JP2020516663A5 - - Google Patents
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- Publication number
- JP2020516663A5 JP2020516663A5 JP2019556183A JP2019556183A JP2020516663A5 JP 2020516663 A5 JP2020516663 A5 JP 2020516663A5 JP 2019556183 A JP2019556183 A JP 2019556183A JP 2019556183 A JP2019556183 A JP 2019556183A JP 2020516663 A5 JP2020516663 A5 JP 2020516663A5
- Authority
- JP
- Japan
- Prior art keywords
- dihydronaphthalene
- dioxo
- methoxy
- methylidene
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762486033P | 2017-04-17 | 2017-04-17 | |
| US62/486,033 | 2017-04-17 | ||
| PCT/US2018/027786 WO2018194976A1 (en) | 2017-04-17 | 2018-04-16 | Prevention and reversal of inflammation induced dna damage |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2020516663A JP2020516663A (ja) | 2020-06-11 |
| JP2020516663A5 true JP2020516663A5 (https=) | 2021-04-30 |
Family
ID=63856081
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019556183A Pending JP2020516663A (ja) | 2017-04-17 | 2018-04-16 | 炎症によって誘起されるｄｎａ損傷の阻止及び回復 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US20190117602A1 (https=) |
| EP (1) | EP3440047A4 (https=) |
| JP (1) | JP2020516663A (https=) |
| CA (1) | CA3060266A1 (https=) |
| WO (1) | WO2018194976A1 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20190160034A1 (en) * | 2017-03-20 | 2019-05-30 | Indiana University Research And Technology Corporation | Use of ape1/ref-1 inhibitors in combination therapies for treatment of cancer |
| JP7266304B2 (ja) | 2017-04-21 | 2023-04-28 | ユニヴァーシティー オブ タスマニア | 治療化合物および方法 |
| EP3897601A4 (en) * | 2018-12-17 | 2022-08-31 | Indiana University Research And Technology Corporation | TREATMENT OF GASTROINTESTINAL DISEASES AND THEIR SYMPTOMS |
| EP4587003A2 (en) | 2022-09-14 | 2025-07-23 | Opus Genetics, Inc. | Salts and esters of apx3330 and therapeutic uses thereof |
| CN119097711A (zh) * | 2024-09-11 | 2024-12-10 | 山东大学齐鲁医院 | Ape1抑制剂在制备治疗鼻窦炎药物中的应用 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0801949A1 (en) * | 1996-04-15 | 1997-10-22 | Eisai Co., Ltd. | Hypoglycemic quinone derivative |
| JPH1067653A (ja) * | 1996-06-17 | 1998-03-10 | Eisai Co Ltd | 関節疾患治療剤 |
| EP0813866A3 (en) * | 1996-06-17 | 1999-01-20 | Eisai Co., Ltd. | Therapeutic agent for joint diseases |
| US20030229004A1 (en) | 2002-03-20 | 2003-12-11 | Pangene Corporation | Modulation of tumor cells using BER inhibitors in combination with a sensitizing agent and DSBR inhibitors |
| US8710095B2 (en) * | 2002-04-30 | 2014-04-29 | Bionumerik Pharmaceuticals, Inc. | Drugs for prophylaxis or mitigation of taxane-induced neurotoxicity |
| AU2008304619C1 (en) * | 2007-09-26 | 2020-06-04 | Indiana University Research And Technology Corporation | Benzoquinone derivative E3330 in combination with chemotherapeutic agents for the treatment of cancer and angiogenesis |
| KR20110103442A (ko) | 2008-12-23 | 2011-09-20 | 보드 오브 리전츠 더 유니버시티 오브 텍사스 시스템 | 염증 표적화 입자 |
| GB201020397D0 (en) | 2010-12-02 | 2011-01-12 | Univ Nottingham | Compounds |
| WO2012148889A1 (en) | 2011-04-28 | 2012-11-01 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Inhibitors of human apurinic/apyrimidinic endonuclease 1 |
| KR101982669B1 (ko) * | 2011-05-26 | 2019-05-27 | 인디애나 유니버시티 리서치 앤드 테크놀로지 코퍼레이션 | Ape1 매개된 질환을 치료하기 위한 퀴논 화합물 |
| US20140128398A1 (en) * | 2011-06-03 | 2014-05-08 | Indiana University Research And Technology Corporation | Compounds, compositions and methods for treating oxidative dna damage disorders |
| CN107184572B (zh) | 2017-03-09 | 2020-07-28 | 中山大学 | 一种ape1抑制剂及其在制备用于治疗肿瘤和血管异常增生性疾病药物中的应用 |
-
2018
- 2018-04-16 US US16/092,816 patent/US20190117602A1/en not_active Abandoned
- 2018-04-16 WO PCT/US2018/027786 patent/WO2018194976A1/en not_active Ceased
- 2018-04-16 CA CA3060266A patent/CA3060266A1/en active Pending
- 2018-04-16 EP EP18788150.3A patent/EP3440047A4/en active Pending
- 2018-04-16 JP JP2019556183A patent/JP2020516663A/ja active Pending
-
2020
- 2020-04-16 US US16/850,436 patent/US11351130B2/en active Active
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