JP2020508451A - 液体クロマトグラフィー用の統合型照明検出フローセル - Google Patents
液体クロマトグラフィー用の統合型照明検出フローセル Download PDFInfo
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- G—PHYSICS
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- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
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- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/255—Details, e.g. use of specially adapted sources, lighting or optical systems
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- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
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- G01N21/59—Transmissivity
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- G—PHYSICS
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
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- G01N2201/0627—Use of several LED's for spectral resolution
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Abstract
Description
Claims (20)
- 光学的に透明な第1の壁と、前記光学的に透明な第1の壁の反対側に配置される光学的に透明な第2の壁とを含むフローセルと、
前記フローセル内に統合され、前記光学的に透明な第1の壁を通って前記フローセルに移動する光を放出するように構成された複数の光源と、
前記フローセルと統合され、前記フローセルから前記光学的に透明な第2の壁を通って出る光を捕捉するように構成された検出チャンバと、
を含むことを特徴とする検出器システム。 - 前記検出チャンバの内部は、前記捕捉された光を均一に散乱させる拡散反射コーティングを含む請求項1に記載の検出器システム。
- 前記複数の光源の各々は、前記フローセル内に統合された基準フォトダイオードに隣接し、
前記基準フォトダイオードは、前記隣接する光源によって放射される光を検出するように構成される請求項1に記載の検出器システム。 - 前記検出チャンバに結合された光検出器をさらに含む請求項1に記載の検出器システム。
- 前記光検出器は、紫外線および/または可視光を検出するように構成されている請求項4に記載の検出器システム。
- 前記複数の光源のそれぞれと前記フローセルの前記透明な第1の壁との間にカップリング光学系をさらに含む請求項1に記載の検出器システム。
- 前記検出器システムにカップリング光学系を含まない請求項1に記載の検出器システム。
- 前記検出器システムは、高速液体クロマトグラフィーシステムに含まれる請求項1に記載の検出器システム。
- 非一時的メモリに実行可能な命令を格納するコントローラをさらに含み、
実行時、前記コントローラは、
所望の波長の光を放射するために、前記複数の光源のうちの1つの光源を起動し、
前記光源に隣接する前記基準フォトダイオードから受信した入力に基づいて、駆動された光源の出力レベルを制御する請求項3に記載の検出器システム。 - フローセル内に統合された複数のLEDから1つの発光ダイオード(LED)を作動させる工程と、
前記1つのLEDに隣接する基準フォトダイオードからの信号に基づいて、前記フローセルの第1の光学的に透明な壁を通過して、前記フローセルのサンプルチャンバに入る、前記1つのLEDの出力を調整する工程と、
前記フローセルと統合された検出チャンバに結合された1つ以上の光検出器によって、前記第1の光学的に透明な壁の反対側の、前記フローセルの第2の光学的に透明な壁を通して前記サンプルチャンバを透過した光の量を検出する工程と、を有することを特徴とする方法。 - 前記複数のLEDのそれぞれは、異なる波長の光を放出する請求項10に記載の方法。
- 前記検出チャンバは、統合チャンバであり、
前記検出チャンバの底面は、少なくとも部分的に、前記第2の光学的に透明な壁で構成されている請求項10に記載の方法。 - 前記サンプルチャンバを透過した前記検出された光の量に基づいて、前記サンプルチャンバ内のサンプルの吸光度を特定する工程をさらに含む請求項10に記載の方法。
- 前記1つのLEDに隣接する前記基準フォトダイオードからの前記信号に基づいて、前記1つのLEDの前記出力を調整する工程は、前記基準フォトダイオードによって測定される光の量が一定のままであるように、前記1つのLEDの前記出力を変調する工程を含む請求項10に記載の方法。
- 信号対雑音比に基づいて、前記1つ以上の光検出器によって測定された信号に基づいて、前記1つのLEDの前記出力レベルを調整する工程をさらに含む請求項10に記載の方法。
- 複数の光源から放射された光を受け取るように構成されたフローセルと、
前記光が前記フローセルによって受け取られる前に、前記複数の光源によって発せられた前記光を混合するための少なくとも1つの光合成デバイスと、
前記少なくとも1つの光合成デバイスからの光を前記フローセルに向けるための少なくとも1つのコリメート光学系と、
前記フローセルから出る前記光を検出する検出器と、
を含むことを特徴とする多波長照明システム。 - 前記少なくとも1つの光合成デバイスは、光ファイバーケーブルを含む請求項16に記載の多波長照明システム。
- 前記少なくとも1つの光合成デバイスは、導波路を含む請求項16に記載の多波長照明システム。
- 前記少なくとも1つの光合成デバイスは、二色性コーティングを有する請求項16に記載の多波長照明システム。
- 前記少なくとも1つの光合成デバイスは、多角形プリズムを含む請求項16に記載の多波長照明システム。
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PCT/US2018/019277 WO2018156799A1 (en) | 2017-02-23 | 2018-02-22 | Integrated illumination-detection flow cell for liquid chromatography |
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EP (1) | EP3586094B1 (ja) |
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US10823670B2 (en) * | 2016-10-21 | 2020-11-03 | Honeywell International Inc. | Compact ultraviolet light adsorption sensing system |
US11169126B2 (en) | 2017-02-23 | 2021-11-09 | Phoseon Technology, Inc. | Integrated illumination-detection flow cell for liquid chromatography |
JP6549747B2 (ja) * | 2017-04-14 | 2019-07-24 | リオン株式会社 | 粒子測定装置および粒子測定方法 |
EP3862745A4 (en) * | 2018-10-05 | 2022-09-21 | Provigate Inc. | INSTRUMENT FOR THE OPTICAL MEASUREMENT OF TRACE SUBSTANCES AND MEASUREMENT PROCEDURES |
DE102019103035A1 (de) * | 2019-02-07 | 2020-08-13 | Analytik Jena Ag | Atomabsorptionsspektrometer |
WO2020217356A1 (ja) * | 2019-04-24 | 2020-10-29 | 株式会社島津製作所 | クロマトグラフィ検出器用フローセルおよびクロマトグラフィ検出器 |
EP4058781A1 (en) * | 2019-11-14 | 2022-09-21 | World Precision Instruments Germany GmbH | Flow cell system for optical fluid analysis and bioreactor system |
WO2021118982A1 (en) * | 2019-12-10 | 2021-06-17 | Trustees Of Boston University | Apparatus and method for biomolecular analysis |
CN111847905A (zh) * | 2020-07-09 | 2020-10-30 | 南昌航空大学 | 一种用于紫外可见光吸收测试的薄层流动池的制备方法 |
TWI771806B (zh) * | 2020-11-18 | 2022-07-21 | 財團法人工業技術研究院 | 微粒感測裝置 |
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