JP2020130022A - Solid oral composition - Google Patents

Abstract

To provide an acidulant-containing solid oral composition that has improved persistence of sourness while having a high content of ornithine.SOLUTION: A solid oral composition contains following components (A), (B) and (C): (A) at least one selected from ornithine and a salt thereof, (B) caffeine, and (C) acidulant 0.3-50 mass%, with a mass ratio [(B)/(A)] between component (A) and component (B) of 0.001-0.35 and a mass ratio [(A)/(C)] between component (A) and component (C) of 0.05-50.SELECTED DRAWING: None

Description

The present invention relates to solid oral compositions.

Since ornithine is a kind of amino acid and has various health functions, many foods and drinks to which ornithine is added have been put on the market in recent years (Patent Documents 1 to 3).

In addition, sourness is one of the five original tastes along with sweetness, saltiness, bitterness, and umami, and is an extremely important element for constituting the flavor of foods and drinks. Acidulants are often used for the purpose of imparting such sourness to foods and drinks (Patent Document 4).

Japanese Unexamined Patent Publication No. 2012-131735 JP-A-2010-148453 Japanese Unexamined Patent Publication No. 2015-12819 Japanese Patent No. 3481245

The present inventors have a problem that when ornithine is added to a solid oral composition containing an acidulant, not only the sourness is enhanced by ornithine, but also the sourness is excessively maintained and the refreshing feeling is impaired. I found. Then, it was found that such a problem is a problem specific to an oral composition in which the product form is solid.
An object of the present invention is to provide an acidulant-containing solid oral composition having a high content of ornithine and an improved sourness persistence.

As a result of diligent research in view of the above problems, the present inventor surprisingly found ornithine and / or a salt thereof in a solid oral composition containing an ornithine and / or a salt thereof and a specific amount of an acidulant. It was found that the persistence of sourness enhanced by ornithine can be improved by containing caffeine in a specific amount ratio and controlling the amount ratio of ornithine and / or its salt and acidulant within a specific range. It was.

That is, the present invention describes the following components (A), (B) and (C);
(A) At least one selected from ornithine and its salts,
(B) Caffeine and (C) Acidulant 0.3-50% by mass
Contains,
The mass ratio [(B) / (A)] of the component (A) to the component (B) is 0.001 to 0.35.
The mass ratio [(A) / (C)] of the component (A) to the component (C) is 0.05 to 50.
It provides a solid oral composition.

According to the present invention, it is possible to provide an acidulant-containing solid oral composition having a high content of ornithine and an improved sourness persistence.

As used herein, the term "solid oral composition" refers to a solid product that is provided for oral ingestion. The form of the solid oral composition is not particularly limited as long as it is solid at room temperature (20 ° C. ± 15 ° C.), and examples thereof include powder, granule, tablet, rod, plate, and block. it can. Among them, as the product form of the solid oral composition, powders, granules and tablets are preferable, and powders and tablets are more preferable. The solid content in the solid oral composition is usually 80% by mass or more, preferably 90% by mass or more, more preferably 93% by mass or more, still more preferably 95% by mass or more, and particularly preferably 97% by mass or more. The upper limit of the solid content is not particularly limited and may be 100% by mass. Here, the term "solid content" as used herein refers to the mass of the residue obtained by drying the sample in an electric constant temperature dryer at 105 ° C. for 3 hours to remove volatile substances.

The solid oral composition of the present invention contains at least one selected from ornithine and a salt thereof as the component (A).
The component (A) may be L-form, D-form, or a mixture thereof (for example, racemic form), but L-form is preferable. The component (A) may be a naturally derived product, a chemically synthesized product, or a commercially available product. Examples of naturally derived products include extracts from freshwater clams, and examples of chemically synthesized products include those produced by a fermentation method, which may be purified by column chromatography or the like, if necessary.

Examples of the salt of ornithine include acid addition salts, amino acid addition salts, organic amine addition salts, ammonium salts, metal salts and the like. Examples of the acid addition salt include inorganic acid salts such as hydrochloride, sulfate, nitrate and phosphate, acetate, maleate, fumarate, citrate, malate, lactate and α-ketoglutar. Examples thereof include organic acid salts such as acid salts, glucone salts and capryl salts. Examples of the amino acid salt include glycine salt, phenylalanine salt, lysine salt, aspartate, glutamic acid and the like, and examples of the organic amine addition salt include morpholine salt, piperidine salt and the like. Examples of the ammonium salt include ammonium salt, tetramethylammonium salt and the like, and examples of the metal salt include alkali metal salts such as sodium salt and potassium salt, and alkaline earth metal salts such as magnesium salt and calcium salt. Examples include aluminum salt and zinc salt. Two or more kinds of ornithine salts may be used in combination.

Among them, as the component (A), a salt of ornithine is preferable, an ornithine addition salt and an ornithine amino acid salt are more preferable, and L-ornithine hydrochloride and L-ornithine L-aspartate are even more preferable.

The content of the component (A) in the solid oral composition of the present invention is preferably 1% by mass or more, more preferably 2% by mass or more, still more preferably 3% by mass or more, from the viewpoint of strengthening ornithine and physiological effects. 4, 4% by mass or more is further preferable, 6% by mass or more is further preferable, 8% by mass or more is particularly preferable, and from the viewpoint of suppressing the enhancement of acidity by ornithine, 60% by mass or less is preferable, and 30% by mass or less is preferable. More preferably, 25% by mass or less is further preferable, 18% by mass or less is further preferable, 15% by mass or less is further preferable, and 13% by mass or less is particularly preferable. The content of the component (A) is preferably 1 to 60% by mass, more preferably 2 to 30% by mass, and further preferably 3 to 30% by mass in the solid oral composition of the present invention. It is by mass%, more preferably 4 to 25% by mass, further preferably 6 to 18% by mass, even more preferably 6 to 15% by mass, and even more preferably 8 to 13% by mass. .. When the component (A) is in the form of a salt, the content of the component (A) is a value converted to free ornithine. Further, the content of the component (A) can be measured by an analytical method suitable for the condition of the measurement sample among the commonly known measuring methods, and for example, an amino acid analyzer can be used. Specifically, the method described in the examples described later can be mentioned. At the time of measurement, appropriate treatment is performed as necessary, such as freeze-drying the sample to match the detection range of the device and removing impurities in the sample to match the separability of the device. May be given.

The solid oral composition of the present invention contains caffeine as the component (B). The component (B) may be derived from a raw material or newly added. The origin of the component (B) is not particularly limited as long as it is usually used in the field of food and drink, and may be, for example, a chemically synthesized product or a naturally derived product.

The content of the component (B) in the solid oral composition of the present invention is preferably 0.005% by mass or more, more preferably 0.01% by mass or more, and 0.03 from the viewpoint of improving the persistence of acidity. By mass% or more is further preferable, 0.07% by mass or more is particularly preferable, and from the viewpoint of suppressing bitterness derived from caffeine, 5% by mass or less is preferable, 3% by mass or less is more preferable, and 2.5% by mass or less. Is even more preferable, 1.5% by mass or less is further preferable, 0.8% by mass or less is further preferable, 0.3% by mass or less is further preferable, and 0.1% by mass or less is particularly preferable. The content of the component (B) is preferably 0.005 to 5% by mass, more preferably 0.01 to 3% by mass, and further preferably 0.01 to 3% by mass in the solid oral composition of the present invention. It is 0.03 to 2.5% by mass, more preferably 0.07 to 1.5% by mass, further preferably 0.07 to 0.8% by mass, and even more preferably 0.07 to 0.07 to 0.8% by mass. It is 0.3% by mass, and more preferably 0.07 to 0.1% by mass. When the component (B) is in the form of a hydrate, the content of the component (B) is a value converted to anhydrous. Further, the content of the component (B) can be measured by an analysis method suitable for the condition of the measurement sample among the commonly known measurement methods, and can be analyzed by, for example, liquid chromatography. .. Specifically, the method described in the examples described later can be mentioned. At the time of measurement, appropriate treatment is performed as necessary, such as freeze-drying the sample to match the detection range of the device and removing impurities in the sample to match the separability of the device. May be given.

The solid oral composition of the present invention contains an acidulant as a component (C).
The component (C) may be an organic acid, an inorganic acid, or a salt thereof, and is not particularly limited as long as it is usually used in foods and drinks. The component (C) can be contained alone or in combination of two or more.
Examples of the organic acid include citric acid, gluconic acid, malic acid, tartaric acid, ascorbic acid, succinic acid, lactic acid, fumaric acid, adipic acid, phytic acid, fumaric acid and the like. Moreover, as an inorganic acid, for example, phosphoric acid and the like can be mentioned. Examples of the salt include alkali metal salts such as potassium and sodium. Among them, from the viewpoint of sourness quality, one or more selected from citric acid, malic acid, tartaric acid and salts thereof is preferable, and one or more selected from citric acid, malic acid and tartaric acid. More preferred.

The content of the component (C) in the solid oral composition of the present invention is 0.3 to 50% by mass, but from the viewpoint of imparting acidity, 0.5% by mass or more is preferable, and 0.7% by mass or more. Is more preferable, 1.2% by mass or more is further preferable, 1.5% by mass or more is particularly preferable, and from the viewpoint of acidity balance, 40% by mass or less is preferable, 30% by mass or less is more preferable, and 20% by mass is 20% by mass. The following is more preferable, 10% by mass or less is further preferable, and 4% by mass or less is particularly preferable. The content of the component (C) is preferably 0.5 to 40% by mass, more preferably 0.5 to 30% by mass, and further preferably 0.5 to 30% by mass in the solid oral composition of the present invention. It is 0.7 to 20% by mass, more preferably 1.2 to 10% by mass, and even more preferably 1.5 to 4% by mass.

The solid oral composition of the present invention has a mass ratio [(B) / (A)] of the component (A) to the component (B) of 0.001 to 0.35, but it improves the persistence of sourness. From the viewpoint, 0.0015 or more is preferable, 0.003 or more is more preferable, 0.006 or more is further preferable, and from the viewpoint of suppressing the enhancement of sourness by ornithine, 0.3 or less is preferable, and 0.25 or less is more preferable. It is preferable, and 0.15 or less is more preferable. The range of the mass ratio [(B) / (A)] is preferably 0.0015 to 0.3, more preferably 0.0015 to 0.25, and further preferably 0.003 to 0. It is .15, and more preferably 0.006 to 0.15.

The solid oral composition of the present invention has a mass ratio [(A) / (C)] of component (A) to component (C) of 0.05 to 50, but from the viewpoint of fortifying ornithine and physiological effects. , 0.1 or more is preferable, 0.3 or more is more preferable, 1.0 or more is further preferable, 1.5 or more is further preferable, 2.5 or more is particularly preferable, and the enhancement of sourness by ornithine is suppressed. From the viewpoint, 30 or less is preferable, 15 or less is more preferable, and 10 or less is further preferable. The range of the mass ratio [(A) / (C)] is preferably 0.1 to 30, more preferably 0.3 to 15, still more preferably 1.0 to 10, and more. It is more preferably 1.5 to 10, and even more preferably 2.5 to 10.

The solid oral composition of the present invention can contain non-polymer catechins as the component (D). Here, in the present specification, "(D) non-polymeric catechins" refers to non-gallates such as catechin, gallocatechin, epicatechin and epigallocatechin, and catechin gallate, gallocatechin gallate, epicatechin gallate and epigallocate. It is a general term for gallate bodies such as catechin gallate. In the present invention, at least one of the above eight types of non-polymer catechins may be contained. The origin of the component (D) is not particularly limited as long as it is usually used in the field of foods and drinks. For example, it may be a chemically synthesized product or a product extracted from a plant containing non-polymer catechins. Good.

The content of the component (D) of the solid oral composition of the present invention is preferably 0.2% by mass or more, more preferably 2.0% by mass or more, and suppresses bitterness and astringency from the viewpoint of improving the persistence of sourness. From the viewpoint of the above, 20% by mass or less is preferable, and 5% by mass or less is more preferable. The content of the component (D) is preferably 0.2 to 20% by mass, more preferably 2.0 to 5% by mass in the solid oral composition of the present invention. The content of the component (D) is defined based on the total amount of the above eight types of non-polymer catechins. Further, the content of the component (D) can be measured by an analysis method suitable for the condition of the measurement sample among the commonly known measurement methods, and can be analyzed by, for example, liquid chromatography. is there. Specifically, the method described in the examples described later can be mentioned. At the time of measurement, appropriate treatment is performed as necessary, such as freeze-drying the sample to match the detection range of the device and removing impurities in the sample to match the separability of the device. May be given.

In addition, the solid oral composition of the present invention can contain an acceptable carrier, if necessary. Examples of the carrier include excipients (for example, starch decomposition products such as starch or dextrin, monosaccharides such as glucose, galactose and fructose, disaccharides such as sucrose, lactose, lactose and palatinose, maltulose, xylitol and sorbitol, etc. Sugar alcohols such as reduced palatinose); binders (eg, hydroxypropylmethyl cellulose, hydroxypropyl cellulose, gelatin, pregelatinized starch, polyvinylpyrrolidone, polyvinyl alcohol, purulans, methylcellulose, hardened oils, etc.); disintegrants (eg, carmellose, carme) Loin calcium, croscarmellose sodium, crospopidone, corn starch, low-substituted hydroxypropyl cellulose, etc.; Lubricants (eg, calcium stearate, magnesium stearate, sucrose fatty acid ester, sodium stearyl fumarate, talc, silicon dioxide) Etc.); Starch (eg, starch, etc.); Carriers such as oligosaccharides, agar, crystalline cellulose, light anhydrous silicic acid, calcium hydrogen phosphate, bulking agents, surfactants, dispersants, buffers, diluents, etc. Can be mentioned.

Among them, excipients are preferably used as the carrier, and among the excipients, one or more selected from dextrin and sugar alcohol is preferable. Here, the term "dextrin" as used herein is a kind of starch decomposition product, and is a compound obtained by partially hydrolyzing starch by acid treatment or heat treatment to reduce its molecular weight. When the excipient is dextrin, the dextrin may have glycosidic bonds linked in a chain, cyclically, or a mixture thereof, and the sugar binding method is not particularly limited. The dextrin equivalent (DE) of dextrin is preferably 1 to 40, more preferably 2 to 30, still more preferably 3 to 20, and even more preferably 3 to 16. Examples of the method for analyzing dextrin and dextrose equivalents (DE) include the SOMOGYI method.

When the excipient is a sugar alcohol, for example, erythritol, xylitol, mannitol, sorbitol, maltitol, isomaltitol, lactitol, palatinit and the like can be mentioned. As the sugar alcohol, one kind or two or more kinds can be used.

The content of the carrier can be appropriately set depending on the type of carrier within a range that does not impair the object of the present invention.

The solid oral composition of the present invention, if desired, contains sweeteners, acidulants, carbon dioxide, flavors, vitamins, minerals, antioxidants, various esters, emulsifiers, preservatives, seasonings, tea extracts, fruit juice extracts, vegetables. It can contain one or more additives such as extracts, honey extracts, and quality stabilizers. The content of the additive can be appropriately set within a range that does not impair the object of the present invention.

Food and drink can be mentioned as a preferable embodiment of the solid oral composition of the present invention. Examples of foods and drinks include, but are not limited to, instant beverages; confectioneries such as jellies, gummies, candies, snacks, biscuits, chocolates, and rice crackers. Foods and drinks can also be health foods (foods with nutritional function, foods for specified health use, dietary supplements, dietary supplements, supplements, etc.). Of these, granules, tablets, capsules, powders, pills, chewables, troches and the like are preferred.

In addition, the solid oral composition of the present invention may be added to foods and drinks.
Foods and drinks to which the solid oral composition of the present invention is added are not particularly limited, but for example, carbonated drinks, fruit juice drinks, vegetable juices, sports drinks, nutritional drinks, coffee drinks, cocoa drinks, tea drinks, dairy drinks, and lactic acid bacteria drinks. , General beverages such as soy milk beverages, desserts such as yogurt, jelly, pudding, mousse, water sheep syrup, frozen desserts such as ice cream, lacto ice, ice milk, sherbet, cakes, cookies, biscuits, chocolate, pies, crackers, snacks , Chewing gum, hard candy, soft candy, nougat, jelly beans, gummy, bun, roasted rice cake, shaved rice cake, hail, sheep dessert and other sweets, sauce, tomato ketchup, sauce, noodle soup, syrup and other seasonings, cream, jam, bread , Kneaded products, processed meat products, retort foods, canned foods, pickles, boiled foods, frozen foods and the like.

The method for adding the solid oral composition of the present invention is not particularly limited, and for example, the solid oral composition may be directly added to food or drink, or diluted with a liquid such as water and then added to food or drink. Examples thereof include coating on products, filling, use as kneading on dough during a manufacturing process, and the like, as long as the food or drink to be finally eaten contains a solid oral composition. Among them, as a preferable addition method, there is a mode of sprinkling directly on food and drink to eat.

The amount of the solid oral composition added of the present invention can be appropriately selected depending on the type of food and drink, but the solid oral composition is usually 0.01 to 30 parts by mass, preferably 0. It is 03 to 20 parts by mass, more preferably 0.05 to 15 parts by mass, and particularly preferably 0.1 to 10 parts by mass.

The solid oral composition of the present invention can be produced by an appropriate method, and for example, the component (A), the component (B) and the component (C), and if necessary, other components are blended to form the component (C). It can be produced by adjusting the content, mass ratio [(B) / (A)] and mass ratio [(A) / (C)]. The mixing order of the component (A), the component (B) and the component (C) is not particularly limited, and they may be added in any order or the three components may be added at the same time. As the mixing method, an appropriate method such as stirring or shaking can be adopted, and a mixing device may be used. The mixing method of the mixing device may be a container rotating type or a container fixed type. As the container rotating type, for example, a horizontal cylindrical type, a V type, a double cone type, a cubic type and the like can be adopted. As the container fixing type, for example, a ribbon type, a screw type, a conical screw type, a paddle type, a fluidized bed type, a Philips blender and the like can be adopted. Further, it may be a granulated product by a known granulation method. Examples of the granulation method include spray granulation, fluidized bed granulation, compression granulation, rolling granulation, stirring granulation, extrusion granulation, powder coating granulation and the like. The granulation conditions can be appropriately selected depending on the granulation method. Further, in the case of tablets, either wet tableting or dry tableting may be used, and a known compression molding machine can be used.

1. 1. Analysis of ornithine and its salt After weighing 0.5 g of a sample, 25 mL of a 10 w / v% sulfolsalicylic acid solution is added, and a 3 mol / L sodium hydroxide solution is further added and mixed. Then, the pH was adjusted to 2.2 with sodium citrate buffer, and the volume was adjusted to 100 mL. The mixture was filtered through a membrane filter (GL chromatodisc 13A, pore size 0.2 μm, GL Science Co., Ltd.), and then automatically analyzed for amino acids. To serve.

Amino acid automatic analyzer Operating conditions / model: JLC-500 / V (JEOL Ltd.)
-Column: LCR-6, φ4 mm x 120 mm (JEOL Ltd.)
-Mobile phase: Lithium citrate buffer (P-12-P-15, P-21) (JEOL Ltd.)
・ Reaction solution: Ninhydrin coloring solution kit for JEOL-II (Wako Pure Chemical Industries, Ltd.)
-Flow rate: mobile phase 0.50 mL / min, reaction solution 0.30 mL / min
-Measurement wavelength: 570 nm

2. 2. Analysis of caffeine Using a high performance liquid chromatograph (model SCL-10AVP, manufactured by Shimadzu Corporation), a sample dissolved and diluted with pure water is used as a packed column for an octadecyl group-introduced liquid chromatograph (L-column TM ODS, 4.6 mmφ ×). 250 mm: (manufactured by Chemical Substance Evaluation and Research Organization) is attached, and the measurement is performed by the gradient method at a column temperature of 35 ° C. The mobile phase A solution is a distilled aqueous solution containing 0.1 mol / L of acetic acid, the B solution is an acetonitrile solution containing 0.1 mol / L of acetic acid, the flow velocity is 1 mL / min, the sample injection amount is 10 μL, and the UV detector wavelength is The condition is 280 nm. The gradient conditions are as follows.

Concentration gradient condition (% by volume)
Time A liquid concentration B liquid concentration 0 minutes 97% 3%
5 minutes 97% 3%
37 minutes 80% 20%
43 minutes 80% 20%
43.5 minutes 0% 100%
48.5 minutes 0% 100%
49 minutes 97% 3%
60 minutes 97% 3%

3. 3. Analysis of acidulant Analysis of carboxylic acid Add 5 mL of 5% perhydrochloric acid to 10 g of a sample, and adjust the volume to 50 mL with water. If necessary, dilute this with water so that it falls within the range of the calibration curve of various carboxylic acids, and use this as the test solution. The test solution is injected into a high performance liquid chromatograph, the electrical conductivity is measured, and various carboxylic acids are calculated from the calibration curve.

・ Separation column: Shim-pack SCR-102H (manufactured by Shimadzu Corporation)
-Mobile phase: 5 mmol / L p-toluenesulfonic acid-Detection reagent: 5 mmol / L p-toluenesulfonic acid,
100 μmol / L EDTA,
20 mmol / L Bis-Tris buffer solution / injection volume: 10 μL
・ Flow rate: 0.8 mL / min ・ Electrical conductivity detector: CDD-10AVP (manufactured by Shimadzu Corporation)
・ Temperature: 40 ℃

4. Analysis of non-polymer catechins Using a high performance liquid chromatograph (model SCL-10AVP, manufactured by Shimadzu Corporation), a sample dissolved and diluted in pure water is used as a packed column for octadecyl group-introduced liquid chromatograph (L-column TM ODS, 4). .6 mmφ x 250 mm: (manufactured by Chemical Substance Evaluation and Research Organization) is attached, and the measurement is performed by the gradient method at a column temperature of 35 ° C. The mobile phase A solution is a distilled aqueous solution containing 0.1 mol / L of acetic acid, the B solution is an acetonitrile solution containing 0.1 mol / L of acetic acid, the flow velocity is 1 mL / min, the sample injection amount is 10 μL, and the UV detector wavelength is The condition is 280 nm. The gradient conditions are as follows.

Concentration gradient condition (% by volume)
Time A liquid concentration B liquid concentration 0 minutes 97% 3%
5 minutes 97% 3%
37 minutes 80% 20%
43 minutes 80% 20%
43.5 minutes 0% 100%
48.5 minutes 0% 100%
49 minutes 97% 3%
60 minutes 97% 3%

5. Sensory Evaluation Using ornithine hydrochloride and citric acid, the intensity of sourness persistence was adjusted in 5 steps to prepare the "persistence standard solid oral composition" shown in Table 1. Then, four expert panels agreed to give the scores shown in Table 1 for each concentration of "sustainable standard solid oral composition", and then conducted a sensory test according to the following procedure. First, each specialized panel ingests the "sustainable standard solid oral composition" in order from the one with the lowest ornithine concentration, and memorizes the strength of the sourness. Next, each specialized panel ingests each persistent sourness standard solid oral composition, evaluates the degree of sourness persistence, and determines the one with the closest sourness persistence from the "persistent standard solid oral composition". To do. Then, based on the scores decided by each specialized panel, the final score was decided in increments of "0.5" by consultation. The score means that the sourness lasts longer as the number decreases, while the larger the number, the better the sourness lasts.

Examples 1 to 6 and Comparative Examples 1 and 2
Each component shown in Table 2 was uniformly mixed to prepare each solid oral composition. The obtained solid oral composition was analyzed and sensory evaluated. The results are also shown in Table 2.

Examples 7-10 and Comparative Examples 3-5
Each component shown in Table 3 was uniformly mixed to prepare each solid oral composition. The obtained solid oral composition was analyzed and sensory evaluated. The results are also shown in Table 3.

Examples 11-14 and Comparative Examples 6-9
Each component shown in Table 4 was uniformly mixed to prepare each solid oral composition. The obtained solid oral composition was analyzed and sensory evaluated. The results are also shown in Table 4 together with the results of Example 3 and Comparative Example 1.

Examples 15 and 16
Each component shown in Table 5 was uniformly mixed to prepare each solid oral composition. The obtained solid oral composition was analyzed and sensory evaluated. The results are also shown in Table 5 together with the results of Example 3.

Example 17 and Comparative Example 10
Each component shown in Table 6 was uniformly mixed to prepare each solid oral composition. The obtained solid oral composition was analyzed and sensory evaluated. The results are also shown in Table 6.

Example 18
Each component shown in Table 7 was uniformly mixed to prepare each solid oral composition. The obtained solid oral composition was analyzed and sensory evaluated. The results are also shown in Table 7 together with the results of Example 3 and Comparative Example 1.

From Tables 2 to 7, in a solid oral composition containing ornithine and / or a salt thereof and an acidulant, caffeine is contained in a constant amount ratio with respect to ornithine and / or a salt thereof, and ornithine and / or its salt. It can be seen that by controlling the amount ratio of salt and acidulant within a specific range, it is possible to improve the persistence of sourness enhanced by ornithine.

Claims (7)

The following components (A), (B) and (C);
(A) At least one selected from ornithine and its salts,
(B) Caffeine and (C) Acidulant 0.3-50% by mass
Contains,
The mass ratio [(B) / (A)] of the component (A) to the component (B) is 0.001 to 0.35.
The mass ratio [(A) / (C)] of the component (A) to the component (C) is 0.05 to 50.
Solid oral composition. The solid oral composition according to claim 1, wherein the content of the component (A) is 1 to 60% by mass. The solid oral composition according to claim 1 or 2, wherein the content of the component (B) is 0.005 to 5% by mass. The solid oral composition according to any one of claims 1 to 3, wherein the component (C) is one or more selected from citric acid, malic acid, tartaric acid and salts thereof. The solid oral composition according to any one of claims 1 to 4, further comprising non-polymer catechins as the component (D) and having a content of the component (D) of 0.2 to 20% by mass. The solid oral composition according to any one of claims 1 to 5, which is a powder or a tablet. The solid oral composition according to any one of claims 1 to 6, which is a food or drink.