JP2020532578A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2020532578A5 JP2020532578A5 JP2020527860A JP2020527860A JP2020532578A5 JP 2020532578 A5 JP2020532578 A5 JP 2020532578A5 JP 2020527860 A JP2020527860 A JP 2020527860A JP 2020527860 A JP2020527860 A JP 2020527860A JP 2020532578 A5 JP2020532578 A5 JP 2020532578A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- compound
- compound according
- och
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 10
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 229910052736 halogen Inorganic materials 0.000 claims 2
- 150000002367 halogens Chemical class 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 230000004663 cell proliferation Effects 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 0 CCC[C@](C)CNS(C)(CSC(*(C)*C)=CCCC)O Chemical compound CCC[C@](C)CNS(C)(CSC(*(C)*C)=CCCC)O 0.000 description 3
- ULMKNGVHAZDIEL-OLNZRHPYSA-O C/C=N\C/C=C(\NCCN(C)C[SH2+])/Cl Chemical compound C/C=N\C/C=C(\NCCN(C)C[SH2+])/Cl ULMKNGVHAZDIEL-OLNZRHPYSA-O 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762537758P | 2017-07-27 | 2017-07-27 | |
| US62/537,758 | 2017-07-27 | ||
| PCT/US2018/044183 WO2019023635A1 (en) | 2017-07-27 | 2018-07-27 | SUBSTITUTED 3 H-IMIDAZO (4,5-C) PYRIDINE AND 1H-PYRROLO (2,3-C) PYRIDINE SERIES OF A NOVEL ECTONUCLEOTIDE PYROPHOSPHATASE / PHOSPHODIESTERASE-1 (ENPP1) AND STIMULATOR FOR A GENE MODULATOR INTERFERON (STING) AS IMMUNOTHERAPEUTIC AGENTS AGAINST CANCER |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020532578A JP2020532578A (ja) | 2020-11-12 |
| JP2020532578A5 true JP2020532578A5 (OSRAM) | 2021-09-16 |
| JP7274478B2 JP7274478B2 (ja) | 2023-05-16 |
Family
ID=65040330
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020527860A Active JP7274478B2 (ja) | 2017-07-27 | 2018-07-27 | 置換された－３Ｈ－イミダゾ［４，５－ｃ］ピリジン及び１Ｈ－ピロロ［２，３－ｃ］ピリジンシリーズの新規なエクトヌクレオチドピロホスファターゼ／ホスホジエステラーゼ－１（ＥＮＰＰ１）並びにがん免疫治療薬としてのインターフェロン遺伝子（ＳＴＩＮＧ）モジュレータのための刺激剤 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US10689376B2 (OSRAM) |
| EP (1) | EP3658138B1 (OSRAM) |
| JP (1) | JP7274478B2 (OSRAM) |
| CN (1) | CN111615388B (OSRAM) |
| WO (1) | WO2019023635A1 (OSRAM) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US12162863B2 (en) | 2018-06-12 | 2024-12-10 | Ryvu Therapeutics S.A. | Modulators of stimulator of interferon genes (STING) |
| WO2020028724A1 (en) | 2018-08-01 | 2020-02-06 | Stingray Therapeutics, Inc. | Substituted-3h-imidazo[4,5-c]pyridine and 1h-pyrrolo[2,3-c]pyridine series of novel ectonucleotide pyrophosphatase/phosphodiesterase-1 (enpp1) and stimulator for interferon genes (sting) modulators as cancer immunotherapeutics |
| US20220289775A1 (en) * | 2019-02-01 | 2022-09-15 | The Board Of Trustees Of The Leland Stanford Junior University | ENPP1 Inhibitors and Methods of Modulating Immune Response |
| WO2020185859A1 (en) | 2019-03-12 | 2020-09-17 | Arcus Biosciences, Inc. | Treatment of oncogene-driven cancers |
| MA55517A (fr) | 2019-03-28 | 2022-02-09 | Lupin Ltd | Composés macrocycliques utilisés en tant qu'agonistes sting |
| EP3947463A4 (en) | 2019-03-29 | 2022-12-21 | Arcus Biosciences, Inc. | TREATMENT OF CANCER USING AN IDENTIFIED ADENOSINE FINGERPRINT |
| IL288868B2 (en) | 2019-06-12 | 2025-02-01 | Ryvu Therapeutics S A | Next generation of stimulator of interferon genes (STING) modulators |
| PE20220937A1 (es) | 2019-07-22 | 2022-05-31 | Lupin Ltd | Compuestos macrociclicos como agonistas de sting y metodos y usos de los mismos |
| CA3151277A1 (en) | 2019-09-16 | 2021-03-25 | Aten Porus Lifesciences Pvt. Ltd. | 2-amino-s6-substituted thiopurine compounds as inhibitors of the enpp1 protein |
| KR20260022465A (ko) * | 2019-12-11 | 2026-02-19 | 리부 세라퓨틱스 에스.에이. | 인터페론 유전자 자극제(sting)의 조절제인 헤테로사이클릭 화합물 |
| GB202006382D0 (en) | 2020-04-30 | 2020-06-17 | Spermatech As | Use |
| KR102682428B1 (ko) | 2020-05-08 | 2024-07-05 | 주식회사 티씨노바이오사이언스 | 엑토뉴클레오티드 피로포스파타아제-포스포디에스터라아제의 저해 활성을 갖는 신규한 프탈라진 유도체 및 이들의 용도 |
| CN115515939B (zh) | 2020-05-08 | 2024-12-13 | 谛希诺生物科技有限公司 | 具有抑制外核苷酸焦磷酸酶-磷酸二酯酶的活性的新型酞嗪衍生物及它们的用途 |
| KR102720206B1 (ko) | 2020-12-29 | 2024-10-21 | 주식회사 티씨노바이오사이언스 | 엑토뉴클레오티드 피로포스파타아제-포스포디에스터라아제의 저해 활성을 갖는 신규한 나프티리딘온 유도체 및 이들의 용도 |
| WO2022146022A1 (ko) | 2020-12-29 | 2022-07-07 | 주식회사 티씨노바이오사이언스 | 엑토뉴클레오티드 피로포스파타아제-포스포디에스터라아제의 저해 활성을 갖는 신규한 나프티리딘온 유도체 및 이들의 용도 |
| AU2022211957B2 (en) | 2021-01-29 | 2024-05-23 | Txinno Bioscience Inc. | Novel benzotriazole derivative having inhibitory activity against ectonucleotide pyrophosphatase-phosphodiesterase, and use thereof |
| KR102686866B1 (ko) | 2021-01-29 | 2024-07-19 | 주식회사 티씨노바이오사이언스 | 엑토뉴클레오티드 피로포스파타아제-포스포디에스터라아제의 저해 활성을 갖는 신규한 벤조트리아졸 유도체 및 이들의 용도 |
| WO2023143520A1 (en) * | 2022-01-28 | 2023-08-03 | Insilico Medicine Ip Limited | Ectonucleotide pyrophosphatase-phosphodiesterase 1 (enpp1) inhibitors and uses thereof |
| WO2023212154A1 (en) | 2022-04-29 | 2023-11-02 | Petragen, Inc. | Inhibitors of enpp1 and modulation of bone growth |
| WO2026006739A1 (en) * | 2024-06-28 | 2026-01-02 | Riboscience Llc | Bicyclic heteroaryl derivatives as ectonucleotide pyrophosphatase phosphodiesterase 1 inhibitors for the treatment of certain diseases |
| WO2026078593A1 (en) | 2024-10-08 | 2026-04-16 | Sun Pharma Advanced Research Company Limited | Sting agonists and antibody drug conjugates thereof |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5081253A (en) * | 1989-12-21 | 1992-01-14 | American Home Products Corporation | Imidazo(4,5-c)pyridines as antiosteoporotic agents |
| ATE297900T1 (de) * | 1997-03-25 | 2005-07-15 | Kowa Co | Anilidverbindungen und medikamente, die diese enthalten |
| US9643933B2 (en) * | 2013-04-23 | 2017-05-09 | The General Hospital Corporation | Compounds useful as antibiotic tolerance inhibitors |
-
2018
- 2018-07-27 WO PCT/US2018/044183 patent/WO2019023635A1/en not_active Ceased
- 2018-07-27 EP EP18837593.5A patent/EP3658138B1/en active Active
- 2018-07-27 JP JP2020527860A patent/JP7274478B2/ja active Active
- 2018-07-27 CN CN201880063421.5A patent/CN111615388B/zh active Active
- 2018-07-27 US US16/047,915 patent/US10689376B2/en active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2020506951A5 (OSRAM) | ||
| JP2019031560A5 (OSRAM) | ||
| RU2015107803A (ru) | Производные дигидроксипиримидинкарбоновой кислоты и их применение в лечении, облегчении или предотвращении вирусного заболевания | |
| JP2019504890A5 (OSRAM) | ||
| JP2016518434A5 (OSRAM) | ||
| JP2017514839A5 (OSRAM) | ||
| CN114072396A (zh) | 作为dna-pk抑制剂的喹啉和噌啉衍生物 | |
| JP2018537535A5 (OSRAM) | ||
| JP2017527590A5 (OSRAM) | ||
| JP2020515574A5 (OSRAM) | ||
| JP2018510139A5 (OSRAM) | ||
| JP2019518766A5 (OSRAM) | ||
| JP2017528498A5 (OSRAM) | ||
| JP2019537570A5 (OSRAM) | ||
| JP2019529518A5 (OSRAM) | ||
| JP2017514838A5 (OSRAM) | ||
| JP2011500550A5 (OSRAM) | ||
| JP2016520131A5 (OSRAM) | ||
| JP2014520898A5 (OSRAM) | ||
| JP2006517532A5 (OSRAM) | ||
| JP2007502295A5 (OSRAM) | ||
| JP2016531126A5 (OSRAM) | ||
| JP2020128426A5 (OSRAM) | ||
| JP2015536997A5 (OSRAM) | ||
| JP2016522254A5 (OSRAM) |