸化トレハロース,プルラン等が挙げられる。またこれらの化学修飾体等も使用可能である。
(8)高分子の例
アクリル酸エステル/メタクリル酸エステル共重合体(プラスサイズ,互応化学社製),酢酸ビニル/クロトン酸共重合体(レジン28−1310,NSC社製),酢酸ビニル/クロトン酸/ビニルネオデカネート共重合体(28−2930,NSC社製),メチルビニルエーテルマレイン酸ハーフエステル(ガントレッツES,ISP社製),T−ブチルアクリレート/アクリル酸エチル/メタクリル酸共重合体(ルビマー,BASF社製),ビニルピロリドン/ビニルアセテート/ビニルプロピオネート共重合体(ルビスコールVAP,BASF社製),ビニルアセテート/クロトン酸共重合体(ルビセットCA,BASF社製),ビニルアセテート/クロトン酸/ビニルピロリドン共重合体(ルビセットCAP,BASF社製),ビニルピロリドン/アクリレート共重合体(ルビフレックス,BASF社製),アクリレート/アクリルアミド共重合体(ウルトラホールド,BASF社製),ビニルアセテート/ブチルマレエート/イソボルニルアクリラート共重合体(アドバンテージ,ISP社製),カルボキシビニルポリマー(カーボポール,BFGoodrich社製),アクリル酸・メタクリル酸アルキル共重合体(ペミュレン,BF Goodrich社製)等のアニオン性高分子化合物や,ジアルキルアミノエチルメタクリレート重合体の酢酸両性化物(ユカフォーマー,三菱化学社製),アクリル酸オクチルアクリルアミド/アクリル酸ヒドロキシプロピル/メタクリル酸ブチルアミノエチル共重合体(AMPHOMER,NSC社製)等の両性高分子化合物,ビニルピロリドン/ジメチルアミノエチルメタクリレートの4級化物(GAFQUAT,ISP社製),メチルビニルイミダゾリウムクロリド/ビニルピロリドン共重合体(ルビコート,BASF社製)等のカチオン性高分子化合物,ポリビニルピロリドン(ルビスコールK,BASF社製),ビニルピロリドン/酢酸ビニル共重合体(ルビスコールVA,BASF社製),ビニルピロリドン/ジメチルアミノエチルメタクリレート共重合体(コポリマー937,ISP社製),ビニルカプロラクタム/ビニルピロリドン/ジメチルアミノエチルメタクリレート共重合体(コポリマーVC713,ISP社製)等のノニオン性高分子化合物等がある。また,セルロースまたはその誘導体,ケラチン及びコラーゲンまたはその誘導体,アルギン酸カルシウム,プルラン,寒天,ゼラチン,タマリンド種子多糖類,キサンタンガム,カラギーナン,ハイメトキシルペクチン,ローメトキシルペクチン,グアーガム,アラビアゴム,結晶セルロース,アラビノガラクタン,カラヤガム,トラガカントガム,アルギン酸,アルブミン,カゼイン,カードラン,ジェランガム,デキストラン等の天然由来高分子化合物も好適に用いることができる。
(9)生理活性成分の例
生理活性成分としては,皮膚に塗布した場合に皮膚に何らかの生理活性を与える物質が挙げられる。例えば,美白成分,抗炎症剤,老化防止剤,紫外線防御剤,スリミング剤,ひきしめ剤,抗酸化剤,発毛剤,育毛剤,保湿剤,血行促進剤,抗菌剤,殺菌剤,乾燥剤
,冷感剤,温感剤,ビタミン類,アミノ酸,創傷治癒促進剤,刺激緩和剤,鎮痛剤,細胞賦活剤,酵素成分等が挙げられる。これらの好適な配合成分の例としては,例えばアシタバエキス,アボカドエキス,アマチャエキス,アルテアエキス,アルニカエキス,アロエエキス,アンズエキス,アンズ核エキス,イチョウエキス,ウイキョウエキス,ウコンエキス,ウーロン茶エキス,エイジツエキス,エチナシ葉エキス,オウゴンエキス,オウバクエキス,オウレンエキス,オオムギエキス,オトギリソウエキス,オドリコソウエキス,オランダカラシエキス,オレンジエキス,海水乾燥物,海藻エキス,加水分解エラスチン,加水分解コムギ末,加水分解シルク,カモミラエキス,カロットエキス,カワラヨモギエキス,甘草エキス,カルカデエキス,カキョクエキス,キウイエキス,キナエキス,キューカンバ−エキス,グアノシン,クチナシエキス,クマザサエキス,クララエキス,クルミエキス,グレープフルーツエキス,クレマティスエキス,クロレラエキス,クワエキス,ゲンチアナエキス,紅茶エキス,酵母エキス,ゴボウエキス,コメヌカ発酵エキス,コメ胚芽油,コンフリーエキス,コラーゲン,コケモモエキス,サイシンエキス,サイコエキス,サイタイ抽出液,サルビアエキス,サボンソウエキス,ササエキス,サンザシエキス,サンショウエキス,シイタケエキス,ジオウエキス,シコンエキス,シソエキス,シナノキエキス,シモツケソウエキス,シャクヤクエキス,ショウブ根エキス,シラカバエキス,スギナエキス,セイヨウキズタエキス,セイヨウサンザシエキス,セイヨウニワトコエキス,セイヨウノコギリソウエキス,セイヨウハッカエキス,セージエキス,ゼニアオイエキス,センキュウエキス,センブリエキス,ダイズエキス,タイソウエキス,タイムエキス,茶エキス,チョウジエキス,チガヤエキス,チンピエキス,トウキエキス,トウキンセンカエキス,トウニンエキス,トウヒエキス,ドクダミエキス,トマトエキス,納豆エキス,ニンジンエキス,ニンニクエキス,ノバラエキス,ハイビスカスエキス,バクモンドウエキス,パセリエキス,蜂蜜,ハマメリスエキス,パリエタリアエキス,ヒキオコシエキス,ビサボロール,ビワエキス,フキタンポポエキス,フキノトウエキス,ブクリョウエキス,ブッチャーブルームエキス,ブドウエキス,プロポリス,ヘチマエキス,ベニバナエキス,ペパーミントエキス,ボダイジュエキス,ボタンエキス,ホップエキス,マツエキス,マロニエエキス,ミズバショウエキス,ムクロジエキス,メリッサエキス,モモエキス,ヤグルマギクエキス,ユーカリエキス,ユキノシタエキス,ヨクイニンエキス,ヨモギエキス,ラベンダーエキス,リンゴエキス,レタスエキス,レモンエキス,レンゲソウエキス,ローズエキス,ローズマリーエキス,ローマカミツレエキス,ローヤルゼリーエキス等を挙げることができる。
また,デオキシリボ核酸,ムコ多糖類,ヒアルロン酸ナトリウム,コンドロイチン硫酸ナトリウム,コラーゲン,エラスチン,キチン,キトサン,加水分解卵殻膜などの生体高分子,アミノ酸,加水分解ペプチド,乳酸ナトリウム,尿素,ピロリドンカルボン酸ナトリウム,ベタイン,ホエイ,トリメチルグリシンなどの保湿成分,スフィンゴ脂質,セラミド,フィトスフィンゴシン,コレステロール,コレステロール誘導体,リン脂質などの油性成分,ε−アミノカプロン酸,グリチルリチン酸,β−グリチルレチン酸,塩化リゾチーム,グアイアズレン,ヒドロコールチゾン等の抗炎症剤,ビタミンA,ビタミンB2,ビタミンB6,ビタミンC,ビタミンD,ビタミンE,パントテン酸カルシウム,ビオチン,ニコチン酸アミド,ビタミンCエステル等のビタミン類,アラントイン,ジイソプロピルアミンジクロロアセテート,4−アミノメチルシクロヘキサンカルボン酸等の活性成分,トコフェロール,カロチノイド,フラボノイド,タンニン,リグナン,サポニン等の抗酸化剤,α−ヒドロキシ酸,β−ヒドロキシ酸などの細胞賦活剤,γ−オリザノール,ビタミンE誘導体などの血行促進剤,レチノール,レチノール誘導体等の創傷治癒剤,アルブチン,コウジ酸,プラセンタエキス,イオウ,エラグ酸,リノール酸,トラネキサム酸,グルタチオン等の美白剤,セファランチン,カンゾウ抽出物,トウガラシチンキ,ヒノキチオール,ヨウ化ニンニクエキス,塩酸ピリドキシン,DL−α−トコフェロール,酢酸DL−α−トコフェロール,ニコチン酸,ニコチン酸誘導体,パントテン酸カルシウム,D−パントテニルアルコール,アセチルパントテニルエチルエーテル,ビオチン,アラントイン,イソプロピルメチルフェノール,エストラジオール,エチニルエストラジ
オール,塩化カプロニウム,塩化ベンザルコニウム,塩酸ジフェンヒドラミン,タカナール,カンフル,サリチル酸,ノニル酸バニリルアミド,ノナン酸バニリルアミド,ピロクトンオラミン,ペンタデカン酸グリセリル,L−メントール,モノニトログアヤコール,レゾルシン,γ−アミノ酪酸,塩化ベンゼトニウム,塩酸メキシレチン,オーキシン,女性ホルモン,カンタリスチンキ,シクロスポリン,ジンクピリチオン,ヒドロコールチゾン,ミノキシジル,モノステアリン酸ポリオキシエチレンソルビタン,ハッカ油,ササニシキエキス等の育毛剤などが挙げられる。
(10)酸化防止剤の例
亜硫酸水素ナトリウム,亜硫酸ナトリウム,エリソルビン酸,エリソルビン酸ナトリウム,チオジプロピオン酸ジラウリル,トコフェロール,トリルビグアナイド,ノルジヒドログアヤレチン酸,パラヒドロキシアニソール,ブチルヒドロキシアニソール,ジブチルヒドロキシトルエン,ステアリン酸アスコルビル,パルミチン酸アスコルビル,没食子酸オクチル,没食子酸プロピル,カロチノイド,フラボノイド,タンニン,リグナン,サポニン,リンゴエキスやチョウジエキスなどの酸化防止効果の認められる植物エキス等が挙げられる。
(11)溶媒の例
精製水,エタノール,低級アルコール,エーテル類,LPG,フルオロカーボン,N−メチルピロリドン,フルオロアルコール,揮発性直鎖状シリコーン,次世代フロン等が挙げられる。
In addition to the lipin1 gene expression-promoting agent according to the present invention, the above-mentioned form of the external preparation for skin is blended with external preparations for skin such as cosmetics and non-pharmaceutical products as long as the action of promoting the expression of the lipin1 gene expression-promoting agent is not impaired. Ingredients, oils, higher alcohols, fatty acids, UV absorbers, powders, pigments, surfactants, polyhydric alcohols / sugars, polymers, physiologically active ingredients, solvents, antioxidants, fragrances, preservatives, etc. Can be done.
Examples are listed below, but the present invention is not limited to these examples.
(1) Examples of oils Ester-based oil phase components: glyceryl tri2-ethylhexanoate, cetyl 2-ethylhexanoate, isopropyl myristate, butyl myristate, isopropyl palmitate, ethyl stearate, octyl palmitate, isostearic acid Isocetyl, butyl stearate, butyl myristate, ethyl linoleate, isopropyl linoleate, ethyl oleate, isosetyl myristate, isostearyl myristate, isostearyl palmitate, octyldodecyl myristate, isosetyl isostearate, diethyl sebacate, adipine Diisopropyl acid, isoaraquil neopentanoate, glyceryl tri (capryl capric acid), trimethylolpropane tri2-ethylhexanoate, trimethylrolpropane triisostearate, pentaerythritol tetra2-ethylhexanoate, cetyl caprylate, decyl laurate, Hexyl laurate, decyl myristate, myristyl myristate, cetyl myristate, stearyl stearate, decyl oleate, cetyl ricinoleate, isostearyl laurate, isotolideyl myristate, isosetyl myristate, isostearyl myristate, isosetyl palmitate, Isostearyl palmitate, octyl stearate, isosetyl stearate, isodecyl oleate, octyldodecyl oleate, octyldodecyl linoleate, isopropyl isostearate, cetostearyl 2-ethylhexanoate, stearyl 2-ethylhexarate, hexyl isostearate, Ethylene glycol dioctanoate, ethylene glycol diocaneate, propylene glycol dicaprate, propylene glycol di (caprylic capric acid), propylene glycol dicaprylate, neopentyl glycol dicaprate, neopentyl glycol dioctanoate, glyceryl tricaprylate, glyceryl triundecylate, Glyceryl triisopalmitate, glyceryl triisostearate, octyldodecyl neopentaneate, isostearyl octanoate, octyl isononanoate, hexyldecyl neodecanoate, octyldodecyl neodecanoate, isosetyl isostearate, isostearyl isostearate, octyldecyl isostearate, poly Glycerin oleic acid ester, polyglycerin isostearic acid ester, charcoal Dipropyl acid, dialkyl carbonate (C12-18), triisocetyl citrate, triisoaraquil citrate, triisooctyl citrate, lauryl lactate, myristyl lactate, cetyl lactate, octyldecyl lactate, triethyl citrate, acetyltriethyl citrate, citrate Acetyltributyl acid, trioctyl citrate, diisostearyl citrate, 2-ethylhexyl hydroxystearate, di2-ethylhexyl succinate, diisobutyl adipate, diisopropyl sebacate, dioctyl sevacinate, cholesteryl stearate, cholesteryl isostearate, hydroxysteare Examples thereof include cholesteryl acid, cholesteryl oleate, dihydrocholesteryl oleate, phytosteryl isostearate, phytosteryl oleate, isocetyl 12-stearoyl hydroxystearate, stearyl 12-stearoyl hydroxystearate, and isostearyl 12-stearoyl hydroxystearate.
Hydrocarbon-based oil phase components: squalane, liquid paraffin, α-olefin oligomer, isoparaffin, selecin, paraffin, liquid isoparaffin, polybutene, microcrystalline wax, petrolatum and the like.
Animal and vegetable oils and their hardened oils, and naturally occurring waxes: beef oils, hardened beef fats, pork fats, hardened pork fats, horse oils, hardened horse oils, mink oils, orange raffy oils, fish oils, hardened fish oils, egg yolk oils and other animal oils. Its hardened oil, avocado oil, almond oil, olive oil, cacao butter, apricot oil, kukui nut oil, sesame oil, wheat germ oil, rice germ oil, rice bran oil, safflower oil, shea butter, soybean oil, evening primrose oil, perilla oil, Tea seed oil, camellia oil, corn oil, rapeseed oil, hardened rapeseed oil, palm kernel oil, hardened palm kernel oil, palm oil, hardened palm oil, peanut oil, hardened peanut oil, sunflower oil, hardened sunflower oil, sunflower oil, Vegetable oils such as grape seed oil, jojoba oil, hardened jojoba oil, macadamia nut oil, medhome oil, cotton seed oil, hardened cotton seed oil, palm oil, hardened palm oil and their hardened oils, beeswax, high acidity beeswax, lanolin, reduced lanolin, hardened lanolin. , Liquid lanolin, carnauba wax, monttan wax and other waxes.
Silicone-based oil phase components: dimethylpolysiloxane, methylphenylpolysiloxane, methylcyclopolysiloxane, octamethylpolysiloxane, decamethylpolysiloxane, dodecamethylcyclosiloxane, methylhydrogenpolysiloxane, boroether-modified organopolysiloxane, dimethylsiloxane -Methylcetyloxysiloxane copolymer, dimethylsiloxane / methylstealoxysiloxane copolymer, alkyl-modified organopolysiloxane, terminal-modified organopolysiloxane, amino-modified silicone oil, amino-modified organopolysiloxane, dimethiconol, silicone gel, acrylic silicone , Siloxane siloxysilicic acid, silicone RTV rubber and the like.
Fluorine-based oil phase components: perfluoropolyether, fluorine-modified organopolysiloxane, fluoride pitch, fluorocarbon, fluoroalcohol, fluoroalkyl-polyoxyalkylene co-modified organopolysiloxane, and the like can be mentioned.
(2) Examples of higher alcohols Examples of higher alcohols include lauryl alcohol, myristyl alcohol, cetyl alcohol, stearyl alcohol, isostearyl alcohol, oleyl alcohol, behenyl alcohol, 2-ethylhexanol, hexadecyl alcohol, and octyldodecanol.
(3) Examples of fatty acids Caprylic acid, capric acid, undecylene acid, lauric acid, myristic acid, palmitic acid, palmitoleic acid, stearic acid, isostearic acid, oleic acid, linoleic acid, linolenic acid, arachidonic acid, arachidonic acid, behenic acid , Elcaic acid, 2-ethylhexanoic acid and the like.
(4) Examples of UV absorbers Paraaminobenzoic acid, amyl paraaminobenzoate, ethyldihydroxypropyl paraaminobenzoate, glyceryl paraaminobenzoate, ethyl paraaminobenzoate, octyl paraaminobenzoate, octyldimethyl paraaminobenzoate, ethylene glycol salicylate, salicylate Octyl, triethanolamine salicylate, phenyl salicylate, butylphenyl salicylate, benzyl salicylate, homomentyl salicylate, benzyl silicate, octyl paramethoxysylate, 2-ethylhexyl paramethoxysylate, mono2-diparamethoxysylate Glyceryl ethylhexanate, isopropyl paramethoxycinnamate, diethanolamine paramethoxyhydrosilicate diethanolamine, diisopropyl / diisopropylsilicate ester mixture, urocanic acid, ethyl urocanate, hydroxymethoxybenzophenone, hydroxymethoxybenzophenone sulfonic acid and its salts, Dihydroxymethoxybenzophenone, dihydroxymethoxybenzophenone sodium disulfonate, dihydroxybenzophenone, dihydroxydimethoxybenzophenone, hydroxyoctoxybenzophenone, tetrahydroxybenzophenone, butylmethoxydibenzoylmethane, 2,4,6-trianilinolino-p- (carbo-2-ethylhexyl-) 1-oxy) -1,3,5-triazine, 2- (2-hydroxy-5-methylphenyl) benzotriazole, methyl-O-aminobenzoate, 2-ethylhexyl-2-cyano-3,3-diphenylacrylate, Phenylbenzoimidazole sulfate, 3- (4-methylbenzylidene) camphor, isopropyldibenzoylmethane, 4- (3,4-dimethoxyphenylmethylene) -2,5-dioxo-1-imidazolidine propionate 2-ethylhexyl, etc., and Examples thereof include these polymer derivatives and silane derivatives.
(5) Examples of powders and pigments Red No. 104, Red No. 201, Yellow No. 4, Blue No. 1, Black No. 401, etc., Yellow No. 4 AL Lake, Yellow No. 203 BA Lake, etc., Nylon powder , Silk powder, urethane powder, Teflon (registered trademark) powder, silicone powder, polymethyl methacrylate powder, cellulose powder, starch, silicone elastomer spherical powder, polymers such as polyethylene powder, yellow iron oxide, red iron oxide, black Colored pigments such as iron oxide, chromium oxide, carbon black, ultramarine blue and dark blue, white pigments such as zinc oxide, titanium oxide and cerium oxide, extender pigments such as talc, mica, sericite, kaolin and barium plate sulfate, mica titanium Pearl pigments such as barium sulfate, calcium carbonate, magnesium carbonate, aluminum silicate, metal salts such as magnesium silicate, inorganic powders such as silica and alumina, aluminum stearate, magnesium stearate, zinc palmitate, zinc myristine, myristin. Examples thereof include metal pigments such as magnesium acid, zinc laurate, and zinc undecylene, bentonite, smectite, and boron nitride. There are no particular restrictions on the shape (spherical, rod-shaped, needle-shaped, plate-shaped, indefinite-shaped, flaky, spindle-shaped, etc.) and particle size of these powders. These powders are treated with conventionally known surface treatments such as fluorine compound treatment, silicone treatment, silicone resin treatment, pendant treatment, silane coupling agent treatment, titanium coupling agent treatment, oil agent treatment, N-acylated lysine treatment, and so on. It may or may not be surface-treated in advance by polyacrylic acid treatment, metal silane treatment, amino acid treatment, lecithin treatment, inorganic compound treatment, plasma treatment, mechanochemical treatment, or the like.
(6) Examples of surfactants Anionic surfactants: fatty acid sulphate, α-acyl sulfonate, alkyl sulfonate, alkyl allyl sulfonate, alkylnaphthalene sulfonate, alkyl sulfate, POE alkyl ether sulfate , Alkylamide Sulfate, Alkyl Phosphate, POE Alkyl Phosphate, Alkylamide Phosphate, Alkyril Alkyl Taurine Salt, N-Acyl Amino Acid Salt, POE Alkyl Ether Carbate, Alkyl Sulfosuccinate, Alkyl Sulfoacetate Examples thereof include sodium, acylated hydrolyzed collagen peptide salt, and perfluoroalkyl phosphate ester.
Cationic surfactants: alkyltrimethylammonium chloride, stearyltrimethylammonium chloride, stearyltrimethylammonium bromide, cetostearyltrimethylammonium chloride, distearyldimethylammonium chloride, stearyldimethylbenzylammonium chloride, behenyltrimethylammonium bromide, benzalconium chloride , Behenic acid amidopropyldimethylhydroxypropylammonium chloride, diethylaminoethylamide stearate, dimethylaminopropylamide stearate, quaternary ammonium salt of lanolin derivative and the like.
Amphoteric tensides: carboxybetaine type, amide betaine type, sulfobetaine type, hydroxysulfobetaine type, amide sulfobetaine type, phosphobetaine type, aminocarboxylate type, imidazoline derivative type, amidoamine type and the like.
Nonionic surfactants: propylene glycol fatty acid ester, glycerin fatty acid ester, polyglycerin fatty acid ester, sorbitan fatty acid ester, POE sorbitan fatty acid ester, POE sorbit fatty acid ester, POE glycerin fatty acid ester, POE alkyl ether, POE fatty acid ester, POE hardened sunflower Examples thereof include oil, POE castor oil, POE / POP copolymer, POE / POP alkyl ether, polyether-modified silicone lauric acid alkanolamide, alkylamine oxide, hydrogenated soybean phospholipid and the like.
Natural surfactants: Lecithin, saponin, sugar-based surfactants and the like can be mentioned.
(7) Examples of polyhydric alcohols and sugars Ethylene glycol, diethylene glycol, polyethylene glycol, propylene glycol, dipropylene glycol, polypropylene glycol, glycerin, diglycerin, polyglycerin, 3-methyl-1,3-butanediol, 1,3 -Butylene glycol, sorbitol, mannitol, raffinose, erythritol, glucose, sucrose, fructose, xylitol, lactose, maltose, martitol, trehalose, alkylated trehalose, mixed isomerized sugar, sulfated trehalose, purulan and the like. Further, these chemically modified products and the like can also be used.
(8) Examples of polymers Acrylic acid ester / methacrylic acid ester copolymer (plus size, manufactured by Reciprocal Chemical Co., Ltd.), vinyl acetate / crotonic acid copolymer (resin 28-1310, manufactured by NSC), vinyl acetate / croton Acid / vinyl neodecaneate copolymer (28-2930, manufactured by NSC), methyl vinyl ether maleic acid half ester (Gantrez ES, manufactured by ISP), T-butyl acrylate / ethyl acrylate / methacrylic acid copolymer (rubimer) , BASF), Vinylpyrrolidone / Vinylacetate / Vinylpropionate copolymer (Rubiscol VAP, BASF), Vinylacetate / Crotonic acid copolymer (Rubiset CA, BASF), Vinylacetate / Croton Acid / vinylpyrrolidone copolymer (Rubiset CAP, manufactured by BASF), vinylpyrrolidone / acrylate copolymer (Rubiflex, manufactured by BASF), acrylate / acrylamide copolymer (Ultrahold, manufactured by BASF), vinyl acetate / Butylmalate / isobornylacryllate copolymer (Advantage, manufactured by ISP), carboxyvinyl polymer (Carbopol, manufactured by BFGoodrich), acrylic acid / alkyl methacrylate copolymer (Pemuren, manufactured by BFGoodrich), etc. Anionic polymer compounds, dialkylaminoethyl methacrylate polymer acetate amphoteric (Yukaformer, manufactured by Mitsubishi Chemical Corporation), octylacrylamide acrylate / hydroxypropyl acrylate / butylaminoethyl methacrylate copolymer (AMPHOMER, NSC) (Manufactured by) and other amphoteric polymer compounds, vinylpyrrolidone / dimethylaminoethyl methacrylate quaternized product (GAFQUAT, manufactured by ISP), methylvinylimidazolium chloride / vinylpyrrolidone copolymer (manufactured by Rubicoat, manufactured by BASF), etc. Polymer compound, polyvinylpyrrolidone (rubicol K, manufactured by BASF), vinylpyrrolidone / vinyl acetate copolymer (rubiscol VA, manufactured by BASF), vinylpyrrolidone / dimethylaminoethyl methacrylate copolymer (copolymer 937, manufactured by ISP) , Vinyl caprolactam / vinylpyrrolidone / dimethylaminoethyl methacrylate copolymer (copolymer VC713, manufactured by ISP) and other nonionic polymer compounds. In addition, cellulose or its derivatives, keratin and collagen or its derivatives, calcium alginate, pullulan, agar, gelatin, tamarind seed polysaccharide, xanthan gum, carrageenan, high methoxyl pectin, low methoxyl pectin, guar gum, gum arabic, crystalline cellulose, arabino Naturally-derived high molecular compounds such as galactan, carrageenan, tragacant gum, alginic acid, albumin, casein, curdlan, gellan gum, and dextran can also be preferably used.
(9) Examples of physiologically active ingredients Examples of the physiologically active ingredients include substances that give some physiological activity to the skin when applied to the skin. For example, whitening ingredients, anti-inflammatory agents, anti-aging agents, UV protection agents, slimming agents, tightening agents, antioxidants, hair growth agents, hair growth agents, moisturizers, blood circulation promoters, antibacterial agents, bactericides, desiccants, Examples include cooling sensation agents, warming sensitizers, vitamins, amino acids, wound healing promoters, stimulant relievers, analgesics, cell activators, and enzyme components. Examples of these suitable compounding ingredients include, for example, Ashitaba extract, Avocado extract, Amacha extract, Artea extract, Arnica extract, Aloe extract, Anzu extract, Anzu nucleus extract, Ginkgo extract, Ukyo extract, Ukon extract, Oolong tea extract, Agetsu. Extract, Echinashi leaf extract, Ogon extract, Oubaku extract, Ouren extract, Omugi extract, Otogirisou extract, Odorikosou extract, Dutch mustard extract, Orange extract, Dried seawater, Seaweed extract, Hydrolyzed elastin, Hydrolyzed wheat powder, Hydrolyzed silk , Chamomile extract, carrot extract, kawarayomogi extract, licorice extract, calcade extract, kakyoku extract, kiwi extract, kina extract, cucumber extract, guanosine, cutinashi extract, kumazasa extract, clara extract, walnut extract, grapefruit extract, clematis extract, chlorella extract , Kwa extract, Gentiana extract, Tea extract, Yeast extract, Gobo extract, Rice bran extract, Rice germ oil, Comfrey extract, Collagen, Kokemomo extract, Saishin extract, Psycho extract, Saitai extract, Salvia extract, Sabonsou extract, Sasa extract , Sanzashi extract, Sansho extract, Shiitake extract, Jio extract, Shikon extract, Shiso extract, Shinanoki extract, Shimotsukesou extract, Shakuyaku extract, Shobu root extract, Shirakaba extract, Sugina extract, Seiyoukizuta extract, Seiyousanzashi extract, Seiyouniwatoko extract, Seiyounokogiri Extract, Seiyouhakka extract, Sage extract, Zeniaoi extract, Senkyu extract, Senburi extract, Soybean extract, Taisou extract, Thyme extract, Tea extract, Chouji extract, Chigaya extract, Chinpi extract, Touki extract, Tokinsenka extract, Tounin extract, Tohi extract, Dokudami extract , Tomato extract, Natto extract, Carrot extract, Garlic extract, Novara extract, Hibiscus extract, Bakumondou extract, Parsley extract, Honey, Hamamelis extract, Parietaria extract, Hikiokoshi extract, Bisaborol, Biwa extract, Fukitanpopo extract, Fukinotou extract, Bukuryo extract , Butcher Bloom Extract, Grape Extract, Propolis, Hechima Extract, Benibana Extract, Peppermint Extract, Bodaiju Extract, Button Extract, Hop Extract, Pine Extract, Maronie Eki Su, Mizubasho extract, Mukuroji extract, Melissa extract, Peach extract, Yagurumagiku extract, Eucalyptus extract, Yukinoshita extract, Yokuinin extract, Yomogi extract, Lavender extract, Apple extract, Lettuce extract, Lemon extract, Rengesou extract, Rose extract, Rosemary extract, Examples include Roman chamomile extract and royal jelly extract.
In addition, biopolymers such as deoxyribonucleic acid, mucopolysaccharide, sodium hyaluronate, sodium chondroitin sulfate, collagen, elastin, chitin, chitosan, hydrolyzed eggshell membrane, amino acids, hydrolyzed peptides, sodium lactate, urea, sodium pyrrolidone carboxylate. , Moisturizing ingredients such as betaine, whey, trimethylglycine, oily ingredients such as sphingolipid, ceramide, phytosphingosin, cholesterol, cholesterol derivative, phospholipid, ε-aminocaproic acid, glycyrrhizinic acid, β-glycyrrhetinic acid, lysoteam chloride, guaiazulene, Anti-inflammatory agents such as hydrocortisone, vitamins such as vitamin A, vitamin B2, vitamin B6, vitamin C, vitamin D, vitamin E, calcium pantothenate, biotin, nicotinic acid amide, vitamin C ester, allantin, diisopropylamine dichloro Active ingredients such as acetate, 4-aminomethylcyclohexanecarboxylic acid, antioxidants such as tocopherol, carotinoid, flavonoid, tannin, lignan, saponin, cell activator such as α-hydroxy acid, β-hydroxy acid, γ-orizanol, Blood circulation promoters such as vitamin E derivatives, wound healing agents such as retinol and retinol derivatives, whitening agents such as arbutine, kodiic acid, placenta extract, sulfur, ellagic acid, linoleic acid, tranexamic acid, glutathione, cepharanthin, can elephant extract, Togarashi tinki, hinokithiol, garlic iodide extract, pyridoxin hydrochloride, DL-α-tocopherol, DL-α-tocopherol acetate, nicotinic acid, nicotinic acid derivative, calcium pantothenate, D-pantothenyl alcohol, acetylpantothenyl ethyl ether, biotin , Allantin, isopropylmethylphenol, estradiol, ethynyl estradiol, capronium chloride, benzalkonium chloride, diphenhydramine hydrochloride, takanal, camphor, salicylic acid, nonyl acid vanillylamide, nonanoic acid vanillylamide, pyrocton olamine, glyceryl pentadecanoate, L-menthol, Mononitroguayacol, resorcin, γ-aminobutyric acid, benzethonium chloride, mexiretin hydrochloride, auxin, female hormone, cantalistinki, cyclosporin, zincpyrythion, hydrocortisone, minoxidil, polyoxyethylene sorbitan monostearate, peppermint oil, sasanishi Hair growth agents such as key extract can be mentioned.
(10) Examples of antioxidants Sodium hydrogen sulfite, sodium sulfite, erythorbic acid, sodium erythorbate, dilauryl thiodipropionate, tocopherol, tolylbiguanide, nordihydroguayaletinic acid, parahydroxyanisole, butylhydroxyanisole, dibutylhydroxy Examples thereof include plant extracts having an antioxidant effect such as toluene, ascorbyl stearate, ascorbyl palmitate, octyl gallate, propyl gallate, carotinoid, flavonoid, tannin, lignan, saponin, apple extract and chowdi extract.
(11) Examples of solvents Purified water, ethanol, lower alcohols, ethers, LPG, fluorocarbons, N-methylpyrrolidone, fluoroalcohols, volatile linear silicones, next-generation chlorofluorocarbons and the like can be mentioned.
以下,本発明の実施例を説明する。なお,以下に示す実施例は,本発明によって得られる組成物のlipin1遺伝子発現促進作用等の確認をするために説明するもので,本発明の範囲は,これらの製品および製法に限定されるものではない。 Hereinafter, examples of the present invention will be described. The examples shown below are for confirming the lipin1 gene expression promoting action of the composition obtained by the present invention, and the scope of the present invention is limited to these products and manufacturing methods. is not it.
試験例:カカオ抽出物における副睾丸脂肪と肝臓重量低下作用,並びにlipin1遺伝子発現促進作用の評価
マウス(ddY, 雄, 5週齡, 日本クレア社)を4日間予備飼育した後,通常食(MF, オリエンタル酵母社,図1において「Normal」とする)または高脂肪食(HFD32, 日本クレア,図1において「Control」とする)を10日間自由摂取させた。カカオ抽出物は,100 mg/kgで1日1回経口投与した。飼育期間中,体重を経時的に測定したその結果を図1に示す。また,最終日に脂肪重量および肝臓重量を測定した。その結果を下記表1に示す。また,肝臓からRNAを抽出し,lipin1のmRNA発現をリアルタイムRT-PCRで調べた。その結果を表2に示す。尚、本試験例ではカカオ抽出物として「カカオエキス-P(オリザ油化株式会社製)」を使用した。
Test example: Evaluation of accessory testicular fat and liver weight-reducing effect and lipin1 gene expression-promoting effect in cacao extract After pre-breeding mice (ddY, male, 5 weeks old, Japan Claire) for 4 days, normal diet (MF) , Oriental Yeast Co., Ltd., "Normal" in Fig. 1) or high-fat diet (HFD32, Japan Claire, "Control" in Fig. 1) was allowed to be freely ingested for 10 days. The cacao extract was orally administered at 100 mg / kg once daily. Figure 1 shows the results of measuring the body weight over time during the breeding period. In addition, fat weight and liver weight were measured on the final day. The results are shown in Table 1 below. In addition, RNA was extracted from the liver, and the mRNA expression of lipin1 was examined by real-time RT-PCR. The results are shown in Table 2. In this test example, "cacao extract-P (manufactured by Oriza Yuka Co., Ltd.)" was used as the cacao extract.
結果及び実施例の効果
図1に示されるように,カカオ抽出物(カカオエキス-P)の投与により,体重増加の抑制が認められた。これにより,カカオ抽出物には高脂肪食飼育マウスにおける体重増加抑制作用を有することが確認された。
また,表1に示されるように,カカオエキス-Pの投与により,副睾丸脂肪と肝臓重量の低下が認められた。これにより,カカオ抽出物には,内臓脂肪の蓄積抑制作用を有することが確認された。
さらに,表2に示されるように,カカオエキス-Pの投与により,lipin1遺伝子の発現の増加が認められた。これにより,カカオ抽出物にはlipin1遺伝子発現促進剤として有用であることが確認された。
Results and Effects of Examples As shown in Fig. 1, administration of cacao extract (cacao extract-P) suppressed body weight gain. From this, it was confirmed that the cacao extract has an inhibitory effect on weight gain in high-fat diet-fed mice.
In addition, as shown in Table 1, administration of cacao extract-P reduced accessory testicular fat and liver weight. From this, it was confirmed that the cacao extract has an action of suppressing the accumulation of visceral fat.
Furthermore, as shown in Table 2, administration of cacao extract-P increased the expression of the lipin1 gene. From this, it was confirmed that the cacao extract is useful as a lipin1 gene expression promoter.
本発明によるlipin1遺伝子発現促進剤(カカオ抽出物)の配合例を示す。
配合例1:チューインガム
砂糖 53.0wt%
ガムベース 20.0
グルコース 10.0
水飴 16.0
香料 0.5
カカオ抽出物 0.5
100.0wt%
A compounding example of the lipin1 gene expression promoter (cacao extract) according to the present invention is shown.
Formulation Example 1: Chewing gum sugar 53.0 wt%
Gum base 20.0
Glucose 10.0
Syrup 16.0
Fragrance 0.5
Cacao extract 0.5
100.0 wt%
配合例2:グミ
還元水飴 40.0wt%
グラニュー糖 20.0
ブドウ糖 20.0
ゼラチン 4.7
水 9.68
ウメ果汁 4.0
ウメフレーバー 0.6
色素 0.02
カカオ抽出物 1.0
100.0wt%
Formulation example 2: Gummy reduced starch syrup 40.0 wt%
Granulated sugar 20.0
Glucose 20.0
Gelatin 4.7
Water 9.68
Plum juice 4.0
Plum flavor 0.6
Dye 0.02
Cacao extract 1.0
100.0 wt%
配合例3:キャンディー
砂糖 50.0wt%
水飴 33.0
水 14.4
有機酸 2.0
香料 0.2
カカオ抽出物 0.4
100.0wt%
Formulation example 3: Candy sugar 50.0 wt%
Syrup 33.0
Water 14.4
Organic acid 2.0
Fragrance 0.2
Cacao extract 0.4
100.0 wt%
配合例4:錠菓
砂糖 76.4wt%
グルコース 19.0
ショ糖脂肪酸エステル 0.2
カカオ抽出物 0.5
精製水 3.9
100.0wt%
Formulation example 4: Tablet sugar 76.4 wt%
Glucose 19.0
Sucrose fatty acid ester 0.2
Cacao extract 0.5
Purified water 3.9
100.0 wt%
配合例5:ヨーグルト(ハード・ソフト)
牛乳 41.5wt%
脱脂粉乳 5.8
砂糖 8.0
寒天 0.15
ゼラチン 0.1
乳酸菌 0.005
カカオ抽出物 0.4
香料 微量
水 残余
100.0wt%
Formulation example 5: Yogurt (hard / soft)
Milk 41.5 wt%
Skim milk powder 5.8
Sugar 8.0
Agar 0.15
Gelatin 0.1
Lactic acid bacteria 0.005
Cacao extract 0.4
Fragrance trace amount
Water residue
100.0 wt%
配合例6:コーヒー飲料(液状)
焙煎コーヒー豆 6.0wt%
砂糖 6.0
重曹 0.2
乳化剤 0.15
カカオ抽出物 1.0
水 残余
100.0wt%
Formulation example 6: Coffee beverage (liquid)
Roasted coffee beans 6.0 wt%
Sugar 6.0
Baking soda 0.2
Emulsifier 0.15
Cacao extract 1.0
Water residue
100.0 wt%
配合例7:コーヒー飲料(粉末)
インスタントコーヒー 90.0wt%
脱脂乳 7.0
カカオ抽出物 3.0
100.0wt%
Formulation example 7: Coffee beverage (powder)
Instant coffee 90.0 wt%
Skim milk 7.0
Cacao extract 3.0
100.0 wt%
配合例8:清涼飲料
果糖ブドウ糖液糖 30.0wt%
乳化剤 0.5
カカオ抽出物 0.3
香料 適量
精製水 残余
100.0wt%
Formulation Example 8: Soft drink Fructose Glucose Liquid sugar 30.0 wt%
Emulsifier 0.5
Cacao extract 0.3
Appropriate amount of fragrance
Purified water residue
100.0 wt%
配合例9:ソフトカプセル
玄米胚芽油 87.0wt%
乳化剤 12.0
カカオ抽出物 1.0
100.0wt%
Formulation example 9: Soft capsule brown rice germ oil 87.0 wt%
Emulsifier 12.0
Cacao extract 1.0
100.0 wt%
配合例10:錠剤
乳糖 54.0wt%
結晶セルロース 30.0
澱粉分解物 10.0
グリセリン脂肪酸エステル 5.0
カカオ抽出物 1.0
100.0wt%
Formulation example 10: Tablet lactose 54.0 wt%
Crystalline cellulose 30.0
Starch decomposition product 10.0
Glycerin fatty acid ester 5.0
Cacao extract 1.0
100.0 wt%
配合例11:化粧クリーム
スクワラン 20.0wt%
ミツロウ 5.0
精製ホホバ油 5.0
グリセリン 5.0
グリセリンモノステアレート 2.0
ポリオキシエチレン(20)ソルビタン・
モノステアレート 2.0
カカオ抽出物 2.0
防腐剤 適量
香料 適量
精製水 残余
100.0wt%
Formulation example 11: Cosmetic cream squalane 20.0 wt%
Beeswax 5.0
Refined jojoba oil 5.0
Glycerin 5.0
Glycerin monostearate 2.0
Polyoxyethylene (20) sorbitan
Monostearate 2.0
Cacao extract 2.0
Preservatives Appropriate amount Fragrances Appropriate amount
Purified water residue
100.0 wt%
配合例12:化粧水
エタノール 5.0wt%
グリセリン 2.0
1,3−ブチレングリコール 2.0
ポリエチレンオレイルエーテル 0.5
クエン酸ナトリウム 0.1
クエン酸 0.1
カカオ抽出物 0.1
精製水 残余
100.0wt%
Formulation example 12: Toner ethanol 5.0 wt%
Glycerin 2.0
1,3-butylene glycol 2.0
Polyethylene oleyl ether 0.5
Sodium citrate 0.1
Citric acid 0.1
Cacao extract 0.1
Purified water residue
100.0 wt%
配合例13:ボディージェル
マカデミアナッツ油 2.0wt%
ミリスチン酸オクチルドデシル 10.0
メチルフェニルポリシロキサン 5.0
ベヘニルアルコール 3.0
ステアリン酸 3.0
バチルアルコール 1.0
モノステアリン酸グリセリル 1.0
テトラオレイン酸ポリオキシエチレンソルビット 2.0
水素添加大豆リン脂質 1.0
セラミド 0.1
パルミチン酸レチノール 0.1
防腐剤 適量
ツボクサエキス 1.0
カカオ抽出物 1.0
1,3−ブチレングリコール 5.0
精製水 残余
100.0wt%
Formulation example 13: Body gel macadamia nut oil 2.0 wt%
Octyldodecyl myristate 10.0
Methylphenyl polysiloxane 5.0
Behenyl alcohol 3.0
Stearic acid 3.0
Bacil alcohol 1.0
Glyceryl monostearate 1.0
Polyoxyethylene sorbitol tetraoleate 2.0
Hydrogenated soybean phospholipid 1.0
Ceramide 0.1
Retinol palmitate 0.1
Preservatives Appropriate amount of Centella asiatica extract 1.0
Cacao extract 1.0
1,3-butylene glycol 5.0
Purified water residue
100.0 wt%
配合例14:乳液
スクワラン 4.0wt%
ワセリン 2.5
セタノール 2.0
グリセリン 2.0
親油型モノステアリン酸グリセリン 1.0
ステアリン酸 1.0
L−アルギニン 1.0
カカオ抽出物 0.5
水酸化カリウム 0.1
香料 微量
精製水 残余
100.0wt%
Formulation example 14: Emulsion squalane 4.0 wt%
Vaseline 2.5
Cetanol 2.0
Glycerin 2.0
Lipophilic glycerin monostearate 1.0
Stearic acid 1.0
L-Arginine 1.0
Cacao extract 0.5
Potassium hydroxide 0.1
Fragrance trace amount
Purified water residue
100.0 wt%
配合例15:浴用剤(液状)
プロピレングリコール 50.0wt%
エタノール 20.0
硫酸ナトリウム 5.0
カカオ抽出物 0.5
ラノリン 0.5
アボガド油 0.5
色素 1.5
香料 22.0
100.0wt%
Formulation example 15: Bathing agent (liquid)
Propylene glycol 50.0 wt%
Ethanol 20.0
Sodium sulfate 5.0
Cacao extract 0.5
Lanolin 0.5
Avocado oil 0.5
Pigment 1.5
Fragrance 22.0
100.0 wt%
以上説明したように,本発明は,新規なlipin1遺伝子発現促進剤を提供することができ,これにより,脂肪蓄積抑制剤,体重抑制剤として有用である。
As described above, the present invention can provide a novel lipin1 gene expression promoter, which is useful as a fat accumulation inhibitor and a weight inhibitor.
Claims (3)
A visceral fat accumulation inhibitor containing either one of claims 1 and 2 as an active ingredient.
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Citations (4)
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JP2006265219A (en) * | 2005-03-23 | 2006-10-05 | Oriza Yuka Kk | Diet composition |
JP2009508850A (en) * | 2005-09-16 | 2009-03-05 | 株式會社アモーレパシフィック | Moisturizing skin external preparation composition containing gallocatechin gallate as an active ingredient |
US20140079836A1 (en) * | 2008-12-01 | 2014-03-20 | LifeSpan Extension, LLC | Methods and compositions for altering health, wellbeing, and lifespan |
WO2016060259A1 (en) * | 2014-10-17 | 2016-04-21 | 株式会社明治 | Polyphenol-containing functional oral composition |
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JP2006265219A (en) * | 2005-03-23 | 2006-10-05 | Oriza Yuka Kk | Diet composition |
JP2009508850A (en) * | 2005-09-16 | 2009-03-05 | 株式會社アモーレパシフィック | Moisturizing skin external preparation composition containing gallocatechin gallate as an active ingredient |
US20140079836A1 (en) * | 2008-12-01 | 2014-03-20 | LifeSpan Extension, LLC | Methods and compositions for altering health, wellbeing, and lifespan |
WO2016060259A1 (en) * | 2014-10-17 | 2016-04-21 | 株式会社明治 | Polyphenol-containing functional oral composition |
Non-Patent Citations (1)
Title |
---|
石本憲司: "脂質代謝におけるLipin1", THE PHARMACEUTICAL SOCIETY OF JAPAN, vol. 131(8), JPN6023032455, 30 March 2011 (2011-03-30), pages 1189 - 1194, ISSN: 0005130875 * |
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