JP2020530459A - 網膜の疾患を処置するための光受容体遺伝子のモジュレーターであるフォトレギュリン３ - Google Patents

網膜の疾患を処置するための光受容体遺伝子のモジュレーターであるフォトレギュリン３ Download PDF

Info

Publication number
JP2020530459A
JP2020530459A JP2020506984A JP2020506984A JP2020530459A JP 2020530459 A JP2020530459 A JP 2020530459A JP 2020506984 A JP2020506984 A JP 2020506984A JP 2020506984 A JP2020506984 A JP 2020506984A JP 2020530459 A JP2020530459 A JP 2020530459A
Authority
JP
Japan
Prior art keywords
retina
retinal
compound
subject
expression
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2020506984A
Other languages
English (en)
Japanese (ja)
Other versions
JP2020530459A5 (enExample
Inventor
リー，トマス・エイ
ナカムラ，ポール
シムチャック，アンディ
タン，シービン
ディン，シェン
Original Assignee
ユニヴァーシティ オブ ワシントン
ユニヴァーシティ オブ ワシントン
ザ ジェイ． デヴィッド グラッドストーン インスティテューツ
ザ ジェイ． デヴィッド グラッドストーン インスティテューツ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ユニヴァーシティ オブ ワシントン, ユニヴァーシティ オブ ワシントン, ザ ジェイ． デヴィッド グラッドストーン インスティテューツ, ザ ジェイ． デヴィッド グラッドストーン インスティテューツ filed Critical ユニヴァーシティ オブ ワシントン
Publication of JP2020530459A publication Critical patent/JP2020530459A/ja
Publication of JP2020530459A5 publication Critical patent/JP2020530459A5/ja
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
JP2020506984A 2017-08-10 2018-08-10 網膜の疾患を処置するための光受容体遺伝子のモジュレーターであるフォトレギュリン３ Pending JP2020530459A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762543782P 2017-08-10 2017-08-10
US62/543,782 2017-08-10
PCT/US2018/046272 WO2019032999A1 (en) 2017-08-10 2018-08-10 PHOTORECEPTOR GENE MODULATOR PHOTOREGULIN 3 FOR THE TREATMENT OF RETINAL DISEASE

Publications (2)

Publication Number Publication Date
JP2020530459A true JP2020530459A (ja) 2020-10-22
JP2020530459A5 JP2020530459A5 (enExample) 2021-09-16

Family

ID=65272549

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2020506984A Pending JP2020530459A (ja) 2017-08-10 2018-08-10 網膜の疾患を処置するための光受容体遺伝子のモジュレーターであるフォトレギュリン３

Country Status (8)

Country Link
US (1) US20200368234A1 (enExample)
EP (1) EP3664801A4 (enExample)
JP (1) JP2020530459A (enExample)
CN (1) CN111093657A (enExample)
AU (1) AU2018313990A1 (enExample)
CA (1) CA3072175A1 (enExample)
MX (1) MX2020001274A (enExample)
WO (1) WO2019032999A1 (enExample)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11241460B2 (en) 2013-03-15 2022-02-08 Astellas Institute For Regenerative Medicine Photoreceptors and photoreceptor progenitors produced from pluripotent stem cells

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016160718A1 (en) * 2015-03-27 2016-10-06 University Of Washington Methods for treatment of retinal disease by photoreceptor gene expression modulation

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9855314B2 (en) * 2013-03-01 2018-01-02 The Schepens Eye Research Insititute, Inc. Methods for modulating development and function of photoreceptor cells
CN105343107A (zh) * 2015-12-03 2016-02-24 上海中医药大学附属岳阳中西医结合医院 雷公藤红素在制备防治视网膜退行性改变相关疾病药物中的应用

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016160718A1 (en) * 2015-03-27 2016-10-06 University Of Washington Methods for treatment of retinal disease by photoreceptor gene expression modulation

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
IOVS, vol. 57(14), JPN6022028422, 2016, pages 6407 - 6415, ISSN: 0004823851 *
PUBCHEM AID 651849, SID 152164087, 2013年12月, JPN6022028420, ISSN: 0004995396 *

Also Published As

Publication number Publication date
CN111093657A (zh) 2020-05-01
CA3072175A1 (en) 2019-02-14
EP3664801A4 (en) 2021-06-23
MX2020001274A (es) 2020-09-22
AU2018313990A1 (en) 2020-02-27
US20200368234A1 (en) 2020-11-26
EP3664801A1 (en) 2020-06-17
WO2019032999A1 (en) 2019-02-14

Similar Documents

Publication Publication Date Title
Kole et al. Activating transcription factor 3 (ATF3) protects retinal ganglion cells and promotes functional preservation after optic nerve crush
Joyce et al. SOD1 and TDP-43 animal models of amyotrophic lateral sclerosis: recent advances in understanding disease toward the development of clinical treatments
TWI396532B (zh) 用視黃基衍生物治療眼疾之方法及組合物
US10849904B2 (en) Methods for treatment of retinal disease by photoreceptor gene expression modulation
Kato et al. Endocannabinoid‐dependent plasticity at spinal nociceptor synapses
US11484576B2 (en) Methods of promoting corticospinal neuronal outgrowth in neuronal lesions using a pro-regenerative human osteopontin fragment
Liu et al. Prolyl-4-hydroxylases inhibitor stabilizes HIF-1α and increases mitophagy to reduce cell death after experimental retinal detachment
JP2018515622A (ja) ニューロン生存因子の相乗組み合わせ及びその使用
Yang et al. Targeting iodothyronine deiodinases locally in the retina is a therapeutic strategy for retinal degeneration
Carrella et al. miR‐181a/b downregulation: A mutation‐independent therapeutic approach for inherited retinal diseases
Feng et al. Trilobatin attenuates cerebral ischaemia/reperfusion‐induced blood–brain barrier dysfunction by targeting matrix metalloproteinase 9: The legend of a food additive
US10918697B2 (en) Co-activation of mTOR and STAT3 pathways to promote neuronal survival and regeneration
Yadav et al. Methotrexate negatively acts on inflammatory responses triggered in Drosophila larva with hyperactive JAK/STAT pathway
JP2020530459A (ja) 網膜の疾患を処置するための光受容体遺伝子のモジュレーターであるフォトレギュリン３
Mu et al. Up-regulation of GPR139 in the medial septum ameliorates cognitive impairment in two mouse models of Alzheimer’s disease
Wong et al. A Novel RANKL‐Targeted Furoquinoline Alkaloid Ameliorates Bone Loss in Ovariectomized Osteoporosis through Inhibiting the NF‐κB Signal Pathway and Reducing Reactive Oxygen Species
US20190105341A1 (en) Compositions and Methods for Treating Alzheimer's Disease and Other Tauopathies
Mohan et al. Unveiling acid-sensing ion channels (ASICs) in neurodegeneration: implications for disease pathogenesis and therapeutic strategies
Townes-Anderson et al. Coming of age for the photoreceptor synapse
Loh et al. Melatonin regulation of phase separation in Neuro-PASC: out-maneuvering Janus-faced amyloids
CN115475247B (zh) β2-微球蛋白或其抑制剂的制药用途
KR20200043401A (ko) 신경 질환을 치료하기 위한 방법 및 조성물
CN110693886B (zh) 防治脑海绵状血管畸形病变的药物
Cheng Exploration of the role of OPN4 in a mouse model of retinal degeneration
Hooshmandi Dysregulated mRNA Translation in Autism Spectrum Disorders

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20210806

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20210806

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20220627

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20220712

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20230221