JP2020528758A5 - - Google Patents
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- JP2020528758A5 JP2020528758A5 JP2020505231A JP2020505231A JP2020528758A5 JP 2020528758 A5 JP2020528758 A5 JP 2020528758A5 JP 2020505231 A JP2020505231 A JP 2020505231A JP 2020505231 A JP2020505231 A JP 2020505231A JP 2020528758 A5 JP2020528758 A5 JP 2020528758A5
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- 229920001184 polypeptide Polymers 0.000 claims 43
- 102000004196 processed proteins & peptides Human genes 0.000 claims 43
- 108090000765 processed proteins & peptides Proteins 0.000 claims 43
- 239000012634 fragment Substances 0.000 claims 30
- 239000000427 antigen Substances 0.000 claims 25
- 102000036639 antigens Human genes 0.000 claims 25
- 108091007433 antigens Proteins 0.000 claims 25
- 239000003446 ligand Substances 0.000 claims 8
- -1 ICOS Proteins 0.000 claims 7
- 125000003275 alpha amino acid group Chemical group 0.000 claims 6
- 108020003175 receptors Proteins 0.000 claims 6
- 102000005962 receptors Human genes 0.000 claims 6
- 102000039446 nucleic acids Human genes 0.000 claims 5
- 108020004707 nucleic acids Proteins 0.000 claims 5
- 150000007523 nucleic acids Chemical class 0.000 claims 5
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- 102100029822 B- and T-lymphocyte attenuator Human genes 0.000 claims 3
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- 102100034458 Hepatitis A virus cellular receptor 2 Human genes 0.000 claims 3
- 101710083479 Hepatitis A virus cellular receptor 2 homolog Proteins 0.000 claims 3
- 101000834898 Homo sapiens Alpha-synuclein Proteins 0.000 claims 3
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- 101000889276 Homo sapiens Cytotoxic T-lymphocyte protein 4 Proteins 0.000 claims 3
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- 101000984186 Homo sapiens Leukocyte immunoglobulin-like receptor subfamily B member 4 Proteins 0.000 claims 3
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- 239000003814 drug Substances 0.000 claims 2
- 108010048507 poliovirus receptor Proteins 0.000 claims 2
- 108010011170 Ala-Trp-Arg-His-Pro-Gln-Phe-Gly-Gly Proteins 0.000 claims 1
- 102000016605 B-Cell Activating Factor Human genes 0.000 claims 1
- 108010028006 B-Cell Activating Factor Proteins 0.000 claims 1
- 102100038080 B-cell receptor CD22 Human genes 0.000 claims 1
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- 108010074708 B7-H1 Antigen Proteins 0.000 claims 1
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- 101000741544 Homo sapiens Properdin Proteins 0.000 claims 1
- 101000914484 Homo sapiens T-lymphocyte activation antigen CD80 Proteins 0.000 claims 1
- 101000611183 Homo sapiens Tumor necrosis factor Proteins 0.000 claims 1
- 101000830603 Homo sapiens Tumor necrosis factor ligand superfamily member 11 Proteins 0.000 claims 1
- 101000830598 Homo sapiens Tumor necrosis factor ligand superfamily member 12 Proteins 0.000 claims 1
- 101000830600 Homo sapiens Tumor necrosis factor ligand superfamily member 13 Proteins 0.000 claims 1
- 101000830596 Homo sapiens Tumor necrosis factor ligand superfamily member 15 Proteins 0.000 claims 1
- 101000597779 Homo sapiens Tumor necrosis factor ligand superfamily member 18 Proteins 0.000 claims 1
- 101000764263 Homo sapiens Tumor necrosis factor ligand superfamily member 4 Proteins 0.000 claims 1
- 102100034980 ICOS ligand Human genes 0.000 claims 1
- 102100026720 Interferon beta Human genes 0.000 claims 1
- 102100026688 Interferon epsilon Human genes 0.000 claims 1
- 101710147309 Interferon epsilon Proteins 0.000 claims 1
- 102100037850 Interferon gamma Human genes 0.000 claims 1
- 102100022469 Interferon kappa Human genes 0.000 claims 1
- 101710145151 Interferon lambda receptor 1 Proteins 0.000 claims 1
- 102100020990 Interferon lambda-1 Human genes 0.000 claims 1
- 108010047761 Interferon-alpha Proteins 0.000 claims 1
- 102000006992 Interferon-alpha Human genes 0.000 claims 1
- 108090000467 Interferon-beta Proteins 0.000 claims 1
- 102000008070 Interferon-gamma Human genes 0.000 claims 1
- 108010002352 Interleukin-1 Proteins 0.000 claims 1
- 102000000589 Interleukin-1 Human genes 0.000 claims 1
- 108090000174 Interleukin-10 Proteins 0.000 claims 1
- 102000003814 Interleukin-10 Human genes 0.000 claims 1
- 102100020788 Interleukin-10 receptor subunit beta Human genes 0.000 claims 1
- 101710199214 Interleukin-10 receptor subunit beta Proteins 0.000 claims 1
- 108090000177 Interleukin-11 Proteins 0.000 claims 1
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- 108060001084 Luciferase Proteins 0.000 claims 1
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- 101100407308 Mus musculus Pdcd1lg2 gene Proteins 0.000 claims 1
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- 102100037589 OX-2 membrane glycoprotein Human genes 0.000 claims 1
- 101710187081 OX-2 membrane glycoprotein Proteins 0.000 claims 1
- 108010042215 OX40 Ligand Proteins 0.000 claims 1
- 102000003992 Peroxidases Human genes 0.000 claims 1
- 102000004211 Platelet factor 4 Human genes 0.000 claims 1
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- 108700030875 Programmed Cell Death 1 Ligand 2 Proteins 0.000 claims 1
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- 108010025832 RANK Ligand Proteins 0.000 claims 1
- 108091079435 SIS family Proteins 0.000 claims 1
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- 108010065158 Tumor Necrosis Factor Ligand Superfamily Member 14 Proteins 0.000 claims 1
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- 101710097155 Tumor necrosis factor ligand superfamily member 12 Proteins 0.000 claims 1
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- 108010005774 beta-Galactosidase Proteins 0.000 claims 1
- 230000003197 catalytic effect Effects 0.000 claims 1
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- FOCAHLGSDWHSAH-UHFFFAOYSA-N difluoromethanethione Chemical compound FC(F)=S FOCAHLGSDWHSAH-UHFFFAOYSA-N 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 229940079322 interferon Drugs 0.000 claims 1
- 229960003130 interferon gamma Drugs 0.000 claims 1
- 108010080375 interferon kappa Proteins 0.000 claims 1
- 229940047124 interferons Drugs 0.000 claims 1
- 108090000681 interleukin 20 Proteins 0.000 claims 1
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- OHDXDNUPVVYWOV-UHFFFAOYSA-N n-methyl-1-(2-naphthalen-1-ylsulfanylphenyl)methanamine Chemical compound CNCC1=CC=CC=C1SC1=CC=CC2=CC=CC=C12 OHDXDNUPVVYWOV-UHFFFAOYSA-N 0.000 claims 1
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023097920A JP2023123588A (ja) | 2017-07-31 | 2023-06-14 | 可変ドメインと定常ドメインとの間のエルボー領域に機能的ドメインを有する抗体 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EPPCT/EP2017/069357 | 2017-07-31 | ||
| PCT/EP2017/069357 WO2019024979A1 (en) | 2017-07-31 | 2017-07-31 | FUNCTIONAL DOMAIN ANTIBODIES IN THE ELBOW REGION |
| PCT/EP2018/070640 WO2019025391A1 (en) | 2017-07-31 | 2018-07-30 | ANTIBODIES HAVING FUNCTIONAL DOMAINS IN THE ELBOW REGION BETWEEN A VARIABLE DOMAIN AND A CONSTANT DOMAIN |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023097920A Division JP2023123588A (ja) | 2017-07-31 | 2023-06-14 | 可変ドメインと定常ドメインとの間のエルボー領域に機能的ドメインを有する抗体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020528758A JP2020528758A (ja) | 2020-10-01 |
| JP2020528758A5 true JP2020528758A5 (https=) | 2021-09-09 |
| JP7297734B2 JP7297734B2 (ja) | 2023-06-26 |
Family
ID=59626578
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020505231A Active JP7297734B2 (ja) | 2017-07-31 | 2018-07-30 | 可変ドメインと定常ドメインとの間のエルボー領域に機能的ドメインを有する抗体 |
| JP2023097920A Withdrawn JP2023123588A (ja) | 2017-07-31 | 2023-06-14 | 可変ドメインと定常ドメインとの間のエルボー領域に機能的ドメインを有する抗体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023097920A Withdrawn JP2023123588A (ja) | 2017-07-31 | 2023-06-14 | 可変ドメインと定常ドメインとの間のエルボー領域に機能的ドメインを有する抗体 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US12331108B2 (https=) |
| EP (1) | EP3661962A1 (https=) |
| JP (2) | JP7297734B2 (https=) |
| KR (1) | KR20200032738A (https=) |
| CN (1) | CN111094341A (https=) |
| AU (1) | AU2018311032B2 (https=) |
| BR (1) | BR112019028180A2 (https=) |
| CA (1) | CA3069265A1 (https=) |
| EA (1) | EA202090364A1 (https=) |
| IL (1) | IL272303A (https=) |
| MX (1) | MX2020001080A (https=) |
| SG (1) | SG11201911658QA (https=) |
| WO (2) | WO2019024979A1 (https=) |
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| CA3066918A1 (en) | 2017-06-12 | 2018-12-20 | Bluefin Biomedicine, Inc. | Anti-il1rap antibodies and antibody drug conjugates |
| CN112512571B (zh) | 2018-03-22 | 2025-02-07 | 表面肿瘤学有限责任公司 | 抗il-27抗体及其用途 |
| AU2019266042B2 (en) * | 2018-05-10 | 2025-08-07 | Mirabiologics Inc. | Artificial protein containing an antibody antigen-binding region, fused with bioactive peptides |
| MX2020012895A (es) | 2018-05-30 | 2021-05-27 | Inst Res Biomedicine | Modificacion de linfocitos b al utilizar citidina desaminasa inducida por activacion endogena. |
| EP3927728A2 (en) | 2019-02-21 | 2021-12-29 | Xencor, Inc. | Untargeted and targeted il-10 fc-fusion proteins |
| JP2023512684A (ja) | 2020-02-03 | 2023-03-28 | ヴィア・バイオテクノロジー・インコーポレイテッド | Ｓａｒｓ－ｃｏｖ－２に対する抗体およびそれを使用する方法 |
| BR112022017048A2 (pt) | 2020-02-26 | 2022-11-16 | Vir Biotechnology Inc | Anticorpos contra sars-cov-2 e métodos para usar os mesmos |
| WO2021203053A1 (en) | 2020-04-03 | 2021-10-07 | Vir Biotechnology, Inc. | Immunotherapy targeting a conserved region in sars coronaviruses |
| US20240059757A1 (en) | 2020-04-14 | 2024-02-22 | Vir Biotechnology, Inc. | Antibodies against sars-cov-2 and methods of using the same |
| WO2021226560A1 (en) | 2020-05-08 | 2021-11-11 | Vir Biotechnology, Inc. | Antibodies against sars-cov-2 |
| WO2021247925A1 (en) | 2020-06-03 | 2021-12-09 | Vir Biotechnology, Inc. | Structure-guided immunotherapy against sars-cov-2 |
| US20250263467A1 (en) | 2020-06-12 | 2025-08-21 | Vir Biotechnology, Inc. | Antibody therapies for sars-cov-2 infection |
| BR112023005684A2 (pt) | 2020-09-28 | 2023-11-07 | Humabs Biomed Sa | Anticorpos contra sars-cov-2 |
| CN113307870B (zh) * | 2020-10-30 | 2022-12-23 | 上海洛启生物医药技术有限公司 | 抗il5纳米抗体及其应用 |
| EP4247845A1 (en) | 2020-11-23 | 2023-09-27 | VIR Biotechnology, Inc. | Anti-influenza antibodies and combinations thereof |
| CA3197537A1 (en) | 2020-11-23 | 2022-05-27 | Davide Corti | Antibodies against influenza a viruses |
| AU2021381778A1 (en) | 2020-11-23 | 2023-06-22 | Humabs Biomed Sa | Broadly neutralizing antibodies against influenza neuraminidase |
| WO2022115486A1 (en) | 2020-11-25 | 2022-06-02 | Vir Biotechnology, Inc. | Antibodies that bind to multiple betacoronaviruses |
| AR124414A1 (es) | 2020-12-18 | 2023-03-22 | Century Therapeutics Inc | Sistema de receptor de antígeno quimérico con especificidad de receptor adaptable |
| WO2022143801A1 (en) * | 2020-12-30 | 2022-07-07 | Wuxi Biologics (Shanghai) Co., Ltd. | Multispecific antigen binding proteins |
| CN112877394A (zh) * | 2021-01-27 | 2021-06-01 | 南京大学 | B7-h4+单核细胞型mdsc在制备ins激素治疗疗效预测试剂中的应用 |
| CN117136197A (zh) * | 2021-02-09 | 2023-11-28 | 胡默波斯生物医学公司 | 抗呼吸道合胞病毒、人偏肺病毒和小鼠肺炎病毒的抗体和其使用方法 |
| WO2022204202A1 (en) | 2021-03-23 | 2022-09-29 | Vir Biotechnology, Inc. | Antibodies that bind to multiple sarbecoviruses |
| AU2022270717A1 (en) * | 2021-05-07 | 2023-12-14 | Senti Biosciences, Inc. | Chimeric receptors and methods of use thereof |
| KR20240035758A (ko) | 2021-05-24 | 2024-03-18 | 비르 바이오테크놀로지, 인코포레이티드 | 조작된 폴리펩타이드 |
| JP2024533166A (ja) | 2021-09-01 | 2024-09-12 | ヴィア・バイオテクノロジー・インコーポレイテッド | 小児被験体におけるＳＡＲＳ－ＣｏＶ－２感染の抗体療法 |
| WO2023034871A1 (en) | 2021-09-01 | 2023-03-09 | Vir Biotechnology, Inc. | High concentration antibody therapies for sars-cov-2 infection |
| CN114934065A (zh) * | 2021-11-25 | 2022-08-23 | 浙江理工大学绍兴生物医药研究院有限公司 | 携带免疫检查点分子tim-3抗体基因的溶瘤腺病毒构建方法和应用 |
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| WO2023201256A1 (en) | 2022-04-12 | 2023-10-19 | Vir Biotechnology, Inc. | High dose antibody therapies for sars-cov-2 infection |
| WO2023230448A1 (en) | 2022-05-23 | 2023-11-30 | Vir Biotechnology, Inc. | Combination immunotherapy for influenza |
| JP2025522295A (ja) | 2022-05-23 | 2025-07-15 | ヒューマブス・バイオメッド・ソシエテ・アノニム | インフルエンザノイラミニダーゼに対する広域中和抗体 |
| WO2023245078A1 (en) | 2022-06-15 | 2023-12-21 | Humabs Biomed Sa | Anti-parvovirus antibodies and uses thereof |
| WO2024006472A1 (en) | 2022-06-30 | 2024-01-04 | Vir Biotechnology, Inc. | Antibodies that bind to multiple sarbecoviruses |
| CN119836435A (zh) | 2022-07-27 | 2025-04-15 | 胡默波斯生物医学公司 | 抗rsv和mpv副粘病毒的广泛中和抗体 |
| WO2024112818A1 (en) | 2022-11-22 | 2024-05-30 | Humabs Biomed Sa | Engineered anti-sars-cov-2 antibodies and uses thereof |
| WO2024118998A2 (en) | 2022-12-01 | 2024-06-06 | Vir Biotechnology, Inc. | Engineered anti-sars-cov-2 antibodies and methods of using the same |
| AU2024255423A1 (en) | 2023-04-10 | 2025-10-30 | Vir Biotechnology, Inc. | Antibodies that bind to multiple sarbecoviruses |
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| US20260048137A1 (en) | 2024-08-16 | 2026-02-19 | Ardeagen Corporation | Anti-mesothelin antibody conjugates and methods of use thereof |
| WO2026055183A1 (en) | 2024-09-03 | 2026-03-12 | Vir Biotechnology, Inc | Antiviral compositions and methods of using the same |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2410551A1 (en) * | 2000-06-30 | 2002-01-10 | Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw (Vib) | Heterodimeric fusion proteins |
| AU2004215125B2 (en) | 2003-02-26 | 2011-01-06 | Institute For Research In Biomedicine | Monoclonal antibody production by EBV transformation of B cells |
| NZ544924A (en) | 2003-06-27 | 2009-03-31 | Biogen Idec Inc | Modified binding molecules comprising connecting peptides |
| EP2158318A2 (en) | 2007-05-14 | 2010-03-03 | Biogen Idec MA, Inc. | Single-chain fc (scfc) regions, binding polypeptides comprising same, and methods related thereto |
| KR20100058509A (ko) * | 2007-07-31 | 2010-06-03 | 메디뮨 엘엘씨 | 다중특이적 에피토프 결합 단백질 및 이의 용도 |
| PL2350128T3 (pl) | 2008-10-22 | 2015-03-31 | Inst Res Biomedicine | Sposoby wytwarzania przeciwciał z komórek plazmatycznych |
| UY33826A (es) * | 2010-12-22 | 2012-07-31 | Abbott Lab | Proteínas de unión con dominios trivariables y sus usos |
| US20140235476A1 (en) * | 2012-12-28 | 2014-08-21 | Abbvie, Inc. | Multivalent binding protein compositions and methods for identifying variants of same |
| WO2014106015A2 (en) * | 2012-12-28 | 2014-07-03 | Abbvie, Inc. | Multivalent binding protein compositions |
| EP2927227A4 (en) | 2013-01-03 | 2015-12-30 | Celltrion Inc | ANTIBODY CONCENTRATOR REMEDY CONJUGATE, METHOD OF MANUFACTURING THEREOF, AND ANTIBODY TOGETHER THEREWITH |
| US10526404B2 (en) * | 2015-04-29 | 2020-01-07 | Institute For Research In Biomedicine | Multispecific anti GM-CSF antibodies |
| MY192870A (en) * | 2015-06-18 | 2022-09-13 | Univ Gent | Immunoglobulin single variable domain antibody against rsv prefusion f protein |
| EA039366B1 (ru) * | 2015-06-24 | 2022-01-19 | Джей Си Ар ФАРМАСЬЮТИКАЛЗ КО., ЛТД. | Антитело к рецептору трансферрина человека, проникающее через гематоэнцефалический барьер |
| WO2016207402A1 (en) | 2015-06-26 | 2016-12-29 | Institute For Research In Biomedicine | Proteins comprising a mutated lair-1 fragment and uses thereof |
| CA3007030A1 (en) * | 2015-12-07 | 2017-06-15 | Xencor, Inc. | Heterodimeric antibodies that bind cd3 and psma |
| AU2019266042B2 (en) * | 2018-05-10 | 2025-08-07 | Mirabiologics Inc. | Artificial protein containing an antibody antigen-binding region, fused with bioactive peptides |
-
2017
- 2017-07-31 WO PCT/EP2017/069357 patent/WO2019024979A1/en not_active Ceased
-
2018
- 2018-07-30 WO PCT/EP2018/070640 patent/WO2019025391A1/en not_active Ceased
- 2018-07-30 SG SG11201911658QA patent/SG11201911658QA/en unknown
- 2018-07-30 CN CN201880048796.4A patent/CN111094341A/zh active Pending
- 2018-07-30 JP JP2020505231A patent/JP7297734B2/ja active Active
- 2018-07-30 EA EA202090364A patent/EA202090364A1/ru unknown
- 2018-07-30 EP EP18752697.5A patent/EP3661962A1/en active Pending
- 2018-07-30 AU AU2018311032A patent/AU2018311032B2/en active Active
- 2018-07-30 US US16/635,506 patent/US12331108B2/en active Active
- 2018-07-30 MX MX2020001080A patent/MX2020001080A/es unknown
- 2018-07-30 CA CA3069265A patent/CA3069265A1/en active Pending
- 2018-07-30 BR BR112019028180-0A patent/BR112019028180A2/pt not_active Application Discontinuation
- 2018-07-30 KR KR1020207006050A patent/KR20200032738A/ko active Pending
-
2020
- 2020-01-28 IL IL272303A patent/IL272303A/en unknown
-
2023
- 2023-06-14 JP JP2023097920A patent/JP2023123588A/ja not_active Withdrawn
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