JP2020512314A - サシツズマブゴビテカンとRAD51阻害剤を用いたTrop−2発現トリプルネガティブ乳癌の治療 - Google Patents

サシツズマブゴビテカンとRAD51阻害剤を用いたTrop−2発現トリプルネガティブ乳癌の治療 Download PDF

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JP2020512314A
JP2020512314A JP2019550156A JP2019550156A JP2020512314A JP 2020512314 A JP2020512314 A JP 2020512314A JP 2019550156 A JP2019550156 A JP 2019550156A JP 2019550156 A JP2019550156 A JP 2019550156A JP 2020512314 A JP2020512314 A JP 2020512314A
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cancer
antibody
trop
tumor
hrs7
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JP2020512314A5 (enExample
Inventor
トーマス エム. カルディロ,
トーマス エム. カルディロ,
デイヴィッド エム. ゴールデンバーグ,
デイヴィッド エム. ゴールデンバーグ,
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Immunomedics Inc
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Immunomedics Inc
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    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
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    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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JP2019550156A 2017-03-27 2018-03-20 サシツズマブゴビテカンとRAD51阻害剤を用いたTrop−2発現トリプルネガティブ乳癌の治療 Pending JP2020512314A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762477216P 2017-03-27 2017-03-27
US62/477,216 2017-03-27
PCT/US2018/023344 WO2018183041A1 (en) 2017-03-27 2018-03-20 Treatment of trop-2 expressing triple negative breast cancer with sacituzumab govitecan and a rad51 inhibitor

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JP2020512314A true JP2020512314A (ja) 2020-04-23
JP2020512314A5 JP2020512314A5 (enExample) 2021-03-18

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US (1) US10918734B2 (enExample)
EP (1) EP3600283A4 (enExample)
JP (1) JP2020512314A (enExample)
CN (1) CN110392570A (enExample)
CA (1) CA3050332A1 (enExample)
RU (1) RU2758234C2 (enExample)
WO (1) WO2018183041A1 (enExample)

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US20240148873A1 (en) * 2012-12-13 2024-05-09 Immunomedics, Inc. Dosages of immunoconjugates of antibodies and sn-38 for improved efficacy and decreased toxicity
US20210393617A1 (en) * 2012-12-13 2021-12-23 Immunomedics, Inc. Therapy for metastatic urothelial cancer with the antibody-drug conjugate, sacituzumab govitecan (immu-132)
EP3617221A4 (en) 2017-04-19 2021-04-14 Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. CYTOTOXIN AND CONJUGATE, USES THEREOF AND MANUFACTURING PROCESSES THEREFORE
EP4667495A2 (en) 2017-12-15 2025-12-24 Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. Bioactive molecule conjugate, preparation method and use thereof
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