JP2020531454A5 - - Google Patents
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- JP2020531454A5 JP2020531454A5 JP2020508581A JP2020508581A JP2020531454A5 JP 2020531454 A5 JP2020531454 A5 JP 2020531454A5 JP 2020508581 A JP2020508581 A JP 2020508581A JP 2020508581 A JP2020508581 A JP 2020508581A JP 2020531454 A5 JP2020531454 A5 JP 2020531454A5
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- JP
- Japan
- Prior art keywords
- alkyl
- pharmaceutically acceptable
- alkoxy
- methoxy
- cycloalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- STHBHEYNLYNJAM-UHFFFAOYSA-N Cc1n[nH]c2c1cccn2 Chemical compound Cc1n[nH]c2c1cccn2 STHBHEYNLYNJAM-UHFFFAOYSA-N 0.000 description 1
- JJLBTVYCYWUHCH-UHFFFAOYSA-N Cc1n[nH]c2c1nccc2 Chemical compound Cc1n[nH]c2c1nccc2 JJLBTVYCYWUHCH-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762546290P | 2017-08-16 | 2017-08-16 | |
| US62/546,290 | 2017-08-16 | ||
| PCT/US2018/046801 WO2019036534A1 (en) | 2017-08-16 | 2018-08-16 | INDAZOLE COMPOUNDS AS MGLUR4 ALLOSTERIC POTENTIALIZERS, COMPOSITIONS, AND METHODS FOR TREATING NEUROLOGICAL DYSFUNCTIONS |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020531454A JP2020531454A (ja) | 2020-11-05 |
| JP2020531454A5 true JP2020531454A5 (US07794700-20100914-C00152.png) | 2021-09-16 |
| JP7253832B2 JP7253832B2 (ja) | 2023-04-07 |
Family
ID=63579734
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020508581A Active JP7253832B2 (ja) | 2017-08-16 | 2018-08-16 | ｍＧＬｕＲ４アロステリック増強剤としてのインダゾール化合物、組成物、および神経機能不全を治療する方法 |
Country Status (17)
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018089544A1 (en) | 2016-11-08 | 2018-05-17 | Vanderbilt University | Isoquinoline amine compounds as mglur4 allosteric potentiators, compositions, and methods of treating neurological dysfunction |
| US10968227B2 (en) | 2016-11-08 | 2021-04-06 | Vanderbilt University | Isoquinoline ether compounds as mGluR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction |
| WO2019006157A1 (en) | 2017-06-28 | 2019-01-03 | Vanderbilt University | QUINOLINE PYRIDINE COMPOUNDS AS MGLUR4 ALLOSTERIC POTENTIALIZERS, COMPOSITIONS, AND METHODS FOR TREATING NEUROLOGICAL DYSFUNCTIONS |
| CA3072493A1 (en) | 2017-08-16 | 2019-02-21 | Vanderbilt University | Indazole compounds as mglur4 allosteric potentiators, compositions, and methods of treating neurological dysfunction |
| MX2021015996A (es) | 2019-07-11 | 2022-06-08 | Escape Bio Inc | Indazoles y azaindazoles como inhibidores de cinasa de repetición rica en leucina 2 (lrrk2). |
| WO2023114224A1 (en) | 2021-12-13 | 2023-06-22 | Sage Therapeutics, Inc. | Combination of muscarinic receptor positive modulators and nmda positive allosteric modulators |
| WO2024121367A1 (en) * | 2022-12-08 | 2024-06-13 | Boehringer Ingelheim International Gmbh | Novel substituted pyrazine-carboxamide-imidazopyridine derivatives |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2089018A2 (en) | 2006-11-07 | 2009-08-19 | Lexicon Pharmaceuticals, Inc. | Methods of treating cognitive impairment and dementia |
| US20080153810A1 (en) | 2006-11-15 | 2008-06-26 | Forest Laboratories Holdings Limited | Indazole derivatives useful as melanin concentrating receptor ligands |
| PL2120932T3 (pl) | 2006-12-20 | 2015-02-27 | Nerviano Medical Sciences Srl | Indazolowe pochodne jako inhibitory kinazy do leczenia raka |
| GB0713686D0 (en) * | 2007-07-13 | 2007-08-22 | Addex Pharmaceuticals Sa | New compounds 2 |
| JP2012516355A (ja) | 2009-01-28 | 2012-07-19 | ヴァンダービルト ユニバーシティー | ｍＧＬｕＲ４アロステリック増強剤としての置換された１，１，３，３−テトラオキシドベンゾ［ｄ］［１，３，２］ジチアゾール、組成物、および神経機能不全を治療する方法 |
| SG177740A1 (en) | 2009-07-23 | 2012-02-28 | Univ Vanderbilt | Substituted benzoimidazolesulfonamides and substituted indolesulfonamides as mglur4 potentiators |
| US8779157B2 (en) | 2009-09-04 | 2014-07-15 | Vanderbilt University | MGLUR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction |
| WO2011050316A1 (en) | 2009-10-22 | 2011-04-28 | Vanderbilt University | Mglur4 allosteric potentiators, compositions, and methods of treating neurological dysfunction |
| AU2010314891A1 (en) | 2009-11-06 | 2012-06-07 | Vanderbilt University | Aryl and heteroaryl sulfones as MGLUR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction |
| US8759377B2 (en) | 2009-11-23 | 2014-06-24 | Vanderbilt University | Substituted dioxopiperidines and dioxopyrrolidines as MGLUR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction |
| CN102892288B (zh) | 2010-02-11 | 2016-02-24 | 范德比尔特大学 | 作为亲代谢性谷氨酸受体4(mGLuR4)变构增效剂的吡唑并吡啶化合物、吡唑并吡嗪化合物、吡唑并吡嘧啶化合物、吡唑并噻吩化合物和吡唑并噻唑化合物，组合物，以及其治疗神经学上的功能失调的方法 |
| EP2533642A4 (en) | 2010-02-11 | 2013-08-07 | Univ Vanderbilt | BENZISOXAZOLES AND AZABENZISOXAZOLES AS ALLOSTERIC POTENTIALIZERS OF METABOTROPIC GLUTAMATE RECEPTOR SUBType 4 (MGLUR4), COMPOSITIONS, AND METHODS OF TREATING NEUROLOGICAL DYSFUNCTIONS |
| RU2012154447A (ru) | 2010-05-12 | 2014-06-20 | Вандербилт Юниверсити | Гетероциклические сульфоновые аллостерические потенциаторы mglur4, композиции и способы лечения неврологических дисфункций |
| TWI667233B (zh) | 2013-12-19 | 2019-08-01 | 德商拜耳製藥公司 | 新穎吲唑羧醯胺，其製備方法、含彼等之醫藥製劑及其製造醫藥之用途 |
| SG10201914111XA (en) | 2014-03-20 | 2020-03-30 | Samumed Llc | 5-substituted indazole-3-carboxamides and preparation and use thereof |
| JO3705B1 (ar) | 2014-11-26 | 2021-01-31 | Bayer Pharma AG | إندازولات مستبدلة جديدة، عمليات لتحضيرها، مستحضرات دوائية تحتوي عليها واستخدامها في إنتاج أدوية |
| US9980945B2 (en) | 2015-01-13 | 2018-05-29 | Vanderbilt University | Benzoisoxazole-substituted compounds as MGLUR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction |
| WO2016115272A1 (en) | 2015-01-13 | 2016-07-21 | Vanderbilt University | Benzothiazole and benzisothiazole-substituted compounds as mglur4 allosteric potentiators, compositions, and methods of treating neurological dysfunction |
| US10526323B2 (en) | 2015-01-30 | 2020-01-07 | Vanderbilt University | Indazole and azaindazole substituted compounds as mGluR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction |
| WO2016123627A1 (en) | 2015-01-30 | 2016-08-04 | Vanderbilt University | Isoquiniline and napthalene-substituted compounds as mglur4 allosteric potentiators, compounds, and methods of treating neurological dysfunction |
| US10294222B2 (en) | 2016-09-01 | 2019-05-21 | Vanderbilt University | Benzomorpholine and benzomorpholine-substituted compounds as MGLUR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction |
| US10710997B2 (en) | 2016-09-01 | 2020-07-14 | Vanderbilt University | Isoquinoline amide and isoquinoline amide-substituted compounds as mGluR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction |
| US10968227B2 (en) | 2016-11-08 | 2021-04-06 | Vanderbilt University | Isoquinoline ether compounds as mGluR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction |
| WO2018089544A1 (en) | 2016-11-08 | 2018-05-17 | Vanderbilt University | Isoquinoline amine compounds as mglur4 allosteric potentiators, compositions, and methods of treating neurological dysfunction |
| CA3072493A1 (en) | 2017-08-16 | 2019-02-21 | Vanderbilt University | Indazole compounds as mglur4 allosteric potentiators, compositions, and methods of treating neurological dysfunction |
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2018
- 2018-08-16 CA CA3072493A patent/CA3072493A1/en active Pending
- 2018-08-16 EP EP18769523.4A patent/EP3668865A1/en active Pending
- 2018-08-16 EA EA202090467A patent/EA202090467A1/ru unknown
- 2018-08-16 WO PCT/US2018/046801 patent/WO2019036534A1/en unknown
- 2018-08-16 BR BR112020003292-1A patent/BR112020003292A2/pt unknown
- 2018-08-16 US US16/639,539 patent/US11427573B2/en active Active
- 2018-08-16 AU AU2018317403A patent/AU2018317403B2/en active Active
- 2018-08-16 CN CN201880067616.7A patent/CN111225913B/zh active Active
- 2018-08-16 US US16/104,011 patent/US10508105B2/en active Active
- 2018-08-16 PE PE2020000257A patent/PE20200756A1/es unknown
- 2018-08-16 IL IL272575A patent/IL272575B2/en unknown
- 2018-08-16 UA UAA202001405A patent/UA128084C2/uk unknown
- 2018-08-16 SG SG11202001264UA patent/SG11202001264UA/en unknown
- 2018-08-16 JP JP2020508581A patent/JP7253832B2/ja active Active
- 2018-08-16 KR KR1020207007596A patent/KR20200054204A/ko active IP Right Grant
-
2020
- 2020-02-12 CL CL2020000360A patent/CL2020000360A1/es unknown
- 2020-02-28 ZA ZA2020/01321A patent/ZA202001321B/en unknown
- 2020-03-04 CO CONC2020/0002576A patent/CO2020002576A2/es unknown
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2022
- 2022-04-26 US US17/730,112 patent/US20220259190A1/en active Pending
