JP2020515620A5 - - Google Patents
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- Publication number
- JP2020515620A5 JP2020515620A5 JP2019554003A JP2019554003A JP2020515620A5 JP 2020515620 A5 JP2020515620 A5 JP 2020515620A5 JP 2019554003 A JP2019554003 A JP 2019554003A JP 2019554003 A JP2019554003 A JP 2019554003A JP 2020515620 A5 JP2020515620 A5 JP 2020515620A5
- Authority
- JP
- Japan
- Prior art keywords
- salt
- dihydrospiro
- oxo
- cyclohexane
- carboxylic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000003839 salts Chemical class 0.000 claims 14
- 239000003814 drug Substances 0.000 claims 4
- 150000001875 compounds Chemical class 0.000 claims 3
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims 2
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 1
- 125000006376 (C3-C10) cycloalkyl group Chemical group 0.000 claims 1
- ZHZPSQJHTGGBDQ-UHFFFAOYSA-N 2-oxo-4'-(2,4,6-trichlorophenoxy)spiro[1H-indole-3,1'-cyclohexane]-5-carboxylic acid Chemical compound O=C1NC2=CC=C(C=C2C11CCC(CC1)OC1=C(C=C(C=C1Cl)Cl)Cl)C(=O)O ZHZPSQJHTGGBDQ-UHFFFAOYSA-N 0.000 claims 1
- QLLFLUYOTLEAGN-UHFFFAOYSA-N 4'-(2,4-dichlorophenoxy)-2-oxospiro[1H-indole-3,1'-cyclohexane]-5-carboxylic acid Chemical compound ClC1=C(OC2CCC3(C(NC4=CC=C(C=C34)C(=O)O)=O)CC2)C=CC(=C1)Cl QLLFLUYOTLEAGN-UHFFFAOYSA-N 0.000 claims 1
- BLNKDHKPWXFSNI-UHFFFAOYSA-N 4'-(2,4-dichlorophenoxy)-2-oxospiro[1H-pyrrolo[3,2-b]pyridine-3,1'-cyclohexane]-5-carboxylic acid Chemical compound ClC1=C(OC2CCC3(C(NC=4C3=NC(=CC=4)C(=O)O)=O)CC2)C=CC(=C1)Cl BLNKDHKPWXFSNI-UHFFFAOYSA-N 0.000 claims 1
- CZKCQEAQCVKSAR-UHFFFAOYSA-N 4'-(3,5-dichloropyridin-2-yl)oxy-2-oxospiro[1H-indole-3,1'-cyclohexane]-5-carboxylic acid Chemical compound ClC=1C(=NC=C(C=1)Cl)OC1CCC2(C(NC3=CC=C(C=C23)C(=O)O)=O)CC1 CZKCQEAQCVKSAR-UHFFFAOYSA-N 0.000 claims 1
- SGJACBCGAWBJAV-UHFFFAOYSA-N 4'-(3,5-dichloropyridin-2-yl)oxy-2-oxospiro[1H-pyrrolo[3,2-b]pyridine-3,1'-cyclohexane]-5-carboxylic acid Chemical compound ClC=1C(=NC=C(C=1)Cl)OC1CCC2(C(NC=3C2=NC(=CC=3)C(=O)O)=O)CC1 SGJACBCGAWBJAV-UHFFFAOYSA-N 0.000 claims 1
- OPNVAOLWYYVIND-UHFFFAOYSA-N 4'-(3,5-difluoropyridin-2-yl)oxy-2-oxospiro[1H-indole-3,1'-cyclohexane]-5-carboxylic acid Chemical compound FC=1C(=NC=C(C=1)F)OC1CCC2(C(NC3=CC=C(C=C23)C(=O)O)=O)CC1 OPNVAOLWYYVIND-UHFFFAOYSA-N 0.000 claims 1
- VPRJIRIRZLKCBZ-UHFFFAOYSA-N 4'-(4-chloro-2-methoxyphenoxy)-2-oxospiro[1H-indole-3,1'-cyclohexane]-5-carboxylic acid Chemical compound ClC1=CC(=C(OC2CCC3(C(NC4=CC=C(C=C34)C(=O)O)=O)CC2)C=C1)OC VPRJIRIRZLKCBZ-UHFFFAOYSA-N 0.000 claims 1
- KTFXARCMMJJUFY-UHFFFAOYSA-N 4'-(5-chloro-3-fluoropyridin-2-yl)oxy-2-oxospiro[1H-indole-3,1'-cyclohexane]-5-carboxylic acid Chemical compound ClC=1C=C(C(=NC=1)OC1CCC2(C(NC3=CC=C(C=C23)C(=O)O)=O)CC1)F KTFXARCMMJJUFY-UHFFFAOYSA-N 0.000 claims 1
- MJSRDLUGJSWLMD-UHFFFAOYSA-N 4'-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy-2-oxospiro[1H-indole-3,1'-cyclohexane]-5-carboxylic acid Chemical compound ClC=1C(=NC=C(C=1)C(F)(F)F)OC1CCC2(C(NC3=CC=C(C=C23)C(=O)O)=O)CC1 MJSRDLUGJSWLMD-UHFFFAOYSA-N 0.000 claims 1
- PJKBBJHLZZNOLA-UHFFFAOYSA-N ClC1=CC(=C(OC2CCC3(C(NC4=CC=C(C=C34)C(=O)O)=O)CC2)C=C1)F Chemical compound ClC1=CC(=C(OC2CCC3(C(NC4=CC=C(C=C34)C(=O)O)=O)CC2)C=C1)F PJKBBJHLZZNOLA-UHFFFAOYSA-N 0.000 claims 1
- 206010019280 Heart failures Diseases 0.000 claims 1
- 229910019142 PO4 Inorganic materials 0.000 claims 1
- 125000002029 aromatic hydrocarbon group Chemical group 0.000 claims 1
- 125000002102 aryl alkyloxo group Chemical group 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 1
- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 125000005843 halogen group Chemical group 0.000 claims 1
- CDAISMWEOUEBRE-UHFFFAOYSA-N inositol Chemical compound OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 claims 1
- 229940043355 kinase inhibitor Drugs 0.000 claims 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims 1
- 239000010452 phosphate Substances 0.000 claims 1
- 239000003757 phosphotransferase inhibitor Substances 0.000 claims 1
- 230000000069 prophylactic effect Effects 0.000 claims 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2017066579 | 2017-03-30 | ||
| JP2017066579 | 2017-03-30 | ||
| PCT/JP2018/014502 WO2018182051A1 (en) | 2017-03-30 | 2018-03-29 | Ip6k inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020515620A JP2020515620A (ja) | 2020-05-28 |
| JP2020515620A5 true JP2020515620A5 (https=) | 2021-05-06 |
| JP7063915B2 JP7063915B2 (ja) | 2022-05-09 |
Family
ID=62134158
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019554003A Active JP7063915B2 (ja) | 2017-03-30 | 2018-03-29 | Ｉｐ６ｋ阻害剤 |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US10968178B2 (https=) |
| EP (1) | EP3601256A1 (https=) |
| JP (1) | JP7063915B2 (https=) |
| KR (1) | KR102597117B1 (https=) |
| CN (1) | CN110461828B (https=) |
| AR (1) | AR111307A1 (https=) |
| AU (1) | AU2018246053B2 (https=) |
| CA (1) | CA3057821A1 (https=) |
| CL (1) | CL2019002662A1 (https=) |
| CO (1) | CO2019012125A2 (https=) |
| EA (1) | EA038177B1 (https=) |
| EC (1) | ECSP19077969A (https=) |
| IL (1) | IL269347B2 (https=) |
| JO (1) | JOP20180029A1 (https=) |
| MA (1) | MA49006A (https=) |
| MX (1) | MX393896B (https=) |
| NZ (1) | NZ758061A (https=) |
| PE (1) | PE20191656A1 (https=) |
| PH (1) | PH12019502248A1 (https=) |
| SG (1) | SG11201908894SA (https=) |
| TW (1) | TWI778038B (https=) |
| UA (1) | UA125445C2 (https=) |
| WO (1) | WO2018182051A1 (https=) |
| ZA (1) | ZA201907136B (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUE064141T2 (hu) | 2017-01-20 | 2024-02-28 | Arcus Biosciences Inc | Azolopirimidin rákkal összefüggõ rendellenességek kezelésére |
| EP3601259B1 (en) | 2017-03-30 | 2022-02-23 | F. Hoffmann-La Roche AG | Isoquinolines as inhibitors of hpk1 |
| CA3090922A1 (en) | 2018-02-16 | 2019-08-22 | Arcus Biosciences, Inc. | Dosing with an azolopyrimidine compound |
| TW202019905A (zh) | 2018-07-24 | 2020-06-01 | 瑞士商赫孚孟拉羅股份公司 | 異喹啉化合物及其用途 |
| TW202024053A (zh) | 2018-10-02 | 2020-07-01 | 美商建南德克公司 | 異喹啉化合物及其用途 |
| US11612606B2 (en) | 2018-10-03 | 2023-03-28 | Genentech, Inc. | 8-aminoisoquinoline compounds and uses thereof |
| EP4146648A1 (en) * | 2020-05-04 | 2023-03-15 | Otsuka Pharmaceutical Co., Ltd. | Iap antagonist compounds and intermediates and methods for synthesizing the same |
| UY39609A (es) * | 2021-01-12 | 2022-08-31 | Servier Lab | Nuevos derivados de espirociclohexano, composiciones farmacéuticas que los contienen y sus usos como inhibidores antiapoptóticos |
| US20250154115A1 (en) * | 2022-02-11 | 2025-05-15 | The University Of North Carolina At Chapel Hill | Arylbenzoisoxazole compounds as ip6k and ipmk inhibitors and methods of use thereof |
| CN115747325A (zh) * | 2022-11-10 | 2023-03-07 | 上海交通大学医学院附属新华医院 | Ip6k1及其产物作为增加血液脂联素药物靶点的应用 |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4617302A (en) * | 1984-10-15 | 1986-10-14 | Eli Lilly And Company | Inotropic agents |
| AR035016A1 (es) | 1999-08-25 | 2004-04-14 | Takeda Chemical Industries Ltd | Composicion de azol promotor de produccion/secrecion de neurotrofina, compuesto prodroga del mismo, composicion farmaceutica que lo comprende y uso del mismo para preparar esta ultima. |
| US7045527B2 (en) | 2002-09-24 | 2006-05-16 | Amgen Inc. | Piperidine derivatives |
| AU2003278600A1 (en) | 2002-11-01 | 2004-05-25 | Takeda Pharmaceutical Company Limited | Agent for preventing or treating neuropathy |
| CA2505322A1 (en) | 2002-11-08 | 2004-05-21 | Takeda Pharmaceutical Company Limited | Receptor function regulator |
| EP1630152A4 (en) | 2003-05-30 | 2009-09-23 | Takeda Pharmaceutical | CONDENSED CYCLIC COMPOUND |
| AU2004309271A1 (en) | 2003-12-25 | 2005-07-14 | Takeda Pharmaceutical Company Limited | 3-(4-benzyloxyphenyl)propanoic acid derivatives |
| WO2005063725A1 (ja) | 2003-12-26 | 2005-07-14 | Takeda Pharmaceutical Company Limited | フェニルプロパン酸誘導体 |
| JP4875978B2 (ja) | 2004-03-15 | 2012-02-15 | 武田薬品工業株式会社 | アミノフェニルプロパン酸誘導体 |
| US7517910B2 (en) | 2004-03-30 | 2009-04-14 | Takeda Pharmaceutical Company Limited | Alkoxyphenylpropanoic acid derivatives |
| US8957070B2 (en) | 2005-04-20 | 2015-02-17 | Takeda Pharmaceutical Company Limited | Glucokinase activator compounds, methods of activating glucokinase and methods of treating diabetes and obesity |
| US20090054435A1 (en) | 2005-07-29 | 2009-02-26 | Hiroshi Imoto | Phenoxyalkanoic Acid Compound |
| EP1916234B1 (en) | 2005-07-29 | 2014-11-12 | Takeda Pharmaceutical Company Limited | Cyclopropanecarboxylic acid compound |
| TW200740435A (en) | 2005-08-10 | 2007-11-01 | Takeda Pharmaceuticals Co | Therapeutic agent for diabetes |
| JP2007063225A (ja) | 2005-09-01 | 2007-03-15 | Takeda Chem Ind Ltd | イミダゾピリジン化合物 |
| RS53230B (sr) | 2006-06-27 | 2014-08-29 | Takeda Pharmaceutical Company Limited | Kondenzovana ciklična jedinjenja kao modulatori gpr40 receptora |
| US8492405B2 (en) | 2006-10-18 | 2013-07-23 | Takeda Pharmaceutical Company Limited | Glucokinase-activating fused heterocyclic compounds and methods of treating diabetes and obesity |
| RU2454415C9 (ru) | 2006-10-19 | 2013-02-27 | Такеда Фармасьютикал Компани Лимитед | Производное индола |
| EP2128138A1 (en) | 2007-01-29 | 2009-12-02 | Takeda Pharmaceutical Company Limited | Pyrazole compound |
| JP2010517935A (ja) | 2007-02-09 | 2010-05-27 | 武田薬品工業株式会社 | Ｐｐａｒ−ガンマのパーシャルアゴニストとしての縮合環化合物 |
| JPWO2008136428A1 (ja) | 2007-04-27 | 2010-07-29 | 武田薬品工業株式会社 | 含窒素５員複素環化合物 |
| WO2008156757A1 (en) | 2007-06-19 | 2008-12-24 | Takeda Pharmaceutical Company Limited | Indazole compounds for activating glucokinase |
| EP2108641A1 (en) * | 2008-04-11 | 2009-10-14 | Laboratorios Almirall, S.A. | New substituted spiro[cycloalkyl-1,3'-indo]-2'(1'H)-one derivatives and their use as p38 mitogen-activated kinase inhibitors |
| EP3601259B1 (en) | 2017-03-30 | 2022-02-23 | F. Hoffmann-La Roche AG | Isoquinolines as inhibitors of hpk1 |
| JP6453507B2 (ja) | 2017-03-30 | 2019-01-16 | アムジエン・インコーポレーテツド | Ｍｃｌ−１タンパク質を阻害する化合物 |
-
2018
- 2018-03-28 AR ARP180100763A patent/AR111307A1/es active IP Right Grant
- 2018-03-29 MA MA049006A patent/MA49006A/fr unknown
- 2018-03-29 JP JP2019554003A patent/JP7063915B2/ja active Active
- 2018-03-29 MX MX2019011783A patent/MX393896B/es unknown
- 2018-03-29 PE PE2019001965A patent/PE20191656A1/es unknown
- 2018-03-29 JO JOP/2018/0029A patent/JOP20180029A1/ar unknown
- 2018-03-29 EA EA201992306A patent/EA038177B1/ru unknown
- 2018-03-29 NZ NZ758061A patent/NZ758061A/en unknown
- 2018-03-29 CA CA3057821A patent/CA3057821A1/en active Pending
- 2018-03-29 KR KR1020197031524A patent/KR102597117B1/ko active Active
- 2018-03-29 CN CN201880022971.2A patent/CN110461828B/zh active Active
- 2018-03-29 IL IL269347A patent/IL269347B2/en unknown
- 2018-03-29 UA UAA201910745A patent/UA125445C2/uk unknown
- 2018-03-29 EP EP18723386.1A patent/EP3601256A1/en active Pending
- 2018-03-29 TW TW107110992A patent/TWI778038B/zh active
- 2018-03-29 US US16/496,530 patent/US10968178B2/en active Active
- 2018-03-29 SG SG11201908894S patent/SG11201908894SA/en unknown
- 2018-03-29 WO PCT/JP2018/014502 patent/WO2018182051A1/en not_active Ceased
- 2018-03-29 AU AU2018246053A patent/AU2018246053B2/en active Active
-
2019
- 2019-09-16 CL CL2019002662A patent/CL2019002662A1/es unknown
- 2019-09-27 PH PH12019502248A patent/PH12019502248A1/en unknown
- 2019-10-29 CO CONC2019/0012125A patent/CO2019012125A2/es unknown
- 2019-10-29 ZA ZA2019/07136A patent/ZA201907136B/en unknown
- 2019-10-30 EC ECSENADI201977969A patent/ECSP19077969A/es unknown
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