JP2020516663A5 - - Google Patents
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- Publication number
- JP2020516663A5 JP2020516663A5 JP2019556183A JP2019556183A JP2020516663A5 JP 2020516663 A5 JP2020516663 A5 JP 2020516663A5 JP 2019556183 A JP2019556183 A JP 2019556183A JP 2019556183 A JP2019556183 A JP 2019556183A JP 2020516663 A5 JP2020516663 A5 JP 2020516663A5
- Authority
- JP
- Japan
- Prior art keywords
- dihydronaphthalene
- dioxo
- methoxy
- methylidene
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762486033P | 2017-04-17 | 2017-04-17 | |
| US62/486,033 | 2017-04-17 | ||
| PCT/US2018/027786 WO2018194976A1 (en) | 2017-04-17 | 2018-04-16 | Prevention and reversal of inflammation induced dna damage |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2020516663A JP2020516663A (ja) | 2020-06-11 |
| JP2020516663A5 true JP2020516663A5 (https=) | 2021-04-30 |
Family
ID=63856081
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019556183A Pending JP2020516663A (ja) | 2017-04-17 | 2018-04-16 | 炎症によって誘起されるｄｎａ損傷の阻止及び回復 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US20190117602A1 (https=) |
| EP (1) | EP3440047A4 (https=) |
| JP (1) | JP2020516663A (https=) |
| CA (1) | CA3060266A1 (https=) |
| WO (1) | WO2018194976A1 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018175429A1 (en) * | 2017-03-20 | 2018-09-27 | Indiana University Research And Technology Corporation | Use of ape1/ref-1 inhibitors in combination therapies for treatment of cancer |
| CN110582480B (zh) | 2017-04-21 | 2023-11-10 | 塔斯马尼亚大学 | 治疗化合物和方法 |
| WO2020131511A1 (en) | 2018-12-17 | 2020-06-25 | Indiana University Research And Technology Corporation | Treatment of gastrointestinal disorders and symptoms thereof |
| CA3267730A1 (en) | 2022-09-14 | 2024-03-21 | Opus Genetics, Inc. | APX3330 SALTS AND ESTERS AND THEIR THERAPEUTIC USES |
| CN119097711A (zh) * | 2024-09-11 | 2024-12-10 | 山东大学齐鲁医院 | Ape1抑制剂在制备治疗鼻窦炎药物中的应用 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0801949A1 (en) * | 1996-04-15 | 1997-10-22 | Eisai Co., Ltd. | Hypoglycemic quinone derivative |
| EP0813866A3 (en) * | 1996-06-17 | 1999-01-20 | Eisai Co., Ltd. | Therapeutic agent for joint diseases |
| JPH1067653A (ja) * | 1996-06-17 | 1998-03-10 | Eisai Co Ltd | 関節疾患治療剤 |
| US20030229004A1 (en) | 2002-03-20 | 2003-12-11 | Pangene Corporation | Modulation of tumor cells using BER inhibitors in combination with a sensitizing agent and DSBR inhibitors |
| US8710095B2 (en) * | 2002-04-30 | 2014-04-29 | Bionumerik Pharmaceuticals, Inc. | Drugs for prophylaxis or mitigation of taxane-induced neurotoxicity |
| ES2653855T3 (es) * | 2007-09-26 | 2018-02-09 | Indiana University Research And Technology Corporation | Derivado de la benzoquinona e3330 en combinación con agentes quimioterapéuticos para el tratamiento del cáncer y la angiogénesis |
| EP2373292A1 (en) | 2008-12-23 | 2011-10-12 | Board of Regents of the University of Texas System | Inflammation targeting particles |
| GB201020397D0 (en) | 2010-12-02 | 2011-01-12 | Univ Nottingham | Compounds |
| WO2012148889A1 (en) | 2011-04-28 | 2012-11-01 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Inhibitors of human apurinic/apyrimidinic endonuclease 1 |
| MX357284B (es) * | 2011-05-26 | 2018-07-04 | Univ Indiana Res & Tech Corp | Compuestos de quinona para tratar enfermedades mediadas por ape1. |
| US20140128398A1 (en) * | 2011-06-03 | 2014-05-08 | Indiana University Research And Technology Corporation | Compounds, compositions and methods for treating oxidative dna damage disorders |
| CN107184572B (zh) | 2017-03-09 | 2020-07-28 | 中山大学 | 一种ape1抑制剂及其在制备用于治疗肿瘤和血管异常增生性疾病药物中的应用 |
-
2018
- 2018-04-16 CA CA3060266A patent/CA3060266A1/en active Pending
- 2018-04-16 JP JP2019556183A patent/JP2020516663A/ja active Pending
- 2018-04-16 EP EP18788150.3A patent/EP3440047A4/en active Pending
- 2018-04-16 US US16/092,816 patent/US20190117602A1/en not_active Abandoned
- 2018-04-16 WO PCT/US2018/027786 patent/WO2018194976A1/en not_active Ceased
-
2020
- 2020-04-16 US US16/850,436 patent/US11351130B2/en active Active
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