JP2020505075A5 - - Google Patents
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- Publication number
- JP2020505075A5 JP2020505075A5 JP2019561375A JP2019561375A JP2020505075A5 JP 2020505075 A5 JP2020505075 A5 JP 2020505075A5 JP 2019561375 A JP2019561375 A JP 2019561375A JP 2019561375 A JP2019561375 A JP 2019561375A JP 2020505075 A5 JP2020505075 A5 JP 2020505075A5
- Authority
- JP
- Japan
- Prior art keywords
- cancer
- seq
- antigen
- binding portion
- antibody
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000427 antigen Substances 0.000 claims 14
- 102000036639 antigens Human genes 0.000 claims 14
- 108091007433 antigens Proteins 0.000 claims 14
- 102000039446 nucleic acids Human genes 0.000 claims 9
- 108020004707 nucleic acids Proteins 0.000 claims 9
- 150000007523 nucleic acids Chemical class 0.000 claims 9
- 239000013598 vector Substances 0.000 claims 8
- 206010028980 Neoplasm Diseases 0.000 claims 4
- 125000003275 alpha amino acid group Chemical group 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 3
- 201000011510 cancer Diseases 0.000 claims 2
- 210000004602 germ cell Anatomy 0.000 claims 2
- 229940124597 therapeutic agent Drugs 0.000 claims 2
- 206010005003 Bladder cancer Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 206010008342 Cervix carcinoma Diseases 0.000 claims 1
- 208000005243 Chondrosarcoma Diseases 0.000 claims 1
- 206010014733 Endometrial cancer Diseases 0.000 claims 1
- 206010014759 Endometrial neoplasm Diseases 0.000 claims 1
- 208000000461 Esophageal Neoplasms Diseases 0.000 claims 1
- 101001037153 Homo sapiens Immunoglobulin heavy variable 3-7 Proteins 0.000 claims 1
- 101001047617 Homo sapiens Immunoglobulin kappa variable 3-11 Proteins 0.000 claims 1
- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 claims 1
- 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 claims 1
- 102000017727 Immunoglobulin Variable Region Human genes 0.000 claims 1
- 108010067060 Immunoglobulin Variable Region Proteins 0.000 claims 1
- 102100040231 Immunoglobulin heavy variable 3-7 Human genes 0.000 claims 1
- 102100022955 Immunoglobulin kappa variable 3-11 Human genes 0.000 claims 1
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 241000282567 Macaca fascicularis Species 0.000 claims 1
- 208000003445 Mouth Neoplasms Diseases 0.000 claims 1
- 206010030155 Oesophageal carcinoma Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 208000009565 Pharyngeal Neoplasms Diseases 0.000 claims 1
- 206010034811 Pharyngeal cancer Diseases 0.000 claims 1
- 208000007913 Pituitary Neoplasms Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 208000015634 Rectal Neoplasms Diseases 0.000 claims 1
- 206010038389 Renal cancer Diseases 0.000 claims 1
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 1
- 208000024313 Testicular Neoplasms Diseases 0.000 claims 1
- 206010057644 Testis cancer Diseases 0.000 claims 1
- 208000024770 Thyroid neoplasm Diseases 0.000 claims 1
- 108060008683 Tumor Necrosis Factor Receptor Proteins 0.000 claims 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 1
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 1
- 208000002495 Uterine Neoplasms Diseases 0.000 claims 1
- 208000009956 adenocarcinoma Diseases 0.000 claims 1
- 201000005188 adrenal gland cancer Diseases 0.000 claims 1
- 208000024447 adrenal gland neoplasm Diseases 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- 201000009036 biliary tract cancer Diseases 0.000 claims 1
- 208000020790 biliary tract neoplasm Diseases 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 201000000220 brain stem cancer Diseases 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 201000007455 central nervous system cancer Diseases 0.000 claims 1
- 201000010881 cervical cancer Diseases 0.000 claims 1
- 230000000112 colonic effect Effects 0.000 claims 1
- 201000004101 esophageal cancer Diseases 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 108020001507 fusion proteins Proteins 0.000 claims 1
- 102000037865 fusion proteins Human genes 0.000 claims 1
- 206010017758 gastric cancer Diseases 0.000 claims 1
- 239000003862 glucocorticoid Substances 0.000 claims 1
- 201000010982 kidney cancer Diseases 0.000 claims 1
- 208000012987 lip and oral cavity carcinoma Diseases 0.000 claims 1
- 201000007270 liver cancer Diseases 0.000 claims 1
- 208000014018 liver neoplasm Diseases 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 201000008968 osteosarcoma Diseases 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 208000029255 peripheral nervous system cancer Diseases 0.000 claims 1
- 201000002511 pituitary cancer Diseases 0.000 claims 1
- 206010038038 rectal cancer Diseases 0.000 claims 1
- 201000001275 rectum cancer Diseases 0.000 claims 1
- 210000000813 small intestine Anatomy 0.000 claims 1
- 201000002314 small intestine cancer Diseases 0.000 claims 1
- 201000011549 stomach cancer Diseases 0.000 claims 1
- 201000003120 testicular cancer Diseases 0.000 claims 1
- 201000002510 thyroid cancer Diseases 0.000 claims 1
- 210000001519 tissue Anatomy 0.000 claims 1
- 102000003298 tumor necrosis factor receptor Human genes 0.000 claims 1
- 201000005112 urinary bladder cancer Diseases 0.000 claims 1
- 206010046766 uterine cancer Diseases 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1701351.7A GB201701351D0 (en) | 2017-01-27 | 2017-01-27 | Binding agents |
| GB1701351.7 | 2017-01-27 | ||
| GBGB1713296.0A GB201713296D0 (en) | 2017-08-18 | 2017-08-18 | Binding agents |
| GB1713296.0 | 2017-08-18 | ||
| PCT/GB2018/050239 WO2018138521A1 (en) | 2017-01-27 | 2018-01-26 | Binding agents |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020505075A JP2020505075A (ja) | 2020-02-20 |
| JP2020505075A5 true JP2020505075A5 (https=) | 2021-03-11 |
| JP7169296B2 JP7169296B2 (ja) | 2022-11-10 |
Family
ID=61132825
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019561375A Active JP7169296B2 (ja) | 2017-01-27 | 2018-01-26 | 結合剤 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US10457736B2 (https=) |
| EP (1) | EP3574013A1 (https=) |
| JP (1) | JP7169296B2 (https=) |
| KR (1) | KR20190112299A (https=) |
| CN (1) | CN110475787A (https=) |
| AU (1) | AU2018213124A1 (https=) |
| BR (1) | BR112019015453A2 (https=) |
| CA (1) | CA3051797A1 (https=) |
| IL (1) | IL268288A (https=) |
| MX (1) | MX2019008905A (https=) |
| RU (1) | RU2019125975A (https=) |
| SG (1) | SG11201906963QA (https=) |
| WO (1) | WO2018138521A1 (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102123322B1 (ko) | 2019-11-01 | 2020-06-16 | 주식회사 미래에스엠 | 상판 오픈형 다용도 선반 |
| KR20210132400A (ko) | 2020-04-27 | 2021-11-04 | 유미경 | 다용도 선반 |
| TW202246334A (zh) * | 2021-02-02 | 2022-12-01 | 美商美國禮來大藥廠 | Gitr拮抗劑及其使用方法 |
| CN116782942A (zh) * | 2021-02-02 | 2023-09-19 | 伊莱利利公司 | Gitr拮抗剂和使用其的方法 |
| EP4339209A4 (en) * | 2021-05-10 | 2025-05-28 | MediMabbio Inc. | ANTI-GITR ANTIBODIES AND THEIR USES |
| US20240400671A1 (en) * | 2021-10-05 | 2024-12-05 | Richard A. Shimkets | Monoconal antibodies to il-25 and uses thereof |
| IL314907A (en) | 2022-03-15 | 2024-10-01 | Yeda Res & Dev | Antibodies against GITR and their uses |
| CN118050505B (zh) * | 2024-04-15 | 2024-06-21 | 南京佰抗生物科技有限公司 | 一种多联检荧光免疫层析检测卡 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT2343320T (pt) * | 2005-03-25 | 2018-01-23 | Gitr Inc | Anticorpos anti-gitr e as suas utilizações |
| KR101790802B1 (ko) * | 2009-09-03 | 2017-10-27 | 머크 샤프 앤드 돔 코포레이션 | 항-ｇｉｔｒ 항체 |
| TW201605896A (zh) * | 2013-08-30 | 2016-02-16 | 安美基股份有限公司 | Gitr抗原結合蛋白 |
| SI3148579T1 (sl) * | 2014-05-28 | 2021-07-30 | Agenus Inc. | Proti GITR antitelesa in postopki z njihovo uporabo |
| PE20170441A1 (es) * | 2014-06-06 | 2017-04-26 | Bristol Myers Squibb Co | Anticuerpos contra el receptor del factor de necrosis tumoral inducido por glucocorticoides (gitr) y sus usos |
| MA41044A (fr) * | 2014-10-08 | 2017-08-15 | Novartis Ag | Compositions et procédés d'utilisation pour une réponse immunitaire accrue et traitement contre le cancer |
-
2018
- 2018-01-26 SG SG11201906963QA patent/SG11201906963QA/en unknown
- 2018-01-26 WO PCT/GB2018/050239 patent/WO2018138521A1/en not_active Ceased
- 2018-01-26 MX MX2019008905A patent/MX2019008905A/es unknown
- 2018-01-26 AU AU2018213124A patent/AU2018213124A1/en not_active Abandoned
- 2018-01-26 RU RU2019125975A patent/RU2019125975A/ru unknown
- 2018-01-26 KR KR1020197025095A patent/KR20190112299A/ko not_active Ceased
- 2018-01-26 JP JP2019561375A patent/JP7169296B2/ja active Active
- 2018-01-26 CN CN201880020490.8A patent/CN110475787A/zh active Pending
- 2018-01-26 BR BR112019015453-1A patent/BR112019015453A2/pt not_active IP Right Cessation
- 2018-01-26 EP EP18702550.7A patent/EP3574013A1/en not_active Withdrawn
- 2018-01-26 CA CA3051797A patent/CA3051797A1/en active Pending
- 2018-08-17 US US16/104,434 patent/US10457736B2/en active Active
-
2019
- 2019-05-29 US US16/424,676 patent/US20190375846A1/en not_active Abandoned
- 2019-07-28 IL IL268288A patent/IL268288A/en unknown
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