JP2020193185A - クサソテツ抽出物を調製する方法 - Google Patents
クサソテツ抽出物を調製する方法 Download PDFInfo
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- JP2020193185A JP2020193185A JP2019101423A JP2019101423A JP2020193185A JP 2020193185 A JP2020193185 A JP 2020193185A JP 2019101423 A JP2019101423 A JP 2019101423A JP 2019101423 A JP2019101423 A JP 2019101423A JP 2020193185 A JP2020193185 A JP 2020193185A
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- nanobubble
- extract
- water
- hair
- carbon dioxide
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Abstract
Description
(1)ナノ化した微細な気泡を含有するナノバブル液とクサソテツ(Matteuccia struthiopteris)とを接触させることによりクサソテツ抽出物を調製する方法。
(2)ナノ化した微細な気泡が二酸化炭素である、(1)に記載の方法。
(3)ナノバブル液がナノバブル水である、(1)又は(2)に記載の方法。
(4)ナノ化した微細な気泡を含有するナノバブル液を用いてクサソテツ(Matteuccia struthiopteris)から抽出されたクサソテツ抽出物。
(5)ナノ化した微細な気泡が二酸化炭素である、(4)に記載のクサソテツ抽出物。
(6)ナノバブル液がナノバブル水である、(4)又は(5)に記載のクサソテツ抽出物。
(7)(4)〜(6)のいずれか1つに記載のクサソテツ抽出物を含む組成物。
(8)ナノ化した微細な気泡を含有するナノバブル液をさらに含む、(7)に記載の組成物。
(9)ナノ化した微細な気泡が二酸化炭素である、(8)に記載の組成物。
(10)ナノバブル液がナノバブル水である、(8)又は(9)に記載の組成物。
(11)縮毛矯正作用を有する縮毛矯正用組成物である、(7)〜(10)のいずれか1つに記載の組成物。
(12)抗酸化機能を有する抗酸化用組成物である、(7)〜(11)のいずれか1つに記載の組成物。
(13)(4)〜(6)のいずれか1つに記載のクサソテツ抽出物又は(7)〜(12)のいずれか1つに記載の組成物を含む化粧料。
コラーゲン、コラーゲン加水分解物、ゼラチン、ゼラチン加水分解物、エラスチン、エラスチン加水分解物、ラクトフェリン、ケラチン、ケラチン加水分解物、カゼイン、アルブミン、ローヤルゼリー由来タンパク加水分解物、ハチミツ由来タンパク加水分解物などのタンパク質及びタンパク質の加水分解物;
ホオズキ、ラカンカ、ナツメ、ハト麦、甘草、杜仲、ショウガ、ウドなどの生薬;
酵母エキスなどの微生物由来物;
菌体、菌核、キノコなどの菌由来物;
海藻末や海藻エキスなどの海藻由来の多糖類;
プラセンタエキスなどの動物由来物;
炭酸水や温泉水、精製水、蒸留水などの水;
カルボキシビニルポリマー及びその塩、ポリアクリル酸及びその塩、カルボキシメチルセルロース及びその塩などの酸性ポリマー、ポリビニルアルコール、ヒドロキシエチルセルロース、ヒドロキシプロピルセルロース、メチルセルロース、ポリエチレングリコール、ポリビニルピロリドン、ニトロセルロースポリビニルメチルエーテルなどの中性ポリマー;
エタノール、イソプロピルアルコールなどの低級アルコール類;
パラアミノ安息香酸系紫外線吸収剤、サリチル酸系紫外線吸収剤、桂皮酸系紫外線吸収剤、アントラニエール酸系紫外線吸収剤、ベンゾフェノン系紫外線吸収剤などの紫外線吸収剤;
ステアリン酸エステル、ノルジヒドログアセレテン酸、ジブチルヒドロキシトルエン、ブチルヒドロキシアニソール、パラヒドロキシアニソール、没食子酸プロピル、セサモール、セサモリン、ゴシポールなどの抗酸化剤;
パラ安息香酸メチル、パラ安息香酸エチル、パラ安息香酸プロピル、パラ安息香酸ブチルなどのパラ安息香酸エステル類、ソルビン酸、デヒドロ酢酸、フェノキシエタノール、安息香酸などの防腐剤;
グリセリン、1,3−ブチレングリコール、プロピレングリコールなどの多価アルコール類;
L−アスパラギン酸、DL−アラニン、L−アルギニン、L−システイン、L−グルタミン酸、グリシンなどのアミノ酸類及びその塩;
マルチトール、ソルビトール、キシロビオース、N−アセチル−D−グルコサミン、蜂蜜などの糖類;
クエン酸、乳酸、α−ヒドロキシ酢酸、ピロリドンカルボン酸などの有機酸類及びその塩類;
流動パラフィン、スクワラン、ワセリンなどの炭化水素類;
オリーブ油、ヤシ油、月見草油、ホホバ油、ヒマシ油、硬化ヒマシ油などの油脂類;
ラウリン酸、ミリスチル酸、パルミチン酸、ステアリン酸、ベヘニン酸などの脂肪酸類;
ミリスチルアルコール、セタノール、セトステアリルアルコール、ステアリルアルコール、ベヘニルアルコールなどの高級アルコール類;
ミリスチン酸イソプロピル、パルミチン酸イソプロピル、オクタン酸セチル、トリオクタン酸グリセリン、ミリスチン酸オクチルドデシル、ステアリン酸オクチル、ステアリン酸ステアリルなどのエステル類;
ウシ骨髄脂やウシ脳脂質などの動植物由来脂質;
ラウリル硫酸アンモニウム、ラウリル硫酸エタノールアミン、ラウリル硫酸ナトリウム、ラウリル硫酸トリエタノールアミンなどのアルキル硫酸塩;
ポリオキシエチレン(2EO)ラウリルエーテル硫酸トリエタノールアミン(なお、EOはエチレンオキサイドでEOの前の数値はエチレンオキサイドの付加モル数を示す;)、ポリオキシエチレン(3EO)アルキル(炭素数11〜15のいずれか又は2種以上の混合物)エーテル硫酸ナトリウムなどのポリオキシエチレンアルキル硫酸塩;
ポリオキシエチレン(3EO)トリデシルエーテル酢酸ナトリウムなどのポリオキシエチレンアルキルエーテル硫酸塩;
チオグリコール酸及びその塩;
システアミン及びその塩;
過酸化水素、過硫酸塩、過ほう酸塩、過酸化尿素などの過酸化物;
臭素酸ナトリウム、臭素酸カリウムなどの臭素酸塩;並びに
少なくともこれらの成分は本発明の化粧料と共に配合し、併用して用いることができる。
これら実施例に限定されるものではない。
ウォーターナノサイクロン方式の多機能型混合装置(CO2システムズ株式会社製)に流量5L/min、水温38℃の脱塩水を流しながら、供給圧力0.3Mpaに設定した二酸化炭素を注入し、二酸化炭素ナノバブル水を10L調製した。
クサソテツの若芽であるコゴミの乾燥物の粉砕物、フキノトウ乾燥物の粉砕物、タラの芽乾燥物の粉砕物、ゼンマイ乾燥物の粉砕物各10gを上述の通り調製した二酸化炭素ナノバブル水190gに浸漬し、室温で24時間かけて抽出をおこなった。抽出後の溶液を10,000gで10分間遠心分離し、溶液中の沈殿物を濾過により除去し、清澄な各植物の二酸化炭素ナノバブル水抽出物を得た。その後固形分濃度を算出し、1%になるように二酸化炭素ナノバブル水にて希釈調整した。各植物の二酸化炭素ナノバブル水抽出物を以下にまとめる。
実施例1:クサソテツ二酸化炭素ナノバブル水抽出物
比較例1:フキノトウ二酸化炭素ナノバブル水抽出物
比較例2:タラの芽二酸化炭素ナノバブル水抽出物
比較例3:ゼンマイ二酸化炭素ナノバブル水抽出物
クサソテツの若芽であるコゴミの乾燥物の粉砕物、フキノトウ乾燥物の粉砕物、タラの芽乾燥物の粉砕物、ゼンマイ乾燥物の粉砕物各10gを脱塩水190gに浸し、室温で24時間かけて抽出をおこなった。抽出後の溶液を10,000gで10分間遠心分離し、溶液中の沈殿物を濾過により除去し、清澄な各植物の水抽出物を得た。その後固形分濃度を算出し、1%になるように脱塩水にて希釈調整した。各植物の水抽出物を以下にまとめる。
比較例4:クサソテツ水抽出物
比較例5:フキノトウ水抽出物
比較例6:タラの芽水抽出物
比較例7:ゼンマイ水抽出物
実施例1のクサソテツ二酸化炭素ナノバブル水抽出物の縮毛矯正作用を評価した。縮毛モデルであるインド人毛髪束を脱塩水にて水洗し、汚れを除去した後、一晩自然乾燥させた。この時点を試験前とし、毛髪束の状態を撮影した。その後、毛髪束を実施例1のクサソテツ二酸化炭素ナノバブル水抽出物又は水道水に3分間浸漬した。軽くタオルドライし、毛髪束を真っすぐに伸ばした状態で整え、ドライヤーで乾燥させた。その後1時間放置した。この時点を試験後として毛髪束の状態を撮影し、試験前のものと比較した。
各植物の二酸化炭素ナノバブル水抽出物と各植物の水抽出物の抗酸化作用を、DPPHラジカル消去法により評価した。DPPHラジカル消去法とは、可視部に吸収を持ち、かつ還元されると吸収を示さなくなる安定ラジカルであるDPPH(1,1−ジフェニル−2−ピクリル−ヒドラジル)と抗酸化物質(すなわち、実施例1及び比較例1〜7)とを反応させた後、抗酸化物質で還元されなかったDPPH量を吸光度測定により決定することに基づいて、抗酸化物質の抗酸化能を評価する方法である。試験液は、実施例1及び比較例1〜3の各植物の二酸化炭素ナノバブル水抽出物と、比較例4〜7の各植物の水抽出物とした。実施例1及び比較例1〜3の抽出物は二酸化炭素ナノバブル水、比較例4〜7の抽出物は脱塩水にて1000ppm(終濃度250ppm)、2000ppm(終濃度500ppm)になるように希釈調整した。反応指示薬(800μM 1,1−ジフェニル−2−ピクリル−ヒドラジル12mL,400mM 2−モルホリノエタンスルホン酸緩衝液12mL,50%エタノール水溶液24mL)900μLを試験管に分注し、そこに試験液300μLを加え、ボルテックスミキサーでミキシングし、試験液添加の20分後に520nmでの吸光度を測定した。コントロールとして各試験液の代わりに、各試験液の抽出溶媒と対応した二酸化炭素ナノバブル水又は脱塩水を添加して、同様の反応及び測定をおこなった。各試験液のラジカル消去率を、コントロールの測定値と比較して以下のように算出した。
*コントロールは二酸化炭素ナノバブル水又は脱塩水
各植物の二酸化炭素ナノバブル水抽出物と各植物の水抽出物のスーパーオキシド消去作用を評価した。試験液は、実施例1及び比較例1〜3の各植物の二酸化炭素ナノバブル水抽出物と、比較例4〜7の各植物の水抽出物とした。実施例1及び比較例1〜3の抽出物は二酸化炭素ナノバブル水、比較例4〜7の抽出物は脱塩水にて1000ppmに希釈調整した。その後、各抽出物を段階希釈することで125ppm、250ppm、500ppmの試験液を調製した。Nitroblue tetrazolium(NBT)(+)試薬[2.5mM NBT水溶液、10mM EDTA−2Na水溶液、5mM Hypoxanthine水溶液、PBS(−)含有]、NBT(−)試薬[蒸留水、10mM EDTA−2Na水溶液、5mM Hypoxanthine水溶液、PBS(−)含有]、1mg/mL BSAにてXanthine oxidase溶液を調製し、96wellプレートを用いて各wellに試験液25μLとNBT(+)試薬又はNBT(−)試薬それぞれ25μL添加して混合した。そこにXanthine oxidase溶液を25μL添加混合し、37℃のインキュベーターにて30分間静置後に、マイクロプレートリーダーを使用し、560nmの吸光度を測定した。コントロールとして各試験液の代わりに、各試験液の抽出溶媒と対応した二酸化炭素ナノバブル水又は脱塩水を添加して、同様の反応及び測定をおこなった。各試験液のスーパーオキシド消去率を、各抽出物の抽出溶媒に対応したコントロールの測定値と比較して以下のように算出した。
各植物の二酸化炭素ナノバブル水抽出物と各植物の水抽出物の活性酸素産生抑制作用を評価した。96well細胞培養プレートにて5%FBS(ウシ胎児血清)添加DMEM培地に懸濁した正常ヒト新生児皮膚由来線維芽細胞を、セミコンフルエントになるまで培養した(37℃、CO2インキュベーター)。培地を除去し、リン酸緩衝液(−)にて1回洗浄した細胞に、実施例1若しくは比較例1〜3の各植物の二酸化炭素ナノバブル水抽出物、又は比較例4〜7の各植物の水抽出物を500ppmになるように調整したDMEM培地(FBS0.5%)を試験液として加え、一晩培養した。培養後、培地を除去し、Hanks緩衝液(+)にて2回洗浄した。Hanks緩衝液(+)にて20μMに希釈した 2’,7’−Dichlorofluorescin diacetate(H2DCFDA)を100μL添加し、30分間培養した。培養後、培地を除去し、Hanks緩衝液(+)にて2回洗浄した。その後、人為的に細胞内に活性酸素を産生させるため、過酸化水素(H2O2)を添加したH2O2処理区を作成するために、Hanks緩衝液(+)にて調製した500μMH2O2を100μL/添加し、15分間培養した。Hanks緩衝液(+)にて2回洗浄後、Hanks緩衝液(+)100μLを添加し、well内の蛍光強度(Ex485nm、Em535nm)をマイクロプレートリーダーにて測定した。測定後、0.5%TritonX−100含有のリン酸緩衝液(−)を添加し、ホモジナイズして細胞を破砕し細胞破砕液を得た。各wellあたりのタンパク質量は、この細胞破砕液を用いてDC Protein Assay Kit(BIO−RAD)にて測定した。コントロールとして、各試験液の抽出溶媒と対応した二酸化炭素ナノバブル水又は脱塩水を添加したDMEM培地(FBS0.5%)を添加し、同様に操作した。各試験液の活性酸素産生抑制作用を、活性酸素産生量を以下のように算出することで示した。
2.ややキシミがあり、かつ櫛通りも少し悪い
3.変わらず
4.やや滑らかで、かつ櫛通りも少し良い
5.滑らかでしなやかさもあり、かつ櫛通りも良い
2.刺激を感じる
3.やや刺激を感じる
4.刺激を感じない
2.やや悪化した
3.変わらず
4.やや改善した
5.改善した
2.やや悪化した
3.変わらず
4.やや改善した
5.改善した
Claims (13)
- ナノ化した微細な気泡を含有するナノバブル液とクサソテツ(Matteuccia struthiopteris)とを接触させることによりクサソテツ抽出物を調製する方法。
- ナノ化した微細な気泡が二酸化炭素である、請求項1に記載の方法。
- ナノバブル液がナノバブル水である、請求項1又は2に記載の方法。
- ナノ化した微細な気泡を含有するナノバブル液を用いてクサソテツ(Matteuccia struthiopteris)から抽出されたクサソテツ抽出物。
- ナノ化した微細な気泡が二酸化炭素である、請求項4に記載のクサソテツ抽出物。
- ナノバブル液がナノバブル水である、請求項4又は5に記載のクサソテツ抽出物。
- 請求項4〜6のいずれか一項に記載のクサソテツ抽出物を含む組成物。
- ナノ化した微細な気泡を含有するナノバブル液をさらに含む、請求項7に記載の組成物。
- ナノ化した微細な気泡が二酸化炭素である、請求項8に記載の組成物。
- ナノバブル液がナノバブル水である、請求項8又は9に記載の組成物。
- 縮毛矯正作用を有する縮毛矯正用組成物である、請求項7〜10のいずれか一項に記載の組成物。
- 抗酸化機能を有する抗酸化用組成物である、請求項7〜11のいずれか一項に記載の組成物。
- 請求項4〜6のいずれか一項に記載のクサソテツ抽出物又は請求項7〜12のいずれか一項に記載の組成物を含む化粧料。
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