JP2020520388A - Ｌｄｈａ活性阻害剤 - Google Patents

Ｌｄｈａ活性阻害剤 Download PDF

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Publication number
JP2020520388A
JP2020520388A JP2020514351A JP2020514351A JP2020520388A JP 2020520388 A JP2020520388 A JP 2020520388A JP 2020514351 A JP2020514351 A JP 2020514351A JP 2020514351 A JP2020514351 A JP 2020514351A JP 2020520388 A JP2020520388 A JP 2020520388A
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JP
Japan
Prior art keywords
thiophen
alkyl
thio
group
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
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JP2020514351A
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English (en)
Japanese (ja)
Other versions
JP2020520388A5 (enExample
Inventor
クラベネス、ジョー
シエン、ボラ
ランドバル、シュテフィ
アレハンドラ ボーエン、クラウディア
アレハンドラ ボーエン、クラウディア
ニーダー、カトリン
Original Assignee
アークティック ファルマ アーエス
アークティック ファルマ アーエス
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by アークティック ファルマ アーエス, アークティック ファルマ アーエス filed Critical アークティック ファルマ アーエス
Publication of JP2020520388A publication Critical patent/JP2020520388A/ja
Publication of JP2020520388A5 publication Critical patent/JP2020520388A5/ja
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2020514351A 2017-05-16 2018-05-16 Ｌｄｈａ活性阻害剤 Pending JP2020520388A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1707856.9A GB201707856D0 (en) 2017-05-16 2017-05-16 Compounds
GB1707856.9 2017-05-16
PCT/GB2018/051333 WO2018211277A1 (en) 2017-05-16 2018-05-16 Ldha activity inhibitors

Publications (2)

Publication Number Publication Date
JP2020520388A true JP2020520388A (ja) 2020-07-09
JP2020520388A5 JP2020520388A5 (enExample) 2021-07-26

Family

ID=59201440

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2020514351A Pending JP2020520388A (ja) 2017-05-16 2018-05-16 Ｌｄｈａ活性阻害剤

Country Status (7)

Country Link
US (1) US11142520B2 (enExample)
EP (1) EP3625225B1 (enExample)
JP (1) JP2020520388A (enExample)
CN (1) CN110709393A (enExample)
ES (1) ES2923652T3 (enExample)
GB (1) GB201707856D0 (enExample)
WO (1) WO2018211277A1 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020221899A1 (en) * 2019-05-02 2020-11-05 Université Catholique de Louvain Lactate dehydrogenase inhibitor polypeptides for use in the treatment of cancer
US20230346862A1 (en) 2022-05-02 2023-11-02 Athanor Biosciences, Inc. Cancer eradicating - bio-nanoparticles (ce-bnp)
WO2025011479A1 (en) * 2023-07-13 2025-01-16 Meta Pharmaceuticals (Hk) Limited Pyrazole based inhibitors of LDH and their use in immune and inflammatory diseases

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015140133A1 (en) * 2014-03-17 2015-09-24 F. Hoffmann-La Roche Ag Piperidine-dione derivatives
WO2015142903A2 (en) * 2014-03-17 2015-09-24 Genentech, Inc. Method of controlling lactate production with piperdine-dione derivatives

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69430671T2 (de) 1993-11-19 2002-11-21 Parke, Davis & Company 5,6-dihydropyron derivate als protease inhibitoren und antivirusmitteln
US5789440A (en) * 1993-11-19 1998-08-04 Warner-Lambert Company 5,6-dihydropyrone derivatives as protease inhibitors and antiviral agents
EP3356331A1 (en) * 2015-09-30 2018-08-08 Selvita S.A. Pyrazolidine derivatives and related compounds
GB201707852D0 (en) * 2017-05-16 2017-06-28 Arctic Pharma As Compounds
GB201707846D0 (en) * 2017-05-16 2017-06-28 Spermatech As Use

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015140133A1 (en) * 2014-03-17 2015-09-24 F. Hoffmann-La Roche Ag Piperidine-dione derivatives
WO2015142903A2 (en) * 2014-03-17 2015-09-24 Genentech, Inc. Method of controlling lactate production with piperdine-dione derivatives

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
ACS MED. CHEM. LETT., vol. 7, JPN6022017870, 2016, pages 896 - 901, ISSN: 0004768392 *

Also Published As

Publication number Publication date
US11142520B2 (en) 2021-10-12
ES2923652T3 (es) 2022-09-29
CN110709393A (zh) 2020-01-17
EP3625225B1 (en) 2022-06-29
US20200165233A1 (en) 2020-05-28
WO2018211277A1 (en) 2018-11-22
GB201707856D0 (en) 2017-06-28
EP3625225A1 (en) 2020-03-25

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