JP2021017418A - Vitamin c preparation that can remove residual chlorine in tap water - Google Patents

Abstract

To provide a vitamin C preparation that is for neutralizing residual chlorine in tap water and can be stored stably for a long time.SOLUTION: A vitamin C preparation contains ascorbic acid 2-glucoside of 1.0% to 40.0%, and one or two of sodium hydroxide and potassium hydroxide of 0.1% or more and 8.0% or less in total, the vitamin C preparation to form a water-soluble solution.SELECTED DRAWING: None

Description

The present invention relates to a method for neutralizing residual chlorine in tap water using an ascorbic acid derivative as a vitamin C preparation.
It relates to the fact that a vitamin C preparation containing an ascorbic acid derivative can neutralize residual chlorine in tap water, eliminate the odor of tap water, and can be consumed without impairing the taste of tap water. The present invention also relates to a preparation capable of easily storing a vitamin C preparation for a long period of time.

In general, tap water contains chlorine for the purpose of sterilization. Tap water that has been sterilized by chlorine treatment is stipulated by the Waterworks Law to contain residual chlorine of 0.1 ppm or more and 1.0 ppm or less, but the human body such as the generation of trihalomethane and the generation of karuki odor. There are also disadvantages to.

It is well known that ascorbic acid, which is vitamin C, neutralizes residual chlorine in tap water and reduces the disadvantages of tap water due to chlorination. Ascorbic acid has a reducing property, and when ascorbic acid is dissolved in chlorinated tap water, residual chlorine is reduced to harmless chlorine ions.

However, ascorbic acid has poor stability, and when it absorbs moisture, the white crystals of ascorbic acid discolor and turn yellow, and at the same time, they lose their reducing property. Therefore, it must be stored in a container that does not easily absorb moisture. Therefore, there is a drawback that ascorbic acid cannot be stored for a long time when left in the natural environment. In order to formulate ascorbic acid as a vitamin C preparation, it is necessary to store it in a container that does not absorb moisture, and most of the conventional preparations use ascorbic acid as a powder and store it in a container that does not easily absorb moisture. It will be a formulation that is inconvenient to do.

Patent 2002 189217

The present invention is a water-soluble preparation that can be easily handled by using ascorbic acid 2-glucoside, which is an ascorbic acid derivative, as vitamin C for neutralizing residual chlorine in tap water, and is easily stored for a long period of time. With respect to possible formulations.

Ascorbic acid 2-glucoside is 1.0% to 40.0%, and either sodium hydroxide or potassium hydroxide or two of the above, the total amount of which is 0.1% or more and 8.0% or less. A vitamin C preparation that forms a water-soluble solution.

The vitamin C preparation of the present invention formulates ascorbic acid 2-glucoside, suppresses decomposition due to moisture absorption, which is a drawback of conventional ascorbic acid, and is stably stored for a long period of time, and easily removes residual chlorine contained in tap water. It enables a neutralizing formulation.

Ascorbic acid 2-glucoside, which is widely used as an ascorbic acid derivative in cosmetics and health foods, is obtained by binding glucose to the hydroxyl group at the 2-position of ascorbic acid. The hydroxyl group at the 2-position of ascorbic acid is highly reactive and causes inactivation and decomposition. Ascorbic acid 2-glucoside has an advantage of being excellent in stability because the hydroxyl group at the 2-position is glucosidic bonded. However, the hydroxyl group at the 2-position is greatly involved in the reducing property which is a characteristic of ascorbic acid, and when glucose is bound to the hydroxyl group at the 2-position, it loses its own reducing power. Therefore, ascorbic acid 2-glucoside is widely used in cosmetics and health foods as an ascorbic acid derivative that is decomposed into ascorbic acid and glucose by an enzyme in the living body and exerts an effect as ascorbic acid.

The vitamin C preparation of the present invention has been found that ascorbic acid 2-glucoside has a weak reducing power and can neutralize residual chlorine contained in tap water.
Since ascorbic acid has excellent reducing power, residual chlorine contained in tap water can be immediately neutralized. Since ascorbic acid 2-glucoside has a weak reducing power, it has time to neutralize residual chlorine contained in tap water. The time is about 60 seconds, which is a slow reaction. The residual chlorine concentration, which indicates the bactericidal activity, contained in tap water is 0.1 ppm or more to 1 ppm or less according to the water quality standard by the Waterworks Law. Within this residual chlorine concentration, the residual chlorine concentration contained in tap water can be sufficiently neutralized even with the weak reducing power of ascorbic acid 2-glucoside.

2-Glucoside ascorbic acid is widely used in cosmetics and health foods as an ascorbic acid derivative having excellent stability because the hydroxyl group at the 2-position is glucosidic bonded. The reason for this is that not only stability but also ascorbic acid 2-glucoside is water-soluble and easily dissolved in water, so that it can be widely blended in creams and lotions for cosmetics and in drinks, jellies and agars for health foods. In addition, ascorbic acid aminopropyl phosphate, ascorbic magnesium phosphate, in which the hydroxyl group at the 2-position is ester-bonded to the phosphate group, to a substance that is water-soluble and has similar properties like ascorbic acid 2-glucoside, Similarly, ascorbic acid sulfate disodium in which the hydroxyl group at the 2-position is ester-bonded to a sulfate group is known as glyceryl ascorbic acid in which the hydroxyl group at the 2-position is ester-bonded to glycerin. Ascorbyl tetrahexyl decanoate is known as an oil-soluble substance in which the hydroxyl group at the 2-position is ester-bonded. Next, the results of four experiments in which the ascorbic acid derivative in which the hydroxyl group at the 2-position is ester-bonded can neutralize the residual chlorine contained in tap water are shown.
(1) Add 1 ml of each of the following ascorbic acid derivatives dissolved in 10% to 100 ml of tap water and stir until uniform. Then, leave it for 1 minute, add 0.05 ml of orthotrizine reagent which is a residual chlorine measuring reagent, and observe the change in the color of tap water.
Tested ascorbic acid derivative ascorbic acid 2-glucoside, ascorbic acid aminopropyl phosphate, ascorbic magnesium phosphate, ascorbic acid sulfate disodium, glyceryl ascorbic acid, ascorbic tetrahexyldecanoate Rating ○: Tap water remains transparent and does not change △: Tap water turns yellow and turns slightly transparent after being left for 10 minutes or more ×: Tap water turns yellow and remains yellow even after being left for 1 hour Result Ascorbic acid 2-glucoside ・ ・ ・ ○, Ascorbic Phosphate Aminopropyl ・ ・ ・ △, Ascorbic Magnesium Phosphate ・ ・ ・ ×, Ascorbic Acid Sulfate Disodium ・ ・ ・ ×, Glyceryl Ascorbic Acid ・ ・ ・ △, Ascorbic Tetrahexyl Decanoate ・ ・ ・ ×
(2) To 100 ml of tap water, add 0.05 ml of orthotrizine reagent as a residual chlorine measuring reagent, and stir until the solution turns yellow. Then, 1 ml of each of the following ascorbic acid derivatives dissolved in 10% is added, left for 1 minute, and the change in color of tap water is observed.
Tested ascorbic acid derivative ascorbic acid 2-glucoside, ascorbic acid aminopropyl phosphate, ascorbic magnesium phosphate, ascorbic acid sulfate disodium, glyceryl ascorbic acid, ascorbic tetrahexyldecanoate Rating ○: Tap water changed from yellow to transparent , No yellow △: Tap water changed from yellow to slightly transparent after being left for 10 minutes or more, and some yellow was observed ×: Tap water maintained yellow even after being left for 1 hour Result Ascorbic acid 2-glucoside ・・ ・ ○, Ascorbic phosphate aminopropyl ・ ・ ・ △, Ascorbic magnesium phosphate ・ ・ ・ ×, Ascorbic acid sulfate disodium ・ ・ ・ ×, Glyceryl ascorbic acid ・ ・ ・ △, Ascorbic tetrahexyldecanoate ・ ・ ・ ×
The tests (1) and (2) are qualitative tests for measuring residual chlorine using an orthotridin reagent. The tests under the two conditions (1) and (2) take into consideration the variation in the residual chlorine concentration. Tap water is public water from water purification plants, and it is thought that the residual chlorine concentration varies considerably depending on the collection location and collection time. For example, in urban areas and areas near water purification plants, the concentration of residual chlorine tends to be high, and the actual concentration seems to be quite high.
(3) Add 1 ml of each of the following ascorbic acid derivatives dissolved in 10% to 100 ml of tap water and stir until uniform. Then, store for 1 minute, add 1 ml of 0.05 mol / L iodine solution, and observe the change in color of the solution.
Tested ascorbic acid derivative ascorbic acid 2-glucoside, ascorbic acid aminopropyl phosphate, ascorbic magnesium phosphate, ascorbic acid sulfate disodium, glyceryl ascorbic acid, ascorbic tetrahexyldecanoate Rating ○: Tap water remains transparent and does not change Δ: Tap water turns yellowish brown and turns slightly transparent after being left for 10 minutes or more ×: Tap water turns yellowish brown and remains yellowish brown even after being left for 1 hour Result Ascorbic acid 2-glucoside ...・ ○, ascorbic phosphate aminopropyl ・ ・ ・ △, ascorbic magnesium phosphate ・ ・ ・ ×, ascorbic acid sulfate disodium ・ ・ ・ ×, glyceryl ascorbic acid ・ ・ ・ △, ascorbic tetrahexyldecanoate ・ ・ ・ ×
(4) Add 1 ml of a 0.05 mol / L iodine solution to 100 ml of tap water, and stir until the solution turns yellowish brown. Then, 1 ml of each of the following ascorbic acid derivatives dissolved in 10% is added, and the change in color of the solution is observed.
Tested ascorbic acid derivative ascorbic acid 2-glucoside, ascorbic acid aminopropyl phosphate, ascorbic magnesium phosphate, ascorbic acid sulfate disodium, glyceryl ascorbic acid, ascorbic tetrahexyldecanoate Evaluation ○: Tap water changed from yellowish brown to transparent However, no yellowish brown is observed. Δ: Tap water changes from yellowish brown to slightly transparent after being left for 10 minutes or more, and some yellowish brown is observed. ×: Tap water maintains yellowish brown even after being left for 1 hour. Result Ascorbic acid Acid 2-glucoside ・ ・ ・ ○, ascorbic aminopropyl phosphate ・ ・ ・ △, ascorbic magnesium phosphate ・ ・ ・ ×, ascorbic acid sulfate disodium ・ ・ ・ ×, glyceryl ascorbic acid ・ ・ ・ △, tetrahexyl decanoic acid Ascorbic ・ ・ ・ ×
The tests (3) and (4) are qualitative tests for measuring residual chlorine using an iodine reagent. The iodine solution is yellowish brown, but when it is reduced, it changes to potassium iodide and becomes colorless, so its reactivity is utilized. The tests under the two conditions (3) and (4) were conducted in consideration of the variation in the residual chlorine concentration. Tap water is public water from water purification plants, and it is thought that the residual chlorine concentration varies considerably depending on the collection location and collection time. For example, in urban areas and areas near water purification plants, the concentration of residual chlorine tends to be high, and the actual concentration seems to be quite high.

The ascorbic acid derivative has an advantage of being excellent in stability because the hydroxyl group at the 2-position is ester-bonded to glucose, phosphoric acid, glycerin, decanoic acid, or the like. It was thought that the hydroxyl group at the 2-position was greatly involved in the reducing property, which is a characteristic of ascorbic acid, and that when the hydroxyl group at the 2-position was ester-bonded, it lost its reducing power.
However, as shown in the above four experimental results, it was found that there is an ascorbic acid derivative that has a weak reducing power. Ascorbic acid 2-glucoside is a result of having reducing property, and ascorbyl aminopropyl phosphate and glyceryl ascorbic acid also have a slight reducing property, and the residual chlorine contained in tap water is medium. Can be harmonized. This seems to be related to the structure of the ascorbic acid derivative. Ascorbic acid 2-glucoside is glucose bonded to the hydroxyl group at the 2-position of ascorbic acid. Glucose is one of the monosaccharides, but it is known to have reducing power. Therefore, even if the hydroxyl group at the 2-position of ascorbic acid binds to glucose and loses the reducing power of ascorbic acid itself, the reducing power of glucose remains, so that it has a weak reducing power as ascorbic acid 2-glucoside. It seems that the result was. Similarly, ascorbic phosphate aminopropyl phosphate, aminopropyl ester-bonded in glyceryl ascorbic acid, and glycerin have a weak reducing power. Therefore, as shown in the above four experimental results, ascorbic phosphate and glyceryl ascorbic acid also have weak reducing power. It seems that the result was that it had a weak reducing property.

The residual chlorine concentration, which indicates the bactericidal activity, contained in tap water is 0.1 ppm or more to 1 ppm or less according to the water quality standard by the Waterworks Law. Theoretically, the amount of ascorbic acid 2-glucoside capable of neutralizing this residual chlorine should be 46 ppm to 460 ppm. The vitamin C preparation of the present invention can sufficiently satisfy this condition.
Since the vitamin C preparation of the present invention is easily dissolved in tap water and has good stability, residual chlorine can be neutralized with the minimum required amount. For example, 0.5 ml of vitamin C preparation is required to neutralize residual chlorine contained in 1 L of tap water. The pH obtained by neutralizing and dissolving residual chlorine with such a small amount is in the neutral region of 6.0 to 8.0 and does not change the properties of tap water, so that it is the same as conventional tap water. Can be drunk.

The vitamin C preparation of the present invention can appropriately contain antioxidants, flavors, colorants, other active ingredients and the like that are generally used as foods and food additives within a stable range.

Next, the present invention will be described in more detail based on Examples, but the present invention is not limited to these.

As Examples 1 to 4, an aqueous solution having the composition shown in Table 1 below was prepared. The value of the compounding ratio shown in Table 1 is mass%. The preparation procedure is as follows.
Add 2-glucoside ascorbic acid, sodium hydroxide, potassium hydroxide and purified water and stir until a uniform aqueous solution is obtained.

(1) Evaluation of reducing power (neutralizing power of residual chlorine) Add 0.05 ml of ortho-trizine test solution, which is an indicator of residual chlorine, to 1 L of tap water, and confirm that the color is yellow, which indicates the presence of chlorine. Then, 0.5 ml of each aqueous solution was added and stirred, and then it was visually determined whether the yellow color indicating the presence of chlorine disappeared. Evaluation of reducing power The prepared powder was evaluated according to the following criteria. The results are shown in Table 1.
⊚: Yellow disappears ×: Yellow does not disappear

(2) PH
Add 0.5 ml of each aqueous solution to 1 L of tap water, stir until uniformly dissolved, and then measure PH.
(3) Appearance and shape 10 ml of each aqueous solution was packed in a 50 ml sealable glass container and left at room temperature. The lid was opened once a day, and changes in offensive odor and discoloration were visually observed for 60 days.
Evaluation of appearance and shape The prepared aqueous solution was evaluated according to the following criteria. The results are shown in Table 1.
⊚: Almost no change for 60 days ○: No offensive odor or discoloration is observed, but slight change is observed (4) Stability 10 ml of each aqueous solution is packed in a 50 ml sealable glass container and set to constant temperature of 5 ° C and 45 ° C. It was left in the tank. The lid was opened once a day, and changes in offensive odor and discoloration were visually observed for 60 days.
Evaluation of stability The prepared powder was evaluated according to the following criteria. The results are shown in Table 1.
⊚: Almost no change for 60 days ○: No offensive odor or discoloration was observed, but slight changes were observed compared to storage at room temperature.

The appearance, shape, and stability were also good in Examples 1 to 4.

Claims (1)

Ascorbic acid 2-glucoside is 1.0% to 40.0%, and either sodium hydroxide or potassium hydroxide or two of the above, the total amount of which is 0.1% or more and 8.0% or less. A vitamin C preparation that forms a water-soluble solution.