JP2020130001A - 泌乳牛の乳におけるタンパク質含量増加剤 - Google Patents
泌乳牛の乳におけるタンパク質含量増加剤 Download PDFInfo
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- JP2020130001A JP2020130001A JP2019025275A JP2019025275A JP2020130001A JP 2020130001 A JP2020130001 A JP 2020130001A JP 2019025275 A JP2019025275 A JP 2019025275A JP 2019025275 A JP2019025275 A JP 2019025275A JP 2020130001 A JP2020130001 A JP 2020130001A
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- ZZVUWRFHKOJYTH-UHFFFAOYSA-N diphenhydramine Chemical group C=1C=CC=CC=1C(OCCN(C)C)C1=CC=CC=C1 ZZVUWRFHKOJYTH-UHFFFAOYSA-N 0.000 description 1
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- 125000001972 isopentyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])C([H])([H])* 0.000 description 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- CSSYQJWUGATIHM-IKGCZBKSSA-N l-phenylalanyl-l-lysyl-l-cysteinyl-l-arginyl-l-arginyl-l-tryptophyl-l-glutaminyl-l-tryptophyl-l-arginyl-l-methionyl-l-lysyl-l-lysyl-l-leucylglycyl-l-alanyl-l-prolyl-l-seryl-l-isoleucyl-l-threonyl-l-cysteinyl-l-valyl-l-arginyl-l-arginyl-l-alanyl-l-phenylal Chemical compound C([C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CS)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)C1=CC=CC=C1 CSSYQJWUGATIHM-IKGCZBKSSA-N 0.000 description 1
- 235000021242 lactoferrin Nutrition 0.000 description 1
- 229940078795 lactoferrin Drugs 0.000 description 1
- 239000004571 lime Substances 0.000 description 1
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- 229910003002 lithium salt Inorganic materials 0.000 description 1
- 159000000002 lithium salts Chemical class 0.000 description 1
- 244000144972 livestock Species 0.000 description 1
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- 239000011777 magnesium Substances 0.000 description 1
- 229940049920 malate Drugs 0.000 description 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-N malic acid Chemical compound OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 1
- 235000012054 meals Nutrition 0.000 description 1
- 229930182817 methionine Natural products 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 150000002780 morpholines Chemical class 0.000 description 1
- 125000001624 naphthyl group Chemical group 0.000 description 1
- 125000004998 naphthylethyl group Chemical group C1(=CC=CC2=CC=CC=C12)CC* 0.000 description 1
- 125000004923 naphthylmethyl group Chemical group C1(=CC=CC2=CC=CC=C12)C* 0.000 description 1
- 125000001971 neopentyl group Chemical group [H]C([*])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 125000004433 nitrogen atom Chemical group N* 0.000 description 1
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- 235000020262 oat milk Nutrition 0.000 description 1
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- 125000005561 phenanthryl group Chemical group 0.000 description 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- 125000004344 phenylpropyl group Chemical group 0.000 description 1
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
- 150000003053 piperidines Chemical class 0.000 description 1
- 238000002264 polyacrylamide gel electrophoresis Methods 0.000 description 1
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 229940002612 prodrug Drugs 0.000 description 1
- 239000000651 prodrug Substances 0.000 description 1
- 125000001725 pyrenyl group Chemical group 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 235000021003 saturated fats Nutrition 0.000 description 1
- DCKVNWZUADLDEH-UHFFFAOYSA-N sec-butyl acetate Chemical compound CCC(C)OC(C)=O DCKVNWZUADLDEH-UHFFFAOYSA-N 0.000 description 1
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 235000020374 simple syrup Nutrition 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- 239000012453 solvate Substances 0.000 description 1
- 239000004455 soybean meal Substances 0.000 description 1
- 238000007619 statistical method Methods 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
- 150000003467 sulfuric acid derivatives Chemical class 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 229940095064 tartrate Drugs 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- QEMXHQIAXOOASZ-UHFFFAOYSA-N tetramethylammonium Chemical class C[N+](C)(C)C QEMXHQIAXOOASZ-UHFFFAOYSA-N 0.000 description 1
- 229960003495 thiamine Drugs 0.000 description 1
- DPJRMOMPQZCRJU-UHFFFAOYSA-M thiamine hydrochloride Chemical compound Cl.[Cl-].CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N DPJRMOMPQZCRJU-UHFFFAOYSA-M 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 230000005944 tissue migration Effects 0.000 description 1
- 125000002221 trityl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1C([*])(C1=C(C(=C(C(=C1[H])[H])[H])[H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 description 1
- 238000000870 ultraviolet spectroscopy Methods 0.000 description 1
- AYTGUZPQPXGYFS-UHFFFAOYSA-N urea nitrate Chemical compound NC(N)=O.O[N+]([O-])=O AYTGUZPQPXGYFS-UHFFFAOYSA-N 0.000 description 1
- 229940070710 valerate Drugs 0.000 description 1
- NQPDZGIKBAWPEJ-UHFFFAOYSA-N valeric acid Chemical compound CCCCC(O)=O NQPDZGIKBAWPEJ-UHFFFAOYSA-N 0.000 description 1
- 125000003774 valeryl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 235000019155 vitamin A Nutrition 0.000 description 1
- 239000011719 vitamin A Substances 0.000 description 1
- 235000010374 vitamin B1 Nutrition 0.000 description 1
- 239000011691 vitamin B1 Substances 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
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- 235000019166 vitamin D Nutrition 0.000 description 1
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- 235000019165 vitamin E Nutrition 0.000 description 1
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- 229940046009 vitamin E Drugs 0.000 description 1
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- 229940046008 vitamin d Drugs 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 235000015099 wheat brans Nutrition 0.000 description 1
- 235000021119 whey protein Nutrition 0.000 description 1
- 235000013618 yogurt Nutrition 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 235000021247 β-casein Nutrition 0.000 description 1
- 235000021246 κ-casein Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Fodder In General (AREA)
- Feed For Specific Animals (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Description
[1]下記式(I)で示される化合物又はその塩を含有する、泌乳牛の乳におけるタンパク質含量増加剤。
[2]タンパク質が、カゼインであることを特徴とする、上記[1]記載のタンパク質含量増加剤。
[3]上記[1]又は[2]記載のタンパク質含量増加剤を添加した飼料。
[4]5−アミノレブリン酸換算で0.200〜2mg/kg体重/日を泌乳牛に経口投与することを特徴とする泌乳牛の乳におけるタンパク質含量の増加方法。
[5]タンパク質が、カゼインであることを特徴とする、上記[4]記載のタンパク質含量の増加方法。
各牛からの搾乳量はオートミルクレコーダー(オリオン機械製)によって、毎日自動的に記録された。また、A区、B区の各群について14日間のALA投与期及び14日間の未投与期のそれぞれ最後の2日間において一日に2回、各期の牛から50〜100mL採取して、データ分析用乳試料として使用した。乳組成等を分析するまで、乳試料は−30℃にて保存された。
表3から明らかなとおり、5−ALAを添加した飼料を摂取した泌乳牛において、タンパク質及びカゼイン含量が有意に増加した(p<0.05)。しかし、乳量、乳脂肪、ラクトース、非脂肪固形分、総固形分、MUNについては、コントロール群と比較して特に差異は確認できなかった。また、A区のコントロール群Aと、B区のコントロール群Bとの値に有意差は確認されず、ALA投与が、微生物及び原虫等のルーメンへの影響があるとしても、その影響は、7日間の調整期間を置くことにより、除かれることが確認された。
Claims (5)
- タンパク質が、カゼインであることを特徴とする、請求項1記載のタンパク質含量増加剤。
- 請求項1又は2記載のタンパク質含量増加剤を添加した飼料。
- 5−アミノレブリン酸換算で0.200〜2mg/kg体重/日を泌乳牛に経口投与することを特徴とする泌乳牛の乳におけるタンパク質含量の増加方法。
- タンパク質が、カゼインであることを特徴とする、請求項4記載のタンパク質含量の増加方法。
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JP2019025275A JP2020130001A (ja) | 2019-02-15 | 2019-02-15 | 泌乳牛の乳におけるタンパク質含量増加剤 |
US16/789,780 US11273136B2 (en) | 2019-02-15 | 2020-02-13 | Method for increasing protein content in milk of lactating cows |
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JP2019025275A JP2020130001A (ja) | 2019-02-15 | 2019-02-15 | 泌乳牛の乳におけるタンパク質含量増加剤 |
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CN114468130B (zh) * | 2022-01-27 | 2023-08-25 | 内蒙古农业大学 | 黑沙蒿在提升乳铁蛋白含量方面的用途及其提升乳铁蛋白的方法和饲料添加剂 |
Citations (4)
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US20030190404A1 (en) * | 2000-08-08 | 2003-10-09 | Manfred Peisker | Method and system for supplying amino acids or chemical derivatives in liquid form to ruminant livestock |
KR20030097164A (ko) * | 2002-06-19 | 2003-12-31 | (주)엔바이로젠 | 델타아미노레불린산을 함유하는 가축사료 첨가제 |
WO2006025286A1 (ja) * | 2004-09-02 | 2006-03-09 | Cosmo Oil Co., Ltd. | 健康機能向上剤 |
WO2012093533A1 (ja) * | 2011-01-07 | 2012-07-12 | 出光興産株式会社 | 反芻動物の乳量及び/または乳質向上剤、周産期病予防または治療剤、並びに繁殖効率改善剤 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
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FR2564702A1 (fr) | 1984-05-24 | 1985-11-29 | Ralston Purina Co | Supplement alimentaire pour vaches en lactation, et son application au maintien de la proportion de matieres grasses du lait produit |
KR940003473A (ko) | 1992-08-14 | 1994-03-12 | 이순목 | n-3 지방산이 축적된 우유 및 우유용 사료조성물 |
JPH06237701A (ja) | 1993-02-12 | 1994-08-30 | Ajinomoto Co Inc | 乳牛の多泌乳量高安定化用飼料及び乳量高安定化飼育方法 |
US5871773A (en) | 1994-02-23 | 1999-02-16 | Ajinomoto Co., Inc. | Method for supplementing amino acid levels in ruminant animals |
-
2019
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2020
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Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
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US20030190404A1 (en) * | 2000-08-08 | 2003-10-09 | Manfred Peisker | Method and system for supplying amino acids or chemical derivatives in liquid form to ruminant livestock |
KR20030097164A (ko) * | 2002-06-19 | 2003-12-31 | (주)엔바이로젠 | 델타아미노레불린산을 함유하는 가축사료 첨가제 |
WO2006025286A1 (ja) * | 2004-09-02 | 2006-03-09 | Cosmo Oil Co., Ltd. | 健康機能向上剤 |
WO2012093533A1 (ja) * | 2011-01-07 | 2012-07-12 | 出光興産株式会社 | 反芻動物の乳量及び/または乳質向上剤、周産期病予防または治療剤、並びに繁殖効率改善剤 |
Non-Patent Citations (1)
Title |
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