JP2020522506A5 - - Google Patents

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Publication number
JP2020522506A5
JP2020522506A5 JP2019566594A JP2019566594A JP2020522506A5 JP 2020522506 A5 JP2020522506 A5 JP 2020522506A5 JP 2019566594 A JP2019566594 A JP 2019566594A JP 2019566594 A JP2019566594 A JP 2019566594A JP 2020522506 A5 JP2020522506 A5 JP 2020522506A5
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JP
Japan
Prior art keywords
group
psma
tumors
compound
tumor
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Pending
Application number
JP2019566594A
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English (en)
Japanese (ja)
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JP2020522506A (ja
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Priority claimed from PCT/US2018/035220 external-priority patent/WO2018222778A1/en
Publication of JP2020522506A publication Critical patent/JP2020522506A/ja
Publication of JP2020522506A5 publication Critical patent/JP2020522506A5/ja
Priority to JP2023127925A priority Critical patent/JP2023159182A/ja
Priority to JP2024221155A priority patent/JP2025041719A/ja
Pending legal-status Critical Current

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JP2019566594A 2017-05-30 2018-05-30 前立腺がんの内部放射線療法のための前立腺特異的膜抗原をターゲットとした高親和性薬剤 Pending JP2020522506A (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2023127925A JP2023159182A (ja) 2017-05-30 2023-08-04 前立腺がんの内部放射線治療法のための前立腺特異的膜抗原をターゲットとした高親和性薬剤
JP2024221155A JP2025041719A (ja) 2017-05-30 2024-12-17 前立腺がんの内部放射線治療法のための前立腺特異的膜抗原をターゲットとした高親和性薬剤

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762512515P 2017-05-30 2017-05-30
US62/512,515 2017-05-30
PCT/US2018/035220 WO2018222778A1 (en) 2017-05-30 2018-05-30 Prostate-specific membrane antigen targeted high-affinity agents for endoradiotherapy of prostate cancer

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2023127925A Division JP2023159182A (ja) 2017-05-30 2023-08-04 前立腺がんの内部放射線治療法のための前立腺特異的膜抗原をターゲットとした高親和性薬剤

Publications (2)

Publication Number Publication Date
JP2020522506A JP2020522506A (ja) 2020-07-30
JP2020522506A5 true JP2020522506A5 (enExample) 2021-01-07

Family

ID=64455570

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2019566594A Pending JP2020522506A (ja) 2017-05-30 2018-05-30 前立腺がんの内部放射線療法のための前立腺特異的膜抗原をターゲットとした高親和性薬剤
JP2023127925A Pending JP2023159182A (ja) 2017-05-30 2023-08-04 前立腺がんの内部放射線治療法のための前立腺特異的膜抗原をターゲットとした高親和性薬剤
JP2024221155A Pending JP2025041719A (ja) 2017-05-30 2024-12-17 前立腺がんの内部放射線治療法のための前立腺特異的膜抗原をターゲットとした高親和性薬剤

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2023127925A Pending JP2023159182A (ja) 2017-05-30 2023-08-04 前立腺がんの内部放射線治療法のための前立腺特異的膜抗原をターゲットとした高親和性薬剤
JP2024221155A Pending JP2025041719A (ja) 2017-05-30 2024-12-17 前立腺がんの内部放射線治療法のための前立腺特異的膜抗原をターゲットとした高親和性薬剤

Country Status (5)

Country Link
US (2) US11478558B2 (enExample)
EP (1) EP3630733A4 (enExample)
JP (3) JP2020522506A (enExample)
CN (2) CN118146170A (enExample)
WO (1) WO2018222778A1 (enExample)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN120172924A (zh) * 2018-02-06 2025-06-20 约翰霍普金斯大学 用于癌症放射治疗的psma靶向的放射性卤化尿素-聚氨基羧酸盐
CN114364405B (zh) * 2019-04-26 2024-07-16 五一一制药股份有限公司 作为诊断剂和放射性核素治疗剂的前列腺特异性膜抗原(psma)抑制剂
EP3993838A1 (en) * 2019-07-02 2022-05-11 Novartis AG Prostate specific membrane antigen (psma) ligands and uses thereof
CN114341118A (zh) * 2019-07-02 2022-04-12 先进加速器应用意大利公司 前列腺特异性膜抗原(psma)配体及其用途
WO2021202376A1 (en) * 2020-03-30 2021-10-07 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Method for blocking uptake of prostate-specific membrane antigen (psma)-targeted radionuclides by exocrine organs
JP2023522983A (ja) * 2020-04-24 2023-06-01 ラジオメディックス インコーポレイテッド 前立腺がんの診断および処置のための組成物、キットおよび方法
CA3178858A1 (en) * 2020-05-06 2021-11-11 Cornell University Copper-containing theragnostic compounds and methods of use
EP4196175A4 (en) * 2020-08-14 2025-07-30 Clarity Pharmaceuticals Ltd RADIOPHARMACEUTICAL COMPOUNDS, THEIR USES AND PROCESSES FOR THEIR PRODUCTION
EP4204020A1 (en) * 2020-08-31 2023-07-05 Advanced Accelerator Applications International S.A. Method of treating psma-expressing cancers
US20230321285A1 (en) * 2020-08-31 2023-10-12 Advanced Accelerator Applications International Sa Method of treating psma-expressing cancers
WO2022043556A1 (en) * 2020-08-31 2022-03-03 Novartis Ag Stable radiopharmaceutical composition
US20240131206A1 (en) * 2020-12-04 2024-04-25 The Regents Of The University Of California Peptide receptor radionuclide therapy
CN113077840B (zh) * 2021-04-21 2023-01-31 四川大学 基于药效团与alpha-碳特征的金属酶活性位点对比方法
US20250161502A1 (en) * 2022-02-09 2025-05-22 Novartis Ag Pharmaceutical compositions comprising a 225-actinium-labelled complex and a bismuth sequestering agent
CA3258344A1 (en) * 2022-06-07 2023-12-14 Actinium Pharmaceuticals Inc CHELETARIANS AND BIFUNCTIONAL CONJUGATES
WO2024169037A1 (zh) * 2023-02-16 2024-08-22 无锡诺宇医药科技有限公司 Psma靶向放射性药物及其合成和应用
WO2024243315A2 (en) * 2023-05-22 2024-11-28 Actinium Pharmaceuticals, Inc. Multi-arm bifunctional chelators

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2921482B1 (en) * 2007-06-26 2018-09-05 The Johns Hopkins University Labeled inhibitors of prostate-specific membrane antigen (psma), biological evaluation, and use as imaging agents
US9422234B2 (en) 2007-11-30 2016-08-23 The Johns Hopkins University Prostate specific membrane antigen (PSMA) targeted nanoparticles for therapy of prostate cancer
CA2745918C (en) * 2008-12-05 2017-10-10 Molecular Insight Pharmaceuticals, Inc. Technetium- and rhenium-bis(heteroaryl) complexes and methods of use thereof
EP3222617B1 (en) * 2009-03-19 2022-07-06 The Johns Hopkins University Psma-targeting compounds and uses thereof
EP2739316B1 (en) * 2011-08-05 2019-04-10 Molecular Insight Pharmaceuticals, Inc. Radiolabeled prostate specific membrane antigen inhibitors
US9371360B2 (en) * 2011-11-30 2016-06-21 The Johns Hopkins University Homomultivalent and heteromultivalent inhibitors of prostate specific membrane antigen (PSMA) and uses thereof
JP6468602B2 (ja) 2013-01-14 2019-02-13 モレキュラ インサイト ファーマシューティカルズ インコーポレイテッド トリアジン系放射性医薬品及び放射線造影剤
EP2862857A1 (en) * 2013-10-18 2015-04-22 Deutsches Krebsforschungszentrum Labeled inhibitors of prostate specific membrane antigen (PSMA), their use as imaging agents and pharmaceutical agents for the treatment of prostate cancer
HUE066137T2 (hu) * 2013-10-18 2024-07-28 Novartis Ag A prosztata-specifikus membrán antigén (PSMA) jelzett inhibitorai, alkalmazásuk képalkotásban és gyógyszerkészítmények prosztatarák kezelésére
EP3140282B1 (en) * 2014-05-06 2019-07-10 The Johns Hopkins University Metal/radiometal-labeled psma inhibitors for psma-targeted imaging and radiotherapy
PL3183236T3 (pl) * 2014-08-24 2022-07-18 Max-Planck-Gesellschaft Zur Förderung Der Wissenschaften Sposób wytwarzania 18f-znakowanych aktywnych estrów i ich zastosowanie na przykładzie wytwarzania znacznika pet specyficznego dla psma
JP2017530109A (ja) * 2014-09-08 2017-10-12 モレキュラ インサイト ファーマシューティカルズ インコーポレイテッド 前立腺癌についてのpsmaを標的とした放射性核種治療中の臓器の保護
US11420910B2 (en) * 2014-10-30 2022-08-23 Katholieke Universitet Leuven Methods for low temperature fluorine-18 radiolabeling of biomolecules
US10688200B2 (en) * 2015-12-31 2020-06-23 Five Eleven Pharma Inc. Urea-based prostate specific membrane antigen (PSMA) inhibitors for imaging and therapy
SI3925952T1 (sl) * 2016-03-22 2024-03-29 The Johns Hopkins University Za prostato specifična, na membranski antigen usmerjena visoko afinitetna sredstva za endoradioterapijo raka prostate

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