JP2020522697A - 転移性疾患における、循環腫瘍細胞(ctc)の単一細胞特徴づけに基づく治療を検出する方法 - Google Patents

転移性疾患における、循環腫瘍細胞(ctc)の単一細胞特徴づけに基づく治療を検出する方法 Download PDF

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JP2020522697A
JP2020522697A JP2019566358A JP2019566358A JP2020522697A JP 2020522697 A JP2020522697 A JP 2020522697A JP 2019566358 A JP2019566358 A JP 2019566358A JP 2019566358 A JP2019566358 A JP 2019566358A JP 2020522697 A JP2020522697 A JP 2020522697A
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ディッタモア ライアン
ディッタモア ライアン
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エピック サイエンシス, インコーポレイテッド
エピック サイエンシス, インコーポレイテッド
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    • GPHYSICS
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    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
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    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
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    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
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    • G01N33/531Production of immunochemical test materials
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    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/52Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

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JP2019566358A 2017-06-02 2018-06-01 転移性疾患における、循環腫瘍細胞(ctc)の単一細胞特徴づけに基づく治療を検出する方法 Pending JP2020522697A (ja)

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JP2023086656A JP2023120213A (ja) 2017-06-02 2023-05-26 転移性疾患における、循環腫瘍細胞(ctc)の単一細胞特徴づけに基づく治療を検出する方法

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US201762514642P 2017-06-02 2017-06-02
US62/514,642 2017-06-02
US201762531725P 2017-07-12 2017-07-12
US62/531,725 2017-07-12
PCT/US2018/035581 WO2018222979A1 (en) 2017-06-02 2018-06-01 Methods of determining therapies based on single cell characterization of circulating tumor cells (ctcs) in metastatic disease

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JP2023086656A Pending JP2023120213A (ja) 2017-06-02 2023-05-26 転移性疾患における、循環腫瘍細胞(ctc)の単一細胞特徴づけに基づく治療を検出する方法

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US (2) US20220260574A1 (https=)
EP (1) EP3631445B1 (https=)
JP (2) JP2020522697A (https=)
CN (1) CN110998318A (https=)
AU (1) AU2018275265A1 (https=)
CA (1) CA3065316A1 (https=)
IL (1) IL270974A (https=)
WO (1) WO2018222979A1 (https=)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2022092591A (ja) * 2020-12-10 2022-06-22 国立大学法人信州大学 メラノーマ患者の治療効果を判定する方法
JP2022140145A (ja) * 2021-03-12 2022-09-26 シスメックス株式会社 分析方法および分析装置
US12437563B2 (en) 2021-03-12 2025-10-07 Sysmex Corporation Analysis method and analyzer

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020225753A2 (en) * 2019-05-06 2020-11-12 Tesaro, Inc. Methods for characterizing and treating a cancer type using cancer images
CN113826169A (zh) * 2019-05-14 2021-12-21 匹兹堡大学高等教育联邦体系 用于根据多参数细胞和亚细胞成像数据表征细胞表型多样性的系统和方法
WO2021108043A1 (en) * 2019-11-27 2021-06-03 University Of Cincinnati Assessing treatment response with estimated number of tumor cells
AU2021207312A1 (en) * 2020-01-17 2022-06-30 Universität Zürich Single cell pathology analysis of tumour samples
CN114092934A (zh) * 2020-07-31 2022-02-25 骏实生物科技(上海)有限公司 循环肿瘤细胞的分类方法
CN114594252A (zh) * 2020-12-03 2022-06-07 复旦大学附属中山医院 循环肿瘤细胞形态学特征在胃癌临床诊疗中的应用
US20240054640A1 (en) * 2020-12-15 2024-02-15 Carnegie Mellon University System, Method, and Computer Program Product for Classification of Diseases Based on Expansion Microscopic Images
US11735303B2 (en) * 2021-06-22 2023-08-22 David Haase Apparatus and method for determining a composition of a replacement therapy treatment

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20150212089A1 (en) * 2014-01-30 2015-07-30 Epic Sciences, Inc. Circulating tumor cell diagnostics for biomarkers predictive of resistance to androgen receptor (ar) targeted therapies
WO2016033114A1 (en) * 2014-08-25 2016-03-03 The Johns Hopkins University Methods and compositions related to prostate cancer therapeutics
US20160266127A1 (en) * 2013-09-30 2016-09-15 Peter Kuhn Genotypic and Phenotypic Analysis of Circulating Tumor Cells to Monitor Tumor Evolution in Prostate Cancer Patients
WO2016196284A1 (en) * 2015-05-29 2016-12-08 Epic Sciences, Inc. Intra-patient genomic heterogeneity of single circulating tumor cells (ctcs) associated to phenotypic ctc heterogeneity in metastatic castrate resistant prostate cancer (mcrpc)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2920317A1 (en) * 2013-08-12 2015-02-19 Tokai Pharmaceuticals, Inc. Biomarkers for treatment of neoplastic disorders using androgen-targeted therapies
EA201691496A1 (ru) * 2014-01-27 2016-12-30 Эпик Сайенсиз, Инк. Диагностика биомаркеров рака предстательной железы с помощью циркулирующих опухолевых клеток

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20160266127A1 (en) * 2013-09-30 2016-09-15 Peter Kuhn Genotypic and Phenotypic Analysis of Circulating Tumor Cells to Monitor Tumor Evolution in Prostate Cancer Patients
US20150212089A1 (en) * 2014-01-30 2015-07-30 Epic Sciences, Inc. Circulating tumor cell diagnostics for biomarkers predictive of resistance to androgen receptor (ar) targeted therapies
WO2016033114A1 (en) * 2014-08-25 2016-03-03 The Johns Hopkins University Methods and compositions related to prostate cancer therapeutics
WO2016196284A1 (en) * 2015-05-29 2016-12-08 Epic Sciences, Inc. Intra-patient genomic heterogeneity of single circulating tumor cells (ctcs) associated to phenotypic ctc heterogeneity in metastatic castrate resistant prostate cancer (mcrpc)

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
GEORGE LEE ET AL: "Cell Orientation Entropy(COrE):Predicting Biochemical Recurrence from Prostate Cancer Tissue Microa", MICCAI, PARTIII, LNCS, 8151, JPN7022002257, 2013, ISSN: 0004779140 *

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2022092591A (ja) * 2020-12-10 2022-06-22 国立大学法人信州大学 メラノーマ患者の治療効果を判定する方法
JP7836038B2 (ja) 2020-12-10 2026-03-26 国立大学法人信州大学 メラノーマ患者の治療効果を判定する方法
JP2022140145A (ja) * 2021-03-12 2022-09-26 シスメックス株式会社 分析方法および分析装置
US12437563B2 (en) 2021-03-12 2025-10-07 Sysmex Corporation Analysis method and analyzer
JP7824031B2 (ja) 2021-03-12 2026-03-04 シスメックス株式会社 分析方法および分析装置

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CN110998318A (zh) 2020-04-10
EP3631445A1 (en) 2020-04-08
EP3631445B1 (en) 2024-09-25
US20220260574A1 (en) 2022-08-18
EP3631445A4 (en) 2021-05-26
AU2018275265A1 (en) 2020-01-30
CA3065316A1 (en) 2018-12-06
WO2018222979A1 (en) 2018-12-06
US20250155440A1 (en) 2025-05-15
JP2023120213A (ja) 2023-08-29
IL270974A (en) 2020-01-30

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