JP2020524509A - アルツハイマー病の診断のための循環血清マイクロｒｎａバイオマーカー及び方法 - Google Patents

アルツハイマー病の診断のための循環血清マイクロｒｎａバイオマーカー及び方法 Download PDF

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JP2020524509A
JP2020524509A JP2019570475A JP2019570475A JP2020524509A JP 2020524509 A JP2020524509 A JP 2020524509A JP 2019570475 A JP2019570475 A JP 2019570475A JP 2019570475 A JP2019570475 A JP 2019570475A JP 2020524509 A JP2020524509 A JP 2020524509A
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mir
hsa
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JP2020524509A5 (enExample
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サイモン・ゲイル・モーラー
ケタン・パティル
グイド・ワーナー・アルベス
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St Johns University
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/178—Oligonucleotides characterized by their use miRNA, siRNA or ncRNA
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2814—Dementia; Cognitive disorders
    • G01N2800/2821—Alzheimer

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
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  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Pathology (AREA)
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  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
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  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
JP2019570475A 2017-06-19 2018-06-07 アルツハイマー病の診断のための循環血清マイクロｒｎａバイオマーカー及び方法 Pending JP2020524509A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762521768P 2017-06-19 2017-06-19
US62/521,768 2017-06-19
PCT/US2018/036377 WO2018236589A1 (en) 2017-06-19 2018-06-07 Circulating serum microrna biomarkers and methods for alzheimer's disease diagnosis

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JP2020524509A true JP2020524509A (ja) 2020-08-20
JP2020524509A5 JP2020524509A5 (enExample) 2021-07-29

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JP2019570475A Pending JP2020524509A (ja) 2017-06-19 2018-06-07 アルツハイマー病の診断のための循環血清マイクロｒｎａバイオマーカー及び方法

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US (2) US11634775B2 (enExample)
EP (2) EP3642366B1 (enExample)
JP (1) JP2020524509A (enExample)
ES (1) ES2965473T3 (enExample)
WO (1) WO2018236589A1 (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2020000293A (es) * 2017-07-12 2020-07-22 Univ Texas Tech System Microrna-455-3p como un marcador bioperiferico para la enfermedad de alzheimer.
CN111073973A (zh) * 2019-12-10 2020-04-28 石河子大学 一种用于早期诊断2型糖尿病的microRNA序列及其应用

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009009457A1 (en) * 2007-07-06 2009-01-15 University Of Louisville Research Foundation, Inc. Alzheimer's disease-specific micro-rna microarray and related methods
US20120108650A1 (en) * 2010-10-29 2012-05-03 Emory University Micro rna markers and methods related thereto
US20130040303A1 (en) * 2011-08-08 2013-02-14 Eugenia Wang Biomarker for Alzheimer's Disease and/or Mild Cognitive Impairment, and Use Thereof
US20140206777A1 (en) * 2011-08-16 2014-07-24 Rosetta Genomics Ltd. Methods and compositions for diagnosis of alzheimer's disease
JP2014520529A (ja) * 2011-06-27 2014-08-25 エーザイ・アール・アンド・ディー・マネジメント株式会社 アルツハイマー病を示すマイクロｒｎａバイオマーカー
WO2015179909A1 (en) * 2014-05-26 2015-12-03 The University Of Melbourne Mirna biomarkers of alzheimer's disease
WO2016148073A1 (ja) * 2015-03-13 2016-09-22 国立大学法人広島大学 アルツハイマー病又は軽度認知症の検出を補助する方法
JP2016538851A (ja) * 2013-11-18 2016-12-15 ディアミール, エルエルシーDiamir, Llc パーキンソン病（ＰＤ）の検出およびモニタリングのための、体液からのｍｉＲＮＡを使用する方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3985130A1 (en) * 2016-02-05 2022-04-20 St. John's University Circulating serum microrna biomarkers and methods for determining parkinson's disease
EP3433381B1 (en) * 2016-03-21 2024-07-24 Diamir, LLC Methods of using mirnas from bodily fluids for detection and differentiation of neurodegenerative diseases

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009009457A1 (en) * 2007-07-06 2009-01-15 University Of Louisville Research Foundation, Inc. Alzheimer's disease-specific micro-rna microarray and related methods
US20120108650A1 (en) * 2010-10-29 2012-05-03 Emory University Micro rna markers and methods related thereto
JP2014520529A (ja) * 2011-06-27 2014-08-25 エーザイ・アール・アンド・ディー・マネジメント株式会社 アルツハイマー病を示すマイクロｒｎａバイオマーカー
US20130040303A1 (en) * 2011-08-08 2013-02-14 Eugenia Wang Biomarker for Alzheimer's Disease and/or Mild Cognitive Impairment, and Use Thereof
US20140206777A1 (en) * 2011-08-16 2014-07-24 Rosetta Genomics Ltd. Methods and compositions for diagnosis of alzheimer's disease
JP2016538851A (ja) * 2013-11-18 2016-12-15 ディアミール, エルエルシーDiamir, Llc パーキンソン病（ＰＤ）の検出およびモニタリングのための、体液からのｍｉＲＮＡを使用する方法
WO2015179909A1 (en) * 2014-05-26 2015-12-03 The University Of Melbourne Mirna biomarkers of alzheimer's disease
WO2016148073A1 (ja) * 2015-03-13 2016-09-22 国立大学法人広島大学 アルツハイマー病又は軽度認知症の検出を補助する方法

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
BRAIN RESEARCH, vol. 1627, JPN6022031881, 2015, pages 177 - 188, ISSN: 0005004552 *
EXPERIMENTAL NEUROLOGY, vol. 235, JPN6022031882, 2012, pages 491 - 496, ISSN: 0005004553 *

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EP3642366A1 (en) 2020-04-29
EP4289970B1 (en) 2025-12-17
EP3642366B1 (en) 2023-11-15
US11634775B2 (en) 2023-04-25
EP3642366C0 (en) 2023-11-15
ES2965473T3 (es) 2024-04-15
EP4289970A3 (en) 2024-03-13
US20240209444A1 (en) 2024-06-27
US12398427B2 (en) 2025-08-26
US20200190588A1 (en) 2020-06-18
WO2018236589A1 (en) 2018-12-27
EP4289970A2 (en) 2023-12-13

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