JP2020529431A5 - - Google Patents

Info

Publication number

JP2020529431A5

JP2020529431A5 JP2020505827A JP2020505827A JP2020529431A5 JP 2020529431 A5 JP2020529431 A5 JP 2020529431A5 JP 2020505827 A JP2020505827 A JP 2020505827A JP 2020505827 A JP2020505827 A JP 2020505827A JP 2020529431 A5 JP2020529431 A5 JP 2020529431A5

Authority

JP

Japan

Prior art keywords

composition according

enterococcus

pharmaceutical composition

bacterial strain

bacteria

Prior art date

2018-08-10

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
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• 239000000203 mixture Substances 0.000 claims 21
• 230000001580 bacterial effect Effects 0.000 claims 17
• 241000194033 Enterococcus Species 0.000 claims 13
• 239000008194 pharmaceutical composition Substances 0.000 claims 13
• 108020004465 16S ribosomal RNA Proteins 0.000 claims 7
• 241000894006 Bacteria Species 0.000 claims 7
• CMSMOCZEIVJLDB-UHFFFAOYSA-N Cyclophosphamide Chemical compound ClCCN(CCCl)P1(=O)NCCCO1 CMSMOCZEIVJLDB-UHFFFAOYSA-N 0.000 claims 5
• 241000194030 Enterococcus gallinarum Species 0.000 claims 5
• 229960004397 cyclophosphamide Drugs 0.000 claims 5
• 201000010099 disease Diseases 0.000 claims 5
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 5
• 241000927512 Barnesiella Species 0.000 claims 3
• 241000193403 Clostridium Species 0.000 claims 3
• 206010028980 Neoplasm Diseases 0.000 claims 3
• 201000011510 cancer Diseases 0.000 claims 3
• 241000894007 species Species 0.000 claims 3
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
• 208000023275 Autoimmune disease Diseases 0.000 claims 2
• 206010009900 Colitis ulcerative Diseases 0.000 claims 2
• 208000011231 Crohn disease Diseases 0.000 claims 2
• 208000022559 Inflammatory bowel disease Diseases 0.000 claims 2
• 201000006704 Ulcerative Colitis Diseases 0.000 claims 2
• 239000003814 drug Substances 0.000 claims 2
• 208000027866 inflammatory disease Diseases 0.000 claims 2
• 210000000936 intestine Anatomy 0.000 claims 2
• 239000002207 metabolite Substances 0.000 claims 2
• 230000000813 microbial effect Effects 0.000 claims 2
• 244000005706 microflora Species 0.000 claims 2
• 230000004108 pentose phosphate pathway Effects 0.000 claims 2
• 229940124597 therapeutic agent Drugs 0.000 claims 2
• 208000016261 weight loss Diseases 0.000 claims 2
• 230000004580 weight loss Effects 0.000 claims 2
• 241000701474 Alistipes Species 0.000 claims 1
• 241000204018 Anaeroplasma Species 0.000 claims 1
• 241001013579 Anaerotruncus Species 0.000 claims 1
• 241000606125 Bacteroides Species 0.000 claims 1
• NGHMDNPXVRFFGS-IUYQGCFVSA-N D-erythrose 4-phosphate Chemical compound O=C[C@H](O)[C@H](O)COP(O)(O)=O NGHMDNPXVRFFGS-IUYQGCFVSA-N 0.000 claims 1
• KTVPXOYAKDPRHY-SOOFDHNKSA-N D-ribofuranose 5-phosphate Chemical compound OC1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]1O KTVPXOYAKDPRHY-SOOFDHNKSA-N 0.000 claims 1
• 241000194029 Enterococcus hirae Species 0.000 claims 1
• 241000662772 Flavonifractor Species 0.000 claims 1
• 241000509618 Hallella Species 0.000 claims 1
• 241001112693 Lachnospiraceae Species 0.000 claims 1
• 241000160321 Parabacteroides Species 0.000 claims 1
• 241000605861 Prevotella Species 0.000 claims 1
• 241000605947 Roseburia Species 0.000 claims 1
• 241001568331 Vampirovibrio Species 0.000 claims 1
• 230000015572 biosynthetic process Effects 0.000 claims 1
• 239000003795 chemical substances by application Substances 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• 210000001035 gastrointestinal tract Anatomy 0.000 claims 1
• 238000001727 in vivo Methods 0.000 claims 1
• 230000002757 inflammatory effect Effects 0.000 claims 1
• 244000005700 microbiome Species 0.000 claims 1
• 239000000546 pharmaceutical excipient Substances 0.000 claims 1
• JDTUMPKOJBQPKX-GBNDHIKLSA-N sedoheptulose 7-phosphate Chemical compound OCC(=O)[C@@H](O)[C@H](O)[C@H](O)[C@H](O)COP(O)(O)=O JDTUMPKOJBQPKX-GBNDHIKLSA-N 0.000 claims 1
• 230000006641 stabilisation Effects 0.000 claims 1
• 238000011105 stabilization Methods 0.000 claims 1
• 239000003381 stabilizer Substances 0.000 claims 1
• 229960005486 vaccine Drugs 0.000 claims 1