JP2020531535A - Ｃｄ３３標的剤と共に使用するためのｃｄ３３エクソン２欠損型ドナー幹細胞 - Google Patents

Ｃｄ３３標的剤と共に使用するためのｃｄ３３エクソン２欠損型ドナー幹細胞 Download PDF

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JP2020531535A
JP2020531535A JP2020511435A JP2020511435A JP2020531535A JP 2020531535 A JP2020531535 A JP 2020531535A JP 2020511435 A JP2020511435 A JP 2020511435A JP 2020511435 A JP2020511435 A JP 2020511435A JP 2020531535 A JP2020531535 A JP 2020531535A
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cells
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hematopoietic
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JP2020531535A5 (https=
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ムケルジー，シッドハルシャ
アリ，アブドゥラー，マフムード
ボロット，フローレンス
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Columbia University in the City of New York
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Columbia University in the City of New York
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • C—CHEMISTRY; METALLURGY
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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
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    • A61K40/00—Cellular immunotherapy
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    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
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    • A61K40/421—Immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C07K16/2809—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
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    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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JP2020511435A 2017-08-28 2018-08-28 Ｃｄ３３標的剤と共に使用するためのｃｄ３３エクソン２欠損型ドナー幹細胞 Pending JP2020531535A (ja)

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JP2024076658A JP2024105479A (ja) 2017-08-28 2024-05-09 Ｃｄ３３標的剤と共に使用するためのｃｄ３３エクソン２欠損型ドナー幹細胞

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US201762551075P 2017-08-28 2017-08-28
US62/551,075 2017-08-28
PCT/US2018/048317 WO2019046285A1 (en) 2017-08-28 2018-08-28 CD33 EXON 2 DONOR STEM CELLS FOR USE WITH CD33 TARGETING AGENTS

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JP2024076658A Pending JP2024105479A (ja) 2017-08-28 2024-05-09 Ｃｄ３３標的剤と共に使用するためのｃｄ３３エクソン２欠損型ドナー幹細胞

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SG11201907870VA (en) 2017-02-28 2019-09-27 Vor Biopharma Inc Compositions and methods for inhibition of lineage specific proteins
US11718659B2 (en) * 2017-08-28 2023-08-08 The Trustees Of Columbia University In The City Of New York CD33 exon 2 deficient donor stem cells for use with CD33 targeting agents
CA3110837A1 (en) 2018-08-28 2020-03-05 Vor Biopharma Inc. Genetically engineered hematopoietic stem cells and uses thereof
US11866494B2 (en) * 2018-08-31 2024-01-09 Innovative Cellular Therapeutics Holdings, Ltd. CAR T therapy through uses of co-stimulation
MX2021008490A (es) * 2019-01-16 2021-09-28 Univ Columbia Composiciones y metodos para la inhibicion de antigenos con especificidad de linaje.
CN114423865A (zh) * 2019-05-23 2022-04-29 Vor生物制药股份有限公司 Cd33修饰的组合物和方法
AU2020336211A1 (en) * 2019-08-28 2022-03-10 Vor Biopharma Inc. Compositions and methods for CD123 modification
US20220290160A1 (en) 2019-08-28 2022-09-15 Vor Biopharma Inc. Compositions and methods for cll1 modification
CA3153700A1 (en) 2019-09-09 2021-03-18 Scribe Therapeutics Inc. Compositions and methods for use in immunotherapy
WO2021081244A1 (en) * 2019-10-22 2021-04-29 Fred Hutchinson Cancer Research Center Base editor-mediated cd33 reduction to selectively protect therapeutic cells
CN116157135A (zh) * 2020-06-03 2023-05-23 纽约市哥伦比亚大学理事会 使用基于crispr的碱基编辑器系统抑制谱系特异性抗原的组合物和方法
US20240110189A1 (en) 2020-08-28 2024-04-04 Vor Biopharma Inc. Compositions and methods for cll1 modification
US20240238344A1 (en) 2020-08-28 2024-07-18 Vor Biopharma Inc. Compositions and methods for cd123 modification
JP2023541457A (ja) 2020-09-14 2023-10-02 ブイオーアール バイオファーマ インコーポレーテッド Ｃｄ３８修飾のための化合物および方法
WO2022056459A1 (en) 2020-09-14 2022-03-17 Vor Biopharma, Inc. Compositions and methods for cd5 modification
WO2022061115A1 (en) 2020-09-18 2022-03-24 Vor Biopharma Inc. Compositions and methods for cd7 modification
WO2022067240A1 (en) 2020-09-28 2022-03-31 Vor Biopharma, Inc. Compositions and methods for cd6 modification
US20230364146A1 (en) 2020-09-30 2023-11-16 Vor Biopharma Inc. Compositions and methods for cd30 gene modification
CA3199623A1 (en) * 2020-10-27 2022-05-05 Vor Biopharma Inc. Compositions and methods for treating hematopoietic malignancy
WO2022094245A1 (en) 2020-10-30 2022-05-05 Vor Biopharma, Inc. Compositions and methods for bcma modification
WO2022147347A1 (en) 2020-12-31 2022-07-07 Vor Biopharma Inc. Compositions and methods for cd34 gene modification
CN115443333B (zh) * 2021-04-27 2025-04-25 上海驯鹿生物技术有限公司 一种基因编辑的造血干细胞及其与car-t细胞的联合应用
EP4330394A2 (en) * 2021-04-28 2024-03-06 Eisai R&D Management Co., Ltd. Antisense oligonucleotides and their use for treatment of neurodegenerative disorders
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WO2024015925A2 (en) 2022-07-13 2024-01-18 Vor Biopharma Inc. Compositions and methods for artificial protospacer adjacent motif (pam) generation
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EP3676372A1 (en) 2020-07-08
US20240166721A1 (en) 2024-05-23
US11718659B2 (en) 2023-08-08
WO2019046285A1 (en) 2019-03-07
EP3676372A4 (en) 2021-06-02
US20200262891A1 (en) 2020-08-20

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