JP2020510827A5 - - Google Patents
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- JP2020510827A5 JP2020510827A5 JP2019546343A JP2019546343A JP2020510827A5 JP 2020510827 A5 JP2020510827 A5 JP 2020510827A5 JP 2019546343 A JP2019546343 A JP 2019546343A JP 2019546343 A JP2019546343 A JP 2019546343A JP 2020510827 A5 JP2020510827 A5 JP 2020510827A5
- Authority
- JP
- Japan
- Prior art keywords
- rodent
- gene
- symptoms
- locus
- nucleic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762464262P | 2017-02-27 | 2017-02-27 | |
| US62/464,262 | 2017-02-27 | ||
| US201762529916P | 2017-07-07 | 2017-07-07 | |
| US62/529,916 | 2017-07-07 | ||
| US201762583780P | 2017-11-09 | 2017-11-09 | |
| US62/583,780 | 2017-11-09 | ||
| PCT/US2018/019651 WO2018157027A1 (en) | 2017-02-27 | 2018-02-26 | Humanized model of kidney and liver disorders |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020510827A JP2020510827A (ja) | 2020-04-09 |
| JP2020510827A5 true JP2020510827A5 (https=) | 2021-04-01 |
| JP7169979B2 JP7169979B2 (ja) | 2022-11-11 |
Family
ID=61617150
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019546343A Active JP7169979B2 (ja) | 2017-02-27 | 2018-02-26 | 補体関連腎症および肝線維症の候補治療剤の治療有効性を評価する方法 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US10765762B2 (https=) |
| EP (1) | EP3585445B1 (https=) |
| JP (1) | JP7169979B2 (https=) |
| KR (1) | KR102602199B1 (https=) |
| CN (1) | CN110494168B (https=) |
| AU (1) | AU2018225745B2 (https=) |
| CA (1) | CA3054167A1 (https=) |
| ES (1) | ES2975416T3 (https=) |
| IL (1) | IL268748B2 (https=) |
| MX (1) | MX2019010219A (https=) |
| SG (2) | SG10202111663PA (https=) |
| WO (1) | WO2018157027A1 (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20190098879A1 (en) | 2017-09-29 | 2019-04-04 | Regeneron Pharmaceuticals, Inc. | Non-Human Animals Comprising A Humanized TTR Locus And Methods Of Use |
| HRP20240999T1 (hr) | 2018-07-16 | 2024-10-25 | Regeneron Pharmaceuticals, Inc. | Glodavački modeli bolesti ditra i njihova upotreba |
| JP7222075B2 (ja) * | 2018-09-13 | 2023-02-14 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | Ｃ３糸球体症のモデルとしての補体因子ｈ遺伝子ノックアウトラット |
| KR102661779B1 (ko) * | 2019-04-04 | 2024-04-30 | 리제너론 파마슈티칼스 인코포레이티드 | 인간화 응고 인자 12 좌위를 포함하는 비-인간 동물 |
| US11891618B2 (en) | 2019-06-04 | 2024-02-06 | Regeneron Pharmaceuticals, Inc. | Mouse comprising a humanized TTR locus with a beta-slip mutation and methods of use |
| MX2021015122A (es) | 2019-06-07 | 2022-04-06 | Regeneron Pharma | Animales no humanos que comprenden un locus de albumina humanizado. |
| WO2021112235A1 (ja) * | 2019-12-05 | 2021-06-10 | 国立大学法人宮崎大学 | Ｃ３腎症を予防又は治療するための医薬、医薬組成物及び補体Ｃ３ｂ分解促進剤 |
| KR20230078677A (ko) * | 2020-10-01 | 2023-06-02 | 리제너론 파마슈티칼스 인코포레이티드 | 인간 cr1을 발현하는 설치류 동물 |
| WO2025122669A1 (en) | 2023-12-05 | 2025-06-12 | Regeneron Pharmaceuticals, Inc. | Non-human animals having a humanized complement factor b gene |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ207394A (en) | 1983-03-08 | 1987-03-06 | Commw Serum Lab Commission | Detecting or determining sequence of amino acids |
| CA1247080A (en) | 1983-03-08 | 1988-12-20 | Commonwealth Serum Laboratories Commission | Antigenically active amino acid sequences |
| WO1984003506A1 (en) | 1983-03-08 | 1984-09-13 | Commw Serum Lab Commission | Antigenically active amino acid sequences |
| DE229046T1 (de) | 1985-03-30 | 1987-12-17 | Marc Genf/Geneve Ballivet | Verfahren zum erhalten von dns, rns, peptiden, polypeptiden oder proteinen durch dns-rekombinant-verfahren. |
| US6492107B1 (en) | 1986-11-20 | 2002-12-10 | Stuart Kauffman | Process for obtaining DNA, RNA, peptides, polypeptides, or protein, by recombinant DNA technique |
| NZ215865A (en) | 1985-04-22 | 1988-10-28 | Commw Serum Lab Commission | Method of determining the active site of a receptor-binding analogue |
| JP3101690B2 (ja) | 1987-03-18 | 2000-10-23 | エス・ビィ・２・インコーポレイテッド | 変性抗体の、または変性抗体に関する改良 |
| US5266684A (en) | 1988-05-02 | 1993-11-30 | The Reagents Of The University Of California | Peptide mixtures |
| US5571689A (en) | 1988-06-16 | 1996-11-05 | Washington University | Method of N-acylating peptide and proteins with diheteroatom substituted analogs of myristic acid |
| US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| US5663143A (en) | 1988-09-02 | 1997-09-02 | Dyax Corp. | Engineered human-derived kunitz domains that inhibit human neutrophil elastase |
| US5427908A (en) | 1990-05-01 | 1995-06-27 | Affymax Technologies N.V. | Recombinant library screening methods |
| US5723286A (en) | 1990-06-20 | 1998-03-03 | Affymax Technologies N.V. | Peptide library and screening systems |
| US5698426A (en) | 1990-09-28 | 1997-12-16 | Ixsys, Incorporated | Surface expression libraries of heteromeric receptors |
| US5770434A (en) | 1990-09-28 | 1998-06-23 | Ixsys Incorporated | Soluble peptides having constrained, secondary conformation in solution and method of making same |
| AU668347B2 (en) | 1990-11-21 | 1996-05-02 | Torrey Pines Institute For Molecular Studies | Synthesis of equimolar multiple oligomer mixtures, especially of oligopeptide mixtures |
| CA2095633C (en) | 1990-12-03 | 2003-02-04 | Lisa J. Garrard | Enrichment method for variant proteins with altered binding properties |
| US5270170A (en) | 1991-10-16 | 1993-12-14 | Affymax Technologies N.V. | Peptide library and screening method |
| US5644048A (en) | 1992-01-10 | 1997-07-01 | Isis Pharmaceuticals, Inc. | Process for preparing phosphorothioate oligonucleotides |
| AU691811B2 (en) | 1993-06-16 | 1998-05-28 | Celltech Therapeutics Limited | Antibodies |
| GB9521943D0 (en) | 1995-10-26 | 1996-01-03 | Univ Hertfordshire | Coded particles for process sequence tracking in combinatorial compound library preparation |
| ATE375365T1 (de) | 1998-04-02 | 2007-10-15 | Genentech Inc | Antikörper varianten und fragmente davon |
| US6335155B1 (en) | 1998-06-26 | 2002-01-01 | Sunesis Pharmaceuticals, Inc. | Methods for rapidly identifying small organic molecule ligands for binding to biological target molecules |
| US6280946B2 (en) | 1998-08-07 | 2001-08-28 | Boston Probes, Inc. | PNA probes, probe sets, methods and kits pertaining to the universal detection of bacteria and eucarya |
| CA2355215A1 (en) | 1998-12-28 | 2000-07-06 | Jim Wells | Identifying small organic molecule ligands for binding |
| EP2384811A1 (en) | 2006-01-11 | 2011-11-09 | Novo Nordisk A/S | A spherical encoded bead with an ultrasonic identification chip |
| RU2473563C2 (ru) * | 2007-06-07 | 2013-01-27 | Дженентек, Инк. | АНТИТЕЛА ПРОТИВ C3b И СПОСОБЫ ПРОФИЛАКТИКИ И ЛЕЧЕНИЯ СВЯЗАННЫХ С КОМПЛЕМЕНТОМ НАРУШЕНИЙ |
| CA2742802C (en) * | 2008-11-10 | 2019-11-26 | Alexion Pharmaceuticals, Inc. | Methods and compositions for treating complement-associated disorders |
| CA2869477C (en) * | 2012-04-03 | 2020-06-09 | Novelmed Therapeutics, Inc. | Humanized and chimeric anti-factor c3 antibodies and uses thereof |
| EP2867225B1 (en) * | 2012-06-28 | 2017-08-09 | Novartis AG | Pyrrolidine derivatives and their use as complement pathway modulators |
| SI3011345T1 (sl) * | 2013-08-07 | 2017-12-29 | Alexion Pharmaceuticals, Inc. | Biomarkerski proteini za atipični hemolitični uremični sindrom (ahus) |
| US9659904B2 (en) * | 2013-12-12 | 2017-05-23 | Intel Corporation | Distributed on-package millimeter-wave radio |
| US9732103B2 (en) * | 2014-02-25 | 2017-08-15 | Achillion Pharmaceuticals, Inc. | Carbamate, ester, and ketone compounds for treatment of complement mediated disorders |
| EP3636073B1 (en) | 2014-05-05 | 2023-11-15 | Regeneron Pharmaceuticals, Inc. | Humanized c5 and c3 animals |
-
2018
- 2018-02-26 SG SG10202111663PA patent/SG10202111663PA/en unknown
- 2018-02-26 WO PCT/US2018/019651 patent/WO2018157027A1/en not_active Ceased
- 2018-02-26 MX MX2019010219A patent/MX2019010219A/es unknown
- 2018-02-26 CA CA3054167A patent/CA3054167A1/en active Pending
- 2018-02-26 IL IL268748A patent/IL268748B2/en unknown
- 2018-02-26 SG SG11201907606XA patent/SG11201907606XA/en unknown
- 2018-02-26 US US15/904,808 patent/US10765762B2/en active Active
- 2018-02-26 CN CN201880021486.3A patent/CN110494168B/zh active Active
- 2018-02-26 AU AU2018225745A patent/AU2018225745B2/en active Active
- 2018-02-26 EP EP18710242.1A patent/EP3585445B1/en active Active
- 2018-02-26 JP JP2019546343A patent/JP7169979B2/ja active Active
- 2018-02-26 ES ES18710242T patent/ES2975416T3/es active Active
- 2018-02-26 KR KR1020197027971A patent/KR102602199B1/ko active Active
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