JP2020513808A5 - - Google Patents
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- JP2020513808A5 JP2020513808A5 JP2019550715A JP2019550715A JP2020513808A5 JP 2020513808 A5 JP2020513808 A5 JP 2020513808A5 JP 2019550715 A JP2019550715 A JP 2019550715A JP 2019550715 A JP2019550715 A JP 2019550715A JP 2020513808 A5 JP2020513808 A5 JP 2020513808A5
- Authority
- JP
- Japan
- Prior art keywords
- box
- high mobility
- modified high
- mobility group
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 102100037907 High mobility group protein B1 Human genes 0.000 claims description 33
- 101001025337 Homo sapiens High mobility group protein B1 Proteins 0.000 claims description 33
- 238000000034 method Methods 0.000 claims description 32
- 238000006467 substitution reaction Methods 0.000 claims description 30
- 102220491808 Cilia- and flagella-associated protein HOATZ_C45S_mutation Human genes 0.000 claims description 29
- 102220491845 Cilia- and flagella-associated protein HOATZ_C23S_mutation Human genes 0.000 claims description 20
- 102220491822 High mobility group protein B1_C106S_mutation Human genes 0.000 claims description 19
- 229920001184 polypeptide Polymers 0.000 claims description 14
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 14
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 14
- 108020004414 DNA Proteins 0.000 claims description 11
- 230000000813 microbial effect Effects 0.000 claims description 11
- 108091033319 polynucleotide Proteins 0.000 claims description 10
- 102000040430 polynucleotide Human genes 0.000 claims description 10
- 239000002157 polynucleotide Substances 0.000 claims description 10
- 230000027455 binding Effects 0.000 claims description 7
- 239000011248 coating agent Substances 0.000 claims description 7
- 238000000576 coating method Methods 0.000 claims description 7
- 230000002401 inhibitory effect Effects 0.000 claims description 7
- 241000588626 Acinetobacter baumannii Species 0.000 claims description 6
- 241000606749 Aggregatibacter actinomycetemcomitans Species 0.000 claims description 6
- 241000371430 Burkholderia cenocepacia Species 0.000 claims description 6
- 241000588914 Enterobacter Species 0.000 claims description 6
- 241000194031 Enterococcus faecium Species 0.000 claims description 6
- 241000588724 Escherichia coli Species 0.000 claims description 6
- 241000606768 Haemophilus influenzae Species 0.000 claims description 6
- 241000588747 Klebsiella pneumoniae Species 0.000 claims description 6
- 241000589517 Pseudomonas aeruginosa Species 0.000 claims description 6
- 241000191967 Staphylococcus aureus Species 0.000 claims description 6
- 239000003242 anti bacterial agent Substances 0.000 claims description 6
- 230000003115 biocidal effect Effects 0.000 claims description 6
- 229940047650 haemophilus influenzae Drugs 0.000 claims description 6
- 238000000338 in vitro Methods 0.000 claims description 4
- 238000001727 in vivo Methods 0.000 claims description 4
- 230000032770 biofilm formation Effects 0.000 claims description 2
- 230000015572 biosynthetic process Effects 0.000 claims description 2
- 208000015181 infectious disease Diseases 0.000 claims description 2
- 230000004568 DNA-binding Effects 0.000 claims 1
- 102100022124 High mobility group protein B4 Human genes 0.000 description 3
- 101001045782 Homo sapiens High mobility group protein B4 Proteins 0.000 description 3
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 description 3
- 102100022130 High mobility group protein B3 Human genes 0.000 description 2
- 101001045794 Homo sapiens High mobility group protein B3 Proteins 0.000 description 2
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 description 2
- 235000018417 cysteine Nutrition 0.000 description 2
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 description 2
- 102000053602 DNA Human genes 0.000 description 1
- 102100022128 High mobility group protein B2 Human genes 0.000 description 1
- 101001045791 Homo sapiens High mobility group protein B2 Proteins 0.000 description 1
- 125000003275 alpha amino acid group Chemical group 0.000 description 1
- 235000001014 amino acid Nutrition 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 102220236461 rs875989895 Human genes 0.000 description 1
- 125000003607 serino group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C(O[H])([H])[H] 0.000 description 1
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022194227A JP2023014389A (ja) | 2017-03-15 | 2022-12-05 | 付随する炎症のない細菌バイオフィルムの破壊のための組成物および方法 |
| JP2025018512A JP2025065351A (ja) | 2017-03-15 | 2025-02-06 | 付随する炎症のない細菌バイオフィルムの破壊のための組成物および方法 |
| JP2025119036A JP2025148518A (ja) | 2017-03-15 | 2025-07-15 | 付随する炎症のない細菌バイオフィルムの破壊のための組成物および方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762471834P | 2017-03-15 | 2017-03-15 | |
| US62/471,834 | 2017-03-15 | ||
| PCT/US2018/022508 WO2018170178A1 (en) | 2017-03-15 | 2018-03-14 | Composition and methods for disruption of bacterial biofilms without accompanying inflammation |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022194227A Division JP2023014389A (ja) | 2017-03-15 | 2022-12-05 | 付随する炎症のない細菌バイオフィルムの破壊のための組成物および方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020513808A JP2020513808A (ja) | 2020-05-21 |
| JP2020513808A5 true JP2020513808A5 (https=) | 2021-04-22 |
| JP7596069B2 JP7596069B2 (ja) | 2024-12-09 |
Family
ID=62025942
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019550715A Active JP7596069B2 (ja) | 2017-03-15 | 2018-03-14 | 付随する炎症のない細菌バイオフィルムの破壊のための組成物および方法 |
| JP2022194227A Pending JP2023014389A (ja) | 2017-03-15 | 2022-12-05 | 付随する炎症のない細菌バイオフィルムの破壊のための組成物および方法 |
| JP2025018512A Pending JP2025065351A (ja) | 2017-03-15 | 2025-02-06 | 付随する炎症のない細菌バイオフィルムの破壊のための組成物および方法 |
| JP2025119036A Pending JP2025148518A (ja) | 2017-03-15 | 2025-07-15 | 付随する炎症のない細菌バイオフィルムの破壊のための組成物および方法 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022194227A Pending JP2023014389A (ja) | 2017-03-15 | 2022-12-05 | 付随する炎症のない細菌バイオフィルムの破壊のための組成物および方法 |
| JP2025018512A Pending JP2025065351A (ja) | 2017-03-15 | 2025-02-06 | 付随する炎症のない細菌バイオフィルムの破壊のための組成物および方法 |
| JP2025119036A Pending JP2025148518A (ja) | 2017-03-15 | 2025-07-15 | 付随する炎症のない細菌バイオフィルムの破壊のための組成物および方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US11746136B2 (https=) |
| EP (1) | EP3595445B1 (https=) |
| JP (4) | JP7596069B2 (https=) |
| AU (1) | AU2018236271B2 (https=) |
| CA (1) | CA3056088A1 (https=) |
| WO (1) | WO2018170178A1 (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11274144B2 (en) | 2013-06-13 | 2022-03-15 | Research Institute At Nationwide Children's Hospital | Compositions and methods for the removal of biofilms |
| AU2016303688B2 (en) | 2015-07-31 | 2023-06-15 | Research Institute At Nationwide Children's Hospital | Peptides and antibodies for the removal of biofilms |
| AU2018206560B9 (en) | 2017-01-04 | 2025-04-03 | Research Institute At Nationwide Children's Hospital | Antibody fragments for the treatment of biofilm-related disorders |
| JP7514621B2 (ja) | 2017-01-04 | 2024-07-11 | リサーチ インスティチュート アット ネイションワイド チルドレンズ ホスピタル | Ｄｎａｂｉｉワクチンおよび強化された活性を有する抗体 |
| AU2018236271B2 (en) * | 2017-03-15 | 2023-12-21 | Research Institute At Nationwide Children's Hospital | Composition and methods for disruption of bacterial biofilms without accompanying inflammation |
| SG11202103001PA (en) * | 2018-10-05 | 2021-04-29 | Res Inst Nationwide Childrens Hospital | Hmgb1 protein derivatives for the removal of biofilms cross-reference to related application |
| CN116096239B (zh) * | 2020-07-07 | 2025-09-02 | 国家儿童医院研究所 | 治疗和预防生物膜的联合疗法 |
| AU2023375471A1 (en) * | 2022-11-11 | 2025-05-08 | Research Institute At Nationwide Children's Hospital | Compositions and methods for treating biofilms and neutrophil extracellular trap formation |
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| AU2018236271B2 (en) * | 2017-03-15 | 2023-12-21 | Research Institute At Nationwide Children's Hospital | Composition and methods for disruption of bacterial biofilms without accompanying inflammation |
| US20210139610A1 (en) | 2018-06-29 | 2021-05-13 | Research Institute At Nationwide Children's Hospital | Compositions and methods for mediating eps |
| SG11202103001PA (en) | 2018-10-05 | 2021-04-29 | Res Inst Nationwide Childrens Hospital | Hmgb1 protein derivatives for the removal of biofilms cross-reference to related application |
-
2018
- 2018-03-14 AU AU2018236271A patent/AU2018236271B2/en active Active
- 2018-03-14 US US16/492,582 patent/US11746136B2/en active Active
- 2018-03-14 WO PCT/US2018/022508 patent/WO2018170178A1/en not_active Ceased
- 2018-03-14 CA CA3056088A patent/CA3056088A1/en active Pending
- 2018-03-14 JP JP2019550715A patent/JP7596069B2/ja active Active
- 2018-03-14 EP EP18718961.8A patent/EP3595445B1/en active Active
-
2022
- 2022-12-05 JP JP2022194227A patent/JP2023014389A/ja active Pending
-
2025
- 2025-02-06 JP JP2025018512A patent/JP2025065351A/ja active Pending
- 2025-07-15 JP JP2025119036A patent/JP2025148518A/ja active Pending
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