JP2020519660A5 - - Google Patents

Download PDF

Info

Publication number
JP2020519660A5
JP2020519660A5 JP2019563125A JP2019563125A JP2020519660A5 JP 2020519660 A5 JP2020519660 A5 JP 2020519660A5 JP 2019563125 A JP2019563125 A JP 2019563125A JP 2019563125 A JP2019563125 A JP 2019563125A JP 2020519660 A5 JP2020519660 A5 JP 2020519660A5
Authority
JP
Japan
Prior art keywords
inhibitor
cancer
item
combinations
delta
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2019563125A
Other languages
English (en)
Japanese (ja)
Other versions
JP2020519660A (ja
JP7405408B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2018/032755 external-priority patent/WO2018213302A1/en
Publication of JP2020519660A publication Critical patent/JP2020519660A/ja
Publication of JP2020519660A5 publication Critical patent/JP2020519660A5/ja
Priority to JP2022160828A priority Critical patent/JP2022176316A/ja
Application granted granted Critical
Publication of JP7405408B2 publication Critical patent/JP7405408B2/ja
Priority to JP2025100020A priority patent/JP2025123379A/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2019563125A 2017-05-16 2018-05-15 異型braf変異を有するがんを処置するための組成物および方法 Active JP7405408B2 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2022160828A JP2022176316A (ja) 2017-05-16 2022-10-05 異型braf変異を有するがんを処置するための組成物および方法
JP2025100020A JP2025123379A (ja) 2017-05-16 2025-06-16 異型braf変異を有するがんを処置するための組成物および方法

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762506995P 2017-05-16 2017-05-16
US62/506,995 2017-05-16
PCT/US2018/032755 WO2018213302A1 (en) 2017-05-16 2018-05-15 Compositions and methods for treating cancer with atypical braf mutations

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2022160828A Division JP2022176316A (ja) 2017-05-16 2022-10-05 異型braf変異を有するがんを処置するための組成物および方法

Publications (3)

Publication Number Publication Date
JP2020519660A JP2020519660A (ja) 2020-07-02
JP2020519660A5 true JP2020519660A5 (https=) 2021-07-26
JP7405408B2 JP7405408B2 (ja) 2023-12-26

Family

ID=64274828

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2019563125A Active JP7405408B2 (ja) 2017-05-16 2018-05-15 異型braf変異を有するがんを処置するための組成物および方法
JP2022160828A Withdrawn JP2022176316A (ja) 2017-05-16 2022-10-05 異型braf変異を有するがんを処置するための組成物および方法
JP2025100020A Pending JP2025123379A (ja) 2017-05-16 2025-06-16 異型braf変異を有するがんを処置するための組成物および方法

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2022160828A Withdrawn JP2022176316A (ja) 2017-05-16 2022-10-05 異型braf変異を有するがんを処置するための組成物および方法
JP2025100020A Pending JP2025123379A (ja) 2017-05-16 2025-06-16 異型braf変異を有するがんを処置するための組成物および方法

Country Status (8)

Country Link
US (1) US12582635B2 (https=)
EP (1) EP3624896A4 (https=)
JP (3) JP7405408B2 (https=)
CN (2) CN110799245B (https=)
AU (2) AU2018269982B2 (https=)
CA (1) CA3063614A1 (https=)
MX (1) MX2019013634A (https=)
WO (1) WO2018213302A1 (https=)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2017329090B9 (en) 2016-09-19 2019-09-05 Novartis Ag Therapeutic combinations comprising a RAF inhibitor and a ERK inhibitor
ES2952265T3 (es) 2017-05-02 2023-10-30 Novartis Ag Terapia combinada que comprende un inhibidor de Raf y trametinib
US12398209B2 (en) 2018-01-22 2025-08-26 Janssen Biotech, Inc. Methods of treating cancers with antagonistic anti-PD-1 antibodies
CN109771436A (zh) * 2019-03-06 2019-05-21 康赋葆(深圳)生物医药科技有限公司 四氢姜黄素与卡培他滨联合治疗大肠癌的应用
ES3025633T3 (en) 2019-05-13 2025-06-09 Novartis Ag New crystalline forms of n-(3-(2-(2-hydroxyethoxy)-6-morpholinopyridin-4-yl)-4-methvlphenyl)-2(trifluoromethyl)isonicotinamide as raf inhibitors for the treatment of cancer
JP7234418B2 (ja) * 2019-05-16 2023-03-07 イーライ リリー アンド カンパニー Brafv600e大腸癌の治療に使用するためのerk1/2阻害剤と、braf阻害剤およびegfr阻害剤との三重組み合わせ
MX2021014961A (es) 2019-06-06 2022-01-24 Hutchison Medipharma Ltd Compuestos triciclicos y su uso.
GB201913124D0 (en) * 2019-09-11 2019-10-23 Seald As Compositions and methods for treatment of cholangiocarcinoma
GB201913121D0 (en) * 2019-09-11 2019-10-23 Seald As Compositions and methods for treatment of cholangiocarcinoma
GB201913123D0 (en) * 2019-09-11 2019-10-23 Seald As Compositions and methods for treatment of cholangiocarcinoma
CN110538316B (zh) * 2019-10-17 2021-10-15 滨州医学院 5-fu和胰高血糖素联合用于制备治疗结直肠癌的药物的用途和药物组合物
JP7582694B2 (ja) 2020-01-10 2024-11-13 イミューニヤリング コーポレーション Mek阻害剤及びその治療的使用
EP4106756A1 (en) * 2020-02-18 2022-12-28 Novartis AG Therapeutic combinations comprising a raf inhibitor for use in treating braf mutant nsclc
WO2022179568A1 (en) * 2021-02-25 2022-09-01 Westlake Therapeutics (Hangzhou) Co., Limited Neoantigenic peptide and its use for treating braf gene mutation related diseases
JP2024509269A (ja) * 2021-03-09 2024-02-29 ジェネンテック, インコーポレイテッド 脳がんの治療における使用のためのベルバラフェニブ
CN117677398A (zh) * 2021-07-27 2024-03-08 东丽株式会社 用于癌的治疗和/或预防的药品
WO2023049798A1 (en) * 2021-09-22 2023-03-30 Henry Ford Health System Hdac3 inhibitors for the treatment of langerhans cell histiocytosis and langerhans cell sarcoma
CN116570599B (zh) * 2023-07-04 2023-10-20 四川大学华西医院 Vs6766联合ly3009120的应用及药物组合物
CN121243179B (zh) * 2025-12-05 2026-02-24 山东大学 盐酸帕唑帕尼在制备卵巢功能保护药物方面的应用

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2639416C (en) * 2007-09-11 2019-12-31 F. Hoffmann-La Roche Ag Diagnostic test for susceptibility to b-raf kinase inhibitors
BR112015002285B1 (pt) 2012-08-09 2022-05-10 Celgene Corporation Uso do composto 3-(4-((4-(morfolinometil)benzil)oxi)-1-oxoisoindolin-2-il)piperidina-2,6-diona para tratar ou gerenciar câncer
EP3626309B1 (en) 2012-08-13 2023-03-08 The Rockefeller University Lxrbeta agonist for the treatment of cancer
UA118846C2 (uk) * 2013-03-21 2019-03-25 Новартіс Аг Комбінована терапія
US10617723B2 (en) * 2013-03-29 2020-04-14 Biomed Valley Discoveries, Inc. C. novyi for the treatment of solid tumors in humans
CN105530931B (zh) * 2013-07-12 2019-11-08 皮拉马尔企业有限公司 用于治疗黑素瘤的药物组合
WO2015095835A1 (en) * 2013-12-20 2015-06-25 Biomed Valley Discoveries, Inc. Methods of modulating radioiodine uptake for the treatment of radioiodine-refractory cancers
JP6678583B2 (ja) * 2013-12-20 2020-04-22 バイオメッド バレー ディスカバリーズ,インコーポレイティド 2型mek阻害剤およびerk阻害剤の組み合わせを用いるがん処置
WO2015095842A2 (en) * 2013-12-20 2015-06-25 Biomed Valley Discoveries, Inc. Methods and compositions for treating non-erk mapk pathway inhibitor-resistant cancers
JP6727127B2 (ja) * 2013-12-20 2020-07-29 バイオメッド バレー ディスカバリーズ,インコーポレイティド Pi3k/aktシグナル経路阻害剤およびerk阻害剤の組み合わせを使用するがん処置
US20160310477A1 (en) * 2013-12-20 2016-10-27 Biomed Valley Discoveries, Inc. Cancer treatments using combinations of mek type 1 and erk inhibitors
AU2014368927B2 (en) * 2013-12-20 2018-10-25 Biomed Valley Discoveries, Inc. Cancer treatments using combinations of CDK and ERK inhibitors
CA3240745A1 (en) * 2013-12-20 2015-06-25 Biomed Valley Discoveries, Inc. Cancer treatment using combinations of erk and raf inhibitors
JP7036594B2 (ja) 2014-07-14 2022-03-15 ウニベルジテート チューリッヒ プロレクトラット エムエンベー Braf陽性癌を患っている患者を、braf阻害剤に対する非レスポンダーであると及びmapk/erk阻害剤に対するレスポンダーであると同定する手段及び方法
WO2016025650A1 (en) * 2014-08-13 2016-02-18 Celgene Avilomics Research, Inc. Combinations of an erk inhibitor and a cdk4/6 inhibitor and related methods
WO2016205418A1 (en) * 2015-06-15 2016-12-22 Asana Biosciences, Llc Heterocyclic inhibitors of erk1 and erk2 and their use in the treatment of cancer
EP3320093A4 (en) * 2015-07-08 2019-01-30 Dana-Farber Cancer Institute, Inc. COMPOSITIONS AND METHODS FOR IDENTIFYING, EVALUATING, PREVENTING AND TREATING CANCER USING SLNCR ISOFORMS

Similar Documents

Publication Publication Date Title
JP2020519660A5 (https=)
JP7405408B2 (ja) 異型braf変異を有するがんを処置するための組成物および方法
US11679112B2 (en) Cancer treatments using combinations of CDK and ERK inhibitors
Herrera et al. Autologous stem-cell transplantation after second-line brentuximab vedotin in relapsed or refractory Hodgkin lymphoma
Saad et al. SRC kinase inhibition: targeting bone metastases and tumor growth in prostate and breast cancer
Dong et al. Histone deacetylase inhibitor potentiated the ability of MTOR inhibitor to induce autophagic cell death in Burkitt leukemia/lymphoma
JP7788114B2 (ja) ヒトにおける固形腫瘍の処置のためのC.novyi
JP2017502017A5 (https=)
NZ592039A (en) Combination therapy for the treatment of ocular neovascular disorders
Han et al. In vitro and in vivo activity of sacituzumab govitecan, an antibody-drug conjugate targeting trophoblast cell-surface antigen 2 (Trop-2) in uterine serous carcinoma
RU2016129287A (ru) Лечение злокачественных опухолей с применением комбинаций ингибиторов erk и raf
Spigel et al. Efficacy and safety of oral topotecan and bevacizumab combination as second-line treatment for relapsed small-cell lung cancer: an open-label multicenter single-arm phase II study
JP2017500320A5 (https=)
CN101743013A (zh) 使用整联蛋白配体治疗癌的特异疗法和药物
WO2015095831A1 (en) Cancer treatments using combinations of mtor and erk inhibitors
Rocchi et al. The angiogenic asset of soft tissue sarcomas: a new tool to discover new therapeutic targets
Miller et al. Combination treatment options for castration-resistant prostate cancer
Kochar et al. Contemporary updates on clinical trials of antiangiogenic agents in the treatment of glioblastoma multiforme
WO2014160967A9 (en) C. novyi for the treatment of solid tumors in non-human animals
Higano New treatment options for patients with metastatic castration-resistant prostate cancer
CA3118690A1 (en) Use of tivozanib to treat subjects with refractory cancer
RU2024101803A (ru) Композиции и способы для лечения злокачественной опухоли с атипичными мутациями braf
US20220096436A1 (en) Combination product for the treatment of cancer
HK40086947A (zh) 用於治疗具有非典型braf突变的癌症的组合物和方法
HK40086947B (zh) 用於治疗具有非典型braf突变的癌症的组合物和方法