JP2021011475A - External preparation for skin - Google Patents

Abstract

To provide an external preparation for skin capable of sustaining or improving an effect obtained by exercise.SOLUTION: An external preparation for skin comprises a component (A) that promotes fat burning and a component (B) that promotes sweating. The component (A) can include Asteraceae plant extracts (A1), L-carnitine (A2), and/or Cruciferous plant extracts (A3). The component (B) can include Tambourissa trichophylla extracts and/or Asteraceae plant extracts. The external preparation for skin can be applied to the skin during exercise and used for sustaining or improving the exercise effects (such as skin temperature, sweating, blood flow, and refreshing feeling). The external preparation for skin is preferably applied to the skin during or after exercise.SELECTED DRAWING: Figure 1

Description

The present invention relates to an external preparation for skin capable of sustaining or improving the effect of exercise.

As the world becomes more convenient, many people feel lack of exercise because they have less physical activity in their daily lives. For this reason, the number of people who exercise or play sports on a daily basis is increasing. There are various purposes, such as maintaining or improving muscle strength and endurance, improving cardiopulmonary function, maintaining health such as prevention of lifestyle-related diseases, and preventing deterioration of physical function due to aging. In addition to physical effects such as reducing pain in the knees, promoting blood circulation, and losing weight, the spirit of changing mood, relieving stress, preventing dementia, and improving indefinite complaints. It may be aimed at the effect. In addition, there are various types of exercise, from extremely high-intensity exercise aimed at improving muscle strength, endurance, cardiopulmonary function, etc., to moderate-intensity exercise aimed at maintaining health and relieving stress.

For extremely intense exercise aimed at improving muscle strength, endurance, cardiopulmonary function, etc., after exercising, gradually reduce the amount of exercise, stretch, active rest, or apply load. In order to promote the repair of injured muscle tissue, it is said that it is good to cool down the muscle with ice or an external preparation (icing) and massage it (Non-Patent Documents 1 and 2). Therefore, many cool-down devices and external preparations for skin are commercially available.

"How to cure muscle pain quickly and prevent it" Kanagawa Prefectural Sports Center E-mail Magazine "Physical Education Center Communication No. 57" Warmup & Cooldown Special Edition for Selected Athleres (Published by Tokyo Sport Benefits Corporation, Competitiveness Improvement Sports Medicine / Science Support Project)

On the other hand, in the case of exercise that is not so intense, no proposal has been made for care during and after exercise. However, due to changes in the living environment and working environment in recent years, an increasing number of people are doing light exercise for the purpose of maintaining health and relieving stress. The present inventor has found that those who exercise lightly tend to prefer to maintain a pleasant sensation after exercising because the frequency of exercising is low. In other words, we found new needs to get the feeling that we exercised firmly with light exercise, to improve the efficiency of exercise effects, or to shorten the exercise time. Specifically, there are requests such as wanting to feel that you have exercised firmly for a long time and warming down by continuing to feel warm and sweaty.

However, although many topical skin preparations for cooling down muscles are commercially available, it keeps the warm body from cooling after exercise and maintains a pleasant sensation such as warmth and exhilaration obtained by exercise. There are no known external preparations for the skin.

Therefore, it is an object of the present invention to provide an external preparation for skin capable of sustaining or increasing the effect obtained by exercise.

The present inventor has repeated research to solve the above problems, and by applying a composition containing a component that promotes fat burning and a component that promotes sweating to the skin during exercise, body temperature rise, sweating, etc. We found that the effects of exercise were effectively sustained.

The present invention has been completed based on the above findings, and provides the following external preparations for skin.
[1] An external preparation for skin containing (A) a component that promotes fat burning and (B) a component that promotes sweating.
[2] A component (A1) having an action of promoting the decomposition of triglyceride, (A2) a component having an action of promoting the uptake of fatty acid produced by decomposition of triglyceride, and (A3) a component having an action of promoting the uptake of fatty acid in mitochondria. The skin external preparation according to [1], which is at least one selected from the group consisting of components having an action of promoting combustion.
[3] The external preparation for skin according to [2], wherein the component (A1) is an Asteraceae plant extract, the component (A2) is L-carnitine, and the component (A3) is a cruciferous plant extract.
[4] The external preparation for skin according to any one of [1] to [3], which comprises a tambrissa tocophylla extract and / or an Asteraceae plant extract as a component (B).
[5] The total content of the component (A) is 0.0002 to 10% by weight based on the total amount of the external preparation for skin in terms of dry weight for the plant extract, [1] to [4]. ] The external preparation for skin described in any of.
[6] The total content of the component (B) is 0.0001 to 10% by weight based on the total amount of the external preparation for skin in terms of dry weight for the plant extract, [1] to [5]. ] The external preparation for skin described in any of.
[7] The external preparation for skin according to any one of [1] to [6], which further contains a fragrance.
[8] The external preparation for skin according to any one of [1] to [7], which is used for sustaining or improving an exercise effect.
[9] The external preparation for skin according to [8], wherein the duration or improvement of the exercise effect is the maintenance or improvement of skin temperature, sweating, blood flow, and / or refreshing feeling.
[10] The external preparation for external skin according to any one of [1] to [9], which is applied to the skin during or after exercise.
[11] A method for sustaining or improving an exercise effect, which comprises a step of applying an external preparation for skin containing (A) a component that promotes fat burning and (B) a component that promotes sweating to the skin during exercise.

When the external preparation for skin of the present invention is applied to the skin during exercise, the effect obtained by exercise is sustained or improved. For this reason, even with light exercise, a feeling of firm exercise (effectiveness) can be obtained, and a feeling of satisfaction can be obtained. Specifically, the body temperature (particularly the skin or body surface temperature) raised by exercise, the increase in sweating by exercise, the increase in blood flow by exercise, the refreshing state by exercise, and the like are sustained or increased.
Normally, the body temperature (particularly the skin or body surface temperature) rises due to exercise, but when the exercise is stopped, the rise in body temperature slows down or decreases due to the evaporation of sweat. Then, although the sweating continues, the body temperature (particularly the skin or body surface temperature) raised by exercise is maintained, and the body temperature may further rise. In addition, by using the external preparation for skin of the present invention, sweating after exercise is sustained and the amount of sweating is increased.
In addition, a pleasant sensation or sensation after exercise, for example, a warm feeling, a sweating feeling, a feeling of increased blood flow, and a feeling of exhilaration are maintained or increased.

In addition, the external preparation for skin of the present invention is effective even when used before exercise, but when used during or after exercise, the exercise effect, exercise feeling, and exercise experience are maintained or improved more effectively. To do.

The surface temperature of the neck after 10 minutes and 20 minutes of exercise when the external preparations for skin of Example 1, Example 2, and Comparative Example 2 were applied to the neck and when nothing was applied (Comparative Example 1). It is a figure which shows the rate of change of. The surface temperature of the back of the hand after 10 minutes and 20 minutes of exercise when the skin external preparations of Example 1, Example 2, and Comparative Example 2 were applied to the back of the hand and when nothing was applied (Comparative Example 1). It is a figure which shows the rate of change of. The surface temperature of the palm after 10 minutes and 20 minutes of exercise when the external preparations for skin of Example 1, Example 2, and Comparative Example 2 were applied to the palm and when nothing was applied (Comparative Example 1). It is a figure which shows the rate of change of.

The external preparation for skin of the present invention is a preparation containing (A) a component that promotes fat burning and (B) a component that promotes sweating.

(A) Component that promotes fat burning As a component that promotes fat burning, (A1) a component that promotes the decomposition of triglyceride, and (A2) a component that promotes the uptake of fatty acids produced by the decomposition of triglyceride. Examples include the component and (A3) a component having an action of promoting the burning of fatty acids in the mitochondria.
The external preparation for skin of the present invention may contain one or more components that promote fat burning. Further, any one or more of the component (A1), the component (A2), and the component (A3) can be contained. In particular, it is preferable to contain the component (A1), the component (A2), and the component (A3).

(A1) Component having an action of promoting the decomposition of triglyceride The fat accumulated as lipid droplets in adipocytes is neutral fat, that is, triglyceride. Triglycerides in animals, including humans, are a mixture of trixerides of various fatty acid compositions.
In adipocytes, when catecholamine hormones such as adrenaline and noradrenaline bind to cell surface receptors, hormone-sensitive lipase and perilipin are activated by phosphorylation. Lipase is an enzyme that breaks down triglycerides into glycerol and fatty acids. In addition, perilipin is a protein that binds to the surface of lipid droplets and prevents hormone-sensitive lipase from acting on lipid droplets in normal times, but when phosphorylated by catecholamine-based hormone stimulation, it causes the action of hormone-sensitive lipase. Facilitate. In addition, a protein called CGI-58 is present on the surface of lipid droplets in interaction with perilipin, but when perilipin is phosphorylated by catecholamine hormone stimulation, CGI-58 is released from lipid droplets. And activates adipocyte-specific triglyceride lipase. Adipocyte-specific triglyceride lipases act particularly strongly on triglycerides than hormone-sensitive lipases. In addition, monoacylglycerol lipase requires stepwise action for triglycerides to be completely degraded to three fatty acids and glycerol.

The component having an action of promoting the decomposition of triglyceride may be one that promotes any stage until the triglyceride is decomposed into three fatty acids and glycerol.
Such ingredients include extracts of Kiku family plants (among others, plants of the genus Chrysanthemum such as Chrysanthemum indikum (Golden Chamomile), plants of the genus Stevia such as Stevia), neem leaf extract, lemongrass extract, etc. Ashitaba extract, brown algae extract (comb extract, hijiki extract, hibamata extract, wakame extract, etc.), green algae extract (aosa extract, aonori extract, etc.), red algae extract (tengusa extract, asakusanori) Extracts, Susabinori extract, etc.), Natsume (Otsubo) fruit extract, Tochu (Tochu) extract, Chlorella extract, Euglena gracilis (also known as Euglena, Midorimushi) extract, Tsunogeshi leaf extract, Globularia Examples thereof include Cordifolia callus culture extract, Hanashoga extract, Mishima Psycho root extract, Coenteam A, and caffeine.
In addition, as a mixture of the components having the above-mentioned action, a mixture of Euglena gracilis extract, caffeine, and Tsunogeshi leaf extract (Phytosonic (trade name); Cederma), globularia cordifolia callus culture extract, caffeine. , And a mixture of Hanashoga extract (Inteslim (trade name); Cederma), Mishima Psycho root extract, caffeine, and a mixture of Coenteam A (Lipocare (trade name); Cederma) and the like.
Among them, in that it has a strong effect of promoting the decomposition of triglyceride, it is an extract of Asteraceae plants (among others, chrysanthemum indikum, stevia), a mixture of Euglena gracilis extract, caffeine and tsunogeshi leaf extract (for example, phytosonic (cederma)). The company)) is preferable, and the extract of Asteraceae plants (among others, Crysantherum indikum) is more preferable. As a product containing the chrysanthemum indicum extract, Lana Chris (Lucas Meyer) can be mentioned.
As the component having an action of promoting the decomposition of triglyceride, one kind may be used alone or two or more kinds may be used in combination.

The content of the external preparation for skin of the present invention when the component (A1) is contained (particularly, Asteraceae plants, especially plants of the genus Chrysanthemum and / or plants of the genus Stevisa, especially extracts of chrysanthemum indicum and / or stevia). Is preferably 0.000005% by weight or more, more preferably 0.00001% by weight or more, and even more preferably 0.00005% by weight or more, based on the total amount of the external preparation for skin. Further, 1% by weight or less is preferable, 0.5% by weight or less is more preferable, and 0.1% by weight or less is even more preferable. This content is a value calculated from the weight converted to dry weight for the plant extract. Within this range, it is possible to sufficiently sustain or improve the exercise effect by acting together with the component (B).

(A2) A component having a fatty acid uptake promoting action The fatty acid produced by the decomposition of triglyceride binds to albumin, is carried in the blood, and is taken up into the cells of each tissue of the body. Fatty acids taken up into cells are oxidized and decomposed in mitochondria to extract energy. Among fatty acids, medium-chain fatty acids can permeate the mitochondrial membrane without intervening other components, but long-chain fatty acids alone cannot permeate the mitochondrial membrane.
The components having a fatty acid uptake promoting action include a component having an action of promoting the uptake of fatty acid into cells, an action of transporting the fatty acid taken up into cells into the mitochondria, and an action of permeating the mitochondrial membrane. Ingredients are mentioned.

Examples of the component having an action of promoting the intracellular uptake of fatty acids include Bacillus / soybean fermented extract. Ingredients that carry fatty acids into mitochondria or permeate mitochondrial membranes include L-carnitine, salts thereof (tartrates, fumarates, hydrochlorides, etc.), or derivatives thereof (acetic acid, palmitic acid, etc.). Esters with fatty acids, etc.), astaxanthin, and canca (carnitine) extract can be mentioned. Of these, L-carnitine is preferable.
As the component having a fatty acid uptake promoting action, one type can be used alone or two or more types can be used in combination.

When the external preparation for skin of the present invention contains the component (A2) (particularly L-carnitine), the content thereof is preferably 0.0001% by weight or more, preferably 0.001% by weight, based on the total amount of the external preparation for skin. The above is more preferable, and 0.005% by weight or more is even more preferable. Further, 10% by weight or less is preferable, 5% by weight or less is more preferable, and 1% by weight or less is even more preferable. This content is a value calculated from the weight converted to dry weight for the plant extract. Within this range, it is possible to sufficiently sustain or improve the exercise effect by acting together with the component (B).

(A3) A component having an action of promoting the burning of fatty acids in mitochondria As described above, fatty acids taken up into cells undergo β-oxidation in mitochondria to become acetyl-CoA, and further carbon dioxide in the citric acid cycle. It is decomposed into and energy is taken out through the electron transport chain. In the present invention, the component that promotes the combustion of fatty acid in mitochondria may be one that promotes the reaction at any stage of β-oxidation of fatty acid, citric acid cycle, and electron transport chain.
Such components include extracts of Abrana plants (among others, Peppergrasses plants such as Lepidium Mayeni (maca)) (particularly root or leaf extracts), tea leaf extracts, Koryo ginseng extracts, etc. Examples include Ashitaba extract, malic acid, ketooctadecazienoic acid, Bacillus / soybean fermented extract and the like. Of these, extracts of cruciferous plants (particularly Peppergrasses plants such as Lepidium mayeni (maca)) (particularly root or leaf extracts) are preferred.
As a product containing the Lepidium Mayeni (Maca) extract, Macaline (Expan Science Co., Ltd.) can be mentioned.
The components that promote the burning of fatty acids in mitochondria can be used alone or in combination of two or more.

When the external preparation for skin of the present invention contains the component (A3) (particularly, an extract of cruciferous plants such as Lepidium mayeni), the content thereof is 0.00001% by weight or more based on the total amount of the external preparation for skin. Is preferable, 0.0001% by weight or more is more preferable, and 0.0005% by weight or more is even more preferable. Further, 10% by weight or less is preferable, 1% by weight or less is more preferable, and 0.1% by weight or less is even more preferable. This content is a value calculated from the weight converted to dry weight for the plant extract. Within this range, within this range, it is possible to sufficiently sustain or improve the exercise effect by acting together with the component (B).

The total content of the component (A) of the external preparation for skin of the present invention is preferably 0.0002% by weight or more, more preferably 0.002% by weight or more, and 0.006% by weight, based on the total amount of the external preparation for skin. The above is even more preferable. It can be 0.01% by weight or more. Further, 10% by weight or less is preferable, 5% by weight or less is more preferable, and 1% by weight or less is even more preferable. It can also be 0.3% by weight or less. This content is a value calculated from the weight converted to dry weight for the plant extract. Within this range, it is possible to sufficiently sustain or improve the exercise effect by acting together with the component (B).

(B) Ingredients that promote sweating Examples of the components that promote sweating include extracts of Tambourissa trichophylla (particularly leaves) and plants of the Asteraceae family (especially leaves). Ingredients that have both sweating and moisturizing effects, such as extracts of plants of the genus Asteraceae (particularly flowers) such as (stems, roots) and chamomile (also called chamomile, German chamomile, Roman chamomile). Also included are extracts of acorus gramineus (particularly roots), extracts of peppers (particularly fruits), extracts of ginger (particularly rhizomes) and the like.
As the component that promotes sweating, one type can be used alone, or two or more types can be used in combination.

Among them, components having both a sweating action and a moisturizing action are preferable, and an extract of tambrissa trichophylla and an extract of Asteraceae plants (among others, plants of the genus Coltsfoot such as butterbur and plants of the genus Mayweed such as chamomile) are more preferable.
Tambrissa trichophylla is a tree that inhabits Madagascar Island and the Comoros Islands. On Madagascar Island, it is called Ambolasa or Ambora and has been used for wound healing for a long time. A product containing a tambrissa trichophylla leaf extract includes Ambora extract (Bayer Sante Familliale).
Examples of products containing butterbur extract include butterbur extract-WSPC, butterbur extract-PC, butterbur extract-LC (Oriza Yuka Co., Ltd.), and NBA Butter Bur Extract (Arch Personal Care Co., Ltd.).
As chamomile extract, chamomile extract, chamomile extract BG-J, chamomile extract LA (Maruzen Pharmaceutical Co., Ltd., Iwase Kosfa), chamomile extract LS, oil-soluble chamomile extract M, oil-soluble chamomile extract P (Kaei) Kogyosha). In addition, chamomile extract is commercially available under the names such as chamomile extract, chamomile water, Roman chamomile oil, and Roman chamomile flower oil, and can be used.

The total content of the component (B) of the external preparation for skin of the present invention is preferably 0.0001% by weight or more, more preferably 0.001% by weight or more, and 0.005% by weight, based on the total amount of the external preparation for skin. The above is even more preferable. It can be 0.01% by weight or more. Further, 10% by weight or less is preferable, 5% by weight or less is more preferable, and 3% by weight or less is even more preferable. It can be 1% by weight or less. This content is a value calculated from the weight converted to dry weight for the plant extract. Within this range, it is possible to sufficiently sustain or improve the exercise effect by acting together with the component (A).

When the external preparation for skin of the present invention contains an extract of tambrissa trichophylla, the content thereof is preferably 0.00001% by weight or more based on the total amount of the external preparation for skin in terms of dry weight. More preferably, it is 0001% by weight or more. Further, 10% by weight or less is preferable, 5% by weight or less is more preferable, and 1% by weight or less is even more preferable. Within this range, it is possible to sufficiently sustain or improve the exercise effect by acting together with the component (A).
When the external preparation for skin of the present invention contains an extract of a plant belonging to the genus Coltsfoot such as butterbur, the content thereof is preferably 0.0001% by weight or more based on the total amount of the external preparation for skin in terms of dry weight. More preferably 0.001% by weight or more. Further, 10% by weight or less is preferable, and 5% by weight or less is more preferable. Within this range, it is possible to sufficiently sustain or improve the exercise effect by acting together with the component (A).
When the external preparation for skin of the present invention contains an extract of a plant belonging to the genus Mayweed such as chamomile, the content thereof is preferably 0.0001% by weight or more based on the total amount of the external preparation for skin in terms of dry weight. More preferably 0.001% by weight or more. Further, 10% by weight or less is preferable, and 5% by weight or less is more preferable. Within this range, it is possible to sufficiently sustain or improve the exercise effect by acting together with the component (A).

The ratio of the total content of the component (B) to 1 part by weight of the total content of the component (A) is preferably 0.0001 part by weight or more, more preferably 0.001 part by weight or more, and 0.01 part by weight or more. Even more preferable. It can be 0.1 parts by weight or more. Further, 1000 parts by weight or less is preferable, 100 parts by weight or less is more preferable, and 10 parts by weight or less is even more preferable. It can be 1 part by weight or less. This content is a value calculated from the weight converted to dry weight for the plant extract. Within this range, the exercise effect can be sufficiently sustained or improved.

In the present invention, the plant extract may be any extract of leaves, stems, flowers, fruits, roots, rhizomes and the like, and may be an extract of whole plants, unless otherwise specified.

The solvent used for extraction is water; an aqueous solution of an inorganic salt such as sodium chloride, potassium chloride, magnesium chloride, or ammonium carbonate; phosphate buffer, acetate buffer, Tris-hydrochloride buffer, carbonate buffer, borate buffer. Buffer solution such as liquid; aqueous solution of inorganic acid such as hydrochloric acid, carbonic acid, sulfuric acid, nitrate, phosphoric acid; aqueous solution of organic acid such as acetic acid, citric acid, lactic acid, succinic acid, ascorbic acid, fumaric acid, malic acid Aqueous solutions of surfactants such as saponin and lecithin; lower alcohols such as methanol, ethanol, propanol and butanol; hydrophilic and polar solvents such as ketones such as acetone and ethyl methyl ketone.
Also, hydrocarbons such as propane, butane, hexane, cyclohexane; glycerin; ethers such as diethyl ether; glycols such as propylene glycol; dichloromethane, 1,1,1,2-tetrafluoroethane, 1,1,2 -Haloxide hydrocarbons such as trichloroethane; hydrophobic solvents such as ethyl acetate, acetates such as methyl acetate can also be mentioned.
As the solvent, one type can be used alone, or two or more types can be used in combination.

The extraction temperature can be appropriately set, and can be, for example, 4 to 130 ° C., particularly 20 to 100 ° C. It can also be carried out at room temperature.
The extract can be used in a liquid state (including fluid, mucous, etc.), or is dried and solidified (including semi-solid, gel, etc.), for example, powdered. It can also be used.

(C) Warmth component The external preparation for skin of the present invention may further contain (C) warmth component.
Examples of the warming component include compounds having a vanillyl group such as vanillyl ethers typified by vanillyl butyl ether, vanillyl amides of nonanoic acid, and vanillyl amides typified by capsaicin, and the effects of the present invention are effective. Vanillyl ethers are preferable, and vanillyl butyl ether is more preferable from the viewpoint of the effect.
The warming component can act together with the components (A) and (B) of the present invention to significantly or synergistically sustain or improve the exercise effect.

(D) Fragrance The external preparation for skin of the present invention may further contain a fragrance, which masks odors such as sweat and may more effectively sustain or improve the exercise effect.
As the fragrance, essential oil is preferable, and bergamot oil, peppermint oil, lavender oil, eucalyptus oil, rosemary oil, rosehip oil, kidney pepper oil, peppermint oil, sparemint oil, vetiver oil, lithocia cubeba oil, lemon oil, and ebony oil. , Natsumeg oil, cinnamon oil, hissop oil, caraway oil, orange oil, caddy oil, grapefruit oil, lime oil, salvia oil, thyme oil, clove oil, aloe oil, jasmine oil, neroli oil, rose oil, camphor oil, Geranium oil, sandalwood oil, ylang ylang oil, melissa oil, basil oil, patchouli oil, juniper oil, juniper berry oil, sage oil, black pepper oil, marjolam oil, amyris oil, yomogi oil, nigayomogi oil, angelica oil, ginger Oil, All Spice Oil, Cascarilla Oil, Columns Oil, Clarisage Oil, Celoli Oil, Tea Tree Oil, Carrot Oil, Pachori Oil, Vetiba Oil, Hop Oil, Mustic Oil, Milla Oil, Labdanum Oil, Ukon Oil, Origanum Oil, Examples include galanga oil, citronella oil, bay oil, yarrow oil, pimentoberry oil and lobage oil.
Of these, bergamot oil and eucalyptus oil are preferable, and bergamot oil is more preferable. Limonene, linalool, and linalyl acetate, which are the main components of bergamot oil, can also be used.
Further, terpenes such as menthol, camphor, borneol, geraniol, cineole, anator, limonene and eugenol (these may be d-form, l-form or dl-form) are also preferable.

When the external preparation for skin of the present invention contains a fragrance, the content thereof is preferably 0.0001% by weight or more, more preferably 0.001% by weight or more, and 0.01% by weight, based on the total amount of the external preparation for skin. The above is even more preferable. Further, 5% by weight or less is preferable, 1% by weight or less is more preferable, and 0.5% by weight or less is even more preferable. Within this range, a sufficient masking effect can be obtained, and depending on the fragrance, the exercise effect can be sustained or improved.

Other Ingredients The external preparation for skin of the present invention contains the above-mentioned component (A), component (B), and in some cases, component (C) as a base or carrier used in cosmetics or quasi-drugs. And, if necessary, it can be mixed with additives and other physiologically active or pharmacologically active ingredients to make cosmetics or quasi-drugs for external use on the skin.

Examples of the additive include a surfactant, a thickener, a preservative, a pH adjuster, a stabilizer or a chelating agent, an ultraviolet absorber or an ultraviolet scattering agent, an irritation reducing agent, a coloring agent and the like.
As the additive, one type can be used alone, or two or more types can be used in combination.
In addition, the additive can be used as long as the effect of the present invention is not impaired.

Examples of the surfactant include sorbitan monoisostearate, sorbitan monolaurate, sorbitan monopalmitate, sorbitan monostearate, sorbitan sesquiolate, diglycerol sorbitan penta-2-ethylhexylate, and diglycerol sorbitan tetra-2-ethylhexylate. Such as sorbitan fatty acid esters such as, glycerin monostearate, glycerin monostearate, malic acid and other glycerin fatty acids, polyglyceryl monoisostearate, polyglyceryl diisostearate and other polyglycerin fatty acids, propylene glycol monostearate and other propylene glycol fatty acid esters. Kind, cured castor oil derivatives such as polyoxyethylene cured castor oil (polyoxyethylene cured castor oil 40, polyoxyethylene cured castor oil 60, polyoxyethylene cured castor oil 80, etc.), polyoxyethylene monolaurate (20) Polyoxyethylene sorbitan fatty acid esters such as sorbitan (polysorbate 20), polyoxyethylene monostearate (20) sorbitan (polysorbate 60), polyoxyethylene monooleate (20) sorbitan (polysorbate 80), polyoxyethylene monoyashi Examples thereof include oil fatty acid glyceryl, glycerin alkyl ether, alkyl glucoside, polyoxyethylene cetyl ether (cetomacrogol), stearylamine, and oleylamine.

Thickeners include thickening polymers (guar gum, locust bean gum, carrageenan, xanthan gum, dextran, etc.) and cellulose-based thickeners (methyl cellulose, ethyl cellulose, carboxymethyl cellulose, carboxyethyl cellulose, hydroxymethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose). , Hydroxypropyl methylcellulose, etc.), alginic acid, its salts, and derivatives thereof (alginic acid, sodium alginate, propylene glycol alginate, etc.), vinyl thickeners (polyvinyl alcohol, polyvinylpyrrolidone, polyvinylmethyl ether, carboxyvinyl polymer, acrylic acid) (Alkyl methacrylate copolymer, sodium polyacrylate, etc.), bentonite, dextrin fatty acid ester, pectin, etc. may be mentioned.

Preservatives include benzoic acid, sodium benzoate, dehydroacetic acid, sodium dehydroacetate, isobutyl paraoxybenzoate, isopropyl paraoxybenzoate, butyl paraoxybenzoate, ethyl paraoxybenzoate, propyl paraoxybenzoate, benzyl paraoxybenzoate, paraoxy Examples thereof include methyl benzoate, phenoxyethanol, and BHT.

As pH adjusters, inorganic acids (hydrochloride, sulfuric acid, phosphoric acid, polyphosphoric acid, boric acid, etc.), organic acids (lactic acid, acetic acid, citric acid, tartaric acid, malic acid, succinic acid, sodium succinate, oxalic acid, glucon) Acids, fumaric acid, propionic acid, acetic acid, aspartic acid, epsilon-aminocaproic acid, glutamate, aminoethylsulfonic acid, etc.), gluconolactone, ammonium acetate, inorganic bases (sodium hydrogen carbonate, sodium carbonate, potassium hydroxide, hydroxide) Examples include sodium, calcium hydroxide, magnesium hydroxide, etc.), organic bases (monoethanolamine, triethanolamine, diisopropanolamine, triisopropanolamine, lysine, etc.).

Examples of the stabilizer or chelating agent include sodium edetate, tetrasodium edetate, tetrasodium edetate tetrahydrate and the like.

Examples of the ultraviolet absorber or ultraviolet scattering agent include 2-ethylhexyl paramethoxysilicate, 2- [4- (diethylamino) -2-hydroxybenzoyl] benzoic acid hexyl ester, and 2,4,6-tris [4- (2). -Ethylhexyloxycarbonyl) anilino) -1,3,5-triazine, t-butylmethoxydibenzoylmethane, dibenzylenedioxoimidazolidine ethylhexyl propyroate, etruhexyltriazoline, paraaminobenzoic acid and its derivatives, paradimethylamino Examples thereof include octyl benzoate, ethylene glycol salicylate, dihydroxybenzophenone, titanium oxide and zinc oxide.

Examples of the irritation reducing agent include licorice extract and sodium alginate.

Examples of the colorant include pigments described in the Legal Dye Handbook (edited by the Japan Cosmetic Industry Association (2004)).

Other physiologically active or pharmacologically active ingredients include, for example, moisturizing ingredients, vitamins, peptides or derivatives thereof, blood circulation promoting ingredients, cell activating ingredients, antiaging ingredients, whitening ingredients, amino acids, proteins, plant extracts ((A)). Ingredients and (B) are excluded) and the like.
As for other physiologically active or pharmacologically active ingredients, one type may be used alone, or two or more types may be used in combination.
In addition, other physiologically active or pharmacologically active ingredients can be used as long as the effects of the present invention are not impaired.

Moisturizing ingredients include polyhydric alcohols such as glycerin, dipropylene glycol, 1,3-butylene glycol, propylene glycol, polyethylene glycol, diglycerin, pentanediol, hexanediol, octanediol, trehalose, xylitol, sorbitol and the like. Examples include sugars, sodium hyaluronate, heparin analogs, sodium chondroitin sulfate, keratin, chitin, high molecular weight compounds such as chitosan, lipids such as ceramides, cholesterol and phospholipids, hamamelis extracts, plant extracts such as cha extract. Be done.

Examples of vitamins include vitamin Es such as dl-α-tocopherol, dl-α-tocopherol acetate, dl-α-tocopherol succinate, and dl-α-tocopherol calcium succinate, ubiquinone derivatives and their pharmaceutical or physiological. Acceptable salts, riboflavin, flavin mononucleotide, flavin adenine dinucleotide, riboflavin butyrate, riboflavin tetrabutyric acid ester, riboflavin 5'-phosphate sodium, riboflavin tetranicotinic acid ester, dl-α-tocopherol nicotinate, nicotinic acid Benzyl, methyl nicotinate, β-butoxyethyl nicotinate, 1- (4-methylphenyl) nicotinate, ascorbigen-A, ascorbic acid stearate, ascorbic acid palmitate, dipalmitate L-ascorbyl, methyl hesperidine , Ergocalciferol, Cholecalciferol, Phylloquinone, Farnoquinone, γ-Oryzanol, Dibenzoylthiamine, Dibenzoylthiamine hydrochloride, Thiamine hydrochloride, Thiaminecetyl hydrochloride, Thiaminethiocyanate, Thiaminelauryl hydrochloride, Thiamine nitrate, Thiamine Monophosphate, thiamin lysine salt, thiamin triphosphate, thiamin monophosphate ester phosphate, thiamin monophosphate ester, thiamin diphosphate ester, thiamin diphosphate ester hydrochloride, thiamin triphosphate ester, thiamin triphosphate monophosphate , Pyridoxin hydrochloride, Pyridoxin acetate, Pyridoxal hydrochloride, Pyridoxal 5'-phosphate, Pyridoxamine hydrochloride, Cyanocobalamine, Hydroxocobalamine, Deoxyadenosylcobalamine, Folic acid, Pteroylglutamic acid, Nicotinic acid, Nicotinate amide, Pantothenic acid, Calcium pantothenate Pantothenic acids such as pantothenyl alcohol (pantenol), D-pantesin, D-pantetin, coenzyme A, pantothenyl ethyl ether, biotin, bioticin, ascorbic acid, sodium ascorbate, dehydroascorbic acid, ascorbic acid phosphate Sodium, ascorbic acid phosphate magnesium, carnitine, ferulic acid, α-lipoic acid, ollotic acid, hesperidin, γ-orizanol, orotic acid, rutin, eriocitrin and pharmaceutically or physiologically acceptable salts thereof. Be done.

Examples of the peptide or a derivative thereof include keratin-degrading peptide, hydrolyzed keratin, collagen, gelatin, elastin, elastin-degrading peptide, collagen-degrading peptide, hydrolyzed collagen, and hydrolyzed silk.

Blood circulation promoting ingredients include Panax ginseng, Ashitaba, Arnica, Ginkgo, Enmeisou, Dutch oak, Carrot, Gentiana, Burdock, Rice, Sanzashi, Shiitake, Seiyousanzashi, Yuzu, Senkyu, Senburi, Thyme, Chouji, Chimpi, Touki, Tounin, Extracts such as angelica, carrot, garlic, butcher bloom, grape, button, marronnier, melissa, yuzu, yokuinin, rosemary, rosehip, peach, apricot, walnut, corn, glucosyl hesperidin (citrus peel extract), cepharanthin (Tamasaki citrus root extract) and the like.
The blood circulation promoting component can act together with the components (A) and (B) of the present invention to sustain or improve the exercise effect remarkably or synergistically.

Cell-activating components include amino acids such as γ-aminobutyric acid, γ-amino-β-hydroxybutyric acid, and ε-aminocaproic acid, retinol, thiamine, riboflavin, pyridoxine hydrochloride, pantothenic acids, vitamins such as biotin, and glycols. Examples thereof include α-hydroxy acids such as acids and lactic acids, tannins, flavonoids, saponins, allantin, Photosensitizer No. 301, placenta extract, hinokithiol, cepharanthin, and kiwi seed extract.

Examples of the anti-aging component include pangamic acid, kinetin, ursolic acid, turmeric extract, sphingosine derivative, silicon, silicic acid, N-methyl-L-serine, mevalonolactone and the like.

Whitening ingredients include tocopherol, ascorbic acid, tranexamic acid, arbutin, 4-alkylresorcinol 4-methoxysalicylic acid, hydroquinone, kojic acid, salts thereof, or derivatives thereof, placenta extract, botanical extract, yukinoshita extract, Examples include aloe extract, plant extract such as matecha extract.

Examples of the base or carrier base or carrier include oil-based bases and aqueous bases.
Oily bases include liquid paraffins, vaseline, gelled silicones (such as plastibase), ozokelite, α-olefin oligomers, and hydrocarbons such as light liquid paraffins; methylpolysiloxane, crosslinked methylpolysiloxane, highly polymerized methyl. Polysiloxane, cyclic silicone, alkyl-modified silicone, cross-linked alkyl-modified silicone, amino-modified silicone, polyether-modified silicone, polyglycerin-modified silicone, cross-linked polyether-modified silicone, cross-linked alkyl polyether-modified silicone, silicone-alkyl chain Silicone oils such as modified polyether modified silicones, silicone-alkyl chain co-modified polyglycerin modified silicones, polyether modified branched silicones, polyglycerin modified branched silicones, acrylic silicones, phenyl modified silicones, and silicone resins; cetanol, cetostearyl alcohol , Higher alcohols such as stearyl alcohol, and behenyl alcohol; sterols such as cholesterol, phytosterol, and phytosteryl hydroxystearate; vegetable fats such as shea butter, carbanar wax, and candelilla wax; lanolin, orange raffy oil, squalane, Animal fats and oils such as horse oil, whale wax, and beeswax; natural polymer derivatives such as ethyl cellulose, hydroxypropyl cellulose, hydroxyethyl cellulose, hydroxypropyl methyl cellulose, cationized guagam, and acetylated hyaluronic acid; polyvinylpyrrolidone, carboxyvinyl polymer , And synthetic polymers such as alkyl methacrylate copolymers; natural polymers such as carrageenan, alginic acid, cellulose, xanthan gum, guar gum, quince seed, dextran, gellan gum, and hyaluronic acid; isopropyl myristate, myristic acid. Fatty acid esters such as octyldodecyl, isopropyl palmitate, cetyl palmitate, isononyl isononanoate, pentaerythlit tetra2-ethylhexanoate, and tri (caprylic / capric acid) glyceryl; such as dextrin and maltodextrin. Polysaccharides; ethylene glycol monomethyl ether, ethylene glycol monoethyl ether, ethylene glycol monopropyl ether, diethylene glycol monomethyl ether, diethylene glycol monoethyl Examples thereof include ethers, diethylene glycol monopropyl ethers, diethylene glycol monobutyl ethers, propylene glycol monoethyl ethers, propylene glycol monopropyl ethers, dipropylene glycol monoethyl ethers, and glycol ethers such as dipropylene glycol monopropyl ethers.
In addition to water and buffers, aqueous bases include ethanol and lower alcohols such as isopropanol; polyethylene glycol, propylene glycol, 1,3-butylene glycol, glycerin, isoprene glycol, diglycerin, and dipropylene. Examples include polyhydric alcohols such as glycol.
As the base material or carrier, one type can be used alone, or two or more types can be used in combination.

The formulation form of the external preparation for skin of the present invention is not particularly limited, and is a liquid agent, a suspension agent, an emulsion, a cream agent, an ointment agent, a gel agent (gel agent), a liniment agent, a lotion agent, a foam agent, a spray agent, and an aerosol agent. , Powder agent, poultice, non-woven sheet or the like impregnated with a chemical solution. Of these, lotions, gels, emulsions, creams, sprays, and aerosols are preferable because they are easy to spread on the skin and have a good usability.
When the dosage form is in an emulsified state such as an emulsion, a cream, or an emulsion ointment, either an oil-in-water type or a water-in-oil type may be used, but the oil-in-water type is preferable in terms of usability.

Applications The external preparation for skin of the present invention can be applied to the skin during exercise and used to sustain or improve the effect obtained by exercise. Specifically, for maintaining or increasing the temperature of the skin or body (particularly, the temperature of the skin or body increased by exercise), for maintaining or increasing sweating (particularly, sweating increased by exercise), blood flow (particularly, for increasing sweating). In particular, it can be used for maintaining or increasing the refreshing state (particularly, the refreshing state increased by exercise) for maintaining or increasing the blood flow increased by exercise.
When the external preparation for skin of the present invention is used, the exercise effect is sustained or increased even with light exercise, so that a feeling of firm exercise (effectiveness) can be obtained. Therefore, the continuation or improvement of the exercise effect can be regarded as the continuation or improvement of the actual feeling of exercise.
Further, when the exercise effect is sustained, a pleasant sensation or sensation due to exercise is maintained. Therefore, the continuation or improvement of the exercise effect can be regarded as the continuation or improvement of the exercise sensation or sensation. Specifically, the external preparation for skin of the present invention is used for maintaining or improving a feeling of warmth (particularly, a feeling of warmth increased by exercise), and for maintaining or improving a feeling of sweating (particularly, a feeling of sweating increased by exercise). , It can be used for maintaining or improving the feeling of increased blood flow (particularly, the feeling of increased blood flow increased by exercise), and for maintaining or improving the feeling of exhilaration (particularly, the feeling of exhilaration increased by exercise).

Method of use The external preparation for skin of the present invention may be applied to the skin during exercise. It may be used before, during, or after exercise, but it is preferably used during or after exercise, and more preferably after exercise. Before exercising, it can be within 10 minutes before exercising, especially within 5 minutes, and especially within 1 minute. Further, after the exercise, it can be within 30 minutes, particularly within 10 minutes, particularly within 5 minutes, particularly within 1 minute, and particularly within 30 seconds. After exercising, it may be applied as it is, it may be applied by wiping the sweat, or it may be applied after sweating in a shower or the like. When applying, it may be applied so that it is lightly blended, but it is preferable to apply while massaging.
In addition, it can be applied once or multiple times before, during, and after exercise, respectively.

The exercise time suitable for using the external preparation for skin of the present invention is not particularly limited. For example, exercise time such as 1 minute to 12 hours, 3 minutes to 3 hours, 5 minutes to 2 hours, 10 minutes to 1 hour, 20 to 30 minutes, and 10 to 15 minutes can be mentioned.

The application site of the external preparation for skin of the present invention is not particularly limited. Skin such as neck, arms, hands, torso (belly, hips, back, chest, buttocks), legs, and face. Above all, if applied to the neck, arms, hands, torso (belly, waist, back, chest, buttocks), legs, especially arms, hands, torso (belly, hips, back, chest, buttocks), legs, exercise effect The lasting or improving effect is increased.
The amount of the external preparation for skin used of the present invention is not particularly limited as long as it is compatible with the skin. About 0.001 to 0.01 g per 1 cm ^{2 of the} skin can be mentioned.
The method of application to the skin differs depending on the dosage form, and can be applied, sprayed, or applied.

Method for Sustaining or Improving Exercise Effect During exercise, the present invention applies a preparation (external skin preparation of the present invention) containing (A) a component that promotes fat burning and (B) a component that promotes sweating to the skin. Includes methods for sustaining or improving exercise effects, including steps.
This method of sustaining or improving the effect of exercise includes a method of maintaining or increasing the temperature of the skin or body (particularly, the temperature of the skin or body increased by exercise), a method of maintaining or increasing sweating (particularly, a method of maintaining or increasing sweating increased by exercise), and blood. A method of maintaining or increasing flow (particularly, blood flow increased by exercise), a method of maintaining or improving a refreshing state, a method of maintaining or improving a feeling of exercise, a method of maintaining or increasing a feeling of exercise or sensation, a feeling of warmth (particularly by exercise). How to maintain or improve the feeling of increased warmth), how to maintain or improve the feeling of sweating (particularly, the feeling of sweating increased by exercise), how to maintain or improve the feeling of increased blood flow (particularly, the feeling of increased blood flow due to exercise). It can be a method of maintaining or improving a feeling of exhilaration.

Each method of the present invention does not include a medical method. That is, it does not include a treatment method or a preventive method as a medical method.
The type, amount, dose, usage, application site, etc. of each component in the method of the present invention are as described for the external preparation for skin of the present invention.

Hereinafter, the present invention will be described in more detail with reference to examples, but the present invention is not limited thereto.

(1) Evaluation of body surface temperature In a constant temperature environment (22 ° C ± 1 ° C), four subjects (4 women) in their 20s and 30s were asked to exercise bike (registered trademark, Yamato Human Co., Ltd., YAB-881N). ) For 15 minutes under a constant load condition (load 3), and immediately after the exercise bike exercise, thermography (NEC Avio Infrared Technologies Co., Ltd., TVS-500EX) on the skin on the body surface (front of neck, palm) , The temperature of the back of the hand) was measured. Immediately wipe off sweat, apply each composition shown in Table 1 to the neck, palm, and back of the hand at about 2 mg / cm ² , then rest in a sitting position, and 10 minutes and 20 minutes after the end of exercise. The body surface temperature of the application site was measured, and the rate of change of the body surface temperature after exercise was calculated according to the following formula (1).

Rate of change in body surface temperature after exercise = [(body surface temperature 10 or 20 minutes after exercise-body surface temperature immediately after exercise) / body surface temperature immediately after exercise] x 100 (%)
・ ・ ・ ・ ・ ・ ・ Formula (1)

In Comparative Example 1, the composition was not applied and only the body surface temperature was measured.

実施例１、実施例２、比較例２の組成物は、その他成分として、さらに、メチルポリシロキサン、アクリル酸・メタクリル酸アルキル共重合体、高重合メチルポリシロキサン、２−エチルヘキサン酸セチル、ヒアルロン酸Ｎａ、エタノール、ニコチン酸アミド、キレート剤、香料を含む。これらの成分は、実施例１、実施例２、比較例２の各組成物に同濃度が配合されている。

The compositions of Example 1, Example 2, and Comparative Example 2 further include, as other components, methylpolysiloxane, acrylic acid / alkyl methacrylate copolymer, highly polymerized methylpolysiloxane, cetyl 2-ethylhexanoate, hyalurone. Contains sodium acid, ethanol, nicotinic acid amide, chelating agent, and fragrance. These components are blended in the same concentration in each of the compositions of Example 1, Example 2, and Comparative Example 2.

The average value of the body surface temperature change rate is shown in Table 2 and FIGS. 1 to 3.

By applying the external preparations for skin of Examples 1 and 2 after the exercise, the body surface temperature was generally increased 10 minutes or 20 minutes after the exercise. On the other hand, when the external preparation for skin of Comparative Example 2 containing neither the component (A) nor the component (B) of the present invention is applied after exercise, the body surface temperature is higher 10 minutes or 20 minutes after exercise than immediately after exercise. It became low. Therefore, it can be seen that the body surface temperature increased after exercise due to the combination of the components (A) and (B) of the present invention.
In addition, the skin external preparation of Example 2 containing the components (A) and (B) of the present invention and not containing vanillyl butyl, and Example 1 containing the components (A) and (B) of the present invention and vanillyl butyl. The rate of change in body surface temperature was similar to that of external preparations for skin. Considering that the rate of change in body temperature became negative when the external preparation for skin of Comparative Example 2 containing vanillyl butyl but not containing the components (A) and (B) of the present invention was applied, vanillyl butyl and the present invention were used. It can be seen that the components (A) and (B) of (A) and (B) act synergistically to raise the body surface temperature after exercise.

(2) Sensory test In the "(1) Evaluation of body surface temperature" test, the sensations felt by the four subjects were evaluated by the sensory test. The sensory test was performed by the visual analog scale (VAS) method for (1) refreshing sensation, (2) warm sensation (warm sensation), and (3) sweating sensation. For each question item, VAS used a 10 cm line segment that represents the worst state when the left end (0) "does not feel at all" and the best state when the right end (100) "feels very strongly", and each subject felt it. The size of the sensation was answered by putting a diagonal line in the 10 cm line segment. A sensory test was conducted so that the contents of the preparation could not be identified by the subjects.

It was confirmed that the VAS score of all items changed to a downward trend with the passage of time.
According to the following formula (2), in the case of no application (Comparative Example 1), the decrease in VAS score after 10 minutes or 20 minutes of exercise is used as a reference, and the decrease in VAS score when each external composition is applied is suppressed. The ratio was calculated and used as the effect suppression rate.

Effect reduction suppression rate (%)
= {1- (VAS value immediately after exercise in each example-10 minutes or 20 minutes after exercise in each example) / (VAS value immediately after exercise in Comparative Example 1-10 minutes after exercise in Comparative Example 1 or VAS value after 20 minutes)} × 100
・ ・ ・ ・ ・ ・ ・ (2)

The results are shown in Table 3.

By applying the external preparation for skin of Examples 1 and 2 after exercise, a high decrease in effect is suppressed in any of the items of "exhilaration", "warmth", and "sweat" after 10 minutes and 20 minutes of exercise. It was confirmed to be effective. Therefore, it can be seen that the combination of the components (A) and (B) of the present invention enhances the sustained effect of the exercise effect.
Further, when the external preparation for skin of Comparative Example 2 containing vanillyl butyl but not containing the components (A) and (B) of the present invention was applied, the suppression rate of the decrease in sweating sensation was very low at 3.9%, and also. The skin external preparation of Example 2 containing the components (A) and (B) of the present invention and not containing vanillyl butyl was 31.5%, whereas the component (A) and (B) of the present invention were used. In the case of the external preparation for skin of Example 1 containing the component and vanillyl butyl, the rate of suppression of decrease in sweating sensation was very high at 45.5%. It can be seen that vanillyl butyl and the components (A) and (B) of the present invention acted synergistically to maintain a feeling of effect after exercise.

(3) Evaluation of body surface temperature and sweating amount Five subjects in their twenties to forties (three men and two women) drank a protein-containing beverage and then Aerobike (registered trademark, Yamato Human Co., Ltd.) , YAB-881N) under constant load conditions (load 3) for 20 minutes, and immediately after aerobike exercise, 10 minutes and 20 minutes later, using thermography (NEC Avio Infrared Technologies Co., Ltd., TVS-500EX). The temperature of the skin on the surface of the body (front of neck, palm, back of hand) was measured. In addition, the amount of sweating of the forearm 10 minutes after the exercise bike exercise and the amount of sweating for 10 minutes 10 to 20 minutes later were measured using SKN-2000 PERSPIRATION METER (Nishizawa Electric Meters Mfg. Co., Ltd.). Was measured.
The five subjects performed the above exercise and measurement twice, one of which was "no application of external preparation for skin" and the other of two was "immediately after exercise, the gel-like external preparation for skin of Example 1 was applied. The condition was "applying about 2 mg / cm ² to each site".
As the protein-containing beverage, a mixture of protein powder containing black ginger extract and capsicum extract at a protein amount of 7 g / time and 150 mL of water was drunk.

The results are shown in Table 4.
The numerical value of the item of body surface temperature in Table 4 is the average value of the body temperature change rate after exercise calculated by the above formula (1).
In addition, the average value of the integrated value of the sweating amount for 10 minutes is taken as the sweating amount, and the sweating amount ratio is calculated by the following formula (3) based on the sweating amount for 10 minutes immediately after exercise when no external preparation for skin is applied. Calculated. The sweating ratio is also shown in Table 4.

Sweating amount ratio = 10 minutes of sweating from immediately after exercise to 10 minutes after exercise or 10 minutes of sweating from 10 minutes to 20 minutes after exercise) / From immediately after exercise to 10 minutes after exercise without application) Amount of sweating for 10 minutes
・ ・ ・ ・ ・ ・ ・ (3)

By applying the external preparation for skin of the present invention after exercise, the rate of increase in body surface temperature was larger than in the case of no application. Further, in the case of no application, the body surface temperature may decrease after exercise, but by applying the external preparation for skin of the present invention immediately after exercise, even if the body surface temperature once decreases after exercise, it is promptly thereafter. Turned up. The increase in body surface temperature due to the use of external preparations for skin was particularly remarkable in women.
In addition, the amount of sweating was clearly increased by the use of the external preparation for skin, and the tendency of increase was maintained even after a lapse of time after exercise, and the total amount of sweating was significantly increased as compared with the case where the external preparation was not applied. It was confirmed that.

In addition, as a result of interviewing each subject about the experience of using the external preparation for skin, "the part that was easy to get cold when not applied did not get cold due to the application." "The palm and neck became soft after a while after applying the external preparation for skin. It warmed up, but I didn't feel this kind of warmth when it was not applied. "" When it was not applied, I felt that my sweaty body was cold 20 minutes after the exercise, but immediately after the exercise. Even 20 minutes after applying the external preparation for skin, the sweaty body was still warm and not cold. " In the sensory evaluation, it was confirmed that the use of the external preparation for skin of the present invention increased the sensation of an increase in body temperature after exercise. The sensation of an increase in body surface temperature due to the use of external preparations for skin was particularly remarkable in women.

An example of formulation of the external preparation for skin of the present invention is shown below. “%” In the formulation example indicates “% by weight”.
Prescription example 1 (gel cream)
Purified water Remaining ethanol 10%
Squalene 5%
Cetyl ethylhexanoate 1%
Carbomer 0.5%
Dimethicone 0.5%
BG 5%
DPG 5%
TEA Appropriate amount of phenoxyethanol 0.3%
PEG-20 sorbitan isostearate 0.5%
Sorbitan sesquioleate 0.4%
Hyaluronic acid 0.05%
Vanillyl butyl 0.02%
Tambrissa trichophylla leaf extract 0.01%
Japanese butterbur leaf / stem extract 0.005%
Lepidium Mayeni Extract 0.003%
Carnitine 0.1%
Witch hazel leaf extract 0.1%
Bergamot oil 0.1%

Prescription example 2 (gel)
Purified water Remaining ethanol 10%
1,3-Propanediol 7%
Pentane diol 1%
Acrylic acid alkyl methacrylate copolymer 0.7%
Xanthan gum 0.05%
TEA Appropriate amount of methylparaben 0.1%
Polyoxyethylene hardened castor oil 0.5%
Hyaluronic acid 0.01%
Vanillyl butyl 0.01%
Tambrissa trichophylla leaf extract 0.05%
Japanese butterbur leaf / stem extract 0.001%
Lepidium Mayeni Extract 0.001%
Carnitine 0.2%
l-menthol 0.2%
Eucalyptus oil 0.05%
Fragrance 0.1%

Prescription example 3 (gel)
Purified water Remaining ethanol 10%
1,3-Propanediol 5%
Pentane diol 1%
Acrylic acid alkyl methacrylate copolymer 0.5%
Xanthan gum 0.05%
TEA Appropriate amount of methylparaben 0.1%
Polyoxyethylene hardened castor oil 0.5%
Hyaluronic acid 0.01%
Phytosonic (Sederma) 0.1%
Ginseng extract 0.01%
Japanese butterbur leaf / stem extract 0.001%
Lepidium Mayeni Extract 0.001%
Carnitine 0.2%
l-menthol 0.2%
Grapefruit oil 0.05%
Fragrance 0.1%

Prescription example 4 (gel)
Purified water Remaining ethanol 8%
BG 10%
DPG 5%
Alkylate Acrylic Acid Copolymer 0.5%
Xanthan gum 0.05%
TEA Appropriate amount of methylparaben 0.1%
Polyoxyethylene hardened castor oil 0.5%
Hyaluronic acid 0.02%
Pelargonic acid vanillylamide 0.005%
Ashitaba extract 0.1%
Japanese butterbur leaf / stem extract 0.001%
Carrot extract 0.001%
Carnitine 0.2%
l-menthol 0.2%
Lavender oil 0.05%
Fragrance 0.1%

Prescription example 5 (lotion)
Purified water Remaining ethanol 3%
1,3-Propanediol 7%
Glycerin 3%
Pentane diol 1%
Carrageenan 0.05%
Methylparaben 0.2%
Polyoxyethylene hardened castor oil 0.3%
Pepper extract 0.001%
Tambrissa trichophylla leaf extract 0.0001%
Japanese butterbur leaf / stem extract 0.0005%
Lepidium Mayeni Extract 0.005%
Carnitine 0.05%
Fragrance 0.05%

Prescription example 6 (milky lotion)
Purified water remaining amount Vaseline 5%
Liquid paraffin 2%
Tri (caprylic acid / capric acid) glyceryl 3%
Hydroxyethyl cellulose 0.5%
Dimethicone 0.5%
BG 5%
Glycerin 5%
TEA Appropriate amount of hexanediol 2%
Phenoxyethanol 0.5%
PEG-20 sorbitan isostearate 1%
Glyceryl stearate 0.5%
Vanillyl butyl 0.005%
Tambrissa trichophylla leaf extract 0.03%
Japanese butterbur leaf / stem extract 0.01%
Lepidium Mayeni Extract 0.001%
Carnitine 0.01%
Cha extract 0.05%
Camphor 0.01%
Fragrance 0.1%

Prescription example 7 (spray)
Purified water Remaining ethanol 40%
BG 5%
PPG-6 decyltetradeceth 0.3%
Hyaluronic acid 0.01%
Vanillyl butyl 0.03%
Tambrissa trichophylla leaf extract 0.001%
Japanese butterbur leaf / stem extract 0.001%
Lepidium Mayeni Extract 0.005%
Carnitine 0.005%
l-Menthol 0.5%
Bergamot oil 0.05%
Fragrance 0.05%
Talc 3%

Prescription example 8 (gel)
Purified water Remaining ethanol 10%
1,3-butylene glycol 5%
Pentane diol 1.5%
Alkylate Alkylate Copolymer Acrylic Acid 0.6%
Hydroxyethyl cellulose 0.1%
TEA Appropriate amount of methylparaben 0.05%
Polyoxyethylene hardened castor oil 0.5%
Hyaluronic acid 0.01%
Vanillyl butyl 0.01%
Tambrissa trichophylla leaf extract 0.05%
Japanese butterbur leaf / stem extract 0.001%
Stevia extract 0.001%
Carnitine 0.2%
l-menthol 0.2%
Eucalyptus oil 0.05%
Fragrance 0.1%

Prescription example 9 (gel cream)
Purified water Remaining ethanol 8%
Squalene 5%
Cetyl ethylhexanoate 1%
Carbomer 0.5%
Dimethicone 0.2%
1,3-butylene glycol 5%
DPG 2%
TEA Appropriate amount of phenoxyethanol 0.3%
PEG-20 sorbitan isostearate 0.5%
Sorbitan sesquioleate 0.4%
Hyaluronic acid 0.05%
Vanillyl butyl 0.02%
Bacillus / Dice Fermented Extract 0.01%
Tambrissa trichophylla leaf extract 0.05%
Lepidium Mayeni Extract 0.003%
Carnitine 0.1%
Grapefruit oil 0.05%
Bergamot oil 0.03%

By applying the external preparation for skin of the present invention to the skin during exercise, the exercise effect is sustained or improved. Therefore, even a light exercise can obtain a large exercise effect and increase the satisfaction. In recent years, the exercising population has been increasing, and most people are exercising lightly. Therefore, the external preparation for skin of the present invention has a high commercial value that meets the needs.

Claims (11)

An external preparation for skin containing (A) a component that promotes fat burning and (B) a component that promotes sweating. The component (A) has an action of promoting the decomposition of (A1) triglyceride, (A2) a component having an action of promoting the uptake of fatty acid produced by the decomposition of triglyceride, and (A3) burning of fatty acid in mitochondria. The skin external preparation according to claim 1, which is at least one selected from the group consisting of components having a promoting action. The skin external preparation according to claim 2, wherein the component (A1) is an Asteraceae plant extract, the component (A2) is L-carnitine, and the component (A3) is a cruciferous plant extract. The skin external preparation according to any one of claims 1 to 3, which contains a tambrissa tocophylla extract and / or an Asteraceae plant extract as a component (B). According to any one of claims 1 to 4, the total content of the component (A) is 0.0002 to 10% by weight based on the total amount of the external preparation for skin in terms of dry weight for the plant extract. The listed external preparation for skin. According to any one of claims 1 to 5, the total content of the component (B) is 0.0001 to 10% by weight based on the total amount of the external preparation for skin in terms of dry weight for the plant extract. The listed external preparation for skin. The external preparation for skin according to any one of claims 1 to 6, further comprising a fragrance. The external preparation for skin according to any one of claims 1 to 7, which is used for sustaining or improving an exercise effect. The external preparation for skin according to claim 8, wherein the duration or improvement of the exercise effect is the maintenance or improvement of skin temperature, sweating, blood flow, and / or refreshment. The external preparation for external skin according to any one of claims 1 to 9, which is applied to the skin during or after exercise. A method for sustaining or improving an exercise effect, which comprises a step of applying an external preparation for skin containing (A) a component that promotes fat burning and (B) a component that promotes sweating to the skin during exercise.

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