JP2020519675A - 抗folr1イムノコンジュゲートと抗pd−1抗体の組み合わせ - Google Patents

抗folr1イムノコンジュゲートと抗pd−1抗体の組み合わせ Download PDF

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JP2020519675A
JP2020519675A JP2019563246A JP2019563246A JP2020519675A JP 2020519675 A JP2020519675 A JP 2020519675A JP 2019563246 A JP2019563246 A JP 2019563246A JP 2019563246 A JP2019563246 A JP 2019563246A JP 2020519675 A JP2020519675 A JP 2020519675A
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antibody
immunoconjugate
folr1
cancer
antigen
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JP2020519675A5 (cg-RX-API-DMAC10.html
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ルイス・ソト,ロドリーゴ・アール
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Merck Sharp & Dohme LLC
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Merck Sharp & Dohme LLC
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JP2019563246A 2017-05-16 2018-05-15 抗folr1イムノコンジュゲートと抗pd−1抗体の組み合わせ Pending JP2020519675A (ja)

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US201862647008P 2018-03-23 2018-03-23
US62/647,008 2018-03-23
PCT/US2018/032692 WO2018213260A1 (en) 2017-05-16 2018-05-15 Anti-folr1 immunoconjugates and anti-pd-1 antibody combinations

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PT2170959E (pt) 2007-06-18 2014-01-07 Merck Sharp & Dohme Anticorpos para o receptor humano de morte programada pd-1
ES2661466T3 (es) 2011-04-01 2018-04-02 Immunogen, Inc. Métodos para aumentar la eficacia de la terapia contra el cáncer con FOLR1
EP3765521A4 (en) 2018-03-13 2022-03-23 Phanes Therapeutics, Inc. ANTI-FOLATE RECEPTOR-1 ANTIBODIES AND USES THEREOF
JP2022500454A (ja) * 2018-09-17 2022-01-04 ストロ バイオファーマ インコーポレーテッド 抗葉酸受容体抗体コンジュゲートによる併用療法
MX2021008121A (es) * 2019-01-03 2021-12-10 Inst Nat Sante Rech Med Metodos y composiciones farmaceuticas para mejorar las respuestas inmunitarias dependientes de celulas t cd8+ en sujetos que sufren de cancer.
AU2022263376A1 (en) 2021-04-23 2023-11-23 King's College London Composition comprising an ige antibody
TW202409080A (zh) * 2022-07-26 2024-03-01 美商沙塔克實驗室股份有限公司 用於治療卵巢癌之組合療法
CN115960269B (zh) * 2023-01-30 2026-04-03 上海甲贝医药科技有限公司 一种重组长效人cxcr4&pd-1双靶点抗体融合蛋白及其制备方法
CN120919340A (zh) * 2024-05-09 2025-11-11 百奥泰生物制药股份有限公司 抗FRα抗体药物偶联物和PD-1拮抗剂在治疗肿瘤中的应用
CN118684782A (zh) * 2024-07-17 2024-09-24 武汉科技大学 一种muc16和folr1双靶点嵌合抗原受体dcar-16-r1及应用
WO2026056954A1 (en) * 2024-09-12 2026-03-19 LaNova Medicines Limited Anti-folr1 antibodies and conjugates thereof
CN119798405B (zh) * 2024-12-30 2026-06-30 华润生物医药有限公司 Il-21的突变体及其制备方法和应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT2170959E (pt) * 2007-06-18 2014-01-07 Merck Sharp & Dohme Anticorpos para o receptor humano de morte programada pd-1
CN105777907B (zh) * 2010-02-24 2020-03-17 伊缪诺金公司 叶酸受体1抗体与免疫缀合物以及其用途
BR112015007184A2 (pt) * 2012-10-02 2017-08-08 Bristol Myers Squibb Co combinação de anticorpos anti-kir e anticorpos anti-pd-1 para tratar câncer
JP6463744B2 (ja) * 2013-10-08 2019-02-06 イミュノジェン, インコーポレイテッド 抗folr1免疫抱合体投薬レジメン
US20150297744A1 (en) * 2014-03-28 2015-10-22 Immunogen, Inc. Anti-FOLR1 Immunoconjugate Dosing Regimens
SG11201704056XA (en) * 2014-11-20 2017-06-29 Hoffmann La Roche Combination therapy of t cell activating bispecific antigen binding molecules cd3 abd folate receptor 1 (folr1) and pd-1 axis binding antagonists
EP3233918A1 (en) * 2014-12-19 2017-10-25 Novartis AG Combination therapies
CN122075735A (zh) * 2015-09-17 2026-05-26 伊缪诺金公司 包含抗folr1免疫缀合物的治疗组合

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
"Combination Regimens of Mirvetuximab Soravtansine, A Folate Receptor Alpha-Targeting Antibody-Drug C", HEALTH CARE: CURRENT REVIEWS, vol. 5, no. 2, JPN7022002573, April 2017 (2017-04-01), pages 1 - 2, ISSN: 0004792948 *
"History of Changes for Study: NCT02606305", CLINICAL TRIALS.GOV ARCHIVE [ONLINE], JPN6022022495, 7 April 2017 (2017-04-07), ISSN: 0004988503 *
"New therapies for advanced, recurrent, and metastatic endometrial cancers", GYNECOLOGIC ONCOLOGY RESEARCH AND PRACTICE, vol. 4, JPN7022002572, December 2017 (2017-12-01), pages 1 - 12, ISSN: 0004792949 *
"P303 Treatment of tumor cells with mirvetuximab soravtansine, a FRalpha-targeting antibody-drug conj", JOURNAL FOR IMMUNOTHERAPY OF CANCER, vol. Vol.4(Suppl 1):73, JPN7022002571, 2016, pages 1 - 163, ISSN: 0004792950 *
ONCOTARGET, vol. 8, no. 52, JPN7022002574, August 2017 (2017-08-01), pages 90532 - 90544, ISSN: 0004792951 *

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