JP2021019626A5 - - Google Patents
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- Publication number
- JP2021019626A5 JP2021019626A5 JP2020177784A JP2020177784A JP2021019626A5 JP 2021019626 A5 JP2021019626 A5 JP 2021019626A5 JP 2020177784 A JP2020177784 A JP 2020177784A JP 2020177784 A JP2020177784 A JP 2020177784A JP 2021019626 A5 JP2021019626 A5 JP 2021019626A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- variable domain
- domain
- antibody
- polypeptide molecule
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229920001184 polypeptide Polymers 0.000 claims 38
- 102000004965 antibodies Human genes 0.000 claims 21
- 108090001123 antibodies Proteins 0.000 claims 21
- 210000004027 cells Anatomy 0.000 claims 13
- 230000035772 mutation Effects 0.000 claims 8
- 150000007523 nucleic acids Chemical class 0.000 claims 4
- 108020004707 nucleic acids Proteins 0.000 claims 4
- 230000001743 silencing Effects 0.000 claims 3
- 125000003275 alpha amino acid group Chemical group 0.000 claims 2
- 239000000427 antigen Substances 0.000 claims 2
- 108091007172 antigens Proteins 0.000 claims 2
- 102000038129 antigens Human genes 0.000 claims 2
- 230000015572 biosynthetic process Effects 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 238000005755 formation reaction Methods 0.000 claims 2
- 239000000833 heterodimer Substances 0.000 claims 2
- 210000002865 immune cell Anatomy 0.000 claims 2
- 230000035800 maturation Effects 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 108060000228 ADRM1 Proteins 0.000 claims 1
- 102100005861 CCR3 Human genes 0.000 claims 1
- 101700070842 CCR3 Proteins 0.000 claims 1
- 101700027514 CD14 Proteins 0.000 claims 1
- 102100003268 CD14 Human genes 0.000 claims 1
- 102100009326 CD163 Human genes 0.000 claims 1
- 108010009992 CD163 antigen Proteins 0.000 claims 1
- 102100000189 CD22 Human genes 0.000 claims 1
- 101700020617 CD22 Proteins 0.000 claims 1
- 102100019461 CD28 Human genes 0.000 claims 1
- 101700033362 CD28 Proteins 0.000 claims 1
- 102100016493 CD33 Human genes 0.000 claims 1
- 101700017647 CD33 Proteins 0.000 claims 1
- 102100013077 CD4 Human genes 0.000 claims 1
- 101700022938 CD4 Proteins 0.000 claims 1
- -1 CD41b Proteins 0.000 claims 1
- 101700078950 CD44 Proteins 0.000 claims 1
- 102100003735 CD44 Human genes 0.000 claims 1
- 102100013391 CD55 Human genes 0.000 claims 1
- 101710006195 CD55 Proteins 0.000 claims 1
- 102100005833 CD68 Human genes 0.000 claims 1
- 102100019453 CD7 Human genes 0.000 claims 1
- 101700063101 CD7 Proteins 0.000 claims 1
- 102100008191 CD8A Human genes 0.000 claims 1
- 101700054655 CD8A Proteins 0.000 claims 1
- 102100005310 CTLA4 Human genes 0.000 claims 1
- 101700054183 CTLA4 Proteins 0.000 claims 1
- 102100016622 ENPP3 Human genes 0.000 claims 1
- 101700054532 ENPP3 Proteins 0.000 claims 1
- 102100015540 FCGR1A Human genes 0.000 claims 1
- 101710003440 FCGR1A Proteins 0.000 claims 1
- 102100015541 FCGR3A Human genes 0.000 claims 1
- 101710044656 FCGR3A Proteins 0.000 claims 1
- 101710044657 FCGR3B Proteins 0.000 claims 1
- 102100003517 GP1BA Human genes 0.000 claims 1
- 101700034668 GP1BA Proteins 0.000 claims 1
- 102100004438 GP9 Human genes 0.000 claims 1
- 101700055186 GP9 Proteins 0.000 claims 1
- 102100018914 GYPA Human genes 0.000 claims 1
- 101710042158 GYPA Proteins 0.000 claims 1
- 102000006354 HLA-DR Antigens Human genes 0.000 claims 1
- 108010058597 HLA-DR Antigens Proteins 0.000 claims 1
- 102100014734 ICOS Human genes 0.000 claims 1
- 101700078331 ICOS Proteins 0.000 claims 1
- 101700082799 IL2RA Proteins 0.000 claims 1
- 102100018760 IL3RA Human genes 0.000 claims 1
- 101700029869 IL3RA Proteins 0.000 claims 1
- 102100004993 IL5RA Human genes 0.000 claims 1
- 101700082749 IL5RA Proteins 0.000 claims 1
- 102100002950 ISG20 Human genes 0.000 claims 1
- 101700015336 ISG20 Proteins 0.000 claims 1
- 102100019332 ITGA2B Human genes 0.000 claims 1
- 101710044247 ITGA2B Proteins 0.000 claims 1
- 102100019441 ITGAM Human genes 0.000 claims 1
- 101710006572 ITGAM Proteins 0.000 claims 1
- 102100019437 ITGAX Human genes 0.000 claims 1
- 101710006689 ITGAX Proteins 0.000 claims 1
- 102100001475 ITGB2 Human genes 0.000 claims 1
- 101710006663 ITGB2 Proteins 0.000 claims 1
- 102100001477 ITGB3 Human genes 0.000 claims 1
- 101710006664 ITGB3 Proteins 0.000 claims 1
- 206010021425 Immune system disease Diseases 0.000 claims 1
- 102100016985 KIT Human genes 0.000 claims 1
- 101710009391 KIT Proteins 0.000 claims 1
- 102100007895 KLRD1 Human genes 0.000 claims 1
- 101700071001 KLRD1 Proteins 0.000 claims 1
- 102100012223 KLRK1 Human genes 0.000 claims 1
- 101710036390 KLRK1 Proteins 0.000 claims 1
- XUJNEKJLAYXESH-REOHCLBHSA-N L-cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 claims 1
- 108090000028 MMP12 Proteins 0.000 claims 1
- 102100007544 NCAM1 Human genes 0.000 claims 1
- 101700077124 NCAM1 Proteins 0.000 claims 1
- 102000003729 Neprilysin Human genes 0.000 claims 1
- 102100019764 PDCD1 Human genes 0.000 claims 1
- 108060007796 SPATA2 Proteins 0.000 claims 1
- 102100008333 THY1 Human genes 0.000 claims 1
- 101700026084 THY1 Proteins 0.000 claims 1
- 102100003096 TNFRSF18 Human genes 0.000 claims 1
- 101710038603 TNFRSF18 Proteins 0.000 claims 1
- 102100013135 TNFRSF4 Human genes 0.000 claims 1
- 101710040448 TNFRSF4 Proteins 0.000 claims 1
- 102100009537 TNFRSF9 Human genes 0.000 claims 1
- 101710040535 TNFRSF9 Proteins 0.000 claims 1
- 230000004913 activation Effects 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 235000018417 cysteine Nutrition 0.000 claims 1
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims 1
- 201000009910 diseases by infectious agent Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000001483 mobilizing Effects 0.000 claims 1
- 239000000546 pharmaceutic aid Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 108020003175 receptors Proteins 0.000 claims 1
- 102000005962 receptors Human genes 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023198791A JP2024023385A (ja) | 2017-07-14 | 2023-11-24 | 改善された二重特異性ポリペプチド分子 |
Applications Claiming Priority (10)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762532713P | 2017-07-14 | 2017-07-14 | |
| DE102017115966.5A DE102017115966A1 (de) | 2017-07-14 | 2017-07-14 | Polypeptidmolekül mit verbesserter zweifacher Spezifität |
| DE102017115966.5 | 2017-07-14 | ||
| US62/532,713 | 2017-07-14 | ||
| DE102017119866 | 2017-08-30 | ||
| DE102017119866.0 | 2017-08-30 | ||
| US201862658318P | 2018-04-16 | 2018-04-16 | |
| DE102018108995.3 | 2018-04-16 | ||
| US62/658,318 | 2018-04-16 | ||
| DE102018108995 | 2018-04-16 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018134424A Division JP6784724B2 (ja) | 2017-07-14 | 2018-07-17 | 改善された二重特異性ポリペプチド分子 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023198791A Division JP2024023385A (ja) | 2017-07-14 | 2023-11-24 | 改善された二重特異性ポリペプチド分子 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2021019626A JP2021019626A (ja) | 2021-02-18 |
| JP2021019626A5 true JP2021019626A5 (fr) | 2021-08-26 |
Family
ID=70848164
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020177784A Pending JP2021019626A (ja) | 2017-07-14 | 2020-10-23 | 改善された二重特異性ポリペプチド分子 |
Country Status (6)
| Country | Link |
|---|---|
| JP (1) | JP2021019626A (fr) |
| CL (2) | CL2020000097A1 (fr) |
| HR (1) | HRP20210759T1 (fr) |
| IL (2) | IL272046A (fr) |
| PH (2) | PH12020500098A1 (fr) |
| ZA (1) | ZA202000636B (fr) |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2020115527A (ru) * | 2013-03-14 | 2020-07-07 | Макродженикс, Инк. | Биспецифичные молекулы, иммунореактивные с иммунными эффекторными клетками, экспрессирующими активирующий рецептор |
-
2020
- 2020-01-13 CL CL2020000097A patent/CL2020000097A1/es unknown
- 2020-01-13 CL CL2020000098A patent/CL2020000098A1/es unknown
- 2020-01-14 IL IL272046A patent/IL272046A/en unknown
- 2020-01-14 PH PH12020500098A patent/PH12020500098A1/en unknown
- 2020-01-14 PH PH12020500095A patent/PH12020500095A1/en unknown
- 2020-01-14 IL IL272045A patent/IL272045A/en unknown
- 2020-01-30 ZA ZA2020/00636A patent/ZA202000636B/en unknown
- 2020-10-23 JP JP2020177784A patent/JP2021019626A/ja active Pending
-
2021
- 2021-05-12 HR HRP20210759TT patent/HRP20210759T1/hr unknown
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