JP2020520368A - 二本鎖ポリリボヌクレオチドとポリアルキレンイミンとの複合体を含む粒子を含む新規な医薬組成物 - Google Patents

二本鎖ポリリボヌクレオチドとポリアルキレンイミンとの複合体を含む粒子を含む新規な医薬組成物 Download PDF

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JP2020520368A
JP2020520368A JP2019563558A JP2019563558A JP2020520368A JP 2020520368 A JP2020520368 A JP 2020520368A JP 2019563558 A JP2019563558 A JP 2019563558A JP 2019563558 A JP2019563558 A JP 2019563558A JP 2020520368 A JP2020520368 A JP 2020520368A
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cancer
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JP2020520368A5 (OSRAM
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オルティス マリソル キンテロ
オルティス マリソル キンテロ
ルビオ メルセデス ポスエロ
ルビオ メルセデス ポスエロ
カラソ ルルド プラネジェス
カラソ ルルド プラネジェス
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ビオンコテック セラピューティクス エセ.エレ
ビオンコテック セラピューティクス エセ.エレ
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Priority to JP2022157413A priority Critical patent/JP2022188159A/ja
Priority to JP2024131720A priority patent/JP2024160312A/ja
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JP2019563558A 2017-05-17 2017-11-17 二本鎖ポリリボヌクレオチドとポリアルキレンイミンとの複合体を含む粒子を含む新規な医薬組成物 Pending JP2020520368A (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2022157413A JP2022188159A (ja) 2017-05-17 2022-09-30 二本鎖ポリリボヌクレオチドとポリアルキレンイミンとの複合体を含む粒子を含む新規な医薬組成物
JP2024131720A JP2024160312A (ja) 2017-05-17 2024-08-08 二本鎖ポリリボヌクレオチドとポリアルキレンイミンとの複合体を含む粒子を含む新規な医薬組成物

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
EP17171617 2017-05-17
EP17171617.8 2017-05-17
EP17382301 2017-05-26
EP17382301.4 2017-05-26
EP17200469.9 2017-11-07
EP17200469 2017-11-07
PCT/EP2017/079688 WO2018210439A1 (en) 2017-05-17 2017-11-17 Novel pharmaceutical composition comprising particles comprising a complex of a double-stranded polyribonucleotide and a polyalkyleneimine

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JP2020520368A true JP2020520368A (ja) 2020-07-09
JP2020520368A5 JP2020520368A5 (OSRAM) 2021-01-07

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JP2019563558A Pending JP2020520368A (ja) 2017-05-17 2017-11-17 二本鎖ポリリボヌクレオチドとポリアルキレンイミンとの複合体を含む粒子を含む新規な医薬組成物
JP2022157413A Pending JP2022188159A (ja) 2017-05-17 2022-09-30 二本鎖ポリリボヌクレオチドとポリアルキレンイミンとの複合体を含む粒子を含む新規な医薬組成物
JP2024131720A Pending JP2024160312A (ja) 2017-05-17 2024-08-08 二本鎖ポリリボヌクレオチドとポリアルキレンイミンとの複合体を含む粒子を含む新規な医薬組成物

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JP2024131720A Pending JP2024160312A (ja) 2017-05-17 2024-08-08 二本鎖ポリリボヌクレオチドとポリアルキレンイミンとの複合体を含む粒子を含む新規な医薬組成物

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US (6) US10849921B2 (OSRAM)
EP (2) EP3448363B1 (OSRAM)
JP (3) JP2020520368A (OSRAM)
CN (2) CN110831581A (OSRAM)
AU (2) AU2017414660A1 (OSRAM)
CA (1) CA3063805C (OSRAM)
DK (1) DK3448363T3 (OSRAM)
ES (1) ES2924138T3 (OSRAM)
PL (1) PL3448363T3 (OSRAM)
WO (1) WO2018210439A1 (OSRAM)

Families Citing this family (9)

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KR102317281B1 (ko) * 2015-11-17 2021-10-25 하이라이트 테라퓨틱스 에스.엘. 이본쇄 폴리리보뉴클레오타이드 및 폴리알킬렌이민의 복합체를 포함하는 입자를 포함하는 신규 약제학적 조성물
US10849921B2 (en) * 2017-05-17 2020-12-01 Bioncotech Therapeutics Sl Pharmaceutical composition comprising particles comprising a complex of a double-stranded polyribonucleotide and a polyalkyleneimine
WO2020072366A1 (en) * 2018-10-01 2020-04-09 The Regents Of The University Of California Methods for treating cancer with double stranded rna sensor activators and adoptive cell therapy
WO2020077077A1 (en) * 2018-10-10 2020-04-16 The Regents Of The University Of California Combination immunotherapies
EP4603098A3 (en) 2018-11-01 2025-09-03 Alpha Tau Medical Ltd. Intratumoral alpha-emitter radiation and activation of cytoplasmatic sensors for intracellular pathogen
US20210396737A1 (en) * 2018-11-21 2021-12-23 Highlight Therapeutics, S.L. Nanoplexed poly(i:c) formulations and uses thereof
PY2265694A (es) * 2021-07-30 2023-03-08 Salazar Andres Actividad biologica multidimensional optimizada de poli-iclc con tamaño y formulacion de componentes controlados
CN114525253B (zh) * 2022-03-09 2024-03-15 南开大学 一种脂多糖诱导的外泌体及其应用
US20240091348A1 (en) 2022-09-20 2024-03-21 Highlight Therapeutics, S.L. Novel compositions based on polyinosinic-polycytidylic acid

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012531193A (ja) * 2009-07-04 2012-12-10 ファンダシオン セントロ ナショナル デ インベスティゲーショネス オンコロジカス カルロス 3 癌治療剤候補化合物の同定方法
WO2016178233A1 (en) * 2015-05-05 2016-11-10 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd Nucleic acid-cationic polymer compositions and methods of making and using the same

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1194002C (zh) * 1999-02-15 2005-03-23 日本新药株式会社 短链化多核苷酸及其制备方法
WO2005102278A1 (en) 2002-07-03 2005-11-03 Oncovir, Inc. Method for preparation of poly-iclc and uses thereof
US7927792B2 (en) 2002-11-18 2011-04-19 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Targeted double stranded RNA mediated cell killing
US20070166800A1 (en) * 2006-01-13 2007-07-19 Haixiang Lin Immunogenic substances comprising a polyinosinic acid-polycytidilic acid based adjuvant
JP4861036B2 (ja) 2006-03-31 2012-01-25 リンテック株式会社 剥離シートおよびその製造方法
WO2008057696A2 (en) 2006-10-10 2008-05-15 Juvaris Biotherapeutics, Inc. Compositions of pattern recognition receptor-ligand: lipid complexes and methods of use thereof
KR100958293B1 (ko) 2008-03-27 2010-05-19 단국대학교 산학협력단 테오필린에 의해 표적 특이적 rna 치환 활성이 조절되는알로스테릭 트랜스―스플라이싱 그룹 i 리보자임
WO2009130301A1 (en) * 2008-04-25 2009-10-29 Institut Gustave Roussy Improved treatment of cancer using tlr3 agonists in combination with another therapeutic agent
MX2011006720A (es) * 2008-12-22 2011-10-06 Yissum Res Dev Co Vector de acido ribonucleico de cadena doble buscador del receptor del factor de crecimiento epidermico para el tratamiento sistemico del cancer.
CN102988303A (zh) 2011-09-15 2013-03-27 天津泽世德生物医药有限公司 一种多聚肌苷酸多聚胞苷酸冻干粉针的制备方法
WO2013040552A2 (en) 2011-09-16 2013-03-21 Georgia Health Sciences University Methods of promoting immune tolerance
WO2013063019A1 (en) 2011-10-28 2013-05-02 The Wistar Institute Of Anatomy And Biology Methods and compositions for enhancing the therapeutic effect of anti-tumor t cells
WO2013087083A1 (en) * 2011-12-15 2013-06-20 Biontech Ag Particles comprising single stranded rna and double stranded rna for immunomodulation
BR112014026957A8 (pt) 2012-05-03 2018-01-16 Janssen R&D Ireland micropartícula, composição compreendendo a mesma, seu uso e sistema de distribuição nasal relacionados ao tratamento de infecções do trato respiratório superior
ITRM20120480A1 (it) 2012-10-09 2014-04-10 Uni Degli Studi Camerino Nanoparticelle lipidiche multicomponenti e procedimenti per la loro preparazione.
WO2014165296A1 (en) 2013-03-12 2014-10-09 Multicell Immunotherapeutics, Inc. Methods and formulations to achieve tumor targeted double stranded rna mediated cell death
RU2016117398A (ru) * 2013-11-06 2017-12-11 Янссен Сайенсиз Айрлэнд Юси Композиции полиинозиновой-полицитидиловой кислоты (поли (и:ц)) для лечения инфекций верхних дыхательных путей
CN103599071B (zh) 2013-11-08 2016-01-27 杭州美亚药业股份有限公司 一种双链聚肌胞干粉的制备方法
SG10201911695SA (en) 2014-05-14 2020-01-30 Targimmune Therapeutics Ag Improved polyethyleneimine polyethyleneglycol vectors
EP3283059B1 (en) 2015-04-13 2024-01-03 CureVac Manufacturing GmbH Method for producing rna compositions
KR102317281B1 (ko) * 2015-11-17 2021-10-25 하이라이트 테라퓨틱스 에스.엘. 이본쇄 폴리리보뉴클레오타이드 및 폴리알킬렌이민의 복합체를 포함하는 입자를 포함하는 신규 약제학적 조성물
CA3025812A1 (en) 2016-08-19 2018-02-22 Curevac Ag Rna for cancer therapy
US10849921B2 (en) * 2017-05-17 2020-12-01 Bioncotech Therapeutics Sl Pharmaceutical composition comprising particles comprising a complex of a double-stranded polyribonucleotide and a polyalkyleneimine

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012531193A (ja) * 2009-07-04 2012-12-10 ファンダシオン セントロ ナショナル デ インベスティゲーショネス オンコロジカス カルロス 3 癌治療剤候補化合物の同定方法
WO2016178233A1 (en) * 2015-05-05 2016-11-10 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd Nucleic acid-cationic polymer compositions and methods of making and using the same

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
CANCER IMMUNOLOGY RESEARCH, vol. 2(8), JPN6021031971, 2014, pages 720 - 724, ISSN: 0004786655 *
CLINICAL CANCER RESEARCH, vol. 20(5), JPN6021031972, 2014, pages 1355 - 1365, ISSN: 0004786656 *
PHARMACEUTICAL RESEARCH, vol. 28, JPN6021031968, 2011, pages 731 - 741, ISSN: 0004786654 *

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