JP2020530497A5 - - Google Patents
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- JP2020530497A5 JP2020530497A5 JP2020530441A JP2020530441A JP2020530497A5 JP 2020530497 A5 JP2020530497 A5 JP 2020530497A5 JP 2020530441 A JP2020530441 A JP 2020530441A JP 2020530441 A JP2020530441 A JP 2020530441A JP 2020530497 A5 JP2020530497 A5 JP 2020530497A5
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- JP
- Japan
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- 102000002254 Glycogen Synthase Kinase 3 Human genes 0.000 description 2
- 108010014905 Glycogen Synthase Kinase 3 Proteins 0.000 description 2
- QNAQEWTWBYVVSY-UHFFFAOYSA-N 3-(1-benzofuran-3-yl)-4-(1h-indol-3-yl)pyrrole-2,5-dione Chemical class C1=CC=C2C(C=3C(=O)NC(C=3C=3C4=CC=CC=C4NC=3)=O)=COC2=C1 QNAQEWTWBYVVSY-UHFFFAOYSA-N 0.000 description 1
- FARXPFGGGGLENU-UHFFFAOYSA-N 3-(5-fluoro-1-benzofuran-3-yl)-4-(5-methyl-[1,3]dioxolo[4,5-f]indol-7-yl)pyrrole-2,5-dione Chemical compound C12=CC=3OCOC=3C=C2N(C)C=C1C1=C(C=2C3=CC(F)=CC=C3OC=2)C(=O)NC1=O FARXPFGGGGLENU-UHFFFAOYSA-N 0.000 description 1
- 208000008839 Kidney Neoplasms Diseases 0.000 description 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 description 1
- 206010038389 Renal cancer Diseases 0.000 description 1
- 239000012830 cancer therapeutic Substances 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 230000004153 glucose metabolism Effects 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 201000010982 kidney cancer Diseases 0.000 description 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 description 1
- 229930014626 natural product Natural products 0.000 description 1
- 201000002528 pancreatic cancer Diseases 0.000 description 1
- 208000008443 pancreatic carcinoma Diseases 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000012453 solvate Substances 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023123302A JP7778750B2 (ja) | 2017-08-11 | 2023-07-28 | ３－（５－フルオロベンゾフラン－３－イル）－４－（５－メチル－５Ｈ－［１，３］ジオキソロ［４，５－ｆ］インドール－７－イル）ピロール－２，５－ジオンの固体形態 |
| JP2025168516A JP2026012715A (ja) | 2017-08-11 | 2025-10-06 | ３－（５－フルオロベンゾフラン－３－イル）－４－（５－メチル－５Ｈ－［１，３］ジオキソロ［４，５－ｆ］インドール－７－イル）ピロール－２，５－ジオンの固体形態 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762544277P | 2017-08-11 | 2017-08-11 | |
| US62/544,277 | 2017-08-11 | ||
| PCT/US2018/046203 WO2019032958A1 (en) | 2017-08-11 | 2018-08-10 | SOLID FORMS OF 3- (5-FLUOROBENZOFURAN-3-YL) -4- (5-METHYL-5H [1,3] DIOXOLO [4,5-F] INDOL-7-YL) PYRROLE-2,5-DIONE |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023123302A Division JP7778750B2 (ja) | 2017-08-11 | 2023-07-28 | ３－（５－フルオロベンゾフラン－３－イル）－４－（５－メチル－５Ｈ－［１，３］ジオキソロ［４，５－ｆ］インドール－７－イル）ピロール－２，５－ジオンの固体形態 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020530497A JP2020530497A (ja) | 2020-10-22 |
| JP2020530497A5 true JP2020530497A5 (https=) | 2021-09-09 |
| JP7424639B2 JP7424639B2 (ja) | 2024-01-30 |
Family
ID=63405430
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020530441A Active JP7424639B2 (ja) | 2017-08-11 | 2018-08-10 | ３－（５－フルオロベンゾフラン－３－イル）－４－（５－メチル－５Ｈ－［１，３］ジオキソロ［４，５－ｆ］インドール－７－イル）ピロール－２，５－ジオンの固体形態 |
| JP2023123302A Active JP7778750B2 (ja) | 2017-08-11 | 2023-07-28 | ３－（５－フルオロベンゾフラン－３－イル）－４－（５－メチル－５Ｈ－［１，３］ジオキソロ［４，５－ｆ］インドール－７－イル）ピロール－２，５－ジオンの固体形態 |
| JP2025168516A Pending JP2026012715A (ja) | 2017-08-11 | 2025-10-06 | ３－（５－フルオロベンゾフラン－３－イル）－４－（５－メチル－５Ｈ－［１，３］ジオキソロ［４，５－ｆ］インドール－７－イル）ピロール－２，５－ジオンの固体形態 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023123302A Active JP7778750B2 (ja) | 2017-08-11 | 2023-07-28 | ３－（５－フルオロベンゾフラン－３－イル）－４－（５－メチル－５Ｈ－［１，３］ジオキソロ［４，５－ｆ］インドール－７－イル）ピロール－２，５－ジオンの固体形態 |
| JP2025168516A Pending JP2026012715A (ja) | 2017-08-11 | 2025-10-06 | ３－（５－フルオロベンゾフラン－３－イル）－４－（５－メチル－５Ｈ－［１，３］ジオキソロ［４，５－ｆ］インドール－７－イル）ピロール－２，５－ジオンの固体形態 |
Country Status (16)
| Country | Link |
|---|---|
| US (3) | US11136334B2 (https=) |
| EP (1) | EP3665176B1 (https=) |
| JP (3) | JP7424639B2 (https=) |
| KR (3) | KR102700883B1 (https=) |
| CN (2) | CN117362305A (https=) |
| AU (3) | AU2018313259B2 (https=) |
| BR (1) | BR112020002892A2 (https=) |
| CA (1) | CA3072240A1 (https=) |
| DK (1) | DK3665176T3 (https=) |
| ES (1) | ES2974328T3 (https=) |
| FI (1) | FI3665176T3 (https=) |
| IL (2) | IL272556B2 (https=) |
| MX (3) | MX2020001547A (https=) |
| PL (1) | PL3665176T3 (https=) |
| PT (1) | PT3665176T (https=) |
| WO (1) | WO2019032958A1 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL3697794T3 (pl) | 2017-10-16 | 2026-04-07 | Actuate Therapeutics Inc. | Stałe postacie 3-(5-fluorobenzofuran-3-ylo)-4-(5-metylo-5h-[1,3]dioksolo[4,5-f]indol-7-ilo)pirolo-2,5-dionu |
| WO2019222483A1 (en) * | 2018-05-17 | 2019-11-21 | Board Of Regents, The University Of Texas System | Treatment of idiopathic pulmonary fibrosis with glycogen synthase kinase 3 form beta inhibitors |
| US20250325517A1 (en) * | 2022-06-27 | 2025-10-23 | Actuate Therapeutics, Inc. | Oral dosage forms of elraglusib |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2673368C (en) | 2006-12-19 | 2014-10-28 | The Board Of Trustees Of The University Of Illinois | 3-benzofuranyl-4-indolyl maleimides as potent gsk3 inhibitors for neurogenerative disorders |
| PH12012501293A1 (en) | 2009-12-23 | 2013-01-07 | Arqule Inc | Purified pyrroloquinolinyl-pyrrolidine-2,5-dione compositions and methods for preparing and using same |
-
2018
- 2018-08-10 EP EP18760168.7A patent/EP3665176B1/en active Active
- 2018-08-10 FI FIEP18760168.7T patent/FI3665176T3/fi active
- 2018-08-10 AU AU2018313259A patent/AU2018313259B2/en active Active
- 2018-08-10 WO PCT/US2018/046203 patent/WO2019032958A1/en not_active Ceased
- 2018-08-10 PL PL18760168.7T patent/PL3665176T3/pl unknown
- 2018-08-10 CN CN202311213594.XA patent/CN117362305A/zh active Pending
- 2018-08-10 KR KR1020207006706A patent/KR102700883B1/ko active Active
- 2018-08-10 KR KR1020247014386A patent/KR20240063198A/ko not_active Ceased
- 2018-08-10 KR KR1020257015420A patent/KR20250070131A/ko active Pending
- 2018-08-10 MX MX2020001547A patent/MX2020001547A/es unknown
- 2018-08-10 DK DK18760168.7T patent/DK3665176T3/da active
- 2018-08-10 CA CA3072240A patent/CA3072240A1/en active Pending
- 2018-08-10 IL IL272556A patent/IL272556B2/en unknown
- 2018-08-10 CN CN201880059690.4A patent/CN111247153B/zh active Active
- 2018-08-10 PT PT187601687T patent/PT3665176T/pt unknown
- 2018-08-10 BR BR112020002892-4A patent/BR112020002892A2/pt not_active Application Discontinuation
- 2018-08-10 ES ES18760168T patent/ES2974328T3/es active Active
- 2018-08-10 IL IL313800A patent/IL313800A/en unknown
- 2018-08-10 US US16/638,303 patent/US11136334B2/en active Active
- 2018-08-10 JP JP2020530441A patent/JP7424639B2/ja active Active
-
2020
- 2020-02-07 MX MX2023005875A patent/MX2023005875A/es unknown
- 2020-02-07 MX MX2024003249A patent/MX2024003249A/es unknown
-
2021
- 2021-09-24 US US17/484,025 patent/US12145943B2/en active Active
-
2023
- 2023-02-23 AU AU2023201059A patent/AU2023201059B2/en active Active
- 2023-07-28 JP JP2023123302A patent/JP7778750B2/ja active Active
-
2024
- 2024-10-16 US US18/917,541 patent/US20250115616A1/en active Pending
-
2025
- 2025-04-28 AU AU2025202936A patent/AU2025202936A1/en active Pending
- 2025-10-06 JP JP2025168516A patent/JP2026012715A/ja active Pending
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