JP2020512292A - リナクロチドの改変放出製剤または遅延放出製剤による過敏性腸症候群の処置方法 - Google Patents

リナクロチドの改変放出製剤または遅延放出製剤による過敏性腸症候群の処置方法 Download PDF

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Publication number
JP2020512292A
JP2020512292A JP2019533167A JP2019533167A JP2020512292A JP 2020512292 A JP2020512292 A JP 2020512292A JP 2019533167 A JP2019533167 A JP 2019533167A JP 2019533167 A JP2019533167 A JP 2019533167A JP 2020512292 A JP2020512292 A JP 2020512292A
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Japan
Prior art keywords
linaclotide
week
pain
composition
baseline
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2019533167A
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English (en)
Japanese (ja)
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JP2020512292A5 (zh
Inventor
アハマド ハシャシュ，
アハマド ハシャシュ，
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ironwood Pharmaceuticals Inc
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Ironwood Pharmaceuticals Inc
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Publication date
Application filed by Ironwood Pharmaceuticals Inc filed Critical Ironwood Pharmaceuticals Inc
Publication of JP2020512292A publication Critical patent/JP2020512292A/ja
Publication of JP2020512292A5 publication Critical patent/JP2020512292A5/ja
Priority to JP2022073214A priority Critical patent/JP2022093472A/ja
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10—Peptides having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Inorganic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2019533167A 2016-12-21 2017-12-21 リナクロチドの改変放出製剤または遅延放出製剤による過敏性腸症候群の処置方法 Pending JP2020512292A (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2022073214A JP2022093472A (ja) 2016-12-21 2022-04-27 リナクロチドの改変放出製剤または遅延放出製剤による過敏性腸症候群の処置方法

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662437566P 2016-12-21 2016-12-21
US62/437,566 2016-12-21
PCT/US2017/067814 WO2018119191A1 (en) 2016-12-21 2017-12-21 Methods of treating irritable bowel syndrome with modified or delayed release formulations of linaclotide

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2022073214A Division JP2022093472A (ja) 2016-12-21 2022-04-27 リナクロチドの改変放出製剤または遅延放出製剤による過敏性腸症候群の処置方法

Publications (2)

Publication Number Publication Date
JP2020512292A true JP2020512292A (ja) 2020-04-23
JP2020512292A5 JP2020512292A5 (zh) 2021-02-04

Family

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Family Applications (2)

Application Number Title Priority Date Filing Date
JP2019533167A Pending JP2020512292A (ja) 2016-12-21 2017-12-21 リナクロチドの改変放出製剤または遅延放出製剤による過敏性腸症候群の処置方法
JP2022073214A Pending JP2022093472A (ja) 2016-12-21 2022-04-27 リナクロチドの改変放出製剤または遅延放出製剤による過敏性腸症候群の処置方法

Family Applications After (1)

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JP2022073214A Pending JP2022093472A (ja) 2016-12-21 2022-04-27 リナクロチドの改変放出製剤または遅延放出製剤による過敏性腸症候群の処置方法

Country Status (10)

Country Link
EP (1) EP3558337A1 (zh)
JP (2) JP2020512292A (zh)
CN (1) CN110475564A (zh)
AU (1) AU2017379082A1 (zh)
BR (1) BR112019012689A2 (zh)
CA (1) CA3048195A1 (zh)
EA (1) EA201991531A1 (zh)
MA (1) MA47112A (zh)
MX (2) MX2019007574A (zh)
WO (1) WO2018119191A1 (zh)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN118105461A (zh) * 2019-06-10 2024-05-31 硬木药品公司 治疗与腹泻占主导的肠易激综合征相关的腹部疼痛
CA3238619A1 (en) * 2021-11-29 2023-06-01 Michael Gerber Pharmaceutical compositions for the treatment of visceral pain
WO2023196821A2 (en) * 2022-04-04 2023-10-12 Thomas Jefferson University Targeting neuropod cell gucy2c to control visceral pain and appetite

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016197042A1 (en) * 2015-06-05 2016-12-08 Ironwood Pharmaceuticals, Inc. Modified or targeted release formulations of linaclotide

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7371727B2 (en) 2003-01-28 2008-05-13 Microbia, Inc. Methods and compositions for the treatment of gastrointestinal disorders
US7304036B2 (en) 2003-01-28 2007-12-04 Microbia, Inc. Methods and compositions for the treatment of gastrointestinal disorders
WO2010019266A2 (en) 2008-08-15 2010-02-18 Ironwood Pharmaceuticals, Inc. Stable solid formulation of a gc-c receptor agonist polypeptide suitable for oral administration
EP2464373A1 (en) * 2009-08-13 2012-06-20 Ironwood Pharmaceuticals, Inc. Method for modulating the pharmacodynamic effect of orally administered guanylate cyclase receptor agonists
DK2536742T3 (en) 2010-02-17 2017-09-04 Ironwood Pharmaceuticals Inc TREATMENTS FOR GASTROINTESTINAL DISORDERS
US20140005128A1 (en) * 2010-08-11 2014-01-02 Forest Laboratories Holdings Limited Treatments of gastrointestinal disorders
WO2013025969A1 (en) 2011-08-17 2013-02-21 Ironwood Pharmaceuticals, Inc. Treatments for gastrointestinal disorders
CN108057028A (zh) * 2013-01-15 2018-05-22 铁木医药有限公司 片剂形式的肠溶包衣的胃内滞留口服剂型及其应用和药物组合物
UA119335C2 (uk) * 2013-12-11 2019-06-10 Айронвуд Фармасьютикалз, Інк. Композиції лінаклотиду з затриманим вивільненням

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016197042A1 (en) * 2015-06-05 2016-12-08 Ironwood Pharmaceuticals, Inc. Modified or targeted release formulations of linaclotide

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
GASTROENTEROLOGY, 2017.4, VOL.152, NO.5, SUPPL.1, PP.S1314-S1315, JPN6021042902, ISSN: 0004626070 *
STUDY NCT02559206 SUBMITTED DATE: JULY 22, 2016 (V3)，CLINICALTRIALS.GOV ARCHIVE[ONLINE]，2016年7月2, JPN6021042901, ISSN: 0004626069 *
THE AMERICAN JOURNAL OF GASTROENTEROLOGY, 2020.10, VOL.116, PP.354-361, JPN6021042903, ISSN: 0004626071 *

Also Published As

Publication number Publication date
JP2022093472A (ja) 2022-06-23
MA47112A (fr) 2019-10-30
BR112019012689A2 (pt) 2019-11-19
EP3558337A1 (en) 2019-10-30
AU2017379082A1 (en) 2019-07-04
CA3048195A1 (en) 2018-06-28
MX2023008839A (es) 2023-08-14
CN110475564A (zh) 2019-11-19
WO2018119191A1 (en) 2018-06-28
WO2018119191A9 (en) 2018-10-18
MX2019007574A (es) 2019-09-04
EA201991531A1 (ru) 2019-11-29

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