JP2020503390A - 治療用タンパク質の標的細胞特異的な産生のため、および標的細胞に関連する疾患、状態、または障害の治療のための、膜融合性脂質ナノ粒子、ならびにその作製および使用のための方法 - Google Patents
治療用タンパク質の標的細胞特異的な産生のため、および標的細胞に関連する疾患、状態、または障害の治療のための、膜融合性脂質ナノ粒子、ならびにその作製および使用のための方法 Download PDFInfo
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- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
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- A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
- A61K48/0025—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid
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- A61K48/0058—Nucleic acids adapted for tissue specific expression, e.g. having tissue specific promoters as part of a contruct
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
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- C12N2720/00011—Details
- C12N2720/12011—Reoviridae
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- C12N2720/00011—Details
- C12N2720/12011—Reoviridae
- C12N2720/12041—Use of virus, viral particle or viral elements as a vector
- C12N2720/12043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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- C12N2840/00—Vectors comprising a special translation-regulating system
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
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- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
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- Epidemiology (AREA)
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- Proteomics, Peptides & Aminoacids (AREA)
- Pulmonology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762444360P | 2017-01-09 | 2017-01-09 | |
| US62/444,360 | 2017-01-09 | ||
| PCT/US2018/013033 WO2018129563A1 (en) | 2017-01-09 | 2018-01-09 | Fusogenic lipid nanoparticles and methods for manufacturing and use for therapeutic protein production and for treatment |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2020503390A true JP2020503390A (ja) | 2020-01-30 |
| JP2020503390A5 JP2020503390A5 (enExample) | 2021-10-07 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| JP2019557538A Pending JP2020503390A (ja) | 2017-01-09 | 2018-01-09 | 治療用タンパク質の標的細胞特異的な産生のため、および標的細胞に関連する疾患、状態、または障害の治療のための、膜融合性脂質ナノ粒子、ならびにその作製および使用のための方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US11525146B2 (enExample) |
| EP (1) | EP3565607A4 (enExample) |
| JP (1) | JP2020503390A (enExample) |
| CN (1) | CN110678208B (enExample) |
| AU (1) | AU2018206485B2 (enExample) |
| CA (1) | CA3047140A1 (enExample) |
| WO (1) | WO2018129563A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2978854A4 (en) * | 2013-03-24 | 2017-01-11 | Oisin Biotechnologies | Systems and methods for the targeted production of a therapeutic protein within a target cell |
| EP3235908A1 (en) | 2016-04-21 | 2017-10-25 | Ecole Normale Superieure De Lyon | Methods for selectively modulating the activity of distinct subtypes of cells |
| CA3047140A1 (en) | 2017-01-09 | 2018-07-12 | Oisin Biotechnologies | Constructs for expression of therapeutic proteins in target cells |
| JP7592493B2 (ja) | 2018-04-18 | 2024-12-02 | オイシン バイオテクノロジーズ,インク. | 治療用タンパク質の標的細胞に特異的な産生のための、および、標的細胞に関連する疾患、疾病、または障害の処置のための、融合性脂質ナノ粒子、および、融合性脂質ナノ粒子の製造方法と使用方法 |
| CN112955174A (zh) | 2018-07-09 | 2021-06-11 | 旗舰先锋创新V股份有限公司 | 融合剂脂质体组合物和其用途 |
| WO2020102503A2 (en) * | 2018-11-14 | 2020-05-22 | Flagship Pioneering Innovations V, Inc. | Fusosome compositions for t cell delivery |
| CA3120093A1 (en) | 2018-11-14 | 2020-05-22 | Flagship Pioneering Innovations V, Inc. | Compositions and methods for compartment-specific cargo delivery |
| WO2020163408A2 (en) * | 2019-02-04 | 2020-08-13 | Oisin Biotechnologies, Inc. | Fusogenic lipid nanoparticles for the target cell-specific production of rapamycin inducible therapeutic proteins |
| CN112521511B (zh) * | 2020-12-07 | 2023-03-14 | 中山大学 | 一种含EB病毒gB蛋白的自组装纳米颗粒及其制备方法与应用 |
| JP2024532963A (ja) | 2021-04-08 | 2024-09-11 | サナ バイオテクノロジー,インコーポレイテッド | Cd8特異的抗体コンストラクト及びその組成物 |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999009191A1 (fr) * | 1997-08-20 | 1999-02-25 | Dnavec Research Inc. | Vecteurs de traitement du cancer |
| WO2006043354A1 (ja) * | 2004-10-20 | 2006-04-27 | National Institute Of Radiological Sciences | 組込型の低線量放射線誘導性ベクター |
| WO2012177927A1 (en) * | 2011-06-21 | 2012-12-27 | Mayo Foundation For Medical Education And Research | Transgenic animals capable of being induced to delete senescent cells |
| WO2014160661A2 (en) * | 2013-03-24 | 2014-10-02 | Oisin Biotechnologies | Systems and methods for the targeted production of a therapeutic protein within a target cell |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0571390B1 (en) | 1990-11-23 | 2000-03-08 | Peptech Limited | The delay, prevention and/or reversal of cell senescence |
| US5869337A (en) | 1993-02-12 | 1999-02-09 | President And Fellows Of Harvard College | Regulated transcription of targeted genes and other biological events |
| DE69841002D1 (de) | 1997-05-14 | 2009-09-03 | Univ British Columbia | Hochwirksame verkapselung von nukleinsäuren in lipidvesikeln |
| WO1999024582A1 (en) | 1997-11-07 | 1999-05-20 | Dalhousie University | Novel reovirus-derived proteins, nucleic acids encoding same, and uses therefor |
| US6899870B1 (en) | 1998-03-11 | 2005-05-31 | Board Of Regents, The University Of Texas System | Induction of apoptic or cytotoxic gene expression by adenoviral mediated gene codelivery |
| AU2156600A (en) | 1998-11-25 | 2000-06-13 | Cold Spring Harbor Laboratory | Methods and reagents for increasing proliferative capacity and preventing replicative senescence |
| CA2325088A1 (en) | 2000-12-01 | 2002-06-01 | Fusogenix Inc. | Novel membrane fusion proteins derived from poikilothermic reovirus |
| CA2460095A1 (en) | 2001-06-13 | 2003-12-19 | Eastern Virginia Medical School | Methods for targeted expression of therapeutic nucleic acid |
| CN100361710C (zh) | 2004-06-07 | 2008-01-16 | 成都康弘生物科技有限公司 | 肿瘤细胞专一表达免疫调节因子gm-csf的溶瘤性腺病毒重组体的构建及其应用 |
| JP2010531638A (ja) | 2007-06-12 | 2010-09-30 | ケース ウエスタン リザーブ ユニバーシティ | 標的化された細胞死 |
| BRPI0913047A2 (pt) | 2008-05-23 | 2013-03-05 | Siwa Corp | anticorpo monoclonal humanizado, seu uso, bem como aparelho e mÉtodo in vitro para promover processos regenerativos em uma cultura de tecido ou cultura de cÉlula |
| EP3318248B1 (en) | 2009-12-01 | 2019-04-10 | Translate Bio, Inc. | Delivery of mrna for the augmentation of proteins and enzymes in human genetic diseases |
| US9089520B2 (en) | 2010-05-21 | 2015-07-28 | Baylor College Of Medicine | Methods for inducing selective apoptosis |
| WO2012019053A2 (en) | 2010-08-04 | 2012-02-09 | The Ohio State University | Methods for impairing the p53/hdm2 auto-regulatory loop in multiple myeloma development using mir-192, mir-194 and mir-215 |
| WO2012040825A1 (en) | 2010-09-29 | 2012-04-05 | Innovascreen Inc. | Recombinant polypeptides for membrane fusion and uses thereof |
| US20150064137A1 (en) | 2012-04-17 | 2015-03-05 | Kythera Biopharmaceuticals, Inc. | Use of engineered viruses to specifically kill senescent cells |
| US9687448B2 (en) | 2012-12-07 | 2017-06-27 | Alnylam Pharmaceuticals, Inc. | Nucleic acid lipid particle formulations |
| CA2906110C (en) | 2013-03-14 | 2021-07-27 | Dicerna Pharmaceuticals, Inc. | Process for formulating an anionic agent |
| DE112014003136A5 (de) * | 2013-07-01 | 2016-04-21 | Charité - Universitätsmedizin Berlin | Immortalisierte humane Chorionzelllinie sowie Verfahren zur Immortalisierung humaner Chorionzellen |
| HK1245829A1 (zh) | 2014-12-15 | 2018-08-31 | Bellicum Pharmaceuticals, Inc. | 受控消除治疗性细胞的方法 |
| GB201503133D0 (en) | 2015-02-24 | 2015-04-08 | Ucl Business Plc And Syncona Partners Llp | Chimeric protein |
| US10849985B2 (en) | 2015-05-20 | 2020-12-01 | Yeda Research And Development Co. Ltd. | Method of targeting senescent cells |
| CA3047140A1 (en) | 2017-01-09 | 2018-07-12 | Oisin Biotechnologies | Constructs for expression of therapeutic proteins in target cells |
| JP7592493B2 (ja) | 2018-04-18 | 2024-12-02 | オイシン バイオテクノロジーズ,インク. | 治療用タンパク質の標的細胞に特異的な産生のための、および、標的細胞に関連する疾患、疾病、または障害の処置のための、融合性脂質ナノ粒子、および、融合性脂質ナノ粒子の製造方法と使用方法 |
| WO2020163408A2 (en) | 2019-02-04 | 2020-08-13 | Oisin Biotechnologies, Inc. | Fusogenic lipid nanoparticles for the target cell-specific production of rapamycin inducible therapeutic proteins |
-
2018
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- 2018-01-09 CN CN201880015966.9A patent/CN110678208B/zh active Active
- 2018-01-09 WO PCT/US2018/013033 patent/WO2018129563A1/en not_active Ceased
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- 2018-01-09 JP JP2019557538A patent/JP2020503390A/ja active Pending
- 2018-01-09 US US16/476,865 patent/US11525146B2/en active Active
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2022
- 2022-11-08 US US17/983,167 patent/US20230220422A1/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999009191A1 (fr) * | 1997-08-20 | 1999-02-25 | Dnavec Research Inc. | Vecteurs de traitement du cancer |
| WO2006043354A1 (ja) * | 2004-10-20 | 2006-04-27 | National Institute Of Radiological Sciences | 組込型の低線量放射線誘導性ベクター |
| WO2012177927A1 (en) * | 2011-06-21 | 2012-12-27 | Mayo Foundation For Medical Education And Research | Transgenic animals capable of being induced to delete senescent cells |
| WO2014160661A2 (en) * | 2013-03-24 | 2014-10-02 | Oisin Biotechnologies | Systems and methods for the targeted production of a therapeutic protein within a target cell |
Non-Patent Citations (2)
| Title |
|---|
| BIOCHIM. BIOPHYS. ACTA (1993)VOL.1155, ISSUE 2, P.181-205, JPN6022035644, ISSN: 0005062598 * |
| CANCER RES. (2006) VOL.66,ISSUE 14, P.6982-6989, JPN6022035643, ISSN: 0005062599 * |
Also Published As
| Publication number | Publication date |
|---|---|
| US11525146B2 (en) | 2022-12-13 |
| WO2018129563A1 (en) | 2018-07-12 |
| CN110678208A (zh) | 2020-01-10 |
| AU2018206485A1 (en) | 2019-07-11 |
| EP3565607A1 (en) | 2019-11-13 |
| AU2018206485B2 (en) | 2024-12-05 |
| CA3047140A1 (en) | 2018-07-12 |
| EP3565607A4 (en) | 2020-11-18 |
| US20190330657A1 (en) | 2019-10-31 |
| CN110678208B (zh) | 2024-04-05 |
| US20230220422A1 (en) | 2023-07-13 |
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