JP2020501510A5 - - Google Patents
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- Publication number
- JP2020501510A5 JP2020501510A5 JP2019515416A JP2019515416A JP2020501510A5 JP 2020501510 A5 JP2020501510 A5 JP 2020501510A5 JP 2019515416 A JP2019515416 A JP 2019515416A JP 2019515416 A JP2019515416 A JP 2019515416A JP 2020501510 A5 JP2020501510 A5 JP 2020501510A5
- Authority
- JP
- Japan
- Prior art keywords
- anchor domain
- binding
- polypeptide
- tnfα
- eye
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229920001184 polypeptide Polymers 0.000 claims description 69
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 69
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 69
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims description 52
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims description 52
- 230000001225 therapeutic effect Effects 0.000 claims description 48
- 102000037865 fusion proteins Human genes 0.000 claims description 30
- 108020001507 fusion proteins Proteins 0.000 claims description 30
- 102000008186 Collagen Human genes 0.000 claims description 26
- 108010035532 Collagen Proteins 0.000 claims description 26
- 108060008683 Tumor Necrosis Factor Receptor Proteins 0.000 claims description 26
- 229920001436 collagen Polymers 0.000 claims description 26
- 102000003298 tumor necrosis factor receptor Human genes 0.000 claims description 26
- 102000004889 Interleukin-6 Human genes 0.000 claims description 24
- 108090001005 Interleukin-6 Proteins 0.000 claims description 24
- 239000003112 inhibitor Substances 0.000 claims description 24
- 101001076407 Homo sapiens Interleukin-1 receptor antagonist protein Proteins 0.000 claims description 22
- 229940119178 Interleukin 1 receptor antagonist Drugs 0.000 claims description 22
- 102000051628 Interleukin-1 receptor antagonist Human genes 0.000 claims description 22
- 239000003407 interleukin 1 receptor blocking agent Substances 0.000 claims description 22
- 102000004887 Transforming Growth Factor beta Human genes 0.000 claims description 20
- 108090001012 Transforming Growth Factor beta Proteins 0.000 claims description 20
- 239000005557 antagonist Substances 0.000 claims description 20
- 239000008194 pharmaceutical composition Substances 0.000 claims description 20
- 108010038196 saccharide-binding proteins Proteins 0.000 claims description 18
- 102000003814 Interleukin-10 Human genes 0.000 claims description 16
- 108090000174 Interleukin-10 Proteins 0.000 claims description 16
- 108090001090 Lectins Proteins 0.000 claims description 16
- 102000004856 Lectins Human genes 0.000 claims description 16
- 239000002523 lectin Substances 0.000 claims description 16
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 15
- 208000035475 disorder Diseases 0.000 claims description 15
- -1 P144 Proteins 0.000 claims description 14
- 206010061218 Inflammation Diseases 0.000 claims description 10
- 230000004054 inflammatory process Effects 0.000 claims description 10
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 8
- 208000006069 Corneal Opacity Diseases 0.000 claims description 6
- 208000003556 Dry Eye Syndromes Diseases 0.000 claims description 6
- 206010013774 Dry eye Diseases 0.000 claims description 6
- 102000015696 Interleukins Human genes 0.000 claims description 6
- 108010063738 Interleukins Proteins 0.000 claims description 6
- 231100000269 corneal opacity Toxicity 0.000 claims description 6
- 102000039446 nucleic acids Human genes 0.000 claims description 6
- 108020004707 nucleic acids Proteins 0.000 claims description 6
- 150000007523 nucleic acids Chemical class 0.000 claims description 6
- 230000037390 scarring Effects 0.000 claims description 6
- 208000035143 Bacterial infection Diseases 0.000 claims description 4
- 241000193403 Clostridium Species 0.000 claims description 4
- 102000029816 Collagenase Human genes 0.000 claims description 4
- 108060005980 Collagenase Proteins 0.000 claims description 4
- 208000022362 bacterial infectious disease Diseases 0.000 claims description 4
- 229960002424 collagenase Drugs 0.000 claims description 4
- 102000004169 proteins and genes Human genes 0.000 claims description 4
- 108090000623 proteins and genes Proteins 0.000 claims description 4
- 239000003937 drug carrier Substances 0.000 claims description 3
- 238000011200 topical administration Methods 0.000 claims description 3
- 241000224422 Acanthamoeba Species 0.000 claims description 2
- 108010062580 Concanavalin A Proteins 0.000 claims description 2
- 206010017533 Fungal infection Diseases 0.000 claims description 2
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims description 2
- 108060003951 Immunoglobulin Proteins 0.000 claims description 2
- 102000014150 Interferons Human genes 0.000 claims description 2
- 108010050904 Interferons Proteins 0.000 claims description 2
- 208000031888 Mycoses Diseases 0.000 claims description 2
- 208000021386 Sjogren Syndrome Diseases 0.000 claims description 2
- 101710120037 Toxin CcdB Proteins 0.000 claims description 2
- 208000036142 Viral infection Diseases 0.000 claims description 2
- 230000001580 bacterial effect Effects 0.000 claims description 2
- 239000003795 chemical substances by application Substances 0.000 claims description 2
- 239000013604 expression vector Substances 0.000 claims description 2
- 239000012634 fragment Substances 0.000 claims description 2
- 230000002538 fungal effect Effects 0.000 claims description 2
- 229960002897 heparin Drugs 0.000 claims description 2
- 229920000669 heparin Polymers 0.000 claims description 2
- 102000018358 immunoglobulin Human genes 0.000 claims description 2
- 206010023332 keratitis Diseases 0.000 claims description 2
- 108010026228 mRNA guanylyltransferase Proteins 0.000 claims description 2
- ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 claims description 2
- 230000009385 viral infection Effects 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims 29
- 238000004873 anchoring Methods 0.000 claims 3
- 102000009618 Transforming Growth Factors Human genes 0.000 claims 2
- 108010009583 Transforming Growth Factors Proteins 0.000 claims 2
- 108010046516 Wheat Germ Agglutinins Proteins 0.000 claims 2
- 208000030533 eye disease Diseases 0.000 claims 1
- 230000005764 inhibitory process Effects 0.000 claims 1
- 229940047124 interferons Drugs 0.000 claims 1
- 108010084553 jacalin Proteins 0.000 claims 1
- 238000000034 method Methods 0.000 description 14
- 108010047303 von Willebrand Factor Proteins 0.000 description 10
- 102100036537 von Willebrand factor Human genes 0.000 description 10
- 229960001134 von willebrand factor Drugs 0.000 description 10
- 102000004551 Interleukin-10 Receptors Human genes 0.000 description 2
- 108010017550 Interleukin-10 Receptors Proteins 0.000 description 2
- 241000209140 Triticum Species 0.000 description 1
- 235000021307 Triticum Nutrition 0.000 description 1
- 229940079322 interferon Drugs 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662396958P | 2016-09-20 | 2016-09-20 | |
| US62/396,958 | 2016-09-20 | ||
| PCT/US2017/052288 WO2018057522A1 (en) | 2016-09-20 | 2017-09-19 | Harnessing protein-based drugs comprising an anchor domain for use on the ocular surface |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2020501510A JP2020501510A (ja) | 2020-01-23 |
| JP2020501510A5 true JP2020501510A5 (OSRAM) | 2020-10-08 |
Family
ID=61690642
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019515416A Pending JP2020501510A (ja) | 2016-09-20 | 2017-09-19 | 目の表面で使用するためのアンカードメインを含む繋留タンパク質に基づく薬物 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20200331984A1 (OSRAM) |
| EP (1) | EP3516063A4 (OSRAM) |
| JP (1) | JP2020501510A (OSRAM) |
| AU (1) | AU2017330565A1 (OSRAM) |
| WO (1) | WO2018057522A1 (OSRAM) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2019232729B2 (en) * | 2018-03-05 | 2024-08-08 | The University Of Chicago | Methods and compositions for treating cancer with ECM-affinity peptides linked to cytokines |
| EP3762429A4 (en) | 2018-03-09 | 2022-03-23 | University of Pittsburgh - Of the Commonwealth System of Higher Education | DELIVERY OF BIOLOGICAL AGENTS TO TISSUE |
| WO2021081345A1 (en) * | 2019-10-25 | 2021-04-29 | Mayo Foundation For Medical Education And Research | Bi-peptide with affinity to extracellular matrix proteins or cells and to growth factors for tissue healing and regeneration |
| US20230272045A1 (en) * | 2020-06-12 | 2023-08-31 | Monash University | Il-1 receptor antagonist (il-1 ra) fusion proteins binding to the extracellular matrix |
| US20240043818A1 (en) * | 2020-10-15 | 2024-02-08 | Northeastern University | Engineered Cells for Increased Collagen Production |
| WO2023215269A1 (en) * | 2022-05-06 | 2023-11-09 | The Regents Of The University Of California | Lacripep promotes neuroregeneration and maintains epithelial progenitor cell identity |
| EP4615482A2 (en) * | 2022-11-08 | 2025-09-17 | Nextcure, Inc. | Immune checkpoint inhibitor and extracellular matrix component binder combination therapy and methods of use thereof |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6387663B1 (en) * | 1998-07-31 | 2002-05-14 | University Of Southern California | Targeting pharmaceutical agents to injured tissues |
| US20040224010A1 (en) * | 2002-11-15 | 2004-11-11 | Optime Therapeutics, Inc. | Ophthalmic liposome compositions and uses thereof |
| KR20120063475A (ko) * | 2009-07-29 | 2012-06-15 | 글락소 그룹 리미티드 | 항-ｔｇｆ-베타 수용체 타입 ⅱ 단일 도메인 항체 |
| EP3527222B1 (en) * | 2011-02-15 | 2021-04-07 | Vaxiion Therapeutics, LLC | Therapeutic compositions and methods for antibody and fc-containing targeting molecule-based targeted delivery of bioactive molecules by bacterial minicells |
| US9421245B2 (en) * | 2012-06-25 | 2016-08-23 | The Brigham And Women's Hospital, Inc. | Targeted therapeutics |
| WO2014089267A1 (en) * | 2012-12-05 | 2014-06-12 | Eleven Biotherapeutics, Inc. | Galectin-3 fusion proteins |
| EP2934400A1 (en) * | 2012-12-19 | 2015-10-28 | Glaxo Group Limited | Guide device for a liquid dispenser |
| HUE052232T2 (hu) * | 2013-05-06 | 2021-04-28 | Scholar Rock Inc | Készítmények és eljárások növekedési faktor modulálására |
| WO2014197485A1 (en) * | 2013-06-03 | 2014-12-11 | Ansun Biopharma, Inc. | Anti-viral therapeutic for infection of the eye |
-
2017
- 2017-09-19 WO PCT/US2017/052288 patent/WO2018057522A1/en not_active Ceased
- 2017-09-19 AU AU2017330565A patent/AU2017330565A1/en not_active Abandoned
- 2017-09-19 US US16/334,691 patent/US20200331984A1/en not_active Abandoned
- 2017-09-19 JP JP2019515416A patent/JP2020501510A/ja active Pending
- 2017-09-19 EP EP17853753.6A patent/EP3516063A4/en not_active Withdrawn
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